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Production of blocking Rabbit Monoclonal Antibody against human CD97

Department of Health and Human Services, National Institutes of Health | Published August 31, 2016  -  Deadline September 6, 2016
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Contracting Office AddressDepartment of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E1644, Bethesda, MD 20852, UNITED STATES.DescriptionThe National Cancer Institute (NCI), Cancer Center Research (CCR), The Laboratory of Genitourinary Cancer Pathogenesis (LGCP) plans to procure on a sole source basis for 0a custom rabbit monoclonal blocking antibody directed against human CD97 manufactured by Abcam Burlingame, 863 Mitten Road, Suite 103-104, Burlingame, CA 94010-1303. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1). Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The North American Industry Classification System code is 325414 and the business size standard is 1250. Period of performance shall be for twelve (12) months from date of award. It has been determined that there is no opportunity to acquire green products or services under this contract. The Purpose of this acquisition is to procure Production of blocking Rabbit Monoclonal Antibody against human CD97. The human CD97, a G protein-coupled receptor, is absent in normal epithelial cells but increases in expression in parallel with malignant grade in several carcinomas. Current investigative efforts toward understanding the role of CD97 in cancer biology has been hindered by the lack of a reliable CD97 blocking antibody. A blocking antibody does not have a reaction when combined with an antigen, but prevents other antibodies from combining with that antigen. Screening of current commercially available CD97 antibody sources has unfortunately failed to uncover any polyclonal or monoclonal antibodies able to block CD97 binding. Therefore, the LGCP has a need to produce a rabbit monoclonal CD97 blocking antibody to further our investigative efforts, and provide a useful tool for the CD97 research field. Antibodies from rabbits are generally of higher affinity than those from mice. Results obtained from the contractor and other researchers indicate that the binding affinity of rabbit monoclonal antibodies is on average 100 times higher, offering better sensitivity and specificity in biological assays. Rabbit monoclonal antibodies recognize many antigens that are not immunogenic in mice, including small molecule haptens, some cell surface epitopes, modified sites (e.g., phosphorylation, acetylation, methylation, glycosylation, etc.) and most rodent proteins. The rabbit system offers 40 times as many lymphocytes compared to mouse and the 240E cell line used for fusion is much more robust than any of the mouse cell lines used for fusion. Because of the large size of the rabbit spleen, more fusion experiments can be performed, making hybridoma generation at industrial scale a feasible task. The contractor shall generate up to 9 hybridoma subclones from as many as 3 parent hybridoma cell lines chosen by NCI/LGCP as a result of screening. The production required to blocking Rabbit Monoclonal Antibody possesses the following salient characteristics: Phase I: Rabbit Polyclonal Antibody Service - Immunization of two (2) rabbits using standard immunization of five (5) injections and collection of one (1) pre-bleed and two (2) test bleeds per rabbit.- Monitor antiserum titer using standard ELISA.- Counter-screen with Fc fusion protein.- Discuss titer results with NCI to select rabbit for splenectomy.- Final IV and splenectomy (Final IV must be scheduled within 4-8 weeks of last regular injection boost). Phase IIa: Rabbit Monoclonal Antibody Service - Isolate all the lymphocytes from one rabbit spleen.- Store all remaining lymphocytes in liquid nitrogen for up to three (3) months after the termination of the project. Phase IIb: Rabbit Monoclonal Antibody Service - Perform hybridoma fusion of 80 x 96-well plates.- Perform standard ELISA screening of 80 x 96-well plates.- Expand all positive hybridomas to 24-well plates and perform confirming standard ELISA.- Counter-screen with Fc Fusion Protein.- Transfer and deliver all standard ELISA positive multi-clone supernatants (1 ml each) for a two week screening by NCI. Phase IIIa: Rabbit Monoclonal Antibody Service - Subclone up to 3 multclone hybridomas chosen by NCI.- Perform standard ELISA screening of supernatants.- For each hybridoma chosen, deliver supernatants (1 ml each) from subclones for a two week screening by NCI.- Freezing and storage of backup (3) multiclone hybridomas. Phase IIIb: Rabbit Monoclonal Antibody Service - Expand up to nine (9) final hybridoma subclones from each parental clone as frozen cells.- Store subclones for three (3) months following project completion. Phase IIIc: Rabbit Monoclonal Antibody Service- Culture one (1) hybridoma subclone (1L).- Perform two (2) hybridoma supernatant harvest collections.- Perform standard ELISA screening and spectroscopic concentration determination of supernatant.- Purify the hybridoma supernatant using a Protein A column.- Analyze the purify sample via gel electrophoresis, spectroscopic concentration determination, and ELISA. QUESTIONS ARE DUE: September 2, 2016 This is not a solicitation for competitive quotations. However, if any interested parties, especially small businesses, believe they can meet the above requirement, they may submit a statement of capabilities. All information furnished must be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the above unique specifications described herein. A copy of the capability statement must be received in the NCI Office of Acquisition on or before 11:00 AM EST on September 6, 2016. All questions must be in writing and can be faxed (240) 276-5401 or emailed to Kathy Elliott, Contract Specialist at Elliottk@mail.nih.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration and certification on Sam.gov, www.sam.gov. No collect calls will be accepted. Please reference solicitation number N02RC62562-61 all correspondence.

Vitrea software maintenance and support

Department of Health and Human Services, National Institutes of Health | Published August 24, 2016  -  Deadline August 29, 2016
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DescriptionThis is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Federal Acquisition Regulation (FAR) subpart 12.6, "Streamlined Procedures for Evaluation and Solicitation for Commercial Items," as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; being requested, and a written solicitation document will not be issued. This solicitation is a Request for Quotation. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC 2005-88). The associated North American Industrial Classification System (NAICS) code for this procurement is 541519, with a small business size standard of $. The Clinical Center/Radiology & Imaging Sciences is seeking to purchase software maintenance and update support services for Vital Image's Vitrea proprietary software. This software is in daily use in the RAD & IS for critical patient care. All interested companies shall provide quotation for the following: Services  Background The mission of the National Institutes of Health (NIH) is to uncover new knowledge that will lead to better health for everyone. The NIH accomplishes that mission by conducting research in its own laboratories; supporting the research of non-Federal scientists in universities, medical schools, hospitals, and research institutions throughout the country and abroad; helping in the training of research investigators; and fostering communication of biomedical information. The NIH Clinical Center (CC) is a 234-bed federally funded, biomedical research hospital located on the NIH campus in Bethesda, Maryland. The Clinical Center is the delivery setting for all NIH intramural clinical research protocols. The hospital complex consists of two main facilities that are connected to each other by "bridges". The original 14-story building is 2.5 million square feet and continues to house the clinical laboratories, imaging sciences, surgical suites, and several outpatient clinics. The new 870,000 square foot facility houses inpatient units and day hospitals. The Clinical Center accounts for about half of all NIH-funded clinical research beds in the United States and accommodates about 7,000 inpatient and 70,000 outpatient visits a year. Patients are admitted to the NIH Clinical Center from all over the world for the sole purpose of participating in a clinical research protocol. The Department of Radiology and Imaging Sciences (RAD&IS) provides imaging services to the CC patients who participate in research protocols conducted by the various NIH institutes. Imaging services include X-rays, fluoroscopy, mammography, ultrasound, magnetic resonance imaging (MRI) scans, computed tomography (CT) scans and interventional radiology (special procedures). Diagnostic services in ultrasound, digital mammography, positron emission tomography/computed tomography (PET/CT), and nuclear medicine are also provided. All these diagnostic modalities generate clinical diagnostic images that are sent to and archived on the RAD&IS's Picture Archiving and Communication System (PACS). The departmental radiologists review the diagnostic images and dictate clinical findings using a Voice Recognition system (VRS). The finds are saved in reports which are stored in the RAD&IS's Radiology Information System (RIS) and forwarded to the Clinical Research Information System or the Clinical Center's Hospital Information System (CRIS).The Vitrea software applications are medical diagnostic imaging solutions that utilizes computerized visualization techniques to provide enhanced image displays, e.g. 3D or 4D displays. Vitrea provides the departmental radiologists with advanced visualization tools. These tools are used as a means to further process and review patient images stored in the PACS for diagnostic and research purposes. Purpose This request is for continuation of the Vitrea software support services agreement. Coverage is being requested for the period of September 1, 2016 - August 31, 2017 and will include three option periods. The Vitrea software is proprietary software licensed and manufactured by vital Images. The Vitrea software applications are medical diagnostic imaging solutions that utilizes computerized visualization techniques to provide enhanced image displays, e.g. 3D or 4D displays. Vitrea provides the departmental radiologists with advanced visualization tools. These tools are used as a means to further process and review patient images stored in the PACS for diagnostic and research purposes. Scope To provide software maintenance and support for Vital Image's Vitrea Software.1. Software support service must be provided for:a. The following Vitrea Advanced Software applications and packagesi. Vitrea Core, Enterprise enabled systemii. Vitrea Base iii. Ct Brain Perfusion 4D iv. Ct Cardiac EP Planning v. Ct Cardiac Function Analysis vi. Ct SUREPlaque Softwarevii. Ct TAVR Planning viii. Ct Multi-Chamber CFA Analysis b. Vitrea Workstation Basicc. R2 ImageChecker CT Lung, CAD Softwared. R2 AutoPoint Temporal Comparison Software2. Services must include: a. Software upgrades & updates, rapid response telephone assistance, access to interactive online portal, Vital U webinars and on-line library, on-line technical knowledgebase, remote support diagnostics. Support Hours: M-F 8:00 a.m.-5 p.m. b. Hardware support assistance, access to clinical expert for 1:1 application consultation, monthly report and review of issue tracking & resolution with a service account manager. Support Hours: 24/7 Technical Application Support  Period of Performance Base Period: September 1, 2016 - August 31, 2017Option One: September 1, 2017- August 31,2018Option Two: September 1, 2018 - August 31, 2019Option Three: September 1, 2019- August 31,2020  Delivery Location, Schedule, and Instructions National Institutes of HealthClinical Center, Building 10Radiology & Imaging Sciences Security Provisions See attached security clauses Government Furnished Equipment (GFE) There is no government furnished equipment requirements for this order. Inspection and Acceptance Criteria Services are provided on an as needed basis.The full text of FAR provisions or clauses may be accessed electronically at http://acquisition.gov/comp/far/index.html. The following solicitation provisions apply to this acquisition FAR 52.212-1, "Instructions to Offerors-Commercial Items" 1. FAR 52.212-3, "Offerors Representations and Certifications-Commercial Items" (April2016) Offerors must complete annual representations and certifications on-line at http://orca.bpn.gov in accordance with FAR 52.212-3, "Offerors Representations and Certifications-Commercial Items." If paragraph (j) of the provision is applicable, a written submission is required. The following contract clauses apply to this acquisition: • FAR 52.212-4, "Contract Terms and Conditions-Commercial Items" (May 2015)• FAR 52.212-5, "Contract Terms and Conditions Required to Implement Statutes or Executive Orders" (June2016)  All quoters shall submit a quotation which addresses all elements of the Statement of Work, includes two copies. All quotations shall be forwarded to Contract Specialist Gail Akinbinu 6707 Democracy Boulevard, Suite 106, Bethesda, MD 20892. [Electronic copies preferred addressed to gakinbinu@cc.nih.gov. This is an open-market combined synopsis/solicitation for services as defined herein. The government intends to award a purchase order as a result of this combined synopsis/solicitation that will include the terms and conditions set forth herein. To facilitate the award process, all quotes must include a statement regarding the terms and conditions herein as follows:"The terms and conditions in the solicitation are acceptable to be included in the award document without modification, deletion, or addition."  Submission shall be received not later than August 22, 2016 5:00p.m. at 6707 Democracy Boulevard, Suite 106 , Bethesda, MD 20892. Electronic mail submissions will be accepted. Late submissions shall be treated in accordance with the solicitation provision at FAR 52.212-1(f). Any questions or concerns regarding this solicitation should be forwarded in writing via e-mail to the Contract Specialist-Gail Akinbinu 6707 Democracy Boulevard, Suite 106 Bethesda, MD 20892, gakinbinu@cc.nih.gov. Please submit questions no later than August 12,2016.    

Full service maintenance contract for FMRIF 3T-D Siemens Skyra Scanner

Department of Health and Human Services, National Institutes of Health | Published August 24, 2016  -  Deadline September 8, 2016
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This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a separate written solicitation will not be issued. The solicitation number is HHS-NIH-NIDA-SSSA-CSS-2016-709 and the solicitation is issued as a Request for Quotation (RFQ). A fixed price contract type is contemplated for this requirement. This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures; FAR Subpart 13.5- Simplified Procedures for Certain Commercial Items; and FAR Part 12-Acquisition of Commercial Items, and is expected to exceed the simplified acquisition threshold. THIS IS A NON-COMPETITIVE (NOTICE OF INTENT) COMBINED SYNOPSIS SOLICITATION TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Institute on Drug Abuse (NIDA), Station Support and Simplified Acquisitions Branch (SS/SA) on behalf of the National Institute on Mental Health intends to negotiate and award a contract without providing for full and open competition to Siemens Medical Solutions, Inc. This acquisition is conducted as non-competitive for a commercial item or service and is conducted under the authority of the FAR Subpart 13.5-Simplified Procedures for Certain Commercial Items. Pursuant to FAR Subpart 13.501 (a) (1) (iii) the justification (excluding brand name) will be made available within 14 days after contract award or in the case of unusual and compelling urgency within 30 days after contract award. The solicitation document and incorporated provisions and clauses and those in effect through Federal Acquisition Circular 2006 FAC 2008-89 / 8-15-2016 The North American Industry Classification System (NAICS) code for this procurement is 811310 Commercial and Industrial Machinery and Equipment (except Automotive and Electronic) Repair and Maintenance with associated business size standard of $7,500,000.00 Background: FMRIF-3TD is a Siemens Skyra 3 Tesla MRI scanner in the Functional MRI Facility (FMRIF), NIH. It is utilized by over 30 researchers from across the institutes of NIH, on protocols both clinical and research. It is also utilized as a development platform for cutting edge technologies within the MRI community. The scanner is especially crucial for a number of clinical protocols involving Multiple Sclerosis patients. It is envisioned to continue to be a critical resource for the NIH NMR center for the foreseeable future. Scope of work: Independently and not as an agent of the Government, the Contractor will provide standard upkeep and maintenance will be required for the FMRIF-3TD Siemens Skyra 3 Tesla MRI scanner. The Contractor will take service calls for all issues with the FMRIF-#TD scanner, diagnose and repair all issues that arise with the scanner, function as experts regarding the maintenance, repair, and upkeep of the scanner, perform regular preventative maintenance on the scanner, provide the general tools and equipment as required to perform the maintenance and repairs, and provide support for modifications to hardware and software made by the customer. The maintenance services must be performed by an authorized service provider for this equipment. Anticipated period of performance: One base year from Date of AwardThe provision at FAR clause 52.212-1, Instructions to Offerors - Commercial Items, applies to this acquisition. The provision at FAR clause 52.212-2, Evaluation - Commercial Items, applies to this acquisition. This section is an addendum to the FAR clause 52.212-2, Evaluation--Commercial Items applicable to this solicitation. The provision at FAR Clause 52.212-3, Offeror Representations and Certifications Commercial Items, applies to this acquisition. The provision at FAR Clause 52.212-4, Contract Terms and Conditions-Commercial Items, applies to this acquisition. FAR Clause 52.212-5 is attached and is applicable to this acquisition. The provision of FAR clause 52.216-5, PRICE REDETERMINATION-PROSPECTIVE (OCT 1997), is included by reference and shall be applicable to any contract resulting from this solicitation. There are no additional contract requirement(s) or terms and conditions applicable to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. POST AWARD EVALUATION OF CONTRACTOR PERFORMANCE a. Contractor Performance Evaluations Interim and final evaluations of Contractor performance will be prepared on this contract in accordance with FAR Subpart 42.15. The final performance evaluation will be prepared at the time of completion of work. In addition to the final evaluation, interim evaluation(s) will be prepared annually prior to the exercise of options. Interim evaluations will not be prepared for awards with a period of performance of less than 18-months. Interim evaluations will be prepared annually for awards greater than 18-months. Interim and final evaluations will be provided to the Contractor as soon as practicable after completion of the evaluation. The Contractor will be permitted thirty days to review the document and to submit additional information or a rebutting statement. If agreement cannot be reached between the parties, the matter will be referred to an individual one level above the Contracting Officer, whose decision will be final. Copies of the evaluations, Contractor responses, and review comments, if any, will be retained as part of the contract file, and may be used to support future award decisions. b. Electronic Access to Contractor Performance Evaluations Contractors may access evaluations through a secure Web site for review and comment at the following address: http://www.cpars.gov   INSTRUCTIONS TO OFFERORS / EVALUATION CRITERIAResponses received to this RFQ will be evaluated on the basis of technical capability. The Government will award a contract resulting from this solicitation on the basis of best value, technical factors, past performance and price. The below technical factor shall be considered more important than price. The technical evaluation factors are as follows, in order of importance: 1) Factor 1: Technical Capability: Offerors shall clearly indicate their ability to provide a full service maintenance contract for this equipment, as well as documentation showing that they are an authorized service provider. Offerors submitting a response with documented evidence of possessing the technical knowledge, qualifications, capability, management structure and experience needed in successfully performing this requirement will be determined to be technically acceptable. In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All Offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All responses must be received no later than September 8th, 2016, 1:00 PM, Eastern Time, as specified in this announcement. The total number of pages, (combination of technical approach, past performance, and price quote) shall not exceed 25 pages in length, including appendices and any technical features. Pages submitted in excess of this 25-page limit will not be considered in evaluation of responses to this RFQ. A cover page may be submitted that does not count toward the 25 page limit. The Contractor shall submit its quote electronically in a "read only" format with a font size of 11 or 12 point and font type of Arial or Times New Romans. Margins must be 1-inch wide (top, bottom, left, and right). Late responses will not be accepted. All responses must reference solicitation number HHS-NIH-NIDA-SSSA-CSS-2016-709. Responses must be submitted electronically to pamela.daugherty@nih.gov. Facsimile responses will not be accepted. For information regarding this solicitation, contact Pamela Daugherty by email at pamela.daugherty@nih.gov or by phone at (301) 480-2467.  

