Public tenders for molecular in Canada

Find all Healthcare tenders in the world.
Finding business opportunities has never been easier.

Results for healthcare. Make a new search!

Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure

Health Canada | Published August 14, 2014
cpvs

NOTICE OF PROPOSED PROCUREMENT (NPP) 1. SOLICITATION #: 1000162382 2. CLOSING DATE: August 28 2014 2 CLOSING TIME and TIME ZONE: 3:00 p.m. EDT This requirement is for the department of Health Canada. 4. TITLE: Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure 5. INTRODUCTION: The Inhalation Toxicology Laboratory (ITL) and Analytical Biochemistry and Proteomics Laboratory (ABPL) of Health Canada requires expert assistance with the bioinformatic analysis of high content proteomic mass spectral data derived from air pollution toxicology studies. 6. OBJECTIVES OF THE REQUIREMENT The objective of this requirement is to complete expert bioinformatic analyses of the data generated in an investigation of the in vitro toxicity of ambient particulate matter impacted by source emissions on lung epithelial, mouse macrophage and human macrophage cell lines. The analyses will be used by Health Canada researchers to identify molecular changes relevant to air pollution toxicity in cell and animal models, and publish the results of the research in peer reviewed scientific publications. 7. SECURITY REQUIREMENT: There is no security associated with this requirement. 8. MANDATORY REQUIREMENTS: Attention Bidders: Please Write beside each of the criteria the relevant page number(s) from your proposal that addresses the requirement identified in the criteria. M1 The Bidder must provide within their proposal a CV of the proposed resource that describes the capability to perform this work successfully. M2 The Bidder must hold as a minimum a M.Sc. or Ph.D. in biology; and a graduate diploma or degree in bioinformatics. A copy of the certification/diploma must be included in the Bidders proposal. M3 The Bidder must provide two references from previous work/projects that are similar to the work as outlined within this Statement of Work within their proposal. The references must be a Project Authority/Project Lead from a previous project. For all referenced projects the Bidder must provide the following information: 1. Name, phone number, and e-mail address of the client reference 2. Start and end dates of the project 3. Name of project and a brief description of the work involved 4. Role and length of involvement of the proposed resource on the project *Note: Health Canada reserves the right to check references by contacting one or all of the references provided. Health Canada also reserves the right to reject a bidder should one or more of the references provided not be available within one week from completion of bid evaluation and if in checking references they do not confirm the resources work experience, quality of work and information provided by the bidder. M4 The Bidder must provide a resource with at least 6 years of work experience from date of this RFP in conducting bioinformatic analyses of proteomic data. Experience must be in months and years. M5 The Bidder must have a minimum of five (5) years experience by the date of this RFP working as a bioinformatician in a proteomics laboratory. Experience must be in month and years. Address inquiries in writing to: Donna Pettit Senior Procurement and Contracting Officer Ottawa, ON K1A 0K9 Donna.pettit@hc-sc.gc.ca

Automated Gel Permeation Chromatography (GPC)

Environment Canada | Published August 21, 2014
cpvs

Trade Agreement: NAFTA/AIT/Canada FTAs with Peru/Colombia/Panama Tendering Procedures: All interested suppliers may submit a bid Attachment: None Competitive Procurement Strategy: Lowest/Lower Bid Comprehensive Land Claim Agreement: No Nature of Requirements: Automated Gel Permeation Chromatography (GPC) Environment Canada (EC) Burlington, ON, has requested the supply and delivery of one (1) automated gel permeation chromatography (GPC) system equipped with an autosampler, automatic evaporation module, and data system for the removal of lipids and other high molecular weight interferences from biological or other environmental samples. This sample preparation and clean-up system will be used for contaminant monitoring and surveillance activities by Environment Canada's Water Quality Monitoring and Surveillance Division supporting priorities of the Chemicals Management Plan. Primarily, the system will be used to separate lipids from biological extracts which can then be analysed for priority contaminants; however, as a modular system it can be easily expanded and modified to handle many different sample types to accommodate future monitoring and surveillance priorities. Please refer to the Request for Proposal document for the complete details regarding this requirement including the mandatory criteria, evaluation criteria and basis of selection. Delivery Date: Above-mentioned The Crown retains the right to negotiate with suppliers on any procurement. Documents may be submitted in either official language of Canada.

Stable Isotope Ratio Mass Spectrometer (IRMS) - Geological Survey of Canada, NRCan, Quebec

Natural Resources Canada | Published August 28, 2014
cpvs

Trade Agreement: WTO-AGP/NAFTA/AIT/Canada FTAs with Peru/Colombia/Panama Tendering Procedures: Generally only one firm has been invited to bid Attachment: None Non-Competitive Procurement Strategy: Government Objectives Representing Best Interests/Value to Govt Comprehensive Land Claim Agreement: No Vendor Name and Address: ISO-MASS SCIENTIFIC INC #140, 5700 - 1 Street S.W. Calgary Alberta Canada T2H3A9 Nature of Requirements: 1. ADVANCE CONTRACT AWARD NOTICE (ACAN) An ACAN is a public notice indicating to the supplier community that a department or agency intends to award a contract for goods, services or construction to a pre-identified supplier, thereby allowing other suppliers to signal their interest in bidding, by submitting a statement of capabilities. If no supplier submits a statement of capabilities that meets the requirements set out in the ACAN, on or before the closing date stated in the ACAN, the contracting officer may then proceed with the award to the pre-identified supplier. 2. DEFINITION OF THE REQUIREMENT The Geological Survey of Canada (GSC-Québec) of Natural Resources Canada (NRCan), requires a stable isotope ratio mass spectrometer (IRMS). This IRMS system will play a key role in cutting edge research to be carried out under the framework of NRCan's Geo-Mapping for Energy and Minerals (GEM) program. The purpose of the GEM program is to advance geological knowledge in the North to support increased exploration of natural resources and inform decisions on land use that balance conservation and responsible resource development. NRcan Plans to purchase a Thermo-Finnigan MAT 253 stable isotope ratio mass spectrometer to widen the range of masses that can be analyzed with gas source IRMSs in the field of stable isotope geochemistry, so to allow cutting edge research primarily using a new type of indicators, the "clumped isotopes" (unusual combinations of heavy-rare stable isotopes). This instrument can perform precise and accurate measures of this type of isotopic combinations that are less abundant than their common molecules (CO2 of mass 44; CH4 of mass 16), by a factor of 20 000 (for CO2 in carbonates; mass 47) or 100 000 (for CH4; mass 18). To NRCan knowledge, the Thermo-Finnigan MAT 253 IRMS system has the HIGHEST SENSITIVITY and LINEARITY on the market (600 molecules/ion for sensitivity mode, and 900 molecules/ion for linearity mode). As such, it is the ONLY instrument capable of determining precise and accurate measurements of "clumped isotopes" The MAT 253 can perform precise and accurate measures of this type of isotopic combinations that are less abundant than their common molecules (CO2 of mass 44; CH4 of mass 16), by a factor of 20 000 (for CO2 in carbonates; mass 47) or 100 000 (for CH4; mass 18). Determinations of "clumped isotopes" are required in order for the Delta-Lab, Geological Survey of Canada (GSC-Québec), Natural Resources Canada, to carry out high quality research as demanded by NRCan's stakeholders. In particular, these analyses are essential to the research to be carried out under the framework of NRCan's Geo-Mapping for Energy and Minerals (GEM) Program (2013-2020). 3. CRITERIA FOR ASSESSMENT OF THE STATEMENT OF CAPABILITIES (MINIMUM ESSENTIEL REQUIREMENTS) Any interested supplier must demonstrate by way of a statement of capabilities that its system meets the following requirements: 3.1 General Requirements 3.1.1 Track record: The vendor must demonstrate a proven and successful track record of production of IRMS systems. Vendors will be required to identify at least three installations over the past five years and provide points of contact and related information. No prototypes, demonstration models or used/refurbished instruments will be considered. The instrument model offered for sale must be in full production. 3.1.2 Warranty, upgrades and service: The vendor must guarantee a minimum one-year warranty on all parts and labour beginning on the date of acceptance of the system by the site authority (after complete installation). During the warranty period, hardware upgrades developed by the manufacturer to increase performance and/or reliability of the instrument, must be provided free of charge. After the warranty period, the hardware upgrades will be available to be purchased by the user. 3.1.3 Delivery: The instrument must be delivered to the GSC-Québec on or before March 31, 2015. All cables, tubing, power cords, fittings and other accessories required for installation and operation must be included along with complete operation and maintenance manuals. 3.1.4 Safety: The instrument must comply with international regulatory, safety, and electromagnetic compatibility requirements and be designed and manufactured under a quality system registered to ISO 9001. 3.1.5 Installation and Training: The instrument must be installed by a vendor factory-trained representative. 3.2 Technical Specifications "Ion Source and Analyzer": 3.2.1 The electron impact ionization source must be capable of reaching a 10 kV acceleration voltage. 3.2.2 The ion source must allow for variable conductivity. 3.2.3 The ion source must be pumped down using a two-stage turbo molecular pump. 3.2.4 Ion source potentials and parameters must be computer controlled, either manually or automatically. 3.2.5 The ion source manifold must be weld-free, machined from a single piece of stainless steel, and all-metal sealed. 3.2.6 The IRMS system must have a low and stable H3+ factor for accurate and precise determination of D/H ratios by continuous flow. 3.2.7 Must have a 460 mm mass dispersion. 3.2.8 Must be equipped with an optional differential pumping module. "Collectors": 3.2.9 The IRMS system must allow for the installation of up to eight individual Faraday cups. It must be possible to acquire data from any number of these cups simultaneously. 3.2.10 The IRMS system must be capable of static multicollection of CO2 isotopologues (44-49) with 10e12 ohm resistors for 47-48-49. 3.2.11 Sensitivity: 600 molecules CO2 per mass 44 ion at the collector (600 molecules/ion) in dual inlet mode. Ion Source linearity: 900 molecules/ion in continuous flow mode. 3.2.12 Mass range m/z 1 - 150 at full acceleration voltage. 3.2.13 Mass resolution 200 (C,N,O,S). 3.2.14 The IRMS must allow for sequential H2 + CO2 without magnet jump. 3.2.15 The amplifiers must have a linear dynamic range of 50 V. 3.2.16 The amplifier gain must be computer switchable. 3.2.17 Analog digital conversion must occur in the amplifier housing under vacuum. "Dual Inlet System": 3.2.18 The instrument must support a dual inlet system which uses all-metal valve blocks with gold-sealed and gold-seated valves. 3.2.19 It must be possible to adjust the variable bellows between 3 and 40 ml volume. 3.2.20 It must be possible to heat the dual inlet system. 3.2.21 It must be possible to expand the dual inlet system by one or two multiports (10 ports each). 4. APPLICABILITY OF THE TRADE AGREEMENTS TO THE PROCUREMENT This procurement is subject to the following trade agreements: .1 Agreement on Internal Trade (AIT) .2 North American Free Trade Agreement (NAFTA) .3 World Trade Organization Agreement on Government Procurement (WTO-AGP) .4 Canada-Chile Free Trade Agreement (CCFTA) .5 Canada-Peru Free Trade Agreement (CPFTA) 5. JUSTIFICATION FOR THE PRE-IDENTIFIED SUPPLIER We believe that the Thermo-Finnigan MAT 253 stable isotope ratio mass spectrometer is the only product able to perform the work or comply with government requirements. 6. GOVERNMENT CONTRACTS REGULATIONS EXCEPTION The following exception(s) to the Government Contracts Regulations is (are) invoked for this procurement under subsection 6(d) - only one person is capable of performing the work. 7. EXCLUSIONS AND/OR LIMITED TENDERING REASONS The following exclusions and/or limited tendering reasons are invoked under the trade agreements specified: .1 Agreement on Internal Trade (AIT) Article 506: Procedures for Procurement: 12. Where only one supplier is able to meet the requirements of a procurement, an entity may use procurement procedures that are different from those described in paragraphs 1 through 10 in the following circumstances: (b) where there is an absence of competition for technical reasons and the goods or services can be supplied only by a particular supplier and no alternative or substitute exists. .2 North American Free Trade Agreement (NAFTA) Part Four: Government Procurement - Chapter Ten Article 1016: Limited Tendering Procedures: 2. An entity may use limited tendering procedures in the following circumstances and subject to the following conditions: (b) where there is an absence of competition for technical reasons, the goods or services can be supplied only by a particular supplier and no reasonable alternative or substitute exists. .3 World Trade Organization Agreement on Government Procurement (WTO-AGP) Article XV: Limited Tendering: 1. The provisions of Articles VII through XIV governing open and selective tendering procedures need not apply in the following conditions, provided that limited tendering is not used with a view to avoiding maximum possible competition or in a manner which would constitute a means of discrimination among suppliers of other Parties or protection to domestic producers or suppliers: (b) when, for works of art or for reasons connected with protection of exclusive rights, such as patents or copyrights, or in the absence of competition for technical reasons, the products or services can be supplied only by a particular supplier and no reasonable alternative or substitute exists. .4 Canada-Chile Free Trade Agreement (CCFTA) Article Kbis-09: Tendering Procedures: 1. Entities may award contracts by means other than open tendering procedures, provided that the tendering procedure is not used to avoid competition or to protect domestic suppliers in the following circumstances, where applicable: (b) where, for works of art, or for reasons connected with the protection of patents, copyrights or other exclusive rights, or proprietary information or where there is an absence of competition for technical reasons, the goods or services can be supplied only by a particular supplier and no reasonable alternative or substitute exists. .5 Canada-Peru Free Trade Agreement (CPFTA) Article 1409: Limited Tendering: 1. Provided that a procuring entity does not use this provision to avoid competition among suppliers, to protect domestic suppliers, or in a manner that discriminates against suppliers of the other Party, the procuring entity may contact a supplier or suppliers of its choice and may choose not to apply Articles 1405, 1406, 1407, 1408 and 1410 in any of the following circumstances: (b) where the goods or services can be supplied only by a particular supplier and no reasonable alternative or substitute goods or services exist for any of the following reasons: (iii) due to an absence of competition for technical reasons. 8. PERIOD OF THE PROPOSED DELIVERY DATE The goods must be delivered no later than March 31st, 2015. 9. COST ESTIMATE OF THE PROPOSED CONTRACT The estimated value of the contract is between $400,000 $ to $500,000 applicable taxes in extra. 10. NAME AND ADDRESS OF THE PRE-IDENTIFIED SUPPLIER Isomass Scientific Inc. #140, 5700 - 1 Street S.W. Calgary, Alberta CANADA, T2H 3A9 11. SUPPLIER ' RIGHT TO SUBMIT A STATEMENT OF CAPABILITIES Suppliers who consider themselves fully qualified and available to provide the goods, services or construction services described in the ACAN may submit a statement of capabilities in writing to the contact person identified in this notice on or before the closing date of this notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements. 12. CLOSING DATE FOR A SUBMISSION OF A STATEMENT OF CAPABILITIES The closing date and time for accepting statements of capabilities is September 12, 2014 at 2:00 p.m. Eastern standard time (EST). 13. INQUIRIES AND SUBMISSION OF STATEMENTS OF CAPABILITIES Inquiries and statement of capabilities are to be directed to: Marial Tremblay Supply Specialist Public Works and Government Services Canada (PWGSC) CFB Bagotville, P.O. Box 380 Building 62, Room 112 Alouette, Quebec, G0V 1A0 Telephone: (418) 677-4000, Ext.: 4159 Facsimile: (418) 677-3288 E-mail: marial.tremblay@pwgsc.gc.ca Delivery Date: Above-mentioned You are hereby notified that the government intends to negotiate with one firm only as identified above. Should you have any questions concerning this requirement, contact the contracting officer identified above. An Advance Contract Award Notice (ACAN) allows departments and agencies to post a notice, for no less than fifteen (15) calendar days, indicating to the supplier community that it intends to award a good, service or construction contract to a pre-identified contractor. If no other supplier submits, on or before the closing date, a Statement of Capabilities that meets the requirements set out in the ACAN, the contracting authority may then proceed with the award. However, should a Statement of Capabilities be found to meet the requirements set out in the ACAN, then the contracting authority will proceed to a full tendering process. Suppliers who consider themselves fully qualified and available to provide the services/goods described herein, may submit a statement of capabilities in writing to the contact person identified in this Notice on or before the closing date of this Notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements. The PWGSC file number, the contracting officer's name and the closing date of the ACAN must appear on the outside of the envelope in block letters or, in the case of a facsimile transmission, on the covering page. The Crown retains the right to negotiate with suppliers on any procurement. Documents may be submitted in either official language of Canada.

Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure

 | Published September 23, 2014
Winner
Fred Elisma
cpvs

NOTICE OF PROPOSED PROCUREMENT (NPP) 1. SOLICITATION #: 1000162382 2. CLOSING DATE: August 28 2014 2 CLOSING TIME and TIME ZONE: 3:00 p.m. EDT This requirement is for the department of Health Canada. 4. TITLE: Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure 5. INTRODUCTION: The Inhalation Toxicology Laboratory (ITL) and Analytical Biochemistry and Proteomics Laboratory (ABPL) of Health Canada requires expert assistance with the bioinformatic analysis of high content proteomic mass spectral data derived from air pollution toxicology studies. 6. OBJECTIVES OF THE REQUIREMENT The objective of this requirement is to complete expert bioinformatic analyses of the data generated in an investigation of the in vitro toxicity of ambient particulate matter impacted by source emissions on lung epithelial, mouse macrophage and human macrophage cell lines. The analyses will be used by Health Canada researchers to identify molecular changes relevant to air pollution toxicity in cell and animal models, and publish the results of the research in peer reviewed scientific publications. 7. SECURITY REQUIREMENT: There is no security associated with this requirement. 8. MANDATORY REQUIREMENTS: Attention Bidders: Please Write beside each of the criteria the relevant page number(s) from your proposal that addresses the requirement identified in the criteria. M1 The Bidder must provide within their proposal a CV of the proposed resource that describes the capability to perform this work successfully. M2 The Bidder must hold as a minimum a M.Sc. or Ph.D. in biology; and a graduate diploma or degree in bioinformatics. A copy of the certification/diploma must be included in the Bidders proposal. M3 The Bidder must provide two references from previous work/projects that are similar to the work as outlined within this Statement of Work within their proposal. The references must be a Project Authority/Project Lead from a previous project. For all referenced projects the Bidder must provide the following information: 1. Name, phone number, and e-mail address of the client reference 2. Start and end dates of the project 3. Name of project and a brief description of the work involved 4. Role and length of involvement of the proposed resource on the project *Note: Health Canada reserves the right to check references by contacting one or all of the references provided. Health Canada also reserves the right to reject a bidder should one or more of the references provided not be available within one week from completion of bid evaluation and if in checking references they do not confirm the resources work experience, quality of work and information provided by the bidder. M4 The Bidder must provide a resource with at least 6 years of work experience from date of this RFP in conducting bioinformatic analyses of proteomic data. Experience must be in months and years. M5 The Bidder must have a minimum of five (5) years experience by the date of this RFP working as a bioinformatician in a proteomics laboratory. Experience must be in month and years. Address inquiries in writing to: Donna Pettit Senior Procurement and Contracting Officer Ottawa, ON K1A 0K9 Donna.pettit@hc-sc.gc.ca

Construction of pseudotyped lentiviruses

Department of National Defence | Published September 26, 2014
cpvs

Trade Agreement: LCSA/AIT Tendering Procedures: The bidder must supply Canadian goods and/or services Attachment: None Competitive Procurement Strategy: Best Overall Proposal Comprehensive Land Claim Agreement: No Nature of Requirements: IMPORTANT NOTICE TO BIDDERS Notifications about amendments to an opportunity Buyandsell.gc.ca/tenders provides a Web feed to keep you informed about amendments to an opportunity of interest. Get more details on the Government of Canada Web site: https://buyandsell.gc.ca/procurement-data/tenders/follow-opportun ities#20 TITLE: Construction of pseudotyped lentiviruses expressing the envelope proteins of viral biothreat agents REQUIREMENT: Defence Research and Development Canada (DRDC) - Suffield, Medicine Hat, Alberta has a requirement for a contractor to make a pseudotyped lentivirus expressing the envelope protein from ebolavirus MANDATORY CRITERIA: Failure to meet any of the following mandatory requirements at solicitation closing will render your submission non-compliant and given no further consideration. 1. Education: Principal investigator(s) must have a Ph.D. in biology. 2. Experience: 2a). in completion of project(s) related to biodefence program; 2b). in publication in medical countermeasure development against biothreat agents; 2c). in the field of molecular biology and assay development; 3. Price Proposal does not exceed the established budget. CONTRACTOR SELECTION: Contractor selection will be based on the bidder that submits the highest technically acceptable proposal provided that the total evaluated bid price does not exceed the established budget. OWNERSHIP OF INTELLECTUAL PROPERTY: Crown Owned MAXIMUM FUNDING: The maximum funding available for the Contract resulting from the bid solicitation is $76,500.00 (Applicable Taxes extra, as appropriate). Bids valued in excess of this amount will be considered non-responsive. This disclosure does not commit Canada to pay the maximum funding available. PERIOD OF CONTRACT: The period of the contract is from date of award to March 31, 2015 inclusive with one additional one (1) year option period. jasmine.scott@pwgsc-tpsgc.gc.ca Delivery Date: Above-mentioned The Crown retains the right to negotiate with suppliers on any procurement. Documents may be submitted in either official language of Canada.

In Vitro Exposures of Human Lymphoblastoid (TK6) Cells Treated with Diverse Genotoxic and Non-Genotoxic Chemicals

