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Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure

Health Canada | Published November 2, 2015
Winner
8627789 Canada Inc.
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NOTICE OF PROPOSED PROCUREMENT (NPP) Solicitation #: 1000174482 Closing Date: September 2, 2015 Time: 2 p.m. EDT This requirement is for the department of Health Canada. Title: Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure Scope: The Inhalation Toxicology Laboratory (ITL) and Analytical Biochemistry and Proteomics Laboratory (ABPL) of Health Canada requires expert assistance with the bioinformatic analysis of high content proteomic mass spectral data derived from air pollution toxicology studies. Objectives of the Requirement The objective of this requirement is to complete expert bioinformatic analyses of the data generated in an investigation of the in vitro toxicity of ambient particulate matter impacted by source emissions on lung epithelial and mouse macrophage cell lines. The analyses will be used by Health Canada researchers to identify molecular changes relevant to air pollution toxicity in cell and animal models, and publish the results of the research in peer reviewed scientific publications. Ownership of Intellectual Property: The Crown will retain ownership of the copyright. Security Requirement: The Contractor personnel requiring access to PROTECTED information, assets or sensitive work site(s) must EACH hold a valid RELIABILITY STATUS, granted or approved by Canadian Industrial Security Directorate (CISD) of PWGSC. If the winning bidder does not hold this security screening level, the supplier will be required to obtain it before the contract is awarded. Mandatory Requirements: M1. The Bidder's proposed project leader must have a minimum of five (5) years experience by the date of this RFP working as a bioinformatician in a proteomics laboratory. M2. The Bidder's proposed project leader must hold as a minimum an Master of Science (M.Sc.) in biology; and a graduate diploma or degree in bioinformatics. M3. The Bidder must provide two references from previous work/projects conducted by the proposed project leader that are similar to the work outlined in this requirement’s Statement of Work. The references must be a former client’s Project Authority/Project Lead from a previous project. M4. The Bidder must provide a resource with at least 6 years of work experience from the date of this RFP in conducting bioinformatic analyses of proteomic data. Selection Methodology The contract will be awarded based on a determination of best value taking into account both the technical merit of the proposals and the price evaluations. To arrive at an overall score achieved by a firm, a weighting has been established whereby technical merit will be valued at 70% of the bid and price at 30%. Enquiries regarding this Request for Proposals are to be submitted in writing to: Robert Merrick Contracting Authority E-mail: Robert.Merrick@hc-sc.gc.ca

Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure

Health Canada | Published August 18, 2015  -  Deadline February 9, 2015
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NOTICE OF PROPOSED PROCUREMENT (NPP) Solicitation #: 1000174482 Closing Date: September 2, 2015 Time: 2 p.m. EDT This requirement is for the department of Health Canada. Title: Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure Scope: The Inhalation Toxicology Laboratory (ITL) and Analytical Biochemistry and Proteomics Laboratory (ABPL) of Health Canada requires expert assistance with the bioinformatic analysis of high content proteomic mass spectral data derived from air pollution toxicology studies. Objectives of the Requirement The objective of this requirement is to complete expert bioinformatic analyses of the data generated in an investigation of the in vitro toxicity of ambient particulate matter impacted by source emissions on lung epithelial and mouse macrophage cell lines. The analyses will be used by Health Canada researchers to identify molecular changes relevant to air pollution toxicity in cell and animal models, and publish the results of the research in peer reviewed scientific publications. Ownership of Intellectual Property: The Crown will retain ownership of the copyright. Security Requirement: The Contractor personnel requiring access to PROTECTED information, assets or sensitive work site(s) must EACH hold a valid RELIABILITY STATUS, granted or approved by Canadian Industrial Security Directorate (CISD) of PWGSC. If the winning bidder does not hold this security screening level, the supplier will be required to obtain it before the contract is awarded. Mandatory Requirements: M1. The Bidder's proposed project leader must have a minimum of five (5) years experience by the date of this RFP working as a bioinformatician in a proteomics laboratory. M2. The Bidder's proposed project leader must hold as a minimum an Master of Science (M.Sc.) in biology; and a graduate diploma or degree in bioinformatics. M3. The Bidder must provide two references from previous work/projects conducted by the proposed project leader that are similar to the work outlined in this requirement’s Statement of Work. The references must be a former client’s Project Authority/Project Lead from a previous project. M4. The Bidder must provide a resource with at least 6 years of work experience from the date of this RFP in conducting bioinformatic analyses of proteomic data. Selection Methodology The contract will be awarded based on a determination of best value taking into account both the technical merit of the proposals and the price evaluations. To arrive at an overall score achieved by a firm, a weighting has been established whereby technical merit will be valued at 70% of the bid and price at 30%. Enquiries regarding this Request for Proposals are to be submitted in writing to: Robert Merrick Contracting Authority E-mail: Robert.Merrick@hc-sc.gc.ca