3D ASL for General Electric MR-750 3.0T MRI Scanner

Department of Health and Human Services, National Institutes of Health | Published August 5, 2016  -  Deadline August 19, 2016
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INTRODUCTIONTHIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Institute on Drug Abuse (NIDA), Station Support and Simplified Acquisitions (SSSA) Branch intends to solicit by a request for quotation from General Electric Company, GE Healthcare for award on or around August 25, 2016. The purpose of this purchase order will be to provide the National Institute of Mental Health (NIMH) with new software 3D ASL software for the General Electric MR-750 3.0T MRI Scanner. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE and SET ASIDE STATUSThe intended procurement is classified under NAICS code 811310 with a Size Standard of $20.5 Million. This acquisition is NOT set aside for small businesses. REGULATORY AUTHORITYThis acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures. Contracts awarded using FAR Part 13-Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6-Competition Requirements. FAR Subpart 13.106-1 (b) Soliciting from a single source provides that: For purchases not exceeding the simplified acquisition threshold, Contracting officers may solicit from one source IF the contracting officer determines that the circumstances of the contract action deem only one source reasonably available (e.g., urgency, exclusive licensing agreements, brand-name OR industrial mobilization). The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2005-85 dated August 5, 2016. DESCRIPTION OF REQUIREMENTPURPOSE AND OBJECTIVES:This purchase is to provide software to allow the FMRIF 3TC MRI scanner to be able to collect and compute cerebral perfusion maps. Such data will add to that already being collected by researchers engaged in studying patients with a variety of mental conditions, ranging from children with development disorders, to older patients with motion disorders of neural origin, and should enhance understanding of these conditions. PROJECT REQUIREMENTS:The software must run on a General Electric MR-750 3 Tesla MRI scanner, running console software version DV2202. A single option key is required for GE Healthcare system ID 301496MR3T4. From the data collected, the software should compute and display quantitative maps of cerebral perfusion in a human patient. The total scan time should be less than 10 minutes and the software should be capable at providing maps anywhere in the range of 2 mm to 5mm isotropic resolution. The software and the device on which it runs are both FDA approved products, and as such, only GE Healthcare has the knowledge of the hardware and system software to have it certified by the FDA for patient use. CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATIONThe determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, GE Healthcare, Inc. is the only vendor in the marketplace that can provide the products required by NIMH. In accordance with FAR part 10, extensive market research was conducted to reach this determination. Specifically, a sources sought notice was posted to FedBizOpps referencing the above detailed requirements and no responses were received from other vendors. Additionally, contacts with knowledgeable individuals both in industry and Government, as well as reviews of available product literature, revealed no other sources. Finally, a review of the GSA Advantage, Dynamic Small Business Search, and previous government acquisitions returned no results that meet all of the requirements. Therefore, only GE Healthcare, Inc., is capable of meeting the needs of this requirement. The intended source is:General Electric, GE HealthcareP.O. Box 96483Chicago, IL 60693APPLICABLE TERMS AND CONDITIONS INCORPORATED BY REFERENCE The following FAR clauses and provisions shall apply to this solicitation:1. All Offerors MUST be actively registered in the System for Award Management (SAM) www.sam.gov. 2. The provision at FAR clause 52.212-1, Instructions to Offerors - Commercial Items (April 2014), applies to this acquisition. 3. A completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications - Commercial Items (March 2015), is required with any offer submitted. This requirement may be met by completion of the provision in the System for Award Management. 4. FAR clauses 52.212-4, Contract Terms and Conditions - Commercial Items (May 2015) and 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items (June 2016) apply to this acquisition. 5. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. In addition, the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All Offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." CLOSING STATEMENTTHIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. All responsible sources may submit a capability statement, proposal, or quotation which shall be considered by the agency. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All responses must be received by the closing date and time of this announcement and must reference the solicitation number, HHS-NIH-NIDA-SSSA-NOI-2016-607. Responses must be submitted electronically to Pamela Daugherty, Contract Specialist, at pamela.daugherty@nih.gov. U.S. Mail and Fax responses will not be accepted.

OxyCycler A420C Oxygen C02 Dual Chamber Controller

Department of Health and Human Services, National Institutes of Health | Published September 3, 2015  -  Deadline September 7, 2015
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This is a combined synopsis/solicitation for commercial items prepared in accordance notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NIHLM2015643 and is issued as a Request for Quotation (RFQ). The solicitation /contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-82. The North American Industry Classification (NAICS) Code is 334516 with a size standard of 500. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13 as supplemented by FAR Part 12 - Commercial Items. The National Institutes of Health (NIH), National Institute of Digestive, Diabetes & Kidney Diseases (NIDDK) has a requirement to procure a OxyCycler A420C Oxygen C02 Dual Chamber Controller. A420C2 OxyCycler A420C Oxygen C02 Dual Chamber Controller Package CUSA30274P GUS Animal Chamber Medium Opaque Polypropylene - 35" to Accommodate 3 Rat Cages - Same Size Door PCL PC Laptop (NIC Included) WATSOFT OxyCycler PC Operator Interface Software USBCONVERT Communication Converter Kit USB RS485 COMMCAB2 Communication Cable DSUB9 DSUB9 CS11 Cord Set North America For many years, the primary focus of our research has been on the genetic diseases of hemoglobin, including sickle cell anemia and thalassemia. More recently, the Branch had broadened its research to include other diseases of the erythroid lineage, as well as a variety or cardiovascular conditions in which regulation of blood flow via NO and other signaling molecules could have important therapeutic consequences. Most of the work is laboratory-based, but Branch members are also active investigators in multiple clinical protocols. Such clinical studies are paired with matching laboratory programs and relate to a number of areas, including: (1) developing biomarkers to predict the severity of sickle cell disease and the etiology of acute and chronic pain as part of this condition, (2) understanding the regulation of fetal hemoglobin expression during development, (3) studying the effects of erythropoietin and other signalling molecules in erythroid cells, and (4) determining the interactions of intracellular and plasma hemoglobin with NO and nitrite ions in physiology and pathology. The Branch has expanded this final area or research to a collaboration with the Clinical Center animal facility and jointly we will measure nitrite and nitrate ions in the blood of animals equilibrated with various 02 and C02 concentrations ins several cages so that we can relate the biochemical and physiological (including blood clotting) processes. This is the first time we have ordered this apparatus, which we expect to use for the next several years. The system shall provide efficient N2 and 02 gas consumption and maintain constant oxygen with a regulated tolerance of 02 tension within 0.1 %, particularly for the planned studies at normoxia (20% 02) and reduced (10% 02) oxygen environments. Custom size chambers must be available for animals of different sizes such as rats and mice. Regulate ventilation must be available for air quality and use of gas in chamber, particularly for the duration of exercise studies over several hours with regulated humidity and removal of exhaled gasses and waste vapors. The chamber shall be polypropylene and provide a constant gas environment from extreme hypoxia (0.1 % 02) to hypoxia (99.9% 02). The system shall allow upgrade to incorporate additional gasses. The requirement listed is requested to submit a capability statement to assist the Government in determining in accordance with Federal Acquisition Regulation (FAR) 19.502-2(b) whether or not this procurement will be set-aside for any of the programs described above. The intended procurement will be classified under North American Industrial Classification (NAICS) code 334516 with a size standard 500. All respondents are requested to identify their firm's size and type of business. Interested firms responding to this market survey must provide (a) capability statement demonstrating their experience, skills and capability to fulfill the Government's requirements for the above. The capability statement shall be in sufficient enough detail, but not to exceed 15 pages, so that the Government can determine the experience and capability of your firm to provide the requirements above. Your capability statement, not to exceed 15 pages, should include references. The offeror must include a completed copy of the following provisions: 1) FAR Clause 52.212-1 Instructions to Offerors - Commercial items; 2) FAR Clause 52.212-2, Evaluation - Commercial Items. As stated in FAR Clause 52.212-2 (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be advantageous to the Government, price and other factors considered. The following factors will be used equally to evaluate offers: Technical Evaluation, Price, and Past Performance. Note: Past Performance Information: Vendors must submit a listing of the most recent contracts/awards (minimum of 3) which demonstrate similar work in nature to this Solicitation. Contracts/awards may include those entered with the Federal Government, state and local governments and commercial concerns. Include the following information for each contract or subcontract: 1. Name of Contracting Organization 2. Contract Number (for subcontracts provide the prime contract number and the subcontract number) 3. Contract Type 4. Total Contract Value 5. Description of Requirement 6. Contracting Officer's Name and Telephone Number 7. Program Manager's Name and Telephone Number 3) FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items; 4) FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; 5) FAR Clause 52-212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions. The Dun and Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN) and the certification of business size shall be included. The clauses are available in full text at https://www.acquisition.gov PLEASE NOTE: In order to receive an award, contractor must be registered and have valid certification in the System For Award Management (SAM) http://www.sam.gov Interested vendors capable of providing the Government with the items specified in this synopsis should submit their quotation to the below address. Quotations will be due on or before September 7, 2015 at 11:00 a.m. EST. Offersors shall provide an original and one copy of your quotation. The quotation must reference Solicitation number NIHLM2015634. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Responses: E-MAIL will be accepted and can be sent to griffinv@mail.nih.gov and must reference solicitation number NIHLM2015643 in the subject line.

GENERATION OF LLAMA MONOCLONAL ANTIBODIES AGAINST THE E. COLLI BAMA PROTEIN

Department of Health and Human Services, National Institutes of Health | Published August 17, 2015  -  Deadline August 21, 2015
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This is a combined synopsis/solicitation for commercial items prepared in accordance notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NIHLM2015552 and is issued as a Request for Quotation (RFQ). The solicitation /contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-82. The North American Industry Classification (NAICS) Code is 334516 with a size standard of 500. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. The National Institutes of Health (NIH), National Institute of Digestive, Diabetes & Kidney Diseases (NIDDK) has a requirement to procure GENERATION OF LLAMA MONOCLONAL ANTIBODIES AGAINST THE E. COLLI BAMA PROTEIN. Unlike most mammalian antibodies, camelid monoclonal antibodies, called vHHs or nanobodies, generated in llama, camel or alpaca consist of a single heavy chain. In recent years, nanobodies have been increasingly used in structural studies and in biotechnological and pharmaceutical applications. Nanobodies are small in size and can access novel and difficult-to-reach protein epitopes that cannot be accessed by traditional antibodies. Access to smaller epitopes often leads to receptor/active-site neutralization and enzyme inhibition. A lot of research published to date demonstrates remarkable results using nanobodies against flexible multi-domain proteins, large protein complexes and membrane proteins. While the results and applications have been exceptional, the generation of nanobodies is still rather expensive. Unlike conventional antibodies, the very nature of nanobodies makes them ideal for expression in bacteria. In our case, we intend to generate a nanobody against an essential component of a multi-protein outer membrane complex in E. coli called the Bam (barrel assembly machinery) complex. This complex is essential for the biogenesis of outer membrane proteins and hence is critical for cell viability. As an essential factor the Bam complex is a potential target for the development of novel antibiotics. To date, no simple and reliable method of inactivating the Bam complex and studying the subsequent effects on cellular processes has been developed. We would like to generate a nanobody that binds effectively to a key component of the Bam complex called BamA in vivo and inactivates it. For this purpose, we need the services of a commercial vendor who specializes in llama nanobody production. We will supply the purified antigen (BamA) to the vendor who will use it to immunize a llama, generate the nanobodies, and perform screening and sequencing of the best nanobodies. At the end of the contract period, they will deliver the gene sequences of the best nanobodies against BamA to us. The gene encoding the nanobody will be cloned into an appropriate plasmid and expressed with an N-terminal signal sequence in E. coli in our laboratory. Services Required from Outside Vendors: Initially, a llama will be immunized with purified BamA provided by our laboratory. Once the llama generates a stable repertoire of antibodies against BamA, lymphocytes will be collected, the mRNAs for the nanobodies will be extracted and a phage-display vector based cDNA library will be generated by synthesizing cDNA from mRNA followed by PCR amplification and cloning into a standard phage display vector. The generated library of phages will display a different nanobody for each phage. The best binding nanobody clones will be screened from the phage-display library by multiple rounds of panning using an ELISA based screening technique. Only the phages displaying specific nanobodies that bind to BamA with high efficiency will be isolated and the nanobody DNA sequenced from the corresponding vector. The entire process from llama immunization to sequencing of the best nanobody clones will be performed by the vendor over a time frame of approximately 6 months. The vendor shall deliver the sequenced nanobody DNA to us in a plasmid and we will perform the subsequent steps of subcloning and expression in our laboratory. The requirement listed is requested to submit a capability statement to assist the Government in determining in accordance with Federal Acquisition Regulation (FAR) 19.502-2(b) whether or not this procurement will be set-aside for any of the programs described above. The intended procurement will be classified under North American Industrial Classification (NAICS) code 541990 with a size standard 15 Million. All respondents are requested to identify their firm's size and type of business. Interested firms responding to this market survey must provide (a) capability statement demonstrating their experience, skills and capability to fulfill the Government's requirements for the above. The capability statement shall be in sufficient enough detail, but not to exceed 15 pages, so that the Government can determine the experience and capability of your firm to provide the requirements above. Your capability statement, not to exceed 15 pages, should include references. Responses: E-MAIL will be accepted and can be sent to griffinv@mail.nih.gov The offeror must include a completed copy of the following provisions: 1) FAR Clause 52.212-1 Instructions to Offerors - Commercial items; 2) FAR Clause 52.212-2, Evaluation - Commercial Items. As stated in FAR Clause 52.212-2 (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be advantageous to the Government, price and other factors considered. The following factors will be used equally to evaluate offers: Technical Evaluation, Price, and Past Performance. Note: Past Performance Information: Vendors must submit a listing of the most recent contracts/awards (minimum of 3) which demonstrate similar work in nature to this Solicitation. Contracts/awards may include those entered with the Federal Government, state and local governments and commercial concerns. Include the following information for each contract or subcontract: 1. Name of Contracting Organization 2. Contract Number (for subcontracts provide the prime contract number and the subcontract number) 3. Contract Type 4. Total Contract Value 5. Description of Requirement 6. Contracting Officer's Name and Telephone Number 7. Program Manager's Name and Telephone Number 3) FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items; 4) FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; 5) FAR Clause 52-212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions. The Dun and Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN) and the certification of business size shall be included. The clauses are available in full text at https://www.acquisition.gov PLEASE NOTE: In order to receive an award, contractor must be registered and have valid certification in the System For Award Management (SAM) http://www.sam.gov Interested vendors capable of providing the Government with the items specified in this synopsis should submit their quotation to the below address. Quotations will be due on or before August 21, 2015 at 11:00 a.m. EST. Offersors shall provide an original and one copy of your quotation. The quotation must reference Solicitation number NIHLM2015582. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Quotations may be submitted electronically to Verne Griffin at griffinv@mail.nih.gov .