Health Canada | Published October 7, 2014
cpvs

HEALTH CANADA ADVANCE CONTRACT AWARD NOTICE TITLE: In Vitro Exposures of Human Lymphoblastoid (TK6) Cells Treated with Diverse Genotoxic and Non-Genotoxic Chemicals SOLICITATION NUMBER: 1000162248 1. The purpose and explanation of an ACAN An Advance Contract Award Notice (ACAN) allows Health Canada contracting authorities to post a notice on the Government Electronic Tendering System (GETS), for no less than fifteen (15) calendar days, indicating to the supplier community that a good, service or construction contract will be awarded to a pre-identified contractor. If no other supplier submits, on or before the closing date, a Statement of Capabilities that meets the requirements set out in the ACAN, the contracting authority may then proceed with the award. However, should a Statement of Capabilities be found to meet the requirements set out in the ACAN, then the contracting authority will proceed to a full tendering process. 2. Rights of suppliers Suppliers who believe that they are fully qualified and available to provide the services or goods described in this ACAN may submit a Statement of Capabilities clearly demonstrating how they meet the advertised requirement. This Statement of Capabilities must be provided via e-mail only to the contact person identified in Section 12 of the Notice on or before the closing date and time of the Notice. If there is a reasonable level of evidence regarding capability, the requirements will be opened to electronic or traditional bidding processes. 3. Proposed Contractor Georgetown University 3970 Reservoir Road, NW Research Building E504 Washington, DC 20057 4. Definition of Requirements or Expected Results Health Canada is seeking to award a contract to Georgetown University (GU) to perform exposures in human cells treated with diverse genotoxic and non-genotoxic chemicals to further develop and refine a genotoxicity biomarker. The scientific data will be used to assist Health Canada in the development of non-animal based lab methods for the practical application of genomics tools for hazard identification and human health risk assessment of environmental chemicals. Dr. Carole Yauk, a research scientist at Health Canada, was recently awarded a five-year Genomics Research and Development Initiative (GRDI) grant through a competitive, externally reviewed process. Drs. Albert Fornace Jr. and Heng-Hong Li of Georgetown University (GU), who originally developed in their research laboratory the genotoxicity biomarker to be used in this contract, also co-authored with Dr. Yauk, the proposal that won the five-year GRDI grant. In order to further develop and refine the 65-gene biomarker, GU will repeat the human cellular exposures using the original training set of twenty-eight chemicals. This will allow Health Canada to conduct further gene expression analysis to broaden the precision, applicability and utility of the biomarker for public use and formal validation for use in human health risk assessment. 5. Minimum requirements Any interested supplier must demonstrate by way of a Statement of Capabilities that it meets the following minimum requirements: a. The supplier’s principal investigator must have a PhD in biomedical sciences (toxicology, biochemistry, molecular biology, etc.) and at least ten years of direct experience managing in vitro genetic toxicology experiments. b. The project team must have significant expertise in mechanistic-based toxicology research in the area of mutagenesis, toxicogenomics and genotoxicity assessment. c. The supplier must have at least ten years of experience conducting chemical exposures in human TK6 cells. d. The supplier must have demonstrated proficiency conducting cytotoxicity assays to measure cell viability (e.g., MTT or MTS assay) in human TK6 cells. e. The supplier must be extremely knowledgeable with respect to the TGx-28.65 genotoxicity classifier, a 65-gene signature derived from 28 genotoxic and non-genotoxic chemicals in human TK6 cells in culture f. The supplier must be able to reproduce the work necessary to further develop and refine the TGx-28.65 classifier and have the twenty-eight test chemicals available for cellular exposures. g. The project team must include a minimum of 2 members, including a project manager/mechanistic-based toxicologist, specializing in mutagenesis and toxicogenomics, and a laboratory technician. 6. Reason for non-competitive award Section 6 of the Government Contracts Regulations contains four exceptions that permit the contracting authority to set aside the requirement to solicit bids. For the proposed procurement, the following exception applies: (d) Only One Person or Firm is capable of performing the contract. In light of the fact that the work of the proposed contract will build on the genotoxicity biomarker developed by Drs. Albert Fornace Jr. and Heng-Hong Li of Georgetown University (GU), and the fact that Drs Fornace and Li helped to draft the proposal that won the funding for this latest work, it is believed that Georgetown University has unique technical expertise and advantage that makes it highly unlikely any other supplier could do the work, especially for the funding available. 7. Applicable trade agreements and justification for limited tendering or the Procurement Strategy for Aboriginal Business This requirement is subject to the various trade agreements, including the North American Free Trade Agreement (NAFTA) and the Agreement on Internal Trade (AIT). However, this requirement also meets the conditions for limiting the tendering procedures in accordance with: I. AIT, Article 506.12 (b). II. NAFTA, Article 1016.2 (b) which allow for contracts to be directed to a particular firm when the products or services can be supplied only by a particular supplier and no reasonable alternative or substitute exists. This requirement is not subject to the Procurement Strategy for Aboriginal Business. 8. Ownership of Intellectual Property Health Canada will retain ownership of the copyright on the deliverables of this contract by virtue of Section 6.4.1 of the Treasury Board Secretariat Policy on Title to Intellectual Property Arising Under Crown Procurement Contracts, which states that the Crown may retain ownership of intellectual property when the main purpose of the contract is to generate knowledge and information for public dissemination. 9. Period of the proposed contract The contract period shall be from the award of the contract until May 31, 2015. Health Canada reserves the right to exercise four option periods. 10. Estimated value of the proposed contract The initial contract is worth $50,000.00 CAD. However, the contract will include three option years at a maximum of $35,000.00 CAD for the first option year; $30,000.00 CAD for the second year; and $15,000.00 CAD for the third year, for a maximum total potential contract value of $130,000.00 CAD. 11. Closing date and time The closing date and time for accepting Statements of Capabilities is 2 p.m. EDT on the 24th of July 2014. 12. Contact Person All inquiries with regard to this Notice must be addressed by e-mail to: Robert Merrick Senior Contracting Officer Materiel and Assets Management Division Health Canada E-mail: Robert.Merrick@hc-sc.gc.ca

: Cytotoxicity and Genotoxicity Testing in Human Hepatic (HepaRG) Cells Treated with Diverse Chemical Toxicants

Health Canada | Published October 7, 2014
cpvs

HEALTH CANADA ADVANCE CONTRACT AWARD NOTICE TITLE: Cytotoxicity and Genotoxicity Testing in Human Hepatic (HepaRG) Cells Treated with Diverse Chemical Toxicants SOLICITATION NUMBER: 1000162249 1. The purpose and explanation of an ACAN An Advance Contract Award Notice (ACAN) allows Health Canada contracting authorities to post a notice on the Government Electronic Tendering System (GETS), for no less than fifteen (15) calendar days, indicating to the supplier community that a good, service or construction contract will be awarded to a pre-identified contractor. If no other supplier submits, on or before the closing date, a Statement of Capabilities that meets the requirements set out in the ACAN, the contracting authority may then proceed with the award. However, should a Statement of Capabilities be found to meet the requirements set out in the ACAN, then the contracting authority will proceed to a full tendering process. 2. Rights of suppliers Suppliers who believe that they are fully qualified and available to provide the services or goods described in this ACAN may submit a Statement of Capabilities clearly demonstrating how they meet the advertised requirement. This Statement of Capabilities must be provided via e-mail only to the contact person identified in Section 12 of the Notice on or before the closing date and time of the Notice. If there is a reasonable level of evidence regarding capability, the requirements will be opened to electronic or traditional bidding processes. 3. Proposed Contractor Integrated Laboratory Systems Inc. (ILS) PO Box 13501 Research Triangle Park, NC 27709 U.S.A. 4. Definition of Requirements or Expected Results Health Canada is seeking to award a contract to Integrated Laboratory Systems (ILS) to perform cytotoxicity and genotoxicity testing following chemical exposures of human cells to diverse genotoxic and non-genotoxic agents. The scientific data will be used to assist Health Canada in the development of non-animal based lab methods for the practical application of genomics tools for hazard identification and human health risk assessment of environmental chemicals. Dr. Carole Yauk, a research scientist at Health Canada, was recently awarded a five-year Genomics Research and Development Initiative (GRDI) grant through a competitive, externally reviewed process. Dr. Carol Swartz, the In Vitro Toxicology Program Manager at ILS, and Dr. Leslie Recio, the Chief Scientist at ILS, co-authored with Dr. Carole Yauk, the proposal that won the five-year GRDI grant. ILS has worked with Health Canada for the past two years through a contract that was initially awarded through a competitive contracting process. ILS has already optimized the methodology that is required for the next phase of the research. 5. Minimum requirements Any interested supplier must demonstrate by way of a Statement of Capabilities that it meets the following minimum requirements: a. The supplier’s principal investigator must have a PhD in biomedical sciences (toxicology, biochemistry, molecular biology, etc.) and at least ten years of direct experience managing in vitro genetic toxicology experiments. b. The project team must have significant expertise in mechanistic-based toxicology research in the area of mutagenesis, toxicogenomics and regulatory-based genotoxicity assessment. c. The contractor must have at least ten years of experience conducting chemical exposures in human TK6 cells. d. The contractor must have extensive experience using rat liver S9 metabolic activation with human TK6 cells (i.e., optimization of concentration and type of induction based on the chemical of interest). e. The contractor must have at least one year of experience conducting chemical exposures in human HepaRG cells. f. The contractor must have demonstrated proficiency conducting cytotoxicity and genotoxicity testing using high-content flow cytometry-based assays to measure cell viability, apoptosis/ necrosis, cell cycle arrest and micronucleus frequency with the In Vitro MicroFlow test kit in both human TK6 cells and human HepaRG cells. g. The contractor must be familiar with the TGx-28.65 genotoxicity classifier, a 65-gene signature developed using 28 genotoxic and non-genotoxic chemicals in human TK6 cells in culture. h. The contractor’s facility and procedures must be consistent with industry standards for Quality Control (QC) and Quality Assurance (QA), including Standard Operating Protocols (SOPs) for the required testing that meet national or international guidelines (e.g., OECD test guideline 487), established data acceptance criteria, established data management and processing procedures, and established procedures for data analysis, data interpretation, and preparation of final reports. i. The contractor must have managed and executed at least 5 projects of similar nature, size and complexity in the last 5 years. j. The project team must include a minimum of 2 members, including a project manager/mechanistic-based toxicologist, specializing in mutagenesis and toxicogenomics, and a laboratory technician. 6. Reason for non-competitive award Section 6 of the Government Contracts Regulations contains four exceptions that permit the contracting authority to set aside the requirement to solicit bids. For the proposed procurement, the following exception applies: (d) Only One Person or Firm is capable of performing the contract. In light of the fact that the work of the proposed contract will build on work performed by ILS under a previous contract that was competitively awarded, and the fact that senior scientists at ILS helped to draft the proposal that won the funding for this latest work, it is believed that ILS has unique technical expertise and advantage that makes it highly unlikely any other supplier could do the work, especially for the funding available. 7. Applicable trade agreements and justification for limited tendering or the Procurement Strategy for Aboriginal Business This requirement is subject to the various trade agreements, including the North American Free Trade Agreement (NAFTA); the Agreement on Internal Trade (AIT); and the World Trade Organization - Agreement on Government Procurement (WTO-GPA). However, this requirement also meets the conditions for limiting the tendering procedures in accordance with: I. AIT, Article 506.12 (b). II. NAFTA, Article 1016.2 (b) III. WTO-AGP, Article XV which allow for contracts to be directed to a particular firm when the products or services can be supplied only by a particular supplier and no reasonable alternative or substitute exists. This requirement is not subject to the Procurement Strategy for Aboriginal Business. 8. Ownership of Intellectual Property Health Canada will retain ownership of the copyright on the deliverables of this contract by virtue of Section 6.4.1 of the Treasury Board Secretariat Policy on Title to Intellectual Property Arising Under Crown Procurement Contracts, which states that the Crown may retain ownership of intellectual property when the main purpose of the contract is to generate knowledge and information for public dissemination. 9. Period of the proposed contract The contract period shall be from the award of the contract until May 31, 2015. Health Canada reserves the right to exercise four option periods. 10. Estimated value of the proposed contract The initial contract is worth $50,000.00 CAD. However, the contract will include four option years at a maximum of $50,000.00 CAD per year, for a maximum total potential contract value of $250,000.00 CAD. 11. Closing date and time The closing date and time for accepting Statements of Capabilities is 2 p.m. EDT on the 24th of July 2014. 12. Contact Person All inquiries with regard to this Notice must be addressed by e-mail to: Robert Merrick Senior Contracting Officer Materiel and Assets Management Division Health Canada E-mail: Robert.Merrick@hc-sc.gc.ca

Discrete Chemistry Analyzer

Canadian Grain Commission | Published November 4, 2014
cpvs

Trade Agreement: NONE Tendering Procedures: All interested suppliers may submit a bid Attachment: None Competitive Procurement Strategy: Lowest/Lower Bid Comprehensive Land Claim Agreement: No Nature of Requirements: Discrete Chemistry Analyzer The Canadian Grain Commission (CGC), Grain Research Laboratory (GRL) has a requirement for the supply, installation, and training for one (1) Discrete Chemistry Analzyer, including personal computer and software for the assessment of various chemical and biochemical components associated with the quality of barley and malt. The discrete chemistry analyzer is an automated system for the spectrophotometric measurements with computer-controlled sample and reagent aspiration, dispensing, heating, mixing, and absorbance measurement. The system must be capable of conducting multiple assays on one or more sample matrices. Assays to be conducted for barley and malt quality include standard measures of wort quality including free amino nitrogen and high molecular weight beta-glucan as well as activity of target enzymes such as alpha amylase. The CGC is responsible for providing quality assurance for Canadian malting barley. The GRL research programs support grain quality assurance through testing, monitoring, research and development. Bidders must submit a list of names , or other related information as needed, pursuant to section 01 of Standard Instructions 2003 (2014-09-25). The requirement is subject to a preference for Canadian goods and/or services. All deliverables must be received on or before March 18, 2015. 5K003-156449/A Desrochers, Leah leah.desrochers@pwgsc-tpsgc.gc.ca Telephone No. - (204) 984-8872 Fax No. - (204) 983-7796 Delivery Date: Above-mentioned The Crown retains the right to negotiate with suppliers on any procurement. Documents may be submitted in either official language of Canada.