LC-MS/MS

Health Canada | Published December 22, 2015  -  Deadline June 1, 2016
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Trade Agreement: WTO-AGP/NAFTA/AIT/Canada FTAs with Peru/Colombia/Panama Tendering Procedures: Generally only one firm has been invited to bid Non-Competitive Procurement Strategy: Exclusive Rights Comprehensive Land Claim Agreement: No Vendor Name and Address: AB Sciex LP 71 Four Valley Dr Concord Ontario Canada L4K4V8 Nature of Requirements: 1. Advance Contract Award Notice (ACAN) An ACAN is a public notice indicating to the supplier community that a department or agency intends to award a contract for goods, services or construction to a pre-identified supplier, thereby allowing other suppliers to signal their interest in bidding, by submitting a statement of capabilities. If no supplier submits a statement of capabilities that meets the requirements set out in the ACAN, on or before the closing date stated in the ACAN, the contractingofficer may then proceed with the award to the pre-identified supplier. 2. Definition of the requirement Health Canada has a requirement for the supply and installation of 2 LC-MS/MS with user training for up to 3-4 persons for delivery to Ottawa, Ontario. The delivery is required by 31st March 2016. 3. Criteria for assessment of the Statement of Capabilities Any interested supplier must demonstrate by way of a statement of capabilities that its system meets the following requirements: The equipment is required to measure baseline levels of priority chemicals, including those mandated under the Government of Canada Chemicals Management Plan (CMP), and is essential for data collection in a timely manner to support regulatory activities. This equipment is necessary in order to collect ultra-low level exposure data in a wide variety of food matrices that is required for risk management decisions and setting compliance levels for these chemicals. The new system must be equipped with a Differential ion mobility separation (DMS) technology to distinguish isobaric metabolites and to remove isobaric matrix interferences resulting in a reduction in chemical background noise. The new system must be equipped with an off-axis curved LINAC collision cell to prevent neutral molecules entering the last quadrupole analyzer and the ion detection system, thus reduce the noise and lower the limit of detection. In order to analyze high molecular weight analytes (such as long-chain perfluorinated compounds), the new system must have a mass range of both quadrupole mass analyzers not less than 2,000 Da. The new system must have a scanning speed of both quadrupoles not slower than 12,000 Da/sec in all MS/MS scanning modes to obtain enough data points for the ever-narrower UPLC peaks. For multiple analyte analyses, the new system must have a minimum MRM cycle time (including the dwell time and inter-channel setting time) not slower than 5 msec. The responses under this rapid MRM transitionsmust not be different from long dwell time settings (e.g. 100 ms dwell and 10 msec inter-channel setting time). The new system must have a fast polarity switching (