Da Vinci Robot parts

Department of Health and Human Services, National Institutes of Health | Published June 4, 2015  -  Deadline June 10, 2015
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This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Subpart 12.6, in conjunction with FAR 13, as applicable, and as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotations are being requested and a written solicitation will not be issued. Solicitation number HHSNCCOPC15-007653 is being issued as a Request for Quotation (RFQ).The NAICS Code for this solicitationis 3391128 small Business Size Standard 500 This solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisitions Circular 2005-82 dated July 1, 2015. The full text of the Federal Acquisition Regulation (FAR) and Health and Human Services Acquisition Regulation Supplement (HHSAR) can be accessed via the Internet at http://farsite.hill.af.mil/vffara.htm (FAR) and http://farsite.hill.af.mil/vfhhsara.htm (HHSAR). This acquisition will be processed under Simplified Acquisition Procedures (SAP). All responsible sources may submit an offer that will be considered by this agency. The National Institutes of Health (NIH), Clinical Center (CC), Radiology and Imaging Sciences Interventional Oncology intends to procure surgical instruments to be used with the government owned Da Vinci Robot System used to perform surgical resection of prostate tumors for Clinical Center patients. The following specifications for the required instruments are referenced below: DELIVERABLES: 1) Self-contained 8-axis motor control unit with firewire interface and integrated power supplies compatible with cabling interface provided by Intuitive Surgical Includes configuration, assembly, and testing. Each 8-axis unit is designed to control a single arm (master, slave, or camera). Each 8-axis unit contains two FPGA interface boards and two QLA 4-axis motor amplifier boards. • Three units will be configured for the daVinci PSM (Slave) • One units will be configured for the daVinci ECM (Camera) • Two units will be configured for the daVinci MTM (Master) Quantity required: 6 2) Stand-alone 4-axis firewire motor controllers. Each 4-axis controller includes one FPGA and one QLA board (coupled together). These are provided as fully assembled and tested boards sets. They do not include an enclosure, power supplies, or cabling. Includes programming, configuration, and testing. Quantity Required 2 3) Portable rack enclosure. Includes assembly of the control units into the racks and wiring of common signal, power, and emergency stop connections Region-specific power input, firewire, and e-stop cables will be included. Each rack contains two rack-mount motor control units, one rack will be configured for the two MTMs, one for two PSMs, and one for the ECM and one PSM. Includes testing of the fully configured system on dVRK platform. Quantity required: 3 2.2 Schedule: Expected that products will be delivered within a reasonable time frame from receipt of purchase order, 6-8 weeks 2.3 ASSUMPTIONS 1) All products delivered to the government will be quality tested upon delivery 2) devices are intended for non-human subjects The government anticipates the award of a Firm Fixed Price Contract. The applicable North American Industrial Classification (NAICS) code is 339112 (small business size standard is 500 employees). The Clinical Center anticipates delivery of items stated in the SOW to occur within the specified 6- 8 weeks from acceptance of the purchase order. Delivery Location, Schedule, and Instructions The delivery must be noted as an inside delivery to the address listed below. National Institutes of Health Clinical Center, Building 10 Rm 1C351 Radiology & Imaging Sciences Security Provisions There are no government security provisions for this purchase. Government Furnished Equipment (GFE) There is no government furnished equipment requirement for this order. Inspection and Acceptance Criteria The items listed in the scope of this document must be received and in full working order to be accepted as final by the Clinical Center. The following Provisions and Clauses apply: FAR 52.212-1 Instruction to Offerors-/Commercial Items (APRIL 2014); FAR 52.212-2 Evaluation - Commercial Items (Jan 1999) (Additional Evaluation criteria set forth in the combined synopsis/solicitation; FAR 52. 212-3, Offeror Representations and Certifications - Commercial Items (MAR 2015); FAR 52.212-4 Contract Terms and Conditions Commercial Items (DEC 2014),FAR 52.212-5 Contract Terms and Conditions Required to Implement Statues or Executive Orders-Commercial Items (MAR 2015) FAR 52.219-6 Notice of Total Small Business Set-Aside (NOV 2011); FAR 52.219.28 Post Award Small Business Program Representation (APR 2012); FAR 52.222-3 Convict Labor (JUN 2003); FAR 52.223-6 Drug Free Workplace (May 2001), FAR 52.227-14 RIGHTS IN DATA - General (Dec 2007), FAR 52.228-5 Insurance - Working On a Government Installation (JAN 1997) and FAR 52.232-33 Payment by Electronic Funds Transfer - Central Contractor Registration (OCT 2003). The Contractor shall comply with the following clauses, which are incorporated in this contract in full text, to implement provisions of law or Executive orders applicable to acquisitions of commercial items. Contracting Officer's Representative The following Contracting Officer Representative (COR) will represent the Government for the purpose of this contract: To be determined at the time of award. The COR is responsible for: (1) monitoring the Contractor's technical progress, including the surveillance and assessment of performance and recommending to the Contracting Officer changes in requirements; (2) interpreting the statement of work and any other technical performance requirements; (3) performing technical evaluation as required; (4) performing technical inspections and acceptances required by this contract; and (5) assisting in the resolution of technical problems encountered during performance. The Contracting Officer is the only person with authority to act as agent of the Government under this contract. Only the Contracting Officer has authority to: (1) direct or negotiate any changes in the statement of work; (2) modify or extend the period of performance; (3) change the delivery schedule; (4) authorize reimbursement to the Contractor for any costs incurred during the performance of this contract; or (5) otherwise change any terms and conditions of this contract.The Government may unilaterally change its COR designation. Interested Offerors may submit quotations electronically to this notice no later than 3:00p.m. (EST) June 10, 2015. Questions regarding this combined synopsis/solicitation must be received in writing by this office no later than June 8, 2015. Offerors may submit a completed FAR 52.212-3, or cite their Representations and Certifications on SAM.gov. The Government intends to make a single award based upon best value to the Government, technical and price factors considered. The anticipated award date for this requirement shall be on or before June 15, 2015. Facsimile submissions are not authorized and collect calls will not be accepted. Submit offers to Mrs. Gail Akinbinu at the address listed(email) in this solicitation. Please reference the solicitation number HHSNCCOPC on your offer. Requests for information concerning this requirement are to be addressed to Gail Akinbinu via e-mail only to gakinbinu@cc.nih.gov prior to the closing date. NO PHONE CALLS PLEASE.

Anesthetic & Inhalation Gases (Oxygen and CO2), 1 year supply & delivery

Department of Health and Human Services, National Institutes of Health | Published April 8, 2015  -  Deadline April 21, 2015
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This notice is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Federal Acquisition Regulation (FAR) Subpart 12.6 "Streamlined Procedures for Evaluation and Solicitation for Commercial Items," as applicable, and as supplemented with additional information included in this notice. This announcement constitutes the only solicitation (a written solicitation will not be issued) and quotes are being requested. The Solicitation number is RFQ-RML-D-15011 and the solicitation is issued as a Request for Quotes (RFQ). The solicitation documents and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) 05-80 March 2, 2015. The North American Industry Classification System (NAICS) code for this procurement is 325120, Industrial Gas Manufacturing, with a small business size standard of 1,000 employees. This requirement is being competed full and open and the small business set-aside is dissolved. Description of the Requirement: The National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH) requires a contractor to supply and delivery medical grade anesthetic and inhalation gases, Oxygen and Carbon Dioxide, for the Comparative Medicine Branch (CMB), Bethesda, MD. The purchase order will be for one year's worth of gases, not to exceed the total quantities listed, per line item, in the order. The period of performance will be one year from the date of the order (anticipated 05/01/2015), for the total quantities listed below. •1) USP Grade Medical Carbon Dioxide, size 50 lbs cylinder,CGA-320 QTY: 150 ea. •2) USP Grade Medical Carbon Dioxide, sz E cylinder, CGA-940 QTY: 450 ea. •3) Oxygen, USP Grade, size E cylinder, CGA-870 QTY: 550 ea. •4) Oxygen, USP Grade, size EA cylinder, CGA-870 QTY: 200 ea. •5) Delivery fee QTY: 156 ea. •6) Fuel Surcharge QTY: 156 ea. •7) Hazmat Charge QTY: 156 ea. •8) Rental Charge QTY: 144 ea. Place of Performance: The CMB has four unique delivery points associated with this order: •1) NIH, 50 South Dr., BLDG 50, Bethesda, MD 20892 •2) NIH, 33 North Dr., BLDG 33, Bethesda, MD 20892 •3) NIH, 4 Memorial Dr., BLDG 04, Bethesda, MD 20892 •4) NIH, 9000 Rockville Pike, BLDG 14BS Medlars Drive, Bethesda, MD 20892 The CMB requires a reliable and steady supply of the gases to be delivered weekly. The quantities of gas to be delivered will be decided weekly on a "replenish as needed" (pick up old tanks and replace the same number) basis. Additional tanks may be requested to supplement existing weekly deliveries. The government intends to award a firm fixed price purchase order as a result of this RFQ that will include the terms and conditions set forth herein. The award will be based on the following; capability to meet the requirements, delivery, price and the best value to the government. Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product or service. The price quote shall include: unit price, product/catalog numbers and associated fees (per line items 1-8 above). Please include information regarding which days of the week deliveries could be made and minimum lead times associated with order / emergency order requests. By submission of an offer, the offeror acknowledges the requirement that a prospective awardee shall be registered in the System for Award Management (SAM) database prior to award, during performance, and through final payment of any contract, basic agreement, basic ordering agreement, or blanket purchasing agreement resulting from this solicitation (www.sam.gov). In addition the Dun & Bradstreet Number (DUNS) must be included in the response. The following FAR provisions apply to this acquisition: FAR 52.212-1 Instructions to Offerors Commercial Items (April 2014) FAR 52.212-3 Offerors Representations and Certifications - Commercial Items (March 2015) Offerors must complete annual representations and certifications on-line at http://www.sam.gov in accordance with FAR 52.212-3 Offerors Representations and Certifications- Commercial Items (Please ensure 52.209-2 -- Prohibition on Contracting with Inverted Domestic Corporations--Representation. (Dec 2014) is updated in your SAM record) FAR 52.222-25 Affirmative Action Compliance (April 1984) FAR 52.204-16 Commercial and Government Entity Code Reporting (Nov 2014) FAR 52.204-7 System for Award Management (July 2013) FAR 52.203-98 Prohibition on Contracting with Entities that Require Certain Internal Confidentiality Agreements - Representation (DEVIATION 2015-02) The following FAR contract clauses apply to this acquisition: FAR 52-212-4 Contract Terms and Conditions Commercial Items (Dec 2014) FAR 52-212.5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items (March 2015) FAR 52.203-99 Prohibition on Contracting with Entities that Require Certain Internal Confidentiality Agreements (Feb 2015) FAR 52.204-18 Commercial and Government Entity Code Maintenance (Nov 2014) FAR 52.232-40 Providing Accelerated Payments to Small Business Subcontractors (Dec 2013) FAR 52.204-13 System for Award Management Maintenance (July 2013) FAR 52.204-19 Incorporation by Reference of Representations and Certifications (Dec 2014) HHSAR 352.222-70, Contractor Cooperation in Equal Employment Opportunity Investigations (January 2010) *The applicable subparagraphs of FAR52.212-5 are included in the attachment to this posting. Copies of the above-referenced provisions and clauses are available from http://www.acquisition.gov/far/loadmainre.html & http: //www.hhs.gov/regulation/index.html or, upon request, either by telephone or fax. To facilitate the award process all quotes must include a statement regarding the terms and conditions herein as follows: "The Terms and conditions in the solicitation are acceptable to be included in the award document without modification, deletion or addition." OR "The terms and conditions in the solicitation are acceptable to be included in the award document with the exception, deletion, or addition of the following:" (Quoter shall list exception(s) and rationale for the exception(s).) Submissions shall be received not later than 04/21/2015. Offers may be mailed, e-mailed or faxed to Bevin Feutrier; (Fax - 406-363-9329), (E-Mail/ bevin.feutrier@nih.gov). Late submissions shall be treated in accordance with the solicitation provision at FAR 52.212-1(f) All responsible sources may submit an offer that will be considered by this Agency. Any questions or concerns regarding this solicitation should be forwarded in writing via e-mail to Bevin Feutrier @ bevin.feutrier@nih.gov.