High Capacity Multiplexing 3D Syste

Agriculture & Agrifood Canada | Published November 14, 2014
cpvs

Trade Agreement: NAFTA/AIT/Canada FTAs with Peru/Colombia/Panama Tendering Procedures: All interested suppliers may submit a bid Attachment: None Competitive Procurement Strategy: Lowest/Lower Bid Comprehensive Land Claim Agreement: No Nature of Requirements: Marlene Hall Supply Specialist Telephone: 204-984-6423 E-mail: marlene.hall@pwgsc-tpsgc.gc.ca File No.: 01633-141028/A TITLE: High Capacity Multiplexing 3D System Agriculture & Agri-Food Canada (AAFC) in Brandon, Manitoba has a requirement for the supply and delivery one (1) High Capacity Multiplexing 3-D system in accordance with the Minimum Performance Specifications detailed herein. The high capacity multiplexing 3-D system (HCMS) will be used for the crop production pathology program, the six-row and hulless barley breeding program as well as the oat and wheat breeding programs at the Brandon Research Centre (BRC). Currently, this technology is not available at BRC to support ongoing molecular genetic research. An onsite HCMS will provide improved capacity and productivity for the breeding and pathology programs at BRC. The HCMS is essential to support unprecedented progress in research. A complete list of the mandatory performance specifications are detailed in solicitation document. All the deliverables must be received on or before March 31, 2015. FOB destination: Agriculture and Agri-Food Canada, Brandon Research Centre, Brandon, Manitoba Canada. TRADE AGREEMENTS The requirement is subject to the provisions of the North American Free Trade Agreement (NAFTA) and the Agreement on Internal Trade (AIT). Delivery Date: Above-mentioned The Crown retains the right to negotiate with suppliers on any procurement. Documents may be submitted in either official language of Canada.

MiSeq, Hi-ScanSQ & C-Bot Equipment Service Coverage & Preventative Maintenance

Agriculture & Agrifood Canada | Published February 13, 2015  -  Deadline February 27, 2015
cpvs

REQUIREMENT: Agriculture and Agri-Food Canada, Saskatoon Research Centre (SRC) in Saskatoon, SK requires service coverage and preventative maintenance for the Illumina Miseq, Hi-Scan with SQ module, and Illumina C-bot equipment. This includes a comprehensive coverage plan with full coverage on all parts, labour and travel; comprehensive 5 × 24 email support and 5 × 18 telephone support (instrument, applications, bioinformatics); three business day average on-site response time; hardware and software updates; on-site applications support; discounts on advanced training and one preventative maintenance visit per year. This specialized equipment can only be serviced by the original supplier, Illumina. The equipment is proprietary to Illumina and Illumina does not provide licenses to outside contractors to service their machines. SCOPE OF WORK: The Illumina MiSeq, Hi-Scan with SQ module and C-bot were purchased previously from Illumina in 2011, 2012 and 2013. This equipment is essential to a number of projects at SRC. In addition, SRC processes samples for researchers at other AAFC centres and for collaborators in Saskatoon. The Illumina equipment is predominantly used for molecular marker analyses, so it is used for identifying genetic variation and mapping traits of interest and thus is essential for numerous projects in both the Genomics group and the breeding section. Some of the equipment is also used for gene discovery work, in particular for genes controlling resistance to abiotic and biotic stress. The equipment is used by multiple labs in Saskatoon. Labs in Fredericton and Winnipeg have also used the equipment for marker work. CONTRACT PERIOD: The Contract will be for the period from March 19, 2015 to March 18, 2016 with two (2), one (1) year options to extend. INITIAL CONTRACT VALUE: Estimated Value: $63,062.00 USD (plus taxes, if applicable) Option Periods: #1 - March 19, 2016 – March 18, 2017 - $65,406.00 (plus taxes, if applicable) #2 - March 19, 2017 – March 18, 2018 - $68,208.00 (plus taxes, if applicable) PROPOSED CONTRACTOR: Illumina, Inc. 5200 Illumina Way San Diego, CA 92121-1975 United States SOLE SOURCE JUSTIFICATION: Illumina Canada is the only company that can provide guaranteed equipment coverage and servicing for this equipment. The equipment is proprietary to Illumina and Illumina does not provide licenses to outside contractors to service their machines. Any outside servicing of equipment (other than Illumina), will no longer allow us to purchase upgrades, trade-in’s to the equipment, etc. and Illumina will no longer guarantee that they could fix the equipment if there is a breakdown. The equipment is expensive and the most cost effective way to ensure there are no work stoppages is to maintain a service contract with Illumina for comprehensive services. These services will provide efficient response times for any problems which could arise and on-going optimization of the equipment. ACAN NOTICE: You are hereby notified that the government intends to negotiate with one firm only as identified above. Should you have any questions concerning this requirement, contact the Contracting Authority. An Advance Contract Award Notice (ACAN) allows departments and agencies to post a notice, for no less than fifteen (15) calendar days, indicating to the supplier community that it intends to award a good, service or construction contract to a pre-identified contractor. If no other supplier submits, on or before the closing date, a "Statement of Capabilities" that meets the requirements set out in the ACAN, the Contracting Authority may then proceed with the award. However, should a Statement of Capabilities be found to meet the requirements set out in the ACAN, then the Contracting Authority will proceed to a full tendering process. Inquiries on Submission of Statement of Capabilities: Suppliers who consider themselves fully qualified and available to provide the services/goods described herein, may submit a statement of capabilities in writing, either via letter, facsimile or email to the contact person identified in this Notice on or before the closing date of this notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements. The Solicitation Number, Name of Contracting Authority and Closing Date of the ACAN must appear within your Statement of Capabilities in block letters. The Crown retains the right to negotiate with suppliers on any procurement. Contracting Authority: Melissa Smith, Procurement Officer Agriculture and Agri-Food Canada Western Service Centre 300 – 2010 12th Avenue Regina, SK S4P 0M3 Phone: 306-523-6545; Fax: 306-780-5018 Melissa.Smith@agr.gc.ca

Award Notice - MiSeq, Hi-ScanSQ & C-Bot Equipment Service Coverage & Preventative Maintenance

Agriculture & Agrifood Canada | Published March 19, 2015
Winner
Illumina Canada, Inc.
cpvs

REQUIREMENT: Agriculture and Agri-Food Canada, Saskatoon Research Centre (SRC) in Saskatoon, SK requires service coverage and preventative maintenance for the Illumina Miseq, Hi-Scan with SQ module, and Illumina C-bot equipment. This includes a comprehensive coverage plan with full coverage on all parts, labour and travel; comprehensive 5 × 24 email support and 5 × 18 telephone support (instrument, applications, bioinformatics); three business day average on-site response time; hardware and software updates; on-site applications support; discounts on advanced training and one preventative maintenance visit per year. This specialized equipment can only be serviced by the original supplier, Illumina. The equipment is proprietary to Illumina and Illumina does not provide licenses to outside contractors to service their machines. SCOPE OF WORK: The Illumina MiSeq, Hi-Scan with SQ module and C-bot were purchased previously from Illumina in 2011, 2012 and 2013. This equipment is essential to a number of projects at SRC. In addition, SRC processes samples for researchers at other AAFC centres and for collaborators in Saskatoon. The Illumina equipment is predominantly used for molecular marker analyses, so it is used for identifying genetic variation and mapping traits of interest and thus is essential for numerous projects in both the Genomics group and the breeding section. Some of the equipment is also used for gene discovery work, in particular for genes controlling resistance to abiotic and biotic stress. The equipment is used by multiple labs in Saskatoon. Labs in Fredericton and Winnipeg have also used the equipment for marker work. CONTRACT PERIOD: The Contract will be for the period from March 19, 2015 to March 18, 2016 with two (2), one (1) year options to extend. INITIAL CONTRACT VALUE: Estimated Value: $63,062.00 USD (plus taxes, if applicable) Option Periods: #1 - March 19, 2016 – March 18, 2017 - $65,406.00 (plus taxes, if applicable) #2 - March 19, 2017 – March 18, 2018 - $68,208.00 (plus taxes, if applicable) PROPOSED CONTRACTOR: Illumina, Inc. 5200 Illumina Way San Diego, CA 92121-1975 United States SOLE SOURCE JUSTIFICATION: Illumina Canada is the only company that can provide guaranteed equipment coverage and servicing for this equipment. The equipment is proprietary to Illumina and Illumina does not provide licenses to outside contractors to service their machines. Any outside servicing of equipment (other than Illumina), will no longer allow us to purchase upgrades, trade-in’s to the equipment, etc. and Illumina will no longer guarantee that they could fix the equipment if there is a breakdown. The equipment is expensive and the most cost effective way to ensure there are no work stoppages is to maintain a service contract with Illumina for comprehensive services. These services will provide efficient response times for any problems which could arise and on-going optimization of the equipment. ACAN NOTICE: You are hereby notified that the government intends to negotiate with one firm only as identified above. Should you have any questions concerning this requirement, contact the Contracting Authority. An Advance Contract Award Notice (ACAN) allows departments and agencies to post a notice, for no less than fifteen (15) calendar days, indicating to the supplier community that it intends to award a good, service or construction contract to a pre-identified contractor. If no other supplier submits, on or before the closing date, a "Statement of Capabilities" that meets the requirements set out in the ACAN, the Contracting Authority may then proceed with the award. However, should a Statement of Capabilities be found to meet the requirements set out in the ACAN, then the Contracting Authority will proceed to a full tendering process. Inquiries on Submission of Statement of Capabilities: Suppliers who consider themselves fully qualified and available to provide the services/goods described herein, may submit a statement of capabilities in writing, either via letter, facsimile or email to the contact person identified in this Notice on or before the closing date of this notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements. The Solicitation Number, Name of Contracting Authority and Closing Date of the ACAN must appear within your Statement of Capabilities in block letters. The Crown retains the right to negotiate with suppliers on any procurement. Contracting Authority: Melissa Smith, Procurement Officer Agriculture and Agri-Food Canada Western Service Centre 300 – 2010 12th Avenue Regina, SK S4P 0M3 Phone: 306-523-6545; Fax: 306-780-5018 Melissa.Smith@agr.gc.ca

Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure

Health Canada | Published August 18, 2015  -  Deadline February 9, 2015
cpvs

NOTICE OF PROPOSED PROCUREMENT (NPP) Solicitation #: 1000174482 Closing Date: September 2, 2015 Time: 2 p.m. EDT This requirement is for the department of Health Canada. Title: Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure Scope: The Inhalation Toxicology Laboratory (ITL) and Analytical Biochemistry and Proteomics Laboratory (ABPL) of Health Canada requires expert assistance with the bioinformatic analysis of high content proteomic mass spectral data derived from air pollution toxicology studies. Objectives of the Requirement The objective of this requirement is to complete expert bioinformatic analyses of the data generated in an investigation of the in vitro toxicity of ambient particulate matter impacted by source emissions on lung epithelial and mouse macrophage cell lines. The analyses will be used by Health Canada researchers to identify molecular changes relevant to air pollution toxicity in cell and animal models, and publish the results of the research in peer reviewed scientific publications. Ownership of Intellectual Property: The Crown will retain ownership of the copyright. Security Requirement: The Contractor personnel requiring access to PROTECTED information, assets or sensitive work site(s) must EACH hold a valid RELIABILITY STATUS, granted or approved by Canadian Industrial Security Directorate (CISD) of PWGSC. If the winning bidder does not hold this security screening level, the supplier will be required to obtain it before the contract is awarded. Mandatory Requirements: M1. The Bidder's proposed project leader must have a minimum of five (5) years experience by the date of this RFP working as a bioinformatician in a proteomics laboratory. M2. The Bidder's proposed project leader must hold as a minimum an Master of Science (M.Sc.) in biology; and a graduate diploma or degree in bioinformatics. M3. The Bidder must provide two references from previous work/projects conducted by the proposed project leader that are similar to the work outlined in this requirement’s Statement of Work. The references must be a former client’s Project Authority/Project Lead from a previous project. M4. The Bidder must provide a resource with at least 6 years of work experience from the date of this RFP in conducting bioinformatic analyses of proteomic data. Selection Methodology The contract will be awarded based on a determination of best value taking into account both the technical merit of the proposals and the price evaluations. To arrive at an overall score achieved by a firm, a weighting has been established whereby technical merit will be valued at 70% of the bid and price at 30%. Enquiries regarding this Request for Proposals are to be submitted in writing to: Robert Merrick Contracting Authority E-mail: Robert.Merrick@hc-sc.gc.ca