CRYOGENIC DETECTOR SYSTEM

National Research Council Canada | Published October 19, 2016  -  Deadline March 11, 2016
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Trade Agreement: WTO-AGP/NAFTA/AIT/Canada FTAs with Peru/Colombia/Panama Tendering Procedures: Generally only one firm has been invited to bid Non-Competitive Procurement Strategy: Exclusive Rights Comprehensive Land Claim Agreement: No Vendor Name and Address:  Photon Spot Inc 142 W Olive Ave Monrovia California United States 91016 Nature of Requirements:   CRYOGENIC DETECTOR SYSTEM  31184-168665/A Shannahan, Cassandra Telephone No. - (819) 420-1068 E-mail: cassandra.shannahan@pwgsc-tpsgc.gc.ca  1. Advance Contract Award Notice (ACAN)   An ACAN is a public notice indicating to the supplier community that a department or agency intends to award a contract for goods, services or construction to a pre-identified supplier, thereby allowing other suppliers to signal their interest in bidding, by submitting a statement of capabilities. If no supplier submits a statement of capabilities that meets the requirements set out in the ACAN, on or before the closing date stated in the ACAN, the contracting officer may then proceed with the award to the pre-identified supplier.   2. Definition of the requirement   The National Research Council (NRC) requires three superconducting single photon detectors (SSPDs), or two WSi Single-Element Nanowire Detectors and Cryospot 4 with Freeze4 Sorption Fridge from the company Photon Spot to allow >70% detection efficiency of single photons throughout the spectral range from 900nm to 1600nm.  3. Criteria for assessment of the Statement of Capabilities (Minimum Essential Requirements)   Any interested supplier must demonstrate by way of a statement of capabilities that its SSPDs meet the following requirements:   a) The SSPDs must have a broad spectral response, with greater than 70% efficiency over the 900nm-1600nm spectral range and peak detection efficiency of 90% or greater.   b) The timing jitter must be less than 100ps or less, with a detector dead time of 50ns or less.  c) The cryostat must be able to accommodate 8 detectors or similar devices.  d) The cryostat temperature must be below 1K.  e) The company must provide on-site training.  4. Applicability of the trade agreements to the procurement   This procurement is subject to the following trade agreements:  - Agreement on Internal Trade (AIT) - World Trade Organization - Agreement on Government Procurement (WTO-AGP) - North American Free Trade Agreement (NAFTA)  5. Justification for the Pre-Identified Supplier   The WSi Single-Element Nanowire Detectors and Cryospot 4 with Freeze4 Sorption Fridge from Photon Spot have the following unique technical features not available through other vendors, and which are required by the NRC.   a) The SSPDs must have a broad spectral response, with greater than 70% efficiency over the 900nm-1600nm spectral range and peak detection efficiency of 90% or greater.   The SSPDs will be sharedbetween two research groups, the Molecular Photonics (MP) group and the Quantum Physics (QP) group. In the MP group, broad-band femtosecond-picosecond laser pulses are used to generate broad-band single photons which can be tuned from ~900nm to ~1600nm;greater than 70% detection efficiency is required to allow probabilistic photon coincidence experiments to be carried out promptly, and with high confidence bounds. In the QP group, quantum dots emit photons throughout the near- to mid-infrared spectralrange; efficient, broad-band detection is necessary to allow accurate characterization of these sources.   b) The timing jitter must be less than 100ps, with a detector dead time of 50ns or less.  Frequently, the MP group wishes to distinguish temporally between femtosecond/picosecond-duration photons emitted from materials with short (sub-nanosecond) coherence times (e.g. photons emitted from a quantum memory); the group is currently lacking this capability. A timing jitter of less than 100ps willenable resolution of multiple time-bins within the coherence lifetime of the materials that the group studies. A detector dead time of less than 50ns will allow the MP group to operate experiments at MHz repetition rates, which is important to enable probabilistic photon coincidence experiments.  c) The cryostat must be able to accommodate 8 detectors or similar devices.   Initially, the MP group wishes to do probabilistic photon coincidence experiments involving two detectors; however, as the sophistication of the groups experiments increases, the ability to upgrade the system with additional detectors (possibly operating in different spectral ranges) is critical. The QP group design and build quantum dot photon sources which must be operated in cryogenic conditions; there must be room in the purchased cryostat for both the SSPDs, and for the quantum dot devices.  