Undercounter laboratory freezers and refrigerators

Other Defense Agencies, Uniformed Services University of the Health Sciences | Published June 1, 2015  -  Deadline June 11, 2015
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* Refer to the attachments for the complete detail General Overview: The Uniformed Services University of the Health Sciences (USU) is the Nation's federal health sciences university and is committed to excellence in military medicine and public health during peace and war. We provide the Nation with health professionals dedicated to career service in the Department of Defense and the United States Public Health Service and with scientists who serve the common good. We serve the uniformed services and the Nation as an outstanding academic health sciences center with a worldwide perspective for education, research, service, and consultation; we are unique in relating these activities to military medicine, disaster medicine, and military medical readiness. USU is located in Bethesda, MD on the grounds of the Naval Support Activity Bethesda. Additional information regarding USU can be found on our website: www.usuhs.mil. USU has a requirement for 9 undercounter laboratory freezers and 12 undercounter laboratory refrigerators. This is a combined synopsis/solicitation for commercial items in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotes are being requested and a written solicitation will not be issued. This is a request for quotes (RFQ) for commercial items in accordance with the procedures of FAR Part 12 Acquisition of Commercial Items and FAR Part 13 Simplified Acquisition Procedures. This RFQ incorporates all provisions and clauses in effect through Federal Acquisition Circular FAC 2005-82, effective May 7, 2015 and Defense Federal Acquisition Regulation Supplement (DFARS), effective April 20, 2015. This requirement is set-aside for small business concerns under North American Industry Classification System (NAICS) Code 333415 Air-Conditioning and Warm Air Heating Equipment and Commercial and Industrial Refrigeration Equipment Manufacturing with a size standard of 750 employees. This requirement is not subject to the non-manufacturer rule. Offerors responding to this requirement may offer items manufactured by large and/or small business. All offerors submitting a quote for this requirement manufactured by a company other than themselves must provide the full, official name of the manufacturer. The manufacturer's socio-economic status will be verified in SAM.gov. Offerors interested in responding to this requirement must provide a quote for 9 undercounter laboratory freezers and 12 undercounter laboratory refrigerators that best meets the specifications listed below. A single firm-fixed price (FFP) purchase order (PO) will be issued. Offerors are encouraged to submit multiple quotes for 9 undercounter laboratory freezers and 12 undercounter laboratory refrigerators, which will be evaluated separately by the Government. This is a first-time purchase and we do not have any related previous purchase order information. Specifications: Desired Specifications Undercounter laboratory freezer 1. Quantity: 9 freezer units 2. Capacity: 5 cubic ft. 3. Maximum dimensions: 85.4-cm H x 54.3-cm W x 65.7-cm D (33 5/8" H x 21 3/8" W x 25 7/8"D) 4. Temperature range: -20° to -15°C Undercounter laboratory refrigerator 1. Quantity: 12 refrigerator units 2. Capacity: 5 cubic ft. 3. Maximum dimensions: 85.7-cm H x 54.3-cm W x 57.8-cm D (33 ¾" H x 21 3/8" W x 22 34" D) 4. Temperature range: -2° to 10°C USU may consider purchasing the following services, therefore the quote should also offer: 1. Installation (if complex enough to require it) 2. Training (if complex enough to require it) 3. Extended warranty Evaluation / Award Detail: The Government intends to issue a single firm-fixed priced (FFP) purchase order (PO) to the offeror representing the best value to the Government based on the evaluation factors listed below. Evaluation factors are listed in order of importance, with most important listed first. The Government will conduct a trade-off between price and non-price factors. The Government is not required to award to the lowest priced offeror or the offeror quoting the highest technically rated item. The government reserves the right to award without discussions. Evaluation Factors (in order of importance): 1. Technical. Offerors must provide detailed product literature, which demonstrates the offerings of the quoted item. The product literature must demonstrate in what ways the quoted item meets the specification outlined above under Specifications. Information on training (related to the use of the quoted product) and other relevant information must be included in the quote submission. The Government reserves the right to utilize technical, e.g. trade magazines and websites, and customer reviews and/or references, as part of the technical evaluation. 2. Price. Offerors must include all applicable costs in the quote. The total quoted price including optional items will be the evaluated price. In addition to providing the product literature, offerors must also submit a copy of the completed CLIN Structure spreadsheet* in the quote package. Those offerors who fail to provide this copy in the quote package may be deemed nonresponsive. * Refer to the attached CLIN Structure spreadsheet. Please note there are two sheets to be completed in the Excel file. CLINs 0001 through 0002: 9 undercounter laboratory freezers and 12 undercounter laboratory refrigerators Desired Specifications Quoted Specification Reference Page No. in the Quote Package/Product Literature Undercounter laboratory freezers 1. Quantity: 9 Freezer units 2. Capacity: 5 cubic ft. 3. Maximum dimensions: 85.4-cm H x 54.3-cm W x 65.7-cm D (33 5/8" H x 21 3/8" W x 25 7/8"D) 4. Temperature range: -20° to -15°C Undercounter laboratory refrigerators 1. Quantity: 12 refrigerator units 2. Capacity: 5 cubic ft. 3. Maximum dimensions: 85.7-cm H x 54.3-cm W x 57.8-cm D (33 ¾" H x 21 3/8" W x 22 34" D) 4. Temperature range: -2° to 10°C The Federal Government prefers not to use third-party-payment merchants, e.g. PayPal, to exchange currencies. This is because these merchants can mask the actual merchant/vendor and impede the Government's effort to promote transparency. If these third-party-payment merchants must be used, offeror must include a compelling justification in the quote package. This will be considered as a part of the Price evaluation factor. See attached list for applicable provisions and clauses for this requirement. Offerors must also submit the following required provisions with their quote: a. Completed copy of provision 252.209-7992 b. Completed copy of provision 252.225-7035 c. Completed copy of provision 52.222-48 Quoted items must be new. Quotes for refurbished equipment will not be considered. Offerors must also indicate in quote where item is manufactured. Items will be shipped to Bethesda, MD. Deadlines: Questions/clarifications regarding this solicitation must be submitted via email to andrew.lee@usuhs.edu by 2:00PM ET on June 3, 2015. Any question received after 2:00PM ET on June 3, 2015 will not be answered. Questions will not be answered over the phone or submitted by any other means. All questions will be answered in an amendment to the solicitation posted on or around June 4, 2015. Quote packages are due by 10:00PM ET on June 11, 2015. Quotes must be submitted via email to andrew.lee@usuhs.edu. Quotes will not be accepted by any other means. Late quotes will not be considered. Quote packages should include a cover sheet that provides the following information: a. Official Company Name; b. Point-of-contact (PoC), including name, email address, and phone number; c. DUNS Number; and d. Statement that acknowledges the latest amendment number-only if an amendment had been issued for this RFQ.

QUANTUM IXR220-1000R

Department of Health and Human Services, National Institutes of Health | Published April 30, 2015  -  Deadline May 5, 2015
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This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NIHLM2015443 and is issued as a Request for Quotation (RFQ). The solicitation /contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-78. The North American Industrial Classification (NAICS) code 334516 with a size standard 500 employees. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. The National Institutes of Health (NIH), National Institute of Digestive, Diabetes & Kidney Diseases (NIDDK) has a requirement to procure Quantum IXR220-1000R. BACKGROUND: The NIDDK We study problems in insulin's ability to control the breakdown of fat. This leads to increased levels of free fatty acids (FFA) in the blood. With elevated FFA levels, insulin does not work as well as it should in tissues or cells. A way to measure insulin's effects on fat break down and blood FFA levels would help monitor various conditions of insulin resistance. We are developing an index to show how FFA levels respond to insulin. Many disease complications relate to oxidative stress. These include problems associated with diabetes, Parkinson's, Alzheimer's, and hardening of the arteries. In oxidative stress, the body cannot remove toxins and repair damage caused by reactive oxygen species (ROS). But ROS are not always bad. ROS signaling is important in how cells work. Cellular structures that produce energy, mitochondria, have ROS but do not show oxidative stress. Using math, we develop models to describe how this happens. The goal is to understand the damage of oxidative stress in insulin resistance and obesity. The ultimate goal of our research is to predict the response of human metabolism to dietary changes, and to predict the whole body effects of new therapies. This equipment is required for the diabetes and obesity research at NIDDK Purpose and Objectives for the Procurement: The PI's lab is facing computational bottlenecks in their work on genome scale regulatory logic inference and in islet dynamic graph modeling because there are no high thread count nodes on Biowulf for these problems. The equipment will have 96 threads and will cut the time of analysis for their research by between a factor of 3 to 4, making the difference from 4 weeks to 1 week for each run. In addition the equipment will have a general purpose graphics processing unit for compute intensive OpenCL or CUDA computations. Contractor Requirements The vendor shall provide a Linux Server (CentOS6) with the following specifications: Rackmount Quad CPU chassis 4x E5-4657LV2 2.4 GHz 12C/24T Intel Xeon CPUs or better, with a minimum of 48 total compute cores/96 total compute threads. Nvidia Tesla K80 24 GB GDDR5 384-bit PCI Express 3.0 Passive Cooling graphics card 16 GB X 16 DDR3 ECC/Reg Server Memory 8 x 4TB SAS2 6Gb/s (configured in RAID 5) hard drives 8-port SAS2 6G Hardware RAID card CentOS 6.5 installed Platinum redundant power supplies Dual Gigabit Ethernet Rack mounting rails and hardware Power cables 3 Year next business day on-site 8x5 support Inspection and Acceptance Requirements: The Project Officer and/ or the Project Officer Supervisor will perform inspection and acceptance of materials and services to be provided. Inspection and acceptance will be done AFTER All materials are unpacked, installed, and test run for operation. Receiving will be completed no later than 7 days following date of Delivery, and DOES NOT constitute acceptance and Delivery. Acceptance and Delivery will be complete once the signed packing slip is provided to the Vendor. Inspection and acceptance will be performed at the place of installation - National Institutes of Health, NIDDK, 9000 Rockville Pike, Maryland 20892. PROJECT OFFICER The following Project Officer(s) will represent the Government for the purpose of this Purchase Order: Project Officer: Provided at time of award Alternate Project Officer: Provided at time of award The Project Officer is responsible for: (1) monitoring the Contractor's technical progress, including the surveillance and assessment of performance and recommending to the Contracting Officer changes in requirements; (2) interpreting the statement of work and any other technical performance requirements; (3) performing technical evaluation as required; (4) performing technical inspections and acceptances required by this Purchase Order; and (5) assisting in the resolution of technical problems encountered during performance. The Contracting Officer is the only person with authority to act as agent of the Government under this Purchase Order. Only the Contracting Officer has authority to: (1) direct or negotiate any changes in the statement of work; (2) modify or extend the period of performance; (3) change the delivery schedule; (4) authorize reimbursement to Page 2 of 3 the Contractor any costs incurred during the performance of this Purchase Order; or (5) otherwise change any terms and conditions of this Purchase Order. The offeror must include a completed copy of the following provisions: 1) FAR Clause 52.212-1 Instructions to Offerors - Commercial items; 2) FAR Clause 52.212-2, Evaluation - Commercial Items. As stated in FAR Clause 52.212-2 (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be advantageous to the Government, price and other factors considered. The following factors will be used equally to evaluate offers: Technical Evaluation, Price, and Past Performance. 3) FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items; 4) FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; 5) FAR Clause 52-212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions. Note: Past Performance Information: Vendors must submit a listing of the most recent contracts/awards (minimum of 3) which demonstrate similar work in nature to this Solicitation. Contracts/awards may include those entered with the Federal Government, state and local governments and commercial concerns. Include the following information for each contract or subcontract: 1. Name of Contracting Organization 2. Contract Number (for subcontracts provide the prime contract number and the subcontract number) 3. Contract Type 4. Total Contract Value 5. Description of Requirement 6. Contracting Officer's Name and Telephone Number 7. Program Manager's Name and Telephone Number The Dun and Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN) and the certification of business size shall be included. The clauses are available in full text at http://www.arnet.gov/far. PLEASE NOTE: In order to receive an award, contractor must be registered and have valid certification in the System For Award Management (SAM) http://www.sam.gov Interested vendors capable of providing the Government with the items specified in this synopsis should submit their quotation to the below address. Quotations will be due on or before May 5, 2015 at 11:00 a.m. EST. Offersors shall provide an original and one copy of your quotation. The quotation must reference Solicitation number NIHLM2015443. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Quotations must be submitted to electronically to griffinv@mail.nih.gov .

BIOINFORMATIC CONSULTANT

Department of Health and Human Services, National Institutes of Health | Published February 6, 2015  -  Deadline February 20, 2015
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This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NIHLM2015386 and is issued as a Request for Quotation (RFQ). The solicitation /contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-78. The North American Industrial Classification (NAICS) code 541711 with a size standard 500 employees. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. The National Institutes of Health (NIH), National Institute of Digestive, Diabetes & Kidney Diseases (NIDDK) has a requirement to procure services including big data management and bioinformatics of next generation sequencing data analysis and software development. Specific requirements include the ability to analyze transcription or genomic data related to multiple model systems, including worm (C. elegans), fly, mouse and human. Professional Services Requirement: This fee for service contract is for services rendered to the NIDDK Division of lntramural Research in support of clinical research investigators to support clinical data management activities for a diverse array of clinical protocols. This requirement allows NIDDK to provide direct compensation for the professional consult services performed by offeror for currently operational clinical data information systems within the NIDDK Division of Intramural Research's clinical research program. This agreement is not intended to provide travel related expenses. The anticipated service hours are estimated to not exceed more than 20 hours per week on an averaged basis for the year period this contract is to be approved. The services will be rendered Monday - Friday, excluding Federal holidays. Tasks: The following represent key duties for consultant activities: Provide assistance with the application of computer technology to clinical research by assessing clinical data needs for unique clinical protocols, providing recommendations for cost efficient clinical data systems which will fulfill clinical data management requirements for these protocols; and provide technical expertise review to ensure customizable data solutions meet investigators' requirements for these data systems. Assist with the evaluation of various technical informatics systems to determine applicability for the support of research of specific clinical diseases in a clinical research setting. Provide technical support for NIDDK clinical databases. Train NIDDK clinical and technical support team to independently manage existing databases as appropriate. Coordinate necessary computerrelated activities with the NIDDK Computer Technology Branch as well as the staff supporting clinical database development for other applicable ICs. This task specifically requires knowledge of (1) the commercial, Teleresults system, (2) the Microsoft SQL Server environment, the NICHD's Clinical Trials Database (CTDB), (4) NIDDK's REDCap installation and (4 5) the specific configuration of these systems at NIDDK. Provide programming support for the Lab Grabber data retrieval, BTRIS and other data retrieval tools currently in use by NIDDK or that may be used in the future. Train NIDDK personnel to independently manage BTRIS and other clinical data query tools as appropriate. Maintain the current database source code and modify the database source code in consultation with the user base for applicable clinical databases. Deliverables: Upon request, the contractor will provide documentation of all work product, including, but not limited to, the following tasks: Provide technical support for NIDDK clinical databases. Provide programming support for the data retrieval tools currently in use by NIDDK. Generate research data reports. The contractor shall obtain project approvals prior to commencing new projects. All projects should specify the following: Scope of contractor's involvement with the project; Estimate of hours required to complete the specified scope; Secondary project approvals if the original number of project estimated hour total is exceeded Deliverables shall be established through written communication with NIDDK program office. Invoicing statements generated will need to be communicated to NIDDK program office to ensure prompt processing for invoice payment in addition to the invoice sent to the address specified in the awarded contract. The offeror must include a completed copy of the following provisions: 1) FAR Clause 52.212-1 Instructions to Offerors - Commercial items; 2) FAR Clause 52.212-2, Evaluation - Commercial Items. As stated in FAR Clause 52.212-2 (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be advantageous to the Government, price and other factors considered. The following factors will be used equally to evaluate offers: Technical Evaluation, Price, and Past Performance. Note on Government Issued Accountable Property: The contractor shall be issued government accountable property for the conduct of routine business functions within the scope of this contract. The contractor agrees to take on fiscal responsibility related to the loss, theft, or damage of any issued property. For any work which may require taking the accountable property off-site from the duty station, the contractor shall obtain a government property pass for the device(s). Additionally, the contractor agrees to complete required training, as applicable, for example, NIH privacy and security training (or refresher). Note: Past Performance Information: Vendors must submit a listing of the most recent contracts/awards (minimum of 3) which demonstrate similar work in nature to this Solicitation. Contracts/awards may include those entered with the Federal Government, state and local governments and commercial concerns. Include the following information for each contract or subcontract: 1. Name of Contracting Organization 2. Contract Number (for subcontracts provide the prime contract number and the subcontract number) 3. Contract Type 4. Total Contract Value 5. Description of Requirement 6. Contracting Officer's Name and Telephone Number 7. Program Manager's Name and Telephone Number 3) FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items; 4) FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; 5) FAR Clause 52-212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions. The Dun and Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN) and the certification of business size shall be included. The clauses are available in full text at http://www.arnet.gov/far. PLEASE NOTE: In order to receive an award, contractor must be registered and have valid certification in the System For Award Management (SAM) http://www.sam.gov Interested vendors capable of providing the Government with the items specified in this synopsis should submit their quotation to the below address. Quotations will be due on or before February 20, 2015 at 11:00 a.m. EST. Offersors shall provide an original and one copy of your quotation. The quotation must reference Solicitation number NIHLM2015386. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Quotations must be submitted in writing to the National Institutes of Health, National Library of Medicine, 6707 Democracy Blvd., II Democracy Plaza, Suite 700W, Bethesda, Maryland 20892, Attention: V. Lynn Griffin. Faxed copies will not be accepted.