TRIP. QUAD. ICP MASS SPECTROMETER

Health Canada | Published October 23, 2015  -  Deadline September 11, 2015
cpvs

Trade Agreement: WTO-AGP/NAFTA/AIT/Canada FTAs with Peru/Colombia/Panama Tendering Procedures: Generally only one firm has been invited to bid Non-Competitive Procurement Strategy: Exclusive Rights Comprehensive Land Claim Agreement: No Vendor Name and Address: Agilent Technologies Canada Inc. 6705 Millcreek Unit 5 Mississauga Ontario Canada L5N5M4 Nature of Requirements: TRIPLE QUADRUPOLE ICP MASS SPECTROMETER H4033-151114/A Martins, Christina Telephone No. - (613) 355-1973 Fax No. - (819) 956-3814 1. Advance Contract Award Notice (ACAN) An ACAN is a public notice indicating to the supplier community that a department or agency intends to award a contract for goods, services or construction to a pre-identified supplier, thereby allowing other suppliers to signal their interest in bidding, by submitting a statement of capabilities. If no supplier submits a statement of capabilities that meets the requirements set out in the ACAN, on or before the closing date stated in the ACAN, the contracting officer may then proceed with the award to the pre-identified supplier. 2. Definition of the requirement Health Canada has a requirement for the supply, installation, familiarization, training and manuals for one Triple Quadrupole ICP-MS. The instrument will be used for measurement of long-lived radioactive contaminants in environmental and human urine samples. 3. Criteria for assessment of the Statement of Capabilities Any interested supplier must demonstrate by way of a statement of capabilities that its equipment meets the following requirements: A. Technical Specifications: 1. The triple quadrupole ICP-MS system must have a tandem ICP-MS/MS configuration which consists of a Collision Reaction Cell between the two Quadrupole Mass Filters (QMFs), each of 1 atomic mass unit (amu) resolution. 2. Each of the QMFs must be independently controlled by system software to permit selective mass filtering/transmission capability. 3. The triple quadrupole ICP-MS must have a guaranteed abundance sensitivity specification of less than or equal to 10-10. 4. The triple quadrupole ICP-MS must have a background of less than or equal to 0.2 counts per second (cps) over the mass range 9 to 238 amu. 5. The triple quadrupole ICP-MS must have sensitivity of greater than or equal to 200,000 cps/ppb above mass 205 amu. 6. The triple quadrupole ICP-MS must have oxide ratio (CeO+/Ce+) of less than or equal to 1.5%. 7. The triple quadrupole ICP-MS must have doubly-charged ratio (Ce++/Ce+) of less than or equal to 3%. 8. The triple quadrupole ICP-MS system must to robust enough to handle a total dissolved solid = 1%. 9. The Collision Reaction Cell must accept up to 4 cell gases, each fully and independently mass flow controlled, and must allow mixing of different gases within the cell by the system software. 10. The triple quadrupole ICP-MS system must have an additional (5th) Mass Flow Controller for addition of alternative gas (oxygen/argon) in the plasma for organics/matrix removal. 11. The triple quadrupole ICP-MS system must have a Recirculating Chiller for a controlled supply of cooling water for the radio-frequency (RF) generator, turbo molecular pump, load coil, spray chamber, and interface. 12. The triple quadrupole ICP-MS system must have an auto-sampler with samples racks to accommodate 17mm and 30mm (outer diameter) sample tubes. The auto sampler must be controlled by the system software. 13. The triple quadrupole ICP-MS system must have high purity (2 stage, stainless steel body + diaphragm) gas regulators for Cell gases. 14. The quotation price must include Carrier Gas cleaning kit, connection tubing, tube cutter, wall mounting bracket, and stainless steel tubing for external cell gas lines. 15. The triple quadrupole ICP-MS system must have a noise reduction enclosure for the roughing pump. 16. The triple quadrupole ICP-MS system must include appropriate elemental standard solutions for instrument performance validation and tuning. 17. The triple quadrupole ICP-MS system must include appropriate connection kit for Liquid Chromatography. 18. The triple quadrupole ICP-MS system must include a separate set of inert sample introduction kit, appropriate interface cones and ion lenses for very high sensitivity measurement option. 19. The triple quadrupole ICP-MS system must include a table (84" X 30" X 35"; W, D, H) on heavy duty casters that lock in swivel and roll. The weigh capacity of the table must be adequate to support the auto sampler, the ICP-MS, computer, monitor, keyboard and a printer. 20. The triple quadrupole ICP-MS system must include a Personal Computer (PC) with Windows 7 or higher (64 bit) operating system, a monitor and a laser printer. The PC must have adequate processor speed, memory and disk space for complete instrument control, data acquisition and data analysis. 21. Quoted price must include installation and onsite training on the operation and maintenance of the system. B. Operating Software and Accessories 1. Must provide an instrument and operational manual. 2. Operating software must allow instrument control, data acquisition, and data processing. 3. Must have operating software for chromatographic data analysis. 4. Operating software must be compatible with Windows 7. 5. Operating software must allow for standard and customizable data reporting. 6. Operating software must allow data export to Microsoft Excel. 4. Applicability of the trade agreement(s) to the procurement This procurement is subject to the following trade agreements: Agreement on Internal Trade (AIT) North American Free Trade Agreement (NAFTA) The World Trade Organization Agreement on Government Procurement (WTO-AGP) 5. Justification for the Pre-Identified Supplier Agilent Technologies Canada Inc. offers the only Triple Quadrupole ICP-MS available in the market that meets all of Health Canada's requirements. For this reason, it is proposed to negotiate directly with the OEM, Agilent Technologies Canada Inc., Mississauga, Ontario. 6. Government Contracts Regulations Exception(s) The following exception to the Government Contracts Regulations is invoked for this procurement under subsection 6(d) - "only one person is capable of performing the work". 7. Exclusions and/or Limited Tendering Reasons The following exclusion(s) and/or limited tendering reasons are invoked under the: Agreement on Internal Trade (AIT) Article 506.12 (b) North American Free Trade Agreement (NAFTA) Article 1016.2 (b) The World Trade Organization - Agreement on Government Procurement (WTO-AGP) XV(1b) 8. Period of the proposed contract or delivery date Delivery must be received on or before 31 March 2016. 9. Name and address of the pre-identified supplier Name: Agilent Technologies Canada Inc. Address: Mississauga, ON 10. Suppliers' right to submit a statement of capabilities Suppliers who consider themselves fully qualified and available to provide the goods, services or construction services described in the ACAN, may submit a statement of capabilities in writing to the contact person identified in this notice on or before the closing date of this notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements. 11. Closing date for a submission of a statement of capabilities The closing date and time for accepting statements of capabilities is 9 November, 2016 at 2:00 p.m. EST. 12. Inquiries and submission of statements of capabilities Inquiries and statements of capabilities are to be directed to: Christina Martins Supply Specialist Commercial and Consumer Products Directorate Commercial Acquisitions and Supply Management Sector Public Works and Government Services Canada Gatineau, QC K1A 0S5 Place du Portage, Phase III, 6A2-29 Telephone 613-355-1973 Facsimile 819-956-3814 Christina.Martins@pwgsc.gc.ca Delivery Date: Above-mentioned You are hereby notified that the government intends to negotiate with one firm only as identified above. Should you have any questions concerning this requirement, contact the contracting officer identified above. An Advance Contract Award Notice (ACAN) allows departments and agencies to post a notice, for no less than fifteen (15) calendar days, indicating to the supplier community that it intends to award a good, service or construction contract to a pre-identified contractor. If no other supplier submits, on or before the closing date, a Statement of Capabilities that meets the requirements set out in the ACAN, the contracting authority may then proceed with the award. However, should a Statement of Capabilities be found to meet the requirements set out in the ACAN, then the contracting authority will proceed to a full tendering process. Suppliers who consider themselves fully qualified and available to provide the services/goods described herein, may submit a statement of capabilities in writing to the contact person identified in this Notice on or before the closing date of this Notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements. The PWGSC file number, the contracting officer's name and the closing date of the ACAN must appear on the outside of the envelope in block letters or, in the case of a facsimile transmission, on the covering page. The Crown retains the right to negotiate with suppliers on any procurement. Documents may be submitted in either official language of Canada.

Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure

Health Canada | Published November 2, 2015
Winner
8627789 Canada Inc.
cpvs

NOTICE OF PROPOSED PROCUREMENT (NPP) Solicitation #: 1000174482 Closing Date: September 2, 2015 Time: 2 p.m. EDT This requirement is for the department of Health Canada. Title: Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure Scope: The Inhalation Toxicology Laboratory (ITL) and Analytical Biochemistry and Proteomics Laboratory (ABPL) of Health Canada requires expert assistance with the bioinformatic analysis of high content proteomic mass spectral data derived from air pollution toxicology studies. Objectives of the Requirement The objective of this requirement is to complete expert bioinformatic analyses of the data generated in an investigation of the in vitro toxicity of ambient particulate matter impacted by source emissions on lung epithelial and mouse macrophage cell lines. The analyses will be used by Health Canada researchers to identify molecular changes relevant to air pollution toxicity in cell and animal models, and publish the results of the research in peer reviewed scientific publications. Ownership of Intellectual Property: The Crown will retain ownership of the copyright. Security Requirement: The Contractor personnel requiring access to PROTECTED information, assets or sensitive work site(s) must EACH hold a valid RELIABILITY STATUS, granted or approved by Canadian Industrial Security Directorate (CISD) of PWGSC. If the winning bidder does not hold this security screening level, the supplier will be required to obtain it before the contract is awarded. Mandatory Requirements: M1. The Bidder's proposed project leader must have a minimum of five (5) years experience by the date of this RFP working as a bioinformatician in a proteomics laboratory. M2. The Bidder's proposed project leader must hold as a minimum an Master of Science (M.Sc.) in biology; and a graduate diploma or degree in bioinformatics. M3. The Bidder must provide two references from previous work/projects conducted by the proposed project leader that are similar to the work outlined in this requirement’s Statement of Work. The references must be a former client’s Project Authority/Project Lead from a previous project. M4. The Bidder must provide a resource with at least 6 years of work experience from the date of this RFP in conducting bioinformatic analyses of proteomic data. Selection Methodology The contract will be awarded based on a determination of best value taking into account both the technical merit of the proposals and the price evaluations. To arrive at an overall score achieved by a firm, a weighting has been established whereby technical merit will be valued at 70% of the bid and price at 30%. Enquiries regarding this Request for Proposals are to be submitted in writing to: Robert Merrick Contracting Authority E-mail: Robert.Merrick@hc-sc.gc.ca

SEM METALLIZATION SYSTEM

National Research Council Canada | Published November 12, 2015  -  Deadline November 27, 2015
cpvs