Maintenance Support Services for a Custom LSR II Flow Cytometer

Department of Health and Human Services, National Institutes of Health | Published November 20, 2017  -  Deadline November 27, 2017
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NOTICE OF INTENT to Sole Source1. SOLICITATION NUMBER:HHS-NIH-NIDA-NOI-18-162. TITLE: Maintenance Support Services for a Custom LSR II Flow Cytometer. 3. CLASSIFICATION CODE:J - Maintenance, repair, & rebuilding of equipment 4. NAICS CODE:811219 - OTHER ELECTRONIC AND PRECISION EQUIPMENT REPAIR AND MAINTENANCE5. RESPONSE DATE:November 27, 2017 at 11:00 am EST6. PRIMARY POINT OF CONTACT:Mrs. Sneha Singhsneha.singh@nih.govPhone: 301-480-24437. DESCRIPTION:INTRODUCTIONTHIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Institute on Drug Abuse (NIDA) intends to solicit by a request for quotation from Beckton, Dickenson and Company DBA US BD Biosciences on or around November 30, 2017. The purpose of this purchase order will be to provide the National Institute of Neurological Disorders and Stroke (NINDS) with Maintenance Support Services for a Custom LSR II Flow Cytometer. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE and SET ASIDE STATUSThe intended procurement is classified under NAICS code 811219 with a Size Standard of $20.5 Million. This acquisition is NOT set aside for small businesses. REGULATORY AUTHORITY This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures. Contracts awarded using FAR Part 13-Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6-Competition Requirements. FAR Subpart 13.106-1 (b) Soliciting from a single source provides that: For purchases not exceeding the simplified acquisition threshold, Contracting officers may solicit from one source IF the contracting officer determines that the circumstances of the contract action deem only one source reasonably available (e.g., urgency, exclusive licensing agreements, brand-name OR industrial mobilization). The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2005-85 dated February 26, 2016. DESCRIPTION OF REQUIREMENTPURPOSE AND OBJECTIVES:The purpose of this acquisition is to purchase maintenance services to support a Custom BD LSR II flow cytometer used by the NINDS Laboratory of Viral Immunology and Intravital Imaging (VIIIS). To ensure standardization of research data and continuation of equipment warranties, maintenance may only be performed by the original equipment manufacturer, BD Biosciences.The Viral Immunology and Intravital Imaging Section (VIIIS) of NINDS studies inflammatory diseases processes in the brain induced by injury or infection. As part of this research, the laboratory needs to monitor and quantify expression of various inflammatory biomolecules on cells extracted from various tissues, including brain, spleen, lymph nodes, blood, liver, etc. This type of analysis provides a signature of the inflammatory disease process underway and aids in the evaluation of therapeutic interventions. The Custom BD LSR II is a critical piece of equipment in the VIIIS that is essential to the NINDS mission. The VIIIS requires a service contract for the BD LSR II Flow Cytometer to ensure that the instrument is properly maintained and quickly repaired should a service issue arise. Having a BD LSR II service contract in place helps sustain an uninterrupted research flow within the VIIIS. PROJECT REQUIREMENTS:Contractor must be an Authorized Service Provider of the FACSAriaII flow cytometer (Serial Number H47100213) equipment that provides an OEM Service Technician and Certified Parts for maintenance support services as follows:Contractor shall perform two (2) preventive maintenance inspections during each twelve-month period. Each inspection will evaluate instrument performance and provide calibrations, alignments, lubrication and part replacement as necessary to maintain the instrument operation substantially in accordance with the published technical specifications for the instrument. Inspections must comply with Original Equipment Manufacturer (OEM) equipment manuals.Contractor shall provide unlimited technical support (telephone) and service repairs at no additional cost to the Government. If technical support is unsuccessful, contactor shall provide a service technician on-site within 48 hours. All repairs under warranty must comply with OEM equipment manuals. Contractor shall provide preventative maintenance, service repairs and technical support between the hours of 8:00 AM and 5:00 PM, Bethesda, MD local prevailing time, Monday through Friday. Emergency service repairs and technical support must be provided as needed, based on MD local prevailing time, Monday through Friday, excluding Federal holidays.Contractor shall provide OEM certified parts for all preventative maintenance and service repairs, except for consumables, at no additional cost to the Government. Shipping and handling parts under warranty or contract shall not be charged to the Government. Contractor shall provide an OEM service technician to perform all preventive maintenance inspections, service repairs and technical support. CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATIONThe determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, US BD Biosciences is the only vendor in the marketplace that can provide the products required by NINDS. In accordance with FAR part 10, extensive market research was conducted to reach this determination. Specifically, a sources sought notice was posted to FedBizOpps referencing the above detailed requirements and no responses were received. Additionally, contacts with knowledgeable individuals both in industry and Government, as well as reviews of available product literature, revealed no other sources. Finally, a review of the GSA Advantage, Dynamic Small Business Search, and previous government acquisitions returned no results that meet all of the requirements. Therefore, only US BD Biosciences is capable of meeting the needs of this requirement. The intended source is:US BD Biosciences2350 Qume Dr.San Jose, CA 95131 CLOSING STATEMENTTHIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. All responsible sources may submit a capability statement, proposal, or quotation which shall be considered by the agency. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All responses must be received by the closing date and time of this announcement and must reference the solicitation number, HHS-NIH-NIDA-NOI-18-16. Responses must be submitted electronically to Sneha Singh, Contract Specialist, at sneha.singh@nih.gov. U.S. Mail and Fax responses will not be accepted.  

Maintenance Service -Freezer Monitoring System

Department of Health and Human Services, National Institutes of Health | Published May 7, 2015  -  Deadline May 19, 2015
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This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NIHLM2015479 and is issued as a Request for Quotation (RFQ). The solicitation /contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-72. The North American Industry Classification (NAICS) Code is 334290 with a size standard of 750 employees. The National Institutes of Health (NIH), National Library of Medicine (NLM), NIDDK performs research studies on digestive and kidney diseases. The office of Intramural Research Administrative Branch intends to acquire a one year Maintenance Service Agreement of a freezer monitoring system in Building 8 at the National Institutes of Health. This system will provide annual validation/ calibration to ensure that the freezer system is validated and compliant. This service provides vital protection of invaluable research specimens collected from research studies being conducted by the National Diabetes Digestive and Kidney Disease (NIDDK) in building 8. This solicitation is being processed using FAR Part 13 (Simplified Acquisition Procedures), and as a Commercial Item under FAR Part 12. In addition, offers will be evaluated using procedures from FAR Part 52.212-2 (Evaluation of Commercial Items - January 1999). After review and evaluation, the Contracting Officer will make the selection on a Best Value to the Government. As stated in FAR Clause 52.212-2 (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be advantageous to the Government, price and other factors considered. The following factors will be used equally to evaluate offers: Technical Evaluation, Price, and Past Performance. This service is to be set up as a single acquisition. Vendors may identify in writing their interest and capability in response to this requirement or submit a proposal. This notice of intent is not a request for competitive proposals. However, all responses received before the closing date of this announcement will be considered by the Government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement. All responsible sources may submit a quotation which, if timely received, shall be considered by the agency. Project Requirements This procurement for a maintenance agreement ensures that the company makes the scheduled checks of the system, updates the computer system which controls the alarm system as needed, and provides prompt response time of the service technician should the system require repair. Scope of Work: 1. Perform annual validation, calibration, and maintenance of existing system setup. The contractor shall review and check all system panels and ports. Maintenance shall include software updates, annual measurements of system functionality and connection status. Provide alarm alerts and means of obtaining graphical reports and all other needs commonly associated with environmental management. 2. Provide 24 hours per day and seven days per week monitoring of the equipment associated with the alarm system by a technical support group. During an emergency, the RSC technician(s) should be on site within 4 Hours with the rare exception where new parts are required from the factory. 3. Should the power fail or temperature rise out of the safe range, the RSC technician shall assure that the freezer alarm system electronically notifies the appropriate person (s) on duty by telephone, e-mail and pager. The RSC technician shall also assure that the system in programmed to notify one or more scientists if needed by telephone or e-mail. This notification is needed to ensure that someone responds to the alarm condition. 4. Vendor shall perform an annual Installation Qualification/Operational Qualification test of the freezer alarm system in Bldg. #8. All system inputs will be verified and calibrated, or existing customer calibrations certified as appropriate. 5. Vendor must provide proof from Rees Scientific Corporation that it has legal access to RSC software licenses and must be supplied during service and upgrades. Vendor must also supply only new hardware components/modules. Annual maintenance must also include the latest software release from RSC at the time of validation. Currently this release is Presidio Version 3.0. 6. All Rees Scientific warranties would be void if services were performed by non-authorized service providers. Services include: 1. Annual On-Site IQ/OQ Validation 2. Current Software Validation Manual 3. Software updates to current version(Presi dio Version 3.0) 4. Calibration of all temperature & humidity sensors with NIST traceable device 5. On-Site training at the time of validation 6. 24/7/365 telephone technical support 7. On-Site service that includes new parts and labor Qualifications of the Installer: 1. All installation personnel shall be fully qualified by the manufacturer (Rees Scientific) to install or work on systems of this type, and must be either employees of the system manufacturer, or have completed a manufacturer administered training program. The winning contractor shall provide notarized documentation from Rees Scientific Corporation that the installation personnel meets the above requirements. 2. Vendor must have legal access to Rees Scientific software licenses and must be supplied during service and upgrades. Vendor must also supply only new hardware components/modules. Maintenance must also include the latest software release Presidio Version 3.0 from Rees Scientific at the time of validation. 3. Vendor must be ISO 9001:2000 certified. 4. Vendor must have local technicians (located within 20 miles of campus) and be able to respond to emergency requirements within 2 hours or less. Period of Performance : The maintenance agreement would have a one year period of performance from the date of award. Interested firms with the capability of providing the required items/service are requested to submit a capability statement to assist the Government in determining in accordance with Federal Acquisition Regulation (FAR) 19.502-2(b) whether or not this procurement will be set-aside for any of the programs described above. The intended procurement will be classified under North American Industrial Classification (NAICS) Code 334290 with a business size standard of 750 or less employees. All respondents are requested to identify their firm's size and type of business. Interested firms responding to this market survey must provide a capability statement demonstrating their experience, skills and capability to fulfill the Government's requirements for the above. Your capability statement, not to exceed 15 pages, should include references. The offeror must include a completed copy of the following provisions: 1) FAR Clause 52.212-1 Instructions to Offeror(2)s - Commercial items; 2) FAR Clause 52.212-2, Evaluation - Commercial Items. 3) FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items; 4) FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; 5) FAR Clause 52-212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions. The Dun and Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN) and the certification of business size shall be included. The clauses are available in full text at http://www.arnet.gov/far. Note: Past Performance Information: Vendors must submit a listing of the most recent contracts/awards (minimum of 3) which demonstrate similar work in nature to this Solicitation. Contracts/awards may include those entered with the Federal Government, state and local governments and commercial concerns. Include the following information for each contract or subcontract: 1. Name of Contracting Organization 2. Contract Number (for subcontracts provide the prime contract number and the subcontract number) 3. Contract Type 4. Total Contract Value 5. Description of Requirement 6. Contracting Officer's Name and Telephone Number 7. Program Manager's Name and Telephone Number PLEASE NOTE: In order to receive an award, contractor must be registered and have valid certification in the System For Award Management (SAM) http://www.sam.gov Interested vendors capable of providing the Government with the items specified in this synopsis should submit their quotation to the below address. Quotations will be due fifteen (15) calendar days from the publication date of this synopsis May 19, 2014 at 11:00 a.m. EST. Offeror(s) shall provide an original and two copies of your quotation. The quotation must reference Solicitation number NIHLM2015479. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Quotations must be submitted in writing to the National Institutes of Health, National Library of Medicine, 6707 Democracy Blvd., Suite 700W, Bethesda, Maryland 20892, Attention: Linda Smith. Faxed copies will not be accepted.

70--National Instruments Chassis & Parts

Department of the Navy, Naval Supply Systems Command | Published April 14, 2016  -  Deadline April 25, 2016
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This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice.The solicitation number is N00167-16-T-0041 and is issued as a Request for Quote (RFQ), unless otherwise indicated herein.The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-87. The associated North American Industrial Classification System (NAICS) code for this procurement is 334118 with a small business size standard of 1,000.00 employees.This requirement is unrestricted and only qualified offerors may submit quotes.The solicitation pricing on www.FedBid.com will start on the date this solicitation is posted and will end on 2016-04-25 17:00:00.0 Eastern Time or as otherwise displayed at www.FedBid.com.FOB Destination shall be West Bethesda, MD 20817 The FLC - Norfolk requires the following items, Brand Name Only (Exact Match), to the following: LI 001: National Instruments P/N 778645-01: NI PXI-1045 18-slot 3U Chassis with Universal AC Power Supply, 1, EA; LI 002: National Instruments P/N 763000-01: Power Cord AC, US 120 VAC 2.3 Meters, 1, EA; LI 003: National Instruments P/N 782555-04: NI PXI-8119 Core i7-3610QE 2.3 GHz Controller, Win7 (64bit), 2, EA; LI 004: National Instruments P/N 7778279-01: NI PXI-4472, 8 Simultaneously Sampled Analog Inputs, 24 Bit, Resolution, Multiple Device Synchronization. 102.4kS/s Sampling Rate, 10, EA; LI 005: National Instruments P/N 778726-01: NI PXI-6652 Timing and Synchronization Module with TCXO, 1, EA; LI 006: National Instruments P/N 7778644-01: NI 14/18-Slot Chassis Front Rack Mount Kit, 1, EA; LI 007: National Instruments P/N 7778644-02: NI 14/18-Slot Chassis Rear Rack Mount Kit, 1, EA; LI 008: National Instruments P/N 960903-01: NI Basic Assembly Service, 1 Year Warranty. PXI System Assembly and Test, Recovery Image (selected software in Standard Premium only), 1, EA; Solicitation and Buy Attachments ***Question Submission: Interested offerors must submit any questions concerning the solicitation at the earliest time possible to enable the Buyer to respond. Questions must be submitted by using the 'Submit a Question' feature at www.fedbid.com. Questions not received within a reasonable time prior to close of the solicitation may not be considered.*** For this solicitation, FLC - Norfolk intends to conduct an online competitive reverse auction to be facilitated by the third-party reverse auction provider, FedBid, Inc. FedBid has developed an online, anonymous, browser based application to conduct the reverse auction. An Offeror may submit a series of pricing quotes, which descend in price during the specified period of time for the aforementioned reverse auction. FLC - Norfolk is taking this action in an effort to improve both vendor access and awareness of requests and the agency's ability to gather multiple, competed, real-time quotes.All responsible Offerors that respond to this solicitation MUST submit the pricing portion of their quote using the online exchange located at www.FedBid.com. There is no cost to register, review procurement data or make a quote on www.FedBid.com.Offerors that are not currently registered to use www.FedBid.com should proceed to www.FedBid.com to complete their free registration. Offerors that require special considerations or assistance may contact the FedBid Helpdesk at 877-9FEDBID (877-933-3243) or via email at clientservices@fedbid.com. Offerors may not artificially manipulate the price of a transaction on www.FedBid.com by any means. It is unacceptable to place bad faith quotes, to use decoys in the www.FedBid.com process or to collude with the intent or effect of hampering the competitive www.FedBid.com process.Should offerors require additional clarification, notify the point of contact or FedBid at 877-9FEDBID (877-933-3243) or clientservices@fedbid.com.Use of FedBid: Buyers and Sellers agree to conduct this transaction through FedBid in compliance with the FedBid Terms of Use. Failure to comply with the below terms and conditions may result in offer being determined as non-responsive. This announcement constitutes the only solicitation; a formal, written solicitation will not be issued. PAPER COPIES OF THIS SOLICITATION WILL NOT BE AVAILABLE. This solicitation documents and incorporates provisions and clauses in effect through FAC 2005-60 and DFARS Change Notice 20120724. It is the responsibility of the contractor to be familiar with the applicable clauses and provisions. The clauses may be accessed in full text at these addresses: www.acqnet.gov/far and http://www.acq.osd.mil/dpap/dfars/index.htm The NAICS code is 334118 and the Small Business Standard is 1,000. FAR 52.247-34, F.o.b. Destination applies New Equipment ONLY; NO remanufactured or "gray market" items. All items must be covered by the manufacturer's warranty. No partial shipments are permitted unless specifically authorized at the time of award. Bid MUST be good for 30 calendar days after close of Buy. The full text of the referenced FAR clauses may be accessed electronically at https://www.acquisition.gov/Far/ System for Award Management 52.204-10 Reporting Subcontract Awards. Prohibition on Contracting with Inverted Domestic Corporations Representation (May 2012) Prohibition on Contracting with Inverted Domestic Corporations (May 2012) 52.212-2 Evaluation - Commercial Items. Lowest Price, Technically Acceptable. 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders?Commercial Items. 52.219-28 Post-Award Small Business Program Rerepresentation. 52.222-3 Convict Labor 52.222-19 Child Labor--Cooperation with Authorities and Remedies 52.222-21 Prohibition of Segregated Facilities 52.222-26 Equal Opportunity 52.222-36 Affirmative Action for Workers w/ Disabilities 52.223-18 Contractor Policy to Ban Text Messaging while Driving (SEPT 2010) 52.225-13 Restrictions on Certain Foreign Purchases. Requirements Relating to Compensation of Former DOD Officials (Sep 2011) Control of Government Personnel Work Product (April 1992) Representation Regarding Conviction of a Felony Criminal Violation Under and Federal or State Law (Mar 2012) 252.232-7003 Electronic Submission of Payment Requests and Receiving Reports. 252.247-7023 Transportation of Supplies by Sea (MAY 2002) Buy American-Free Trade Agreements - Balance of Payments Program Certificate Buy American - Free Trade Agreements - Balance of Payments Program System for Award Management Maintenance Incorporation by reference of Representations and Certifications Unenforceability of Unauthorized Obligations Providing Accelerated Pmts to SB Subcontractors Protest After Award Applicable Law for Breach of Contract Claim Clauses Incorporated by Reference http://farsite.hill.af.mil/VFFAR1.HTM http://www.acq.osd.mil/dpap/dars/dfarspgi/current/ Provisions Incorporated by Reference http://farsite.hill.af.mil/VFFAR1.HTM http://www.acq.osd.mil/dpap/dars/dfarspgi/current/ Requirement to Inform Employees of Whistleblower Rights Prohibition on Contracting w/Entities that Require Certain Internal Confidentiality Agreements System for Award Management Oral Attestation of Security Responsibilities Safeguarding Covered Defense Information & Cyber Incident Contractors Qualifying Country Sources as Subcontractors Export Controlled Items Wide Area Workflow Payment Instructions Levies on Contract Payments Cloud Computing Service Pricing of Contract Modifications Subcontracts for Commercial Items Commercial & Government Entity Code Reporting Commercial & Government Entity Code Maintenance Ownership or Control of Offeror Representation by Corporations Regarding Delinquent Tax Instructions to Offerors - Commercial Items Offeror Representations & Certifications - Commercial Items Previous Contracts & Compliance Reports Prohibition on Contracting w/Entities Engaging in Certain Activities of Transactions Relating to Iran - Representation and Certification Prohibition on Contracting w/Entities that Require Certain Internal Confidentiality Agreements Compliance with Safeguarding Covered Defense Information Controls Limitations on the Use or Disclosure of "Third Party Contractor Reported Cyber incident Information Rep by Corporations regarding an Unpaid Delinquent Tax Liability or a Felony Conviction under and Federal Law PPIRS