Trade Agreement: NAFTA/AIT/Canada FTAs with Peru/Colombia/Panama Tendering Procedures: Generally only one firm has been invited to bid Non-Competitive Procurement Strategy: Exclusive Rights Comprehensive Land Claim Agreement: No Vendor Name and Address: Leica Microsystems (Canada) Inc. 71 Four Valley Drive Concord Ontario Canada L4K4V8 Nature of Requirements: Definition of the requirement: The National Research Council (NRC) has a requirement for the supply of a metallization system for non-conductive samples for scanning electron microscopy (Leica Model EM ACE 600) to be be delivered to NRC facilities in Boucherville, Quebec. Criteria for assessment of the Statement of Capabilities (Minimum Essential Requirements) Any interested supplier must demonstrate by way of a statement of capabilities that its product//system meets the following requirements: 1. The system must be compatible with an installation in a class 1000 clean room and must not have any component that contains oil. 2 The system must have a planar magnetron sputter head. 3 The system must be supplied with the following targets: Platinum (2 units) Iridium (2 units) Gold (1 unit) Gold/Palladium (1 unit) 4 The system must allow easy target exchange without any screws or tools. 5 The system must allow control of a fully motorized 3-axis stage (rotation, height andangle) for automatic and programmable adjustments withou t breaking the vacuum. 6 The system must integrate a planetary gear device with a minimum of 4 planets on the motorized stage to rotate independently each of the sample holders. All these movements during the sputtering of the metal mu st ensure complete and even coverage of the coating on all sides of the high aspect ratio structures rapidly and in a single step. 7 The system must include an intuitive touch screen to set parameters and run automatically the whole deposition cycle. 8 The system must be completely automated for the following functions: degassing; pre-sputtering based on metal composition; tooling factor in case the sample height has changed relative to the film thickness monitor; variable rotation; tilt, height adjustment; vent and pumping, without the need to adjust a needle valve. 9 The system must include an automatic process pause if the head gets too hot which could cause damage to the sample or to the target. 10 The system must allow a maximum deposition time up to 30 minutes to allow deposition of thick metal coatings. 11 The system must be able to provide a high vacuum of at least 2x10-6mbar as required for high resolution coating deposits of materials such as pl atinum and iridium in order to obtain having a very fine particle size which will not mask the fine details of the nanostructures of our samples. 12 The system must allow setting the spray current in a continuous manner up to 150 mA which enables a precise and optimum adjustment of the spraying conditions. 13 The system must operate with argon as the process gas and nitrogen as the p urging gas. 14 The system must have a small footprint having a maximum of 400 mm width x 550 mm depth because it must be installed against a wall facing th e mechanical service room to allow connection of the gas cylinders required for its operation and the available space is very limited. 15 The system must incorporate in its housing both a turbo molecular pump and a diaphragm pump. A separate pump is not allowed due to restricted space in the cleanroom. 16 The system must include an integrated monitor for measuring the thickness of the metal film deposited on the sample. The thickness range mu st be from 0 to at least 999 nm with a thickness accuracy of at least 1 nm. A separate box for the thickness monitor is not allowed due to restricted space in the cleanroom. 17 The system must have a metal vacuum chamber having a minimum inside diameter of 150 mm, with a front door for loading samples and be easy to c lean in order to preserve the conditions of cleanliness of the clean room environment. Justification for the Pre-Identified Supplier: To the best of our knowledge, the Leica EM ACE600 is the only system that can provide the combination of technical capabilities and specifications required in a single integrated system to adequately metallize polymer samples with high aspect ratio micro and nanostructures and is the only system compactenough to be installed in the avai lable space. Government Contracts Regulations Exception(s): The following exception(s) to the Government Contracts Regulations is invoked for the procurement under subsection 6 (d) only 1 person is capable of performing the work. Exclusions and/or Limited Tendering Reasons The following exclusion(s) and/or limited tendering reasons are invoked u nder the: Agreement on Internal Trade (AIT) Article(s) 506 12(b) North American Free Trade Agreement(NAFTA) Article(s) 1016 2(b) Delivery date: The product must be delivered on or before March 31, 2016 Name and address of the pre-identified supplier: Leica Microsystems Canada Inc. 71 Four Valley Drive Concord ON Suppliers' right to submit a statement of capabilities Suppliers who consider themselves fully qualified and available to provide the goods, services or construction services described in the ACAN may submit a statement of capabilities in writing to the contact person identified in this notice on or before the closing date of this notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements. Closing date for a submission of a statement of capabilities: The closing date and time for accepting statements of capabilities is November 27, 2015. Inquiries and submission of statements of capabilities are to be directed to: Sharon Joy Supply Specialist Telephone: 819-420-2964 E-mail: Sharon.joy@pwgsc-tpsgc.gc.ca Delivery Date: Above-mentioned You are hereby notified that the government intends to negotiate with one firm only as identified above. Should you have any questions concerning this requirement, contact the contracting officer identified above. An Advance Contract Award Notice (ACAN) allows departments and agencies to post a notice, for no less than fifteen (15) calendar days, indicating to the supplier community that it intends to award a good, service or construction contract to a pre-identified contractor. If no other supplier submits, on or before the closing date, a Statement of Capabilities that meets the requirements set out in the ACAN, the contracting authority may then proceed with the award. However, should a Statement of Capabilities be found to meet the requirements set out in the ACAN, then the contracting authority will proceed to a full tendering process. Suppliers who consider themselves fully qualified and available to provide the services/goods described herein, may submit a statement of capabilities in writing to the contact person identified in this Notice on or before the closing date of this Notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements. The PWGSC file number, the contracting officer's name and the closing date of the ACAN must appear on the outside of the envelope in block letters or, in the case of a facsimile transmission, on the covering page. The Crown retains the right to negotiate with suppliers on any procurement. Documents may be submitted in either official language of Canada.

LC-MS/MS

Health Canada | Published December 22, 2015  -  Deadline June 1, 2016
cpvs

Trade Agreement: WTO-AGP/NAFTA/AIT/Canada FTAs with Peru/Colombia/Panama Tendering Procedures: Generally only one firm has been invited to bid Non-Competitive Procurement Strategy: Exclusive Rights Comprehensive Land Claim Agreement: No Vendor Name and Address: AB Sciex LP 71 Four Valley Dr Concord Ontario Canada L4K4V8 Nature of Requirements: 1. Advance Contract Award Notice (ACAN) An ACAN is a public notice indicating to the supplier community that a department or agency intends to award a contract for goods, services or construction to a pre-identified supplier, thereby allowing other suppliers to signal their interest in bidding, by submitting a statement of capabilities. If no supplier submits a statement of capabilities that meets the requirements set out in the ACAN, on or before the closing date stated in the ACAN, the contractingofficer may then proceed with the award to the pre-identified supplier. 2. Definition of the requirement Health Canada has a requirement for the supply and installation of 2 LC-MS/MS with user training for up to 3-4 persons for delivery to Ottawa, Ontario. The delivery is required by 31st March 2016. 3. Criteria for assessment of the Statement of Capabilities Any interested supplier must demonstrate by way of a statement of capabilities that its system meets the following requirements: The equipment is required to measure baseline levels of priority chemicals, including those mandated under the Government of Canada Chemicals Management Plan (CMP), and is essential for data collection in a timely manner to support regulatory activities. This equipment is necessary in order to collect ultra-low level exposure data in a wide variety of food matrices that is required for risk management decisions and setting compliance levels for these chemicals. The new system must be equipped with a Differential ion mobility separation (DMS) technology to distinguish isobaric metabolites and to remove isobaric matrix interferences resulting in a reduction in chemical background noise. The new system must be equipped with an off-axis curved LINAC collision cell to prevent neutral molecules entering the last quadrupole analyzer and the ion detection system, thus reduce the noise and lower the limit of detection. In order to analyze high molecular weight analytes (such as long-chain perfluorinated compounds), the new system must have a mass range of both quadrupole mass analyzers not less than 2,000 Da. The new system must have a scanning speed of both quadrupoles not slower than 12,000 Da/sec in all MS/MS scanning modes to obtain enough data points for the ever-narrower UPLC peaks. For multiple analyte analyses, the new system must have a minimum MRM cycle time (including the dwell time and inter-channel setting time) not slower than 5 msec. The responses under this rapid MRM transitionsmust not be different from long dwell time settings (e.g. 100 ms dwell and 10 msec inter-channel setting time). The new system must have a fast polarity switching (

Gaussian License

Department of National Defence | Published August 3, 2016  -  Deadline August 18, 2016
cpvs

Trade Agreement: NAFTA/AIT/Canada FTAs with Peru/Colombia/Panama Tendering Procedures: Generally only one firm has been invited to bid Non-Competitive Procurement Strategy: Exclusive Rights Comprehensive Land Claim Agreement: No Vendor Name and Address:  GAUSSIAN INC. Building 40 340 Quinnipiac Street Wallingford Connecticut United States 06492 Nature of Requirements:   Advanced Contract Award Notice (ACAN)  Gaussian License  W7702-178872/A  1. Advance Contract Award Notice (ACAN)   An ACAN is a public notice indicating to the supplier community that a department or agency intends to award a contract for goods, services or construction to a pre-identified supplier, thereby allowing other suppliers to signal their interest in bidding, by submitting a statement of capabilities. If no supplier submits a statement of capabilities that meets the requirements set out in the ACAN, on or before the closing date stated in the ACAN, the contracting officer may then proceed with the award to the pre-identified supplier.   2. Definition of the requirement   The Suffield Research Centre of Defense Research and Development Canada has a requirement for a 20 year license agreement for Gaussian 09, the advanced quantum chemistry software, which is unique to provide state-of-art capabilities for electronic structure modeling with the high accuracy on reaction energies and spectra for the development of advanced energetic materials. To packing simulations of molecular crystals as reaction precursors of advanced energetic materials, in its output file Gaussian 09 provides charges as atom-centered monopoles from molecular electrostatic potential, which are required by the MOLPAK software, developed by the US Army Research Laboratory. Thus, Gaussian 09 is necessary for the development of advanced military energetic materials.  3. Criteria for assessment of the Statement of Capabilities    Any interested supplier must demonstrate that its product meets the following mandatory requirements:    (1). The software must be an advanced quantum chemistry simulation program fully recognized by its high accuracy on reaction energies and spectra in comparison with experiments. For instance, the deviation of the proton affinity from the experimental value for water molecule must be less than 1.10  kcal/mol.    (2). The software must provide access to source code so that the output format can be modified to fit into molecular packing simulation software such as the MOLPAK. (3). The software must provide source code which is able to be compiled in latest Linux operation systems to run most popular Linux based workstations.    (4). The software must have the enhanced methods for hybrid density functional theory simulations such as M06-2x functional. (5). The software must have capabilities to deal with model reactions of very large systems such as the ONIOM model.  4. This procurement is subject to the following trade agreement:  o Agreement on Internal Trade (AIT) o North American Free Trade Agreement (NAFTA)  5. Applicability of the trade agreement(s) to the procurement:   AIT  Article 506, #12 a  12. Where only one supplier is able to meet the requirements of a procurement, an entity may use procurement procedures that are different from those described in paragraphs 1 through 10 in the following circumstances: a. to ensure compatibility with existing products,to recognize exclusive rights, such as exclusive licences, copyright and patent rights, or to maintain specialized products that must be maintained by the manufacturer or its representative;  NAFTA - ARTICLE 1016 2. An entity may use limited tenderingprocedures in the following circumstances and subject to the following conditions, as applicable: (b) where, for works of art, or for reasons connected with the protection of patents, copyrights or other exclusive rights, or proprietary information or where there is an absence of competition for technical reasons, the goods or services can be supplied only by a particular supplier and no reasonable alternative or substitute exists.  6. Justification for the Pre-Identified Supplier   The Contractorholds exclusive copyrights for the Gaussian 09 software.  This software has unique capabilities where the accuracy and output is required by the molecular packing simulation software (MOLPAK) currently being used by DRDC  7. Government Contracts Regulations Exception(s)   The following exception(s) to the Government Contracts Regulations is (are) invoked for this procurement under subsection 6(d) - "only one person is capable of performing the work").   8. Period of the proposed contract or delivery date:   The product and all associate reports must be delivered on or before August 31, 2016.                                  9. Cost estimate of the proposed contract:  The estimated value of the contract, is $52,500   10. Name and address of the pre-identified supplier:   Gaussian Inc. 340 Quinnipiac Street, Bldg 40 Wallingford CT 06492  11. Suppliers' right to submit a statement of capabilities:   Suppliers who consider themselves fully qualified and available to provide the goods described in the ACAN may submit a statement of capabilities in writing to the contact person identified in this notice on or before the closing date of this notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements.  12. The closing date and time for accepting statements of capabilities is:   August 18, 2016 at 2:00 pm MST  13. Inquiries and submission of statements of capabilities:  Laurie Suchodolski, Supply Specialist Public Worksand Government Services Canada Suite 1650,  635  8th Avenue SW Calgary, Alberta  T2P 3M3 Phone:  403-389-6365 Fax: 403-292-5786 Email: laurie.suchodolski@pwgsc.gc.ca Delivery Date: Above-mentioned  You are hereby notified that the government intends to negotiate with one firm only as identified above. Should you have any questions concerning this requirement, contact the contracting officer identified above.  An Advance Contract Award Notice (ACAN) allows departments and agencies to post a notice, for no less than fifteen (15) calendar days, indicating to the supplier community that it intends to award a good, service or construction contract to a pre-identified contractor. If no other supplier submits, on or before the closing date, a Statement of Capabilities that meets the requirements set out in the ACAN, the contracting authority may then proceed with the award.  However, should a Statement of Capabilities be found to meet the requirements set out in the ACAN, then the contracting authority will proceed to a full tendering process.  Suppliers who consider themselves fully qualified and available to provide the services/goods described herein, may submit a statement of capabilities in writing to the contact person identified in this Notice on or before the closing date of this Notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements.  The PWGSC file number, the contracting officer's name and the closing date of the ACAN must appear on the outside of the envelope in block letters or, in the case of a facsimile transmission, on the covering page.  The Crown retains the right to negotiate with suppliers on any procurement.  Documents may be submitted in either official language of Canada.