LactMed Database

Department of Health and Human Services, National Institutes of Health | Published June 14, 2016  -  Deadline June 28, 2016
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This is a Combined Synopsis/Solicitation for commercial items prepared in accordance with the format in FAR 12.6 Streamlined Procedures for Evaluation and Solicitation for Commercial Items, and FAR Part 13, Simplified Acquisition Procedures, as supplemented with additional information in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NIHLM2016828 and is issued as a Request for Quotation (RFQ). This is a firm-fixed price contract and it is anticipated that an award will be made for a base year and two option years. Background: The National Library of Medicine's (NLM) LactMed, is a searchable database of records on drugs and other chemicals, including herbals and diagnostic agents, and their use during lactation. It includes information on the levels of such substances in breast milk and infant blood, and the possible adverse effects in the nursing infant. Suggested therapeutic alternatives to those drugs are provided, where appropriate. Lactmed, https://toxnet.nlm.nih.gov/newtoxnet/lactmed.htm is a component of NLM's Toxicology Data Network (TOXNET), a Web-based collection of resources covering toxicology, chemical safety, environmental health and can be accessed at http://toxnet.nlm.nih.gov. NLM's Toxicology and Environmental Health Information Program (TEHIP), where TOXNET resides organizationally, offers additional databases with information on other aspects of drugs, including their pharmacology and toxicology; these include the Drug Information Portal, Pillbox and the Dietary Supplement Label Database. Bibliographic information related to drugs may be found in the TOXLINE database. LactMed can be searched together with TOXNET's other databases in a multi-database environment to obtain other relevant information about drugs. Objectives: The objective of this requirement is to continue to expand and enhance LactMed, a database on possible adverse effects of prescription and non-prescription drugs, relevant herbals, nutraceuticals and diagnostic agents in infants that result from transmission during human breastfeeding. As a work in progress, LactMed will continue to expand with additional drugs and begin to integrate vitamin and mineral monographs into its content. Future plans call for enhancement with other substances, such as industrial chemical and radiation. Project Requirements: The Contractor will compile the world's professional and scientific literature relating to the use of drugs and related products during human lactation and organize this literature into a professionally acceptable system for ease of access to monographs on specific drugs and, where appropriate, to classes of pharmacologic and/or therapeutic agents. Drug names should be at the generic level and include, at a minimum, United States Adopted Names. Further, the Contractor must be willing to have such data placed in the public domain, without any intellectual property right constraints or fees imposed with respect to its use. While the database will become the property of NLM, this will not preclude the Contractor from reconfiguring or otherwise using the source data for preparing other information products or publications. The database content must be fully supported by an evidence-based approach that involves critical case evaluations of reports in peer-reviewed literature. The database needs to be a principal focus of the Contractor who needs to have a high level of professionally recognized expertise in drugs and lactation. NLM is seeking both to continue to build the database with new records, including vitamins and minerals, and to maintain the existing records to ensure consistency and data currency. New and updated information will be input via the SIS SSEUS data entry system. The Contractor will comprehensively review the literature and conduct necessary online searches and therefore, must be conversant with searching a broad range of bibliographic and other databases. At a minimum, database records should include the drug names specified above, drug class (es), pharmacologic and pharmacokinetic data such as drug concentrations in breast milk and infant serum, time course of such levels, and weight-adjusted percent of maternal dose in breast milk. When it can be determined from case report evaluations and other analyses of published literature, it should also provide possible drug effects on maternal lactation and in breast-fed infants, indicating a quantifiable probable causation. Information should also be provided with respect to those drugs that present no safety problems where published literature specifically makes that determination. All drug data within records must follow the approved drug record template at http://toxnet.nlm.nih.gov/help/LactMedRecordFormat.htm, and be referenced to available source references. Project Deliverables: A monthly status report is required. This information, including the number of records uploaded, the dates, the nature of the changes and additions will be available via the SSEUS system Level of Effort. Annual Labor Hour Estimate for LactMed Database: 1. Direct Labor (Creating New Records): 250 hours2. Direct Labor (Maintenance of Existing Records): 125 hours3. Direct Labor (Uploading Records to Database): 15 hours4. Direct Labor (Answering user queries): 10 hours 508 Compliance Section 508 of the Rehabilitation Act requires agencies' electronic and information technology be accessible to people with disabilities. The LactMed data must be Section 508 compliant. Specifically, the end product must be conformant with all applicable provisions, including: 1194, 41 Information, documentation and supportThis provision can be found at http://www.access-board.gov/sec508/standards.html.NLM follows HHS' Section 508 Documentation Compliance Checklistshttp://www.hhs.gov/web/508/checklists/index.html Section 508 Program NeedRequirements for accessibility based on Section 508 of the Rehabilitation Act of 1973 (29 U.S.C. 794d) are determined to be relevant for the LactMed requirement.Section 508 Product RequirementsInformation, documentation and support requirements from 36 CFR part 1194 Subpart D have been determined to apply to this acquisition. Solicitation respondents must describe how the information, documentation, and support proposed for Electronic and Information Technology (EIT) deliverables meet at least the information, documentation, and support requirement identified as applicable in the attached Government Product/Service Accessibility Template (GPAT).Section 508 Evaluation FactorsResponses to the solicitation will only be considered for award after it has been determined that the proposal adequately addresses the requirements for Section 508. Only proposals which contain adequate information to document their responsiveness to the Section 508 requirements (e.g. a completed GPAT and supporting documentation) will be eligible for any additional merit consideration.Section 508 Acceptance CriteriaThe monthly status report, a deliverable which is part of this solicitation will be accepted based in part on satisfaction of identified Section 508 requirements for accessibility. The proposals for the LactMed data must include a GPAT, which is included as part of the solicitation. Evaluation Criteria: After satisfaction of identified Section 508 requirements for accessibility,the evaluation will be based on the demonstrated capabilities of the perspective vendors to meet the needs of the project as set forth in the Statement of Work. Prospective vendors must submit information sufficient to allow NLM to evaluate based on the stated criteria. Technical factors are of paramount consideration; however, cost is also important to the overall award decision. All evaluation factors other than cost, when combined, are significantly more important than cost.The Government can make tradeoffs among cost and technical factors in determining which Offeror(s) provides the best value by awarding to other than the lowest cost Offeror(s) or other than the highest technically rated Offeror(s). Offeror(s) are advised that award will be made to that Offeror(s) whose quote provides the best overall value to the Government. Offerors are advised that each quotation may be subjected to price analysis, as determined to be appropriate by the Government. In determining which quote represents the best value and results in the lowest overall cost alternative (considering price, special features, administrative costs, etc.) to meet the Government's needs, the Government shall evaluate quotes using the following technical evaluation criteria, which are listed in the order of relative importance with weights assigned for evaluation purposes: Proposals submitted in response to this RFQ will be evaluated in accordance with the factors listed below: Criterion A: Personnel (40 points):Proposal demonstrates that staff is competent and experienced in the skills required in the Statement of Work. Resumes of staff/consultants reflect not only academic qualifications, but also length and variety of experience in similar tasks and clearly demonstrate relevant training and experience. The percentage of time each staff member will contribute to the project is adequately identified. Proposal identifies a clear line of responsibility for the project. The proposal clearly documents the proposed staff's relevant expertise, education, availability and experience. Criterion B: Past Performance (30 points):Offeror has consistently demonstrated a commitment to customer satisfaction and timely delivery of high quality products and services. Past experience will be based upon the offeror's prior experience with similar activities. Criterion C: Understanding the Requirements and Technical Approach (30 points):Proposal demonstrates an understanding of the requirements and indicates a clear awareness of the contract purpose and objectives. The proposal demonstrates in a detailed manner the approach and ability to perform all tasks and deliverables in the Statement of Work. The proposal details the manner in which the project will be carried out and conveys an understanding of the information to be compiled and delivered. Proposal Submission: The proposal shall not exceed 10 pages. The page limitation does not include the cover letter, table of contents, executive summary, resumes, appendix, or past performance information. Quotations shall be submitted in an electronic mail format no later than 12p.m., ET on June 28, 2016 to the Contract Specialist at: josephol@mail.nih.gov. Faxed Proposals will not be accepted. Firms responding to this notice must be able to provide the services as requested by NLM. The respondent shall include all information which documents and/or supports the qualification criteria in one clearly marked section of its quotation. All responses from responsible sources will be considered. Vendor shall comply with all applicable Federal, State and Local laws, executive orders, rules and regulations applicable to its performance under this order. Full text of clauses and provisions are available at Federal Acquisition Regulations (FAR). The following clauses and provisions shall apply to this acquisition and may be obtained from the web sites: FAR 52.212-1, Instructions to Offerors - Commercial Items (February 2012); FAR 52.212-3, Offeror Representations and Certifications - Commercial Items (April 2012) - with DUNS Number Addendum (52.204-6 (April 2008); FAR 52.212-4, Contract Terms and Conditions - Commercial Items) (February 2012); FAR 52.212-4, Addendum to Clause for Year 2000 Compliance (July 1997); and FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items (May 2012).  

Full service maintenance contract for FMRIF 7T Siemens Magnetom Scanner

Department of Health and Human Services, National Institutes of Health | Published August 8, 2016  -  Deadline August 23, 2016
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This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a separate written solicitation will not be issued. The solicitation number is HHS-NIH-NIDA-SSSA-CSS-2016-621 and the solicitation is issued as a Request for Quotation (RFQ). A fixed price contract type is contemplated for this requirement. This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures; FAR Subpart 13.5- Simplified Procedures for Certain Commercial Items; and FAR Part 12-Acquisition of Commercial Items, and is expected to exceed the simplified acquisition threshold. THIS IS A NON-COMPETITIVE (NOTICE OF INTENT) COMBINED SYNOPSIS SOLICITATION TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Institute on Drug Abuse (NIDA), Station Support and Simplified Acquisitions Branch (SS/SA) on behalf of the National Institute on Mental Health intends to negotiate and award a contract without providing for full and open competition to Siemens Medical Solutions, Inc. This acquisition is conducted as non-competitive for a commercial item or service and is conducted under the authority of the FAR Subpart 13.5-Simplified Procedures for Certain Commercial Items. Pursuant to FAR Subpart 13.501 (a) (1) (iii) the justification (excluding brand name) will be made available within 14 days after contract award or in the case of unusual and compelling urgency within 30 days after contract award. The solicitation document and incorporated provisions and clauses and those in effect through Federal Acquisition Circular 2006 FAC 2008-89 / 07-12-2016 The North American Industry Classification System (NAICS) code for this procurement is 811310 Commercial and Industrial Machinery and Equipment (except Automotive and Electronic) Repair and Maintenance with associated business size standard of $7,500,000.00 Background: The Functional MRI Facility (FMRIF) at the National Institute of Mental Health (NIMH) operates a unique actively shielded Government-owned 7 Tesla Siemens Magnetic Resonance Imaging (MRI) system (FL# 400-342363 FMRIF-7T), located in Building 10 (room B1D710), within the in-vivo NMR Center on behalf of the intramural research programs of NIMH and NINDS. This acquisition is in support of this magnet and its operation as research system for NIMH and NINDS. NIMH requires a maintenance agreement for the 7T MRI scanner, which was originally manufactured by Siemens Medical Solutions. This system is currently covered by an extended service contract, including magnet maintenance and repair for the 7T-830/AS, which expires on August 9th, 2016. FMRIF-7T it is the only operational human 7 Tesla MRI system at NIH, making it a unique resource within the NIH intramural research programScope of work: Independently and not as an agent of the Government, the contractor shall be responsible for providing full service maintenance coverage for the following components: 1) Siemens Medical Solutions 7T MRI Scanner 2) 7T 830/AS Magnet (FL#400-342363) This includes all portions of the scanner to ensure operation of the scanner is at maximum performance. The contractor will supply all replacement parts as required on an exchange or new part basis in order to maintain the equipment at Original Equipment Manufacturers (OEM) specifications. The contractor shall provide all necessary documentation, repair parts, spare parts, accessories, maintenance supplies, all special tools, test and support equipment, travel and transportation, personnel skill requirements, and other related services required in performance of maintenance tasks to keep the equipment in good operating condition, except for costs of repairs occasioned by fault or negligence of the Government or its agent. There will be a qualified service engineer on-site from 12:00pm to 8:00pm Monday through Friday, and there will be off-hour coverage available from 8:00pm to 12:00 am Monday through Friday and 8:00am to 5:00pm Saturday and Sunday. The on-call engineer shall be on the site within 4 hours of placing the maintenance request. Technical support and remote diagnostics shall be provided and be available 24 hours per day, 7 days a week. This telephone support shall be available within one hour of request. The contractor shall provide a daily check of the system error logs. The contractor assumes the responsibility for correcting problems as noted therein. The maintenance services must be performed by an authorized service provider for this specific piece of Siemens equipment. Anticipated period of performance: One base year from Date of Award, and one option year. The provision at FAR clause 52.212-1, Instructions to Offerors - Commercial Items, applies to this acquisition. The provision at FAR clause 52.212-2, Evaluation - Commercial Items, applies to this acquisition. This section is an addendum to the FAR clause 52.212-2, Evaluation--Commercial Items applicable to this solicitation. The provision at FAR Clause 52.212-3, Offeror Representations and Certifications Commercial Items, applies to this acquisition. The provision at FAR Clause 52.212-4, Contract Terms and Conditions-Commercial Items, applies to this acquisition. FAR Clause 52.212-5 is attached and is applicable to this acquisition. The provision of FAR clause 52.216-5, PRICE REDETERMINATION-PROSPECTIVE (OCT 1997), is included by reference and shall be applicable to any contract resulting from this solicitation. The provision at FAR clause 52.217-8. Option to Extend Services, applies to this acquisition. FAR Clause 52.217-9 is attached and is applicable to this acquisition. There are no additional contract requirement(s) or terms and conditions applicable to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. POST AWARD EVALUATION OF CONTRACTOR PERFORMANCE a. Contractor Performance Evaluations Interim and final evaluations of Contractor performance will be prepared on this contract in accordance with FAR Subpart 42.15. The final performance evaluation will be prepared at the time of completion of work. In addition to the final evaluation, interim evaluation(s) will be prepared annually prior to the exercise of options. Interim evaluations will not be prepared for awards with a period of performance of less than 18-months. Interim evaluations will be prepared annually for awards greater than 18-months. Interim and final evaluations will be provided to the Contractor as soon as practicable after completion of the evaluation. The Contractor will be permitted thirty days to review the document and to submit additional information or a rebutting statement. If agreement cannot be reached between the parties, the matter will be referred to an individual one level above the Contracting Officer, whose decision will be final. Copies of the evaluations, Contractor responses, and review comments, if any, will be retained as part of the contract file, and may be used to support future award decisions. b. Electronic Access to Contractor Performance Evaluations Contractors may access evaluations through a secure Web site for review and comment at the following address: http://www.cpars.gov   INSTRUCTIONS TO OFFERORS / EVALUATION CRITERIAResponses received to this RFQ will be evaluated on the basis of technical capability. The Government will award a contract resulting from this solicitation on the basis of best value, technical factors, past performance and price. The below technical factor shall be considered more important than price. The technical evaluation factors are as follows, in order of importance: 1) Factor 1: Technical Capability: Offerors shall clearly indicate their ability to provide a full service maintenance contract for this equipment, as well as documentation showing that they are an authorized service provider. Offerors submitting a response with documented evidence of possessing the technical knowledge, qualifications, capability, management structure and experience needed in successfully performing this requirement will be determined to be technically acceptable. In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All Offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All responses must be received no later than August 23th, 11:00 AM, Eastern Time, as specified in this announcement. The total number of pages, (combination of technical approach, past performance, and price quote) shall not exceed 25 pages in length, including appendices and any technical features. Pages submitted in excess of this 25-page limit will not be considered in evaluation of responses to this RFQ. A cover page may be submitted that does not count toward the 25 page limit. The Contractor shall submit its quote electronically in a "read only" format with a font size of 11 or 12 point and font type of Arial or Times New Romans. Margins must be 1-inch wide (top, bottom, left, and right). Late responses will not be accepted. All responses must reference solicitation number HHS-NIH-NIDA-SSSA-CSS-2016-621. Responses must be submitted electronically to pamela.daugherty@nih.gov. Facsimile responses will not be accepted. For information regarding this solicitation, contact Pamela Daugherty by email at pamela.daugherty@nih.gov or by phone at (301) 480-2467.

HIDEX Sense Multi-Technology Microplate Reader

Department of Health and Human Services, National Institutes of Health | Published August 18, 2015  -  Deadline August 22, 2015
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This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NIHLM2015353 and is issued as a Request for Quotation (RFQ). The solicitation /contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-73. The North American Industrial Classification (NAICS) code 334519 with a size standard of 500 employees. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. The National Institutes of Health (NIH), National Institute of Digestive, Diabetes & Kidney Diseases (NIDDK) has a requirement to procure Brand Name or Equal to: Lablogic Systems Inc., Hidex Sense Microplate Reader with the following specifications: HIDEX Sense Multi-Technology Microplate Reader for Luminescence (LUM), Fluorescence Intensity (Fl), Time Resolved Fluorescence (TRF), Fluorescence Polarization (FP) and Absorbance (ABS) measurements. Reader is robot accessible. Includes MS Windows based touch screen operated instrument control/data acquisition software and high performance optics for reading of micro-well plates up to 1536 wells. Features: Shaking prior to measurement of each plate or well Scanning of wells - 1 OOum steps over entire plate area Temperature Control from 2C above ambient to 65C Measurement time/plate - Depends on the plate and measurement type - Minimum 3 S.D. above blank) - Dynamic range up to 6 decades. - Fluorescence Intensity (Fl): < 0.15 fmol fluorescein/ well in a black 384-well plate, 50uL sample vol. - Time-resolved Fluorescence (TRF): < 3 amol Eu/well in a white 384-well plate. 50uL sample vol. - Fluorescence Polarization (FP): < 5 (typical < 3 mP stdev) at 1 nM fluorescein, in a black 96 well plate, 200 uL sample vol. Luminescence Mode - Kinetic and endpoint measurements . - Glow Luminescence with or without filters - Dynamic range up to 6 decades - Sensitivity < 10 pM glow luminescence in a white 96-well plate (> 3 S.D. above blank) - Background < 200 CPS - Cross-talk (sample volume 200 uL):

Animal Brain Section Lab Equipment

Department of Health and Human Services, National Institutes of Health | Published August 14, 2015  -  Deadline August 24, 2015
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INTRODUCTION AND AUTHORITY This is a combined synopsis/solicitation (CSS) for commercial items prepared in accordance with the format in Federal Acquisition Regulation (FAR) subpart 12.6, "Streamlined Procedures for Evaluation and Solicitation for Commercial Items," as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotations are being requested, and a written solicitation document will not be issued. The Government intends to issue a firm fixed price purchase order using simplified acquisition procedures under the authority of FAR Part 13, "Simplified Acquisition Procedures." This solicitation is a request for quotations (RFQ). The solicitation number is HHS-NIH-NIDA-SSSA-CSS-15-722. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-83 dated August 3, 2015. The resultant purchase order will include all applicable provisions and clauses in effect through this date. The National Institute on Drug Abuse, Office of Station Support and Simplified Acquisitions, on behalf of the National Institute of Mental Health (NIMH) is seeking to purchase several pieces of lab equipment to conduct animal brain sections. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE AND SET-ASIDE STATUS The associated North American Industrial Classification System (NAICS) code for this procurement is 339112, with a small business size standard of 500 employees. This acquisition is NOT set aside for small businesses and is available for full and open competition. DESCRIPTION OF REQUIREMENT The National Institute of Mental Health's Intramural Research Program (IRP) will need this lab equipment to generate a large volume of animal brain sections for its research mission. The group will generate a high output of slide-mounted sections per year. The sectioning must be done with high precision, yielding histologically perfect sections for in situ hybridization histochemistry and immunocytochemistry. The sectioning must be done at an exact thickness. The two-stage stereotaxic instrument will be critical for restraining animals during injection and patch clamping. All interested companies shall provide quotations for the following: 1. One (1) Vibratome Semi and fully automated vibrating blade microtome for sectioning fresh and fixed tissues. Must include: • Capability of storing multiple individual sectioning parameters • Adaptability to a wide range of circumstances as demands change • Minimal vertical deflection of cutting blade. Ideally, an optical device for minimizing the vertical deflection of blade • Rapid cutting speed of to allow high volume of sections • Small enough for standard laboratory bench space 2. One (1) Microtome Ergonomic sliding microtome designed to ensure smooth blade movement and accurate sectioning thickness. Must include: • Safety guard to protect users • Quick release clamps for specimen stages • Can section at 0.5 to 60 microns • Compatible knives for paraffin and frozen sections • Small enough for standard laboratory bench space 3. One (1) Recirculating Chiller Chiller used to keep mounting stages of microtomes and vibratomes frozen so that samples do not thaw during sectioning. Must include: • Temperature Range from -20°C to +40°C • Temperature stability of ±0.5 °C • Suitable for continuous operation • Must also include: buffer tray and accessories compatible with recirculating chiller. Must include tray, specimen disk, and all necessary tubes, clamps, hoses and couplings 4. Two (2) Sectioning Knives • For paraffin and frozen sections • Length from 16-22cm • Must be compatible with sectioning instruments in this purchase description 5. One (1) Computer-assisted Stereotaxic Instrument Allows for reproducible stereotaxic surgeries specifically on mice. • Allows for varied angle of injection or probing of small animal brains • Includes computer with software to keep track of electrode placement within brain • Ear Bar Cups Accessory-must include device for holding mice in proper alignment for stereotaxic surgery DELIVERY AND ACCEPTANCE Delivery shall be provided no later than 30 days after the award of the contract to the following address: Porter Neuroscience Research Center 35 Convent Dr. Building 35 Bethesda, MD 20892 The Contracting Officer or authorized representative will perform inspection and acceptance of materials and services to be provided. EVALUATION FOR AWARD Evaluations shall be conducted in accordance with FAR 13.106. Award will be made to the lowest-priced, technically acceptable, responsible offeror. The Government shall consider technical (capability of the items offered to meet the agency need), price, and past performance. APPLICABLE CLAUSES AND PROVISIONS The full text of FAR provisions or clauses may be accessed electronically at https://www.acquisition.gov/?q=browsefar The following contract clauses apply to this acquisition: 1. FAR 52.212-4, "Contract Terms and Conditions-Commercial Items" (May 2015) 2. FAR 52.212-5, "Contract Terms and Conditions Required to Implement Statutes or Executive Orders" (May 2015) The following subparagraphs of FAR 52.212-5 are applicable: (b) The Contractor shall comply with the FAR clauses in this paragraph (b) that the Contracting Officer has indicated as being incorporated in this contract by reference to implement provisions of law or Executive orders applicable to acquisitions of commercial items: (4) 52.204-10, Reporting Executive Compensation and First-Tier Subcontract Awards (JUL 2013) (Pub. L. 109-282) (31 U.S.C. 6101 note). (8) 52.209-6, Protecting the Government's Interest When Subcontracting with Contractors Debarred, Suspended, or Proposed for Debarment (AUG 2013) (31 U.S.C. 6101 note). (12)(i) 52.219-4, Notice of Price Evaluation Preference for HUBZone Small Business Concerns (JAN 2011) (if the offeror elects to waive the preference, it shall so indicate in its offer) (15 U.S.C. 657a). (22) 52.219-28, Post Award Small Business Program Rerepresentation (JUL 2013) (15 U.S.C. 632(a)(2)). (25) 52.222-3, Convict Labor (JUNE 2003) (E.O. 11755). (26) 52.222-19, Child Labor--Cooperation with Authorities and Remedies (JAN 2014) (E.O. 13126). (27) 52.222-21, Prohibition of Segregated Facilities (APR 2015). (28) 52.222-26, Equal Opportunity (APR 2015) (E.O. 11246). (30) 52.222-36, Equal Opportunity for Workers with Disabilities (JUL 2014) (29 U.S.C. 793). (32) 52.222-40, Notification of Employee Rights Under the National Labor Relations Act (DEC 2010) (E.O. 13496) (33)(i) 52.222-50 Combating Trafficking in Persons (MAR 2015) (22 U.S.C. chapter 78 and E.O. 13627). (38) 52.223-15, Energy Efficiency in Energy-Consuming Products (DEC 2007) (42 U.S.C. 8259b). (40) 52.223-18, Encouraging Contractor Policies to Ban Text Messaging While Driving (AUG 2011) (E.O. 13513). (42)(i) 52.225-3, Buy American--Free Trade Agreements--Israeli Trade Act (MAY 2014) (41 U.S.C. chapter 83, 19 U.S.C. 3301 note, 19 U.S.C. 2112 note, 19 U.S.C. 3805 note, 19 U.S.C. 4001 note, Pub. L. 103-182, Pub. L. 108-77, 108-78, 108-286, 108-302, 109-53, 109-169, 109-283, 110-138, Pub. L. 112-41, 112-42 and 112-43). (iii) Alternate II (MAY 2014) of 52.225-3. (44) 52.225-13, Restrictions on Certain Foreign Purchases (JUN 2008) (E.O.'s, proclamations, and statutes administered by the Office of Foreign Assets Control of the Department of the Treasury). (50) 52.232-33, Payment by Electronic Funds Transfer-System for Award Management (JUL 2013) (31 U.S.C. 3332). ---------- The following solicitation provisions apply to this acquisition: 1. FAR 52.212-1, "Instructions to Offerors-Commercial Items" (April 2014) 2. FAR 52.212-3, "Offerors Representations and Certifications-Commercial Items" (March 2015), attached at Appendix A, are to be completed by the offeror. POST AWARD EVALUATION OF CONTRACTOR PERFORMANCE a. Contractor Performance Evaluations Interim and Final evaluations of Contractor performance will be prepared on this contract in accordance with FAR Subpart 42.15. The Final performance evaluation will be prepared at the time of completion of work. In addition to the Final evaluation, Interim evaluation(s) will be prepared Annually as follows on October 31. Interim and Final evaluations will be provided to the Contractor as soon as practicable after completion of the evaluation. The Contractor will be permitted thirty days to review the document and to submit additional information or a rebutting statement. If agreement cannot be reached between the parties, the matter will be referred to an individual one level above the Contracting Officer, whose decision will be final. Copies of the evaluations, Contractor responses, and review comments, if any, will be retained as part of the contract file, and may be used to support future award decisions. b. Electronic Access to Contractor Performance Evaluations Contractors may access evaluations through a secure Web site for review and comment at the following address: http://www.cpars.gov. REQUESTS FOR CLARIFICATION Any questions or concerns regarding this solicitation should be forwarded in writing via e-mail to the contract specialist, Matthew Antonini, at Matthew.Antonini@nih.gov by or before 11:00 a.m. EST on 8/18/2015. Late questions will not be accepted. Questions will be anonymized and answered, with the answers being posted to this solicitation notice by amendment. Interested vendors should monitor this announcement closely for any changes. QUOTATION SUBMISSION Quotes are due on 8/24/2015, no later than 11:00 a.m. EST. All responses must be submitted via email to Matthew.Antonini@nih.gov and reference solicitation number HHS-NIH-NIDA-SSSA-CSS-15-722. Responses to this solicitation must include clear and convincing evidence of the offeror's capability of fulfilling the requirement. The offeror must submit a technical response and a separate price quotation. The technical response should be prepared in reference to the evaluation criteria identified in this solicitation and shall not exceed 15 pages. Submission of existing product literature for commercial items is acceptable. The price quotation must include pricing for the numbered requirements listed under "DESCRIPTION OF REQUIREMENT." Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. Offerors must provide their Company Name, Dun & Bradstreet Number (DUNS), Taxpayer Identification Number (TIN), Business Size, Physical Address, and Point of Contact Information in their responses. All offerors must have an active registration in the System for Award Management (SAM). Late submissions shall be treated in accordance with the solicitation provision at FAR 52.212-1(f).