Nanostring nCounter Sprint

Agriculture and Agri-Food Canada | Published September 2, 2016
cpvs

Trade Agreement: WTO-AGP/NAFTA/AIT/Canada FTAs with Peru/Colombia/Panama Tendering Procedures: Generally only one firm has been invited to bid Non-Competitive Procurement Strategy: Interchangeable Parts Comprehensive Land Claim Agreement: No Vendor Name and Address:  Nanostring Technologies, Inc. 530 Fairview Avenue North Suite 2000 Seattle Washington United States 98109 Nature of Requirements:   01799-170311/A Lomax, Sandra Telephone No. - (506) 636-4362  Fax No. - (506) 636-4376   Nanostring nCounter Sprint  Advance Contract Award Notice (ACAN)  An ACAN is a public notice indicating to the supplier community that a department or agency intends to award a contract for goods, services or construction to a pre-identified supplier, thereby allowing other suppliers to signal their interest in bidding, by submitting a statement of capabilities. If no supplier submits a statement of capabilities that meets the requirements set out in the ACAN, on or before the closing date stated in the ACAN, the contracting officer may then proceed with the award to the pre-identified supplier.  Public Works and Government Services Canada (PWGSC), on behalf of its client, the Department of Agriculture and Agri-Food Canada has requirement for the supply and deliver of one (1) Nanostring nCounter Sprint.  It is a device used to analyze differential expression of genes and proteins.   It used to research projects on plant genomics, physiology and molecular biology.      Any interested supplies must demonstrate by way of a statement of capabilities that it meets the following Mandatory Requirements:  Mandatory Requirements  Item 1.  An integrated system which employs digital barcode technology to hybridize with target molecules to yield precise and sensitive quantification. Up to 800 targets can be measured simultaneously in a single sample, and up to 12 samples can be assayed in a single run.   A NanosSring nCounter Sprint profiler NCT-SPRINT-3Y, Installation and training, 12 month warranty including parts and labor.  Item 2.  Two years maintenance service contract beyond first 12 months.  The procurement is subject to the following trade agreement: - Agreement on Internal Trade (AIT) - North American Free Trade Agreement (NAFTA) - World Trade Organization  Agreement on Government Procurement (WTO-AGP)  The reason for single tendering is; only one firm is capable of performing the contract.  The following exception to the Government Contact Regulations is invoked for this procurement under subsection 6(d)   Articles 506.12(a) and 506.12(b) of AIT are applicable on thebasis of limited tendering due to compatibility with existing products, to recognize exclusive rights, such as exclusive licenses, copyright and patent rights, or to maintain specialized products that must be maintained by the manufacturer or its representative and where there is an absence of competition for technicalreasons and the goods or services can be supplied only by a particular supplier and no alternative or substitute exists, respectively.  Articles 1016.2 (b) and 1016.2 (d) of NAFTA are applicable on the basis of limited tendering due to  where, for works of art, or for reasons connected with the protection of patents, copyrights or other exclusive rights, or proprietary information or where there is an absence of competition for technical reasons, the goods or services can be supplied only by a particular supplier and no reasonable alternative or substitute exists and for additional deliveries by the original supplier that are intended either as replacement parts or continuing services for existing supplies, services or installations, or as the extension of existing supplies, services or installations, where a change of supplier would compel the entity to procure equipment or services not meeting requirements of interchangeability with already existing equipment or services, including software to the extent that the initial procurement of the software was covered by this Chapter;  Article XV.1(b) of WTO-AGP are applicable on the basis of limited tendering due to when, for works of art or for reasons connected with protection of exclusive rights, such as patents or copyrights, or in the absence of competition for technical reasons, the products or services can be supplied only by a particular supplier and no reasonable alternativeor substitute exists;  The product must be delivered on or beforeMarch 31, 2017.  The estimated value of the contract is $231,231.00 HST extra  Suppliers' right to submit a statement of capabilities:  Suppliers who consider themselves fully qualified and available to provide the services described in the ACAN may submit a statement of capabilities in writing to the contact person identified in this notice on or before the closing date of this notice. The statement of capabilities must clearly demonstrate how the supplier meets theadvertised requirements.  Closing date and time for accepting statements of capabilities:   Submissions must be received on or by 2:00 p.m. September 20, 2016.   Inquiries and statement of capabilities are to be directed to:  Sandra Lomax, Supply Officer   Public Works and Government Services Canada 189 Prince William St Saint John, NB   E2L 2B9   Telephone No. (506) 636-4362 Fax No. (506 636-4376 Email sandra.lomax@pwgsc.gc.ca Delivery Date: Above-mentioned  You are hereby notified that the government intends to negotiate with one firm only as identified above. Should you have any questions concerning this requirement, contact the contracting officer identified above.  An Advance Contract Award Notice (ACAN) allows departments and agencies to post a notice, for no less than fifteen (15) calendar days, indicating to the supplier community that it intends to award a good, service or construction contract to a pre-identified contractor. If no other supplier submits, on or before the closing date, a Statement of Capabilities that meets the requirements set out in the ACAN, the contracting authority may then proceed with the award.  However, should a Statement of Capabilities be found to meet the requirements set out in the ACAN, then the contracting authority will proceed to a full tendering process.  Suppliers who consider themselves fully qualified and available to provide the services/goods described herein, may submit a statement of capabilities in writing to the contact person identified in this Notice on or before the closing date of this Notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements.  The PWGSC file number, the contracting officer's name and the closing date of the ACAN must appear on the outside of the envelope in block letters or, in the case of a facsimile transmission, on the covering page.  The Crown retains the right to negotiate with suppliers on any procurement.  Documents may be submitted in either official language of Canada.

MOLECULAR ANALYSIS OF PRIMARY BLAST-INDUCED TRAUMATIC BRAIN INJURY

Department of National Defence | Published September 22, 2016  -  Deadline July 10, 2016
cpvs