Liquid/Compressed Gas Deliveries

Department of Health and Human Services, National Institutes of Health | Published August 3, 2015  -  Deadline August 14, 2015
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Combined Synopsis / Solicitation Title: Liquid/Compressed Gas Deliveries. (i) This is a combined synopsis/solicitation for commercial services prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. (ii) The solicitation number is HHS-NIH-NIDA (SSSA)-2015-CSS-456 and the solicitation is issued as a request for proposal (RFP). This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures; FAR Subpart 13.5-Test Program for Certain Commercial Items; and FAR Part 12-Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition threshold. (iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-83, dated July 7, 2015. (iv) A notice regarding any set-aside restrictions, the associated NAICS code 325120 - Industrial Gas Manufacturing and the small business size standard is 1000 employees. (v) Background The National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people's health and save lives. Purpose The object of this requirement is to provide Liquid Nitrogen Compressed Gas delivery services that must be adequate to meet the needs of the National Institutes of Aging (NIA), Intramural Research Program (IRP) Biomedical Research Center facility in Baltimore Maryland. Scope of Work Independently and not as an agent of the Federal Government, the contractor shall provide to the NIA BRC the rental of gas cylinders and liquid nitrogen compressed gas refills for tanks owned by the NIA IRP. The service is to include (1) cylinder usage fees; (2) TCF Tank Connection fees; (3) monthly liquid nitrogen compressed gas refills; and (4) emergency liquid nitrogen compressed gas refills. The emergency liquid nitrogen compressed gas refills will occur on a per call basis when requested by NIA IRP Procurement personnel for LN2CCF, RLN240 /148/180/240/365/60. The liquid nitrogen compressed gas refills are for delivery to the 1st floor loading dock of the of the Triad Building, 333 Cassell Drive, Baltimore, MD 21224 and the second floor 251 Bayview Boulevard, Suite 100, Baltimore, Maryland. Deliveries will occur for orders placed by 3:00 pm on the previous day twice weekly on Tuesday and Thursday between the hours of 8:30 am and 4:00pm. Emergency deliveries will occur on a per call basis when requested the NIA IRP Procurement Personnel. Contractor delivery personnel must be trained in the proper handling of compressed gas cylinders, which must meet and/or exceed the Occupations Safety and Health Administration (OSHA) Standards pursuant to 29 CFR 1910. All compressed gas deliveries must be in accordance with current, Federal, State, and Local government regulations. ADDITIONAL REQUIREMENT The contractor shall notify the contracting officer immediately of any changes in the negotiated prices as set forth in the contract at least 30 calendar days prior to the changes for the base period and option period of the contract. The contractor shall bill monthly for services provided, the invoice is to be sent to the National Institutes of Health, Office of Financial Management, Commercial Accounts, 2115 East Jefferson Street, Room 4B-432, MSC 8500, Bethesda, MD 20892-8500 within ten (10) business days of the following month. The Invoice must meet the NIH OFM requirements for prompt payment. (vi) The requirement is for a 12-month base period and two 12-month option periods. (vii) The provision at FAR clause 52.212-1, Instructions to Offerors - Commercial Items, applies to this acquisition. (viii) The provision at FAR clause 52.212-2, Evaluation - Commercial Items applies to this acquisition and the specific evaluation criteria to be included in paragraph (a) of that provision are as follows: The Government will award a purchase order resulting from this solicitation on the basis of best value, technical factors and price considered. Technical factors together shall be considered more important than price. The technical evaluation factors are as follows, in order of importance: 1. Factor 1: Technical Capability 10 points The Offeror shall detail in its technical proposal how it meets each of the service requirements as specified in the scope of work. 2. Factor 2: Approach to Delivery and Training 60 points The Offer shall detail in its technical proposal how it shall meet the delivery and training requirements as specified in the scope of work. 3. Factor 3: Experience and Past Performance 30 points The offeror shall detail in its technical proposal past experience in providing the supplies and services as specified in the scope of work. Specifically, the offeror shall provide a list of two (2) contracts completed during the past five (5) years, similar in size and scope to the requirements outlined in the Statement of Work. Offerors shall include the following information for each contract identified: • Name of Contracting Organization • Contract Number • Contract Type • Total Contract Value • Description of Requirement and Specific Responsibilities of the Offeror as they relate to this SOW • Contract Period of Performance (ix) The provision at FAR clause 52.212-3, Offeror Representations and Certifications - Commercial Items, applies to this acquisition. (x) FAR clause at 52.212-4, Contract Terms and Conditions - Commercial Items, applies to this acquisition. An addendum to FAR clause 52.212-4, Contract Terms and Conditions-Commercial Items applies to this acquisition. (xi) FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items, applies to this acquisition. (xii) 52.227-14 Rights in Data-General, (DEC 2007) (xiii) The Defense Priorities and Allocations System (DPAS) are not applicable to this (xiv) Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product or service. In addition, responses must include clear and convincing evidence of the offeror's capability of fulfilling the requirement as it relates to the technical evaluation criteria and a price proposal. The response should be practical, clear, and concise; should use quantitative terms whenever possible; should avoid qualitative adjectives; and should comprehensively address the requirements of this solicitation. Assumptions, conditions, or exceptions with any of the terms and conditions of this solicitation must be noted. If not noted, the Government will assume that no assumptions, conditions, or exceptions are made and the offeror agrees to comply with all of the terms and conditions as set forth in the solicitation. Information requested herein must be furnished in writing fully and completely in compliance with the solicitation. The information requested and the manner of submittal is essential to permit prompt evaluation of all offers on a fair and uniform basis. Simple statements of compliance (i.e., "understood"; "will comply") or phrases such as "standard procedures will be used" or "well known techniques will be utilized" and other generalities, without the detailed description of how compliance will be met, may not be considered sufficient evidence that the proposal can technically meet the project requirements. Accordingly, any response in which material information requested is not furnished or where indirect or incomplete answers or information are provided may be considered not acceptable. The price quote shall include: (1) Flat fee for NIH, NIA, IRP owned Liquid Nitrogen Cylinders Site Top Filled 50 liter cylinders; (2) Cost for a minimum of 160 liters and maximum of 240 liters liquid nitrogen; (3) Cost for per cylinder connection fee; (4) Monthly rental fee for 160 liter cylinder of liquid nitrogen, delivered full and exchanged full and exchanged for empty cylinder; (5) Monthly rental fee for 240 liter cylinder of liquid nitrogen, delivered full and exchanged full and exchanged for empty cylinder; (6) Flat fee for same day service during normal business hours (8:00 AM to 5:00 PM) for emergency delivery; (7) Flat fee for nights, weekends, or holidays for emergency delivery; and as applicable, (8) Cylinder monthly rental fees, hazardous material fees, surcharges, shipping and handling costs, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), etc. In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All questions regarding this combined synopsis/solicitation must be received in this office by 8:00AM (EST) on August 7, 2015. Offers must be received electronically by 12:00 PM (EST) on August 14, 2015. Facsimile submissions are not authorized and collect calls will not be accepted. Submit offers to: Rodney Brooks, Contract Specialist at rodney.brooks@nih.gov and NIDASSSAPurchaseRequ@mail.nih.gov Please reference the solicitation number HHS-NIH-NIDA-(SSSA)-CSS-15-456 on your offer. Requests for information concerning this requirement are to be addressed to Rodney Brooks via e-mail only to rodney.brooks@nih.gov prior to the closing date for questions.

AVANCE III I-ID 600 HIGH PERFORMANCE DIGITAL NMR CONSOLE

Department of Health and Human Services, National Institutes of Health | Published July 29, 2015  -  Deadline August 7, 2015
cpvs

This is a combined synopsis/solicitation for commercial items prepared in accordance notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NIHLM2015552 and is issued as a Request for Quotation (RFQ). The solicitation /contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-82. The North American Industry Classification (NAICS) Code is 334516 with a size standard of 500. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. The National Institutes of Health (NIH), National Institute of Digestive, Diabetes & Kidney Diseases (NIDDK) has a requirement to procure Bruker Bio-Spin AVANCE III I-IDTM 600 HIGH PERFORMANCE DIGITAL NMR CONSOLE NIDDK's LCP studies the structure and dynamics of proteins, protein-protein complexes, and protein-nucleic acid complexes using multidimensional nuclear magnetic resonance (NMR) spectroscopy, and develops and applies novel NMR and computational methods to aid in these studies. Over the past half-dozen years, the use of solution NMR in studying the molecular processes underlying viral replication have expanded from determination of static structures to the study of the transitions between key states in the viral replication process. Examples of this work include NIDDK studies of gp41-mediated membrane fusion, RNA packaging, formation of the HIV-1 capsid shell, and analysis of the conformational space sampled by the protein domains of intact HIV-1 Gag. Technically, the requisite experiments push the limits of what is feasible with available hardware, and, in terms of sensitivity, the observation of transient intermediate states requires lengthy acquisitions. Mandatory Technical Specifications for Avance III HDTM digital NMR console to replace an existing Bruker 600 MHz high-resolution NMR console equipped with pulsed field gradient triple resonance probe head. All specifications shall be guaranteed on site and must have been achieved by the offerer at the time the proposal is being submitted. The spectrometer shall be fully compatible with all 9 other high-resolution solution NMR spectrometers presently in use in the Laboratory of Chemical Physics, NIDDK. These are all of the Bruker Avance III console type. The new instrument shall have the same operating and pulse programming software as the existing instruments. The spectrometer shall provide a minimum of four frequency channels together with the capability of producing different asynchronous or synchronous composite pulse decoupling and different shaped pulses on all of these channels simultaneously and independently. The composite pulse decoupling schemes must be freely programmable by the user and include the option for pulse shaping of the individual elements of the composite pulses. All channels shall have identical specifications at low rf power levels, except that only one channel requires operation over the frequency range from 540 to 601 MHz (for 19F and 1H), and a minimum of three channels shall operate over the frequency range from 29 to 241 MHz (all other nuclei). For the cryogenically cooled probehead the 90° pulse widths shall be ≤ 8 s for 1H, ≤ 13 s for 13C and ≤30 s for 15N, and ≤80 s for 2H, for an aqueous non-saline sample. The sensitivity specifications for the triple resonance pulsed field gradient 5 mm cryogenically cooled probehead, using Wilmad-535 sample tubes shall meet: (i) ASTM 0.1% ethylbenzene ≥ 6500:1 (200 Hz noise region) (ii) 2 mM sucrose/ml D2O ≥950:1 (iii) 2 mM sucrose/ml in 150 mM NaCl in D2O ≥430:1 (iv) 13C sensitivity (ASTM) ≥ 1070:1 (v) 2H sensitivity (1% D2O/990% H2O) ≥ 1150 The system shall be equipped with hardware and software for mapping the magnetic field profile within the sample in three orthogonal dimensions, and software for making the required homogeneity adjustments under computer control. The spectrometer shall be capable of doing this for samples dissolved in D2O and in H2O. The spectrometer shall also include the capability to automatically adjust the homogeneity of the magnetic field during the course of multi-hour experiments which include pulsed field gradients, without interrupting the actual experiments or having any other noticeable effect on the acquisition process. The pulse programming system shall permit implementation of user-developed pulse sequences and shall be capable of conducting all experiments published in the volumes 1-62 of the Journal of Biomolecular NMR. It shall be possible to specify at least 30 independent pulse sequence interval lengths and 30 pulse widths in a single pulse program. The minimum interval length shall be no greater than 500 ns. It shall be possible to specify each interval length in increments of 25 ns or less. It shall be possible to write and execute pulse programs with at least 256 steps (without loops), with each step representing a time period during which any combination of pulses on the four channels is given. The amplitudes and phases of the pulses shall be arbitrarily programmable, subject only to the resolution limits on the phase shifters and rf attenuators. It shall be possible to include at least twenty loops within a single pulse program, with independent loop counters. It shall be possible to nest loops. The console electronics shall be capable of 0.5 degree phase resolution, 0.1 Hz frequency resolution and a 120 dB attenuation range on all four channels. The RF phase shall vary by no more than 3˚ over an attenuation range of 45 dB from full power. At any offset, the excitation profile of a 1H shaped pulse shall be within 50% from its theoretical profile, as tested for the residual HDO line in a D2O sample, for offsets of up to 10 ppm. At any offset, the excitation profile of a 15N or 13C shaped pulse shall be within 50% from its theoretical limit for offsets up to 100 ppm. The console shall be able to pulse and observe 2H nuclei without physically recabling the console, and capable of applying 90˚ 2H pulse widths of less than 80 microseconds. The long term pulse amplitude stability on all channels shall be ≤ 1% and phase stability shall be better than 1˚, as measured over a 24 h period in a room where the temperature changes by less than 1.5 ˚C. This phase and amplitude stability is measured from the relative difference between 1D spectra, recorded with a 30˚ flip angle pulse, at various times during a 24 h period. The system shall be capable of performing spin lock experiments on the 5-mm triple resonance z-axis gradient cryogenically cooled probehead for up to 100 ms for 1H (B1 = 12 kHz), up to 50 ms for the 13C channels (B2 = 12 kHz for 13C), and up to 120 ms for the 15N channel (B2 = 3 kHz for 15N), with droop in the supplied RF power ≤ 2%, and total duty cycles (time with RF on divided by total time) of up to 5%, for a one-hour period. The console electronics shall permit application of user defined shaped pulses to operate independently on each of the available channels. The shaped pulses must allow a minimum of 16000 user-definable elements within a single pulse shape. The dynamic range of each channel for shaped pulses must be at least 70 dB total range with 0.1 dB resolution half range. The system shall be capable of independent and simultaneous control over amplitude, frequency, phase and duration of pulses for all frequency channels and over internal real-time clock pulses for triggering of external devices. The console shall be equipped with a digitizer of at least 16 bits allowing simultaneous sampling of the quadrature receiver channels for spectral widths of up to at least 125 kHz. The system shall also be capable of oversampling and digital filtering of the NMR audio signal. In addition, no DC offset correction in the time domain shall be required on data acquired with a single scan, independent of receiver gain setting. The system shall be equipped with a pulse program controlled pulsed field gradient power supply, capable of generating a field gradient along the z axis with a strength of at least 70 G/cm. The recovery of the magnetic field homogeneity shall be such that a signal acquired 200 s after a 1 ms gradient at 50% of maximum power, differs by less than 3% from that acquired without the preceding gradient pulse. This shall be measured for a sample of 2 mM sucrose in D2O solution, using 1 Hz exponential line broadening and identical phasing. Before high-power amplification, pulse rise and fall times shall be Industrial Classification (NAICS) code 334516 with a size standard 500. All respondents are requested to identify their firm's size and type of business. Interested firms responding to this market survey must provide (a) capability statement demonstrating their experience, skills and capability to fulfill the Government's requirements for the above. The capability statement shall be in sufficient enough detail, but not to exceed 15 pages, so that the Government can determine the experience and capability of your firm to provide the requirements above. Your capability statement, not to exceed 15 pages, should include references. Responses: E-MAIL will be accepted and can be sent to griffinv@mail.nih.gov The offeror must include a completed copy of the following provisions: 1) FAR Clause 52.212-1 Instructions to Offerors - Commercial items; 2) FAR Clause 52.212-2, Evaluation - Commercial Items. As stated in FAR Clause 52.212-2 (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be advantageous to the Government, price and other factors considered. The following factors will be used equally to evaluate offers: Technical Evaluation, Price, and Past Performance. Note: Past Performance Information: Vendors must submit a listing of the most recent contracts/awards (minimum of 3) which demonstrate similar work in nature to this Solicitation. Contracts/awards may include those entered with the Federal Government, state and local governments and commercial concerns. Include the following information for each contract or subcontract: 1. Name of Contracting Organization 2. Contract Number (for subcontracts provide the prime contract number and the subcontract number) 3. Contract Type 4. Total Contract Value 5. Description of Requirement 6. Contracting Officer's Name and Telephone Number 7. Program Manager's Name and Telephone Number 3) FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items; 4) FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; 5) FAR Clause 52-212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions. The Dun and Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN) and the certification of business size shall be included. The clauses are available in full text at https://www.acquisition.gov PLEASE NOTE: In order to receive an award, contractor must be registered and have valid certification in the System For Award Management (SAM) http://www.sam.gov Interested vendors capable of providing the Government with the items specified in this synopsis should submit their quotation to the below address. Quotations will be due on or before August 7, 2015 at 11:00 a.m. EST. Offersors shall provide an original and one copy of your quotation. The quotation must reference Solicitation number NIHLM201552. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Quotations may be submitted electronically to Verne Griffin at griffinv@mail.nih.gov