Trade Agreement: Agreement on Internal Trade (AIT) Tendering Procedures: Generally only one firm has been invited to bid Non-Competitive Procurement Strategy: Government Objectives Representing Best Interests/Value to Govt Comprehensive Land Claim Agreement: No Vendor Name and Address:  Canada West Biosciences Inc 5429-60 Street Camrose Alberta Canada T4V4G9 Nature of Requirements:    TITLE:  MOLECULAR ANALYSIS OF PRIMARY BLAST-INDUCED TRAUMATIC BRAIN INJURY  1. ADVANCE CONTRACT AWARD NOTICE (ACAN)   An ACAN is a public notice indicating to the supplier community that a department or agency intends to award a contract for goods,services or construction to a pre-identified supplier, thereby allowing other suppliers to signal their interest in bidding, by submitting a statement of capabilities. If no supplier submits a statement of capabilities that meets the requirements set out in the ACAN, on or before the closing date stated in the ACAN, the contracting officer may then proceed with the award to the pre-identified supplier.  2. SECURITY:  2.1  The following security requirements apply and form part of the Contract.  SECURITY REQUIREMENT FOR CANADIAN SUPPLIER: PSPC FILE #: W7702-165802  2.1.1 The Contractor/Offeror must, at all times during the performance of the Contract/Standing Offer, hold a valid Designated Organization Screening (DOS), issued by the Canadian Industrial Security Directorate (CISD), Public Services and Procurement Canada (PSPC).  2.1.2.  The Contractor/Offeror personnel requiring access to sensitive work site(s) must EACH hold a valid RELIABILITY STATUS, granted or approved by CISD/PSPC.  2.1.3  Subcontracts which contain security requirements are NOT to be awarded without the prior written permission of CISD/PSPC.  2.1.4  The Contractor/Offeror must comply with the provisions of the:  a)  Security Requirements Check List and security guide (if applicable), attached at Annex C; b)  Industrial Security Manual (Latest Edition).  3.  REQUIREMENT:  Defence Research & Development Canada  Suffield Research Centre (DRDC Suffield) has recently initiated a blast injury program with a major focus on primary blast-induced traumatic brain injury (bTBI). Work is being carried out on a rodent model of TBI, as well as an ex vivo model system. Novel instrumentation is used to expose these model systems to single pulse shock waves, enabling the investigation of their effect on brain tissue, separate from concussive and acceleration/deceleration forces. There is a requirement to comprehensively characterize these effects at a molecular level in order to understand the etiology of the injury aswell as to rationally develop medical countermeasures.  The contractor will generate and analyze data from experiments examining the molecular basis of blast-induced TBI, the time-course of its development, and the relative efficacies of test medical countermeasures against this injury.  The work will also involve the development and characterization of various antibody-based systems.   4.  CRITERIA FOR ASSESSMENT OF THE STATEMENT OF CAPABILITIES (MINIMUM ESSENTIAL REQUIREMENTS)  Any interested supplier must demonstrate by way of a statement of capabilities that it meets the following requirements:  4.1 Mandatory Technical Criteria: The personnel conducting the work must have the following:  a)  Education: Minimum PhD. in Biological Sciencesor a related area. b)  Experience: Demonstrated expertise and experience in the use of antibodies in the detection/quantitation of proteins, and in general molecular biological techniques. c)  Specialized training: experience with Western blot analysis.  5. APPLICABILITY OF THE TRADE AGREEMENT(S) TO THE PROCUREMENT   This procurement is subject to the following trade agreement: Agreement on Internal Trade (AIT).   6. JUSTIFICATION FOR THE PRE-IDENTIFIED SUPPLIER  This contract is a continuation of a previously competitively bid R&D contract (W7702-145639/001/EDM) for which only one bid was received.   The suggested supplier is familiar with the particular idiosyncrasies of the techniques and instrumentation necessary to carry out the duties outlined in the Statement of Work.  This individual has been intimately involved in the blast injury program and the type of blast-injury specific markers that are unique to brain injury caused by blast.  Due to the unique capabilities and facilities at Suffield Research Centre, this program is one of a kind in Canada. An individual not well versed in this kind of research, as well as the laboratory specific methodologies will require a very significant period of time before they are ready to participate independently in the research. This lead time would not be required with the suggested sole source contractor.  This contract falls into the official DRDC 04J Casualty Care research Program. The official program period ends in 2019, which coincides with the period of this contract. Contracts beyond this point will be dependent on the results of the research.   7. GOVERNMENT CONTRACTS REGULATIONS EXCEPTION(S)  The following exception(s) to the Government Contracts Regulations is (are) invokedfor this procurement under subsection 6(d) - only one person is capable of performing the work.  8. EXCLUSIONS AND/OR LIMITED TENDERING REASONS  The following exclusion(s) and/or limited tendering reasons are invoked under the: Agreement on InternalTrade (AIT)  Article 506, paragraph 12 (b).  NAFTA excluded: Annex 1001.1b-2, GSIN AD917700 Military (R&D) is excluded.  WTO-AGP excluded: Annex 4, GSIN AD917700 Military (R&D) is not included.   9. OWNERSHIP OF INTELLECTUAL PROPERTY  Any intellectual property arising from the performance of the Work under the Contract will vest in Canada.  DRDC is exempted from the Treasury Board "Policy on Title to Intellectual Property Arising Under Crown Procurement Contracts"  approved 1 June 2000 as per DRDC ADM (S&T) IP-02.  10. PERIOD OF THE PROPOSED CONTRACT OR DELIVERY DATE  The Contact will be effective from award date to 2019-03-31 with the option to extend the term of the Contract by up to two (2) additional one (1) year periods.  11. COST ESTIMATE OF THE PROPOSED CONTRACT  The estimated value of the contract is $240,000.00 (GST/HST extra) for the contract period excluding option years.    12.   NAME AND ADDRESS OF THE PRE-IDENTIFIED SUPPLIER:  Canada West Biosciences Inc. 5429-60 Street   Camrose, Alberta   T4V 4G9  13.   SUPPLIERS RIGHT TO SUBMIT A STATEMENT OF CAPABILITIES  Suppliers who consider themselves fully qualified and available to provide the goods, services or construction services described in the ACAN may submit a statement of capabilities in writing to the contact person identified in this notice on or before the closing date of this notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements.  14. CLOSING DATE FOR A SUBMISSION OF A STATEMENT OF CAPABILITIES   The closing date and time for accepting statements of capabilities is indicated above.   15. INQUIRIES AND SUBMISSION OF STATEMENTS OF CAPABILITIES  Inquiries and statements of capabilities are to be directed to:  Contracting Authority  Lorraine Jenkinson  Supply Specialist  Public Works and Government Services Canada Acquisitions Branch, Western Region  Telus Plaza North  10025 Jasper Avenue, 5th Floor  Edmonton, AB  T5J 1S6   Telephone:  (780) 497-3593     Facsimile:  (780) 497-3510  E-mail address:  Lorraine.Jenkinson@pwgsc-tpsgc.gc.ca   Delivery Date: Above-mentioned  You are hereby notified that the government intends to negotiate with one firm only as identified above. Should you have any questions concerning this requirement, contact the contracting officer identified above.  An Advance Contract Award Notice (ACAN) allows departments and agencies to post a notice, for no less than fifteen (15) calendar days, indicating to the supplier community that it intends to award a good, service or construction contract to a pre-identified contractor. If no other supplier submits, on or before the closing date, a Statement of Capabilities that meets the requirements set out in the ACAN, the contracting authority may then proceed with the award.  However, should a Statement of Capabilities be found to meet the requirements set out in the ACAN, then the contracting authority will proceed to a full tendering process.  Suppliers who consider themselves fully qualified and available to provide the services/goods described herein, may submit a statement of capabilities in writing to the contact person identified in this Notice on or before the closing date of this Notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements.  The PWGSC file number, the contracting officer's name and the closing date of the ACAN must appear on the outside of the envelope in block letters or, in the case of a facsimile transmission, on the covering page.  The Crown retains the right to negotiate with suppliers on any procurement.  Documents may be submitted in either official language of Canada.

Digital PCR System

Agriculture and Agri-Food Canada | Published September 29, 2016  -  Deadline October 18, 2016
cpvs

Trade Agreement: NAFTA/AIT/Canada FTAs with Peru/Colombia/Panama Tendering Procedures: Generally only one firm has been invited to bid Non-Competitive Procurement Strategy: Exclusive Rights Comprehensive Land Claim Agreement: No Vendor Name and Address:  Bio-Rad Laboratories (Canada) Ltd. 1329 Meyerside Drive Mississauga Ontario Canada L5T1C9 Nature of Requirements:   Droplet Digital PCR System  01633-170824/A Omerzo, Zeljka Telephone No. - (204) 510-2597  Fax No. - (204) 983-7796   Line 1, Digital PCR System  1. Advance Contract Award Notice (ACAN)  An ACAN is a public notice indicating to thesupplier community that a department or agency intends to award a contract for goods, services or construction to a pre-identified supplier, thereby allowing other suppliers to signal their interest in bidding, by submitting a statement of capabilities.If no supplier submits a statement of capabilities that meets the requirements set out in the ACAN, on or before the closing date stated in the ACAN, the contracting officer may then proceed with the award to the pre-identified supplier.   2. Definition of the requirement   Molecular genetics and genomics research at Agriculture and Agri-Food Canada (AAFC) - Brandon involves a broad suite of activities.  Researchers apply genetic approaches using molecular tools, conduct transgenic studies, investigate plant development and physiology and characterize plant pathogens.  A common essential need in these research projects is to quantify nucleic acids with high precision, sensitivity, and specificity at a high throughput level.  These investigations often involve very limited amounts of nucleic acid samples, as from micro-dissected tissues.  The new emerging Droplet Digital PCR (ddPCR) technology offers a very robust system for absolute quantification of nucleic acids and is required to meet the research needs at AAFC-Brandon.  3. Criteria for assessment of the Statement of Capabilities (Minimum Essential Requirements)  Any interested supplier must demonstrate by way of a statement of capabilities that its equipment meets the following requirements:  1. ddPCR samples are amplified in a standard 96 well plate on a gradient enabled thermal cycler to allow for high sample throughput and gradient optimization of new assays. 2. The ddPCR Reader analyzes 32 samples/hour unattended, without manual intervention. 3. The ddPCR system is of a "benchtop" scale must read samples in standard 96-well format plates to enable incorporation into our existing workflows and use standard thermo cyclers already present at AAFC - Brandon. Existing workflows utilise a temperature gradient PCR step to optimise assay conditions and the requested new ddPCR system must be able to incorporate a temperature gradient PCR step.  The temperature gradient ability must NOT require any additional pipetting or liquid handling steps as these will introduce additional errors into the experiment. 4. The ddPCR system must analyze 96 unique samples in less than 5 hours, including the steps of 1) partitioning of sample assays into 12,000 to 20,000 reaction partitions, 2) PCR amplification and3) reading and scoring reaction partitions.  Note: This requirement is necessary in order to analyze multiple samples at once without introducing potential source of error by single tube analyses. Also, these features are needed to meet sample throughput requirements of the multiple users from several AAFC research programs as well as potential industrial partners at Brandon. 5. This ddPCR system should include droplet generator and droplet reader. The droplet reader MUST incorporate a 96-well auto-sampler so that unattended operation is possible to maximize sample throughput, and so that it can accommodate multiple users and/or plates per day. 6. The ddPCR system must produce 12,000 to 20,000 reaction partitions per sample for 96 unique samples in 30 minutes or less. 7. The ddPCR system that is compatible with DNA binding chemistries (e.g. Evagreen) as well as Hydrolysis probe chemistry using FAM and/or HEX dyes and  must detect fluorescence signals corresponding to those derived from VIC-, HEX-,Evagreen-, or FAM-labeled PCR probes. 8. The ddPCR system must distinguish between gene copy number variants of 11 vs. 10 and less using two or less sample assay reactions of one reaction well each (equivalent to one chamber or panel of areaction chip)with an input of nucleic acid template equivalent to 100 ng of plant or microbse' genomic DNA or less so as to minimise amount of nucleic acid sample size required per assay and cost of consumables. This ability must be achieved without the need for a preamplification step which can cause a significant measurement bias by distorting the abundance and relative presence of target nucleic acids.  9. The ddPCR system must enable gene expression analysis and quantification of DNA copies with+/- 10% precision to meet the requirements of the multiple users from several research programs. The system must include gene expression module that can analyze and produce accurate gene expression levels in the sample.  10. The ddPCR system must detect a specific genetic variant at a level as low as 0.001% abundance in a sample mixture that includes other genetic variants, and enable a linear quantification of this variant over four orders of magnitude of abundance of this variant in a complex mixture of nucleic acids.  11. The ddPCR system must NOT require development of standard curves or need an external calibrator to estimate relative abundance of target nucleic acids, thereby minimizing the number of samples to be prepared and analyzed.  Rather, the instrument must generate digital data reflecting absolute quantification of target nucleic acid abundance.  12. The digital PCR system must have a reaction partition volume of 1 nL or less.  13. The relative expanded uncertainty of the ddPCR system from the data for 20,000 reaction partitions is required to be 5% or less to achieve the data precision required by the research programs.  14. The ddPCR system must generate 12,000 to 20,000 reaction partitions from a 20 microlitre sample reaction volume. 15. TheddPCR system must NOT require use of specialized liquid handling equipment or robotic liquid handlers that would typically require specialized training and a dedicated technician to operate since the system will be used by numerous researchers from multiple programs. 16. The ddPCR system must generate and assay reaction partition in a manner that minimize the dead volume of the partition holder and reader to <25% 12 506 1016 1329 starting reaction volume. 17. the system must include all needed software for operation and analysis. 18. can detect one copy of target sequence in a dna sample. 19. system's perform report various results such as absolute concentration, number variation ratio analysis (for gene expression analysis). 4. applicability trade agreement(s) to procurement this is subject following agreement on internal (ait) north american free (nafta) 5. justification pre-identified supplier qx200 ddpcr manufactured by bio-rad laboratories (canada) ltd only known instrument meeting specifications essential requirement listed above. 6. government contracts regulations exception(s) (are) invoked under subsection 6(d) - person capable performing contract. 7. exclusions or limited tendering reasons exclusion(s) are the: article (b) where there an absence competition technical goods services be supplied aparticular no alternative substitute exist. 2(b) where, works art, connected with protection patents, copyrights other exclusive rights, proprietary information reasons, particular reasonable exists. 8. period proposed contract delivery date theequipment delivered before february 28, 2017. 9. name address ltd. meyerside drive mississauga ontario canada l5t1c9 10. suppliers' right submit statement capabilities suppliers who consider themselves fully qualified available provide goods, construction described acan may writing contact personidentified notice closing notice. clearly demonstrate how meets advertised requirements. 11. submission theclosing time accepting statements october 18, 2016. 12. inquiries directed to: zeljka omerzo supply officer public governmentservices compensation suite 100-167 lombard avenue winnipeg, mb r3b 0t6 telephone: (204) 510-2597 facsimile: 983-7796 e-mail address: zeljka.omerzo@tpsgc-pwgsc.gc.ca you hereby notified that intends negotiate firm identified should have any questions concerning requirement, contracting advance award (acan) allows departments agencies post notice, less than fifteen (15) calendar days, indicating community it good, service contractor. if submits, date, requirements set out acan, authority then proceed award. however, found meet will full process. herein, pwgsc file number, officer's theacan appear outside envelope block letters or, case facsimile transmission, covering page. crown retains procurement. documents submitted either official language canada. date: above-mentioned canada.< pre>