d) The cryostat temperature must be below 1K.   The QP group design and build fiber-coupled quantum dot single photon sources (QDSPSs) which must be operated below 1K. Thus, in order to house the QDSPSs along with the SSPDs, the cryostat must maintain sub-1K temperatures.  e) The company must provide on-site training.   SSPDs must be housed in a compatible cryostat, which can be user-maintained and packaged for transfer between the sites where the groups are based. Several of the planned users do not yet have the requisite skills and will require detailed, on-site training.  6. Government Contracts Regulations Exception   The following exception to the Government Contracts Regulations is invoked for this procurement under subsection 6(d)  only one company is capable of performing the work.   7. Exclusions and/or Limited Tendering Reasons   The following exclusions and/or limited tendering reasons are invoked under the: - Agreement on Internal Trade (AIT)  Article 506.12(a) - North American Free Trade Agreement (NAFTA)  Article 1016.2(b) - World Trade Organization - Agreement on Government Procurement (WTO-AGP)  Article XV.1(b)  8. Delivery date   The equipment must be delivered on or before March 31, 2017.  9. Cost estimate of the proposed contract   The estimated value of the contract, including options, is $ 402,732.00 USD.  10. Name and addressof the pre-identified supplier   Photon Spot Inc, 142 W Olive Ave Monrovia, CA 91016  11. Suppliers' right to submit a statement of capabilities   Suppliers who consider themselves fully qualified and available to provide the goods, servicesor construction services described in the ACAN may submit a statement of capabilities in writing to the contact person identified in this notice on or before the closing date of this notice. The statement of capabilities must clearly demonstrate how thesupplier meets the advertised requirements.  12. Closing date for a submission of a statement of capabilities   The closing date and time for accepting statements of capabilities is November 3, 2016 at 2:00 p.m. EDT.   13. Inquiries and submissionof statements of capabilities   Inquiries and statements of capabilities are to be directed to:  Cassandra Shannahan Public Works and Government Services Canada Acquisitions Branch Commercial and Consumer Products Directorate 11 Laurier Street, 6A2, Phase III Place du Portage, Gatineau, Québec, K1A 0S5  Telephone: (819) 420-1068 Facsimile:   (819) 956-3814 E-mail address: cassandra.shannahan@pwgsc-tpsgc.gc.ca  Delivery Date: Above-mentioned  You are hereby notified that the government intends to negotiate with one firm only as identified above. Should you have any questions concerning this requirement, contact the contracting officer identified above.  An Advance Contract Award Notice (ACAN) allows departments and agencies to post a notice, for no less than fifteen (15) calendar days, indicating to the supplier community that it intends to award a good, service or construction contract to a pre-identified contractor. If no other supplier submits, on or before the closing date, a Statement of Capabilities that meets the requirements set out in the ACAN, the contracting authority may then proceed with the award.  However, should a Statement of Capabilities be found to meet the requirements set out in the ACAN, then the contracting authority will proceed to a full tendering process.  Suppliers who consider themselves fully qualified and available to provide the services/goods described herein, may submit a statement of capabilities in writing to the contact person identified in this Notice on or before the closing date of this Notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements.  The PWGSC file number, the contracting officer's name and the closing date of the ACAN must appear on the outside of the envelope in block letters or, in the case of a facsimile transmission, on the covering page.  The Crown retains the right to negotiate with suppliers on any procurement.  Documents may be submitted in either official language of Canada.

TRIP. QUAD. ICP MASS SPECTROMETER

Health Canada | Published October 23, 2015  -  Deadline September 11, 2015
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Trade Agreement: WTO-AGP/NAFTA/AIT/Canada FTAs with Peru/Colombia/Panama Tendering Procedures: Generally only one firm has been invited to bid Non-Competitive Procurement Strategy: Exclusive Rights Comprehensive Land Claim Agreement: No Vendor Name and Address: Agilent Technologies Canada Inc. 6705 Millcreek Unit 5 Mississauga Ontario Canada L5N5M4 Nature of Requirements: TRIPLE QUADRUPOLE ICP MASS SPECTROMETER H4033-151114/A Martins, Christina Telephone No. - (613) 355-1973 Fax No. - (819) 956-3814 1. Advance Contract Award Notice (ACAN) An ACAN is a public notice indicating to the supplier community that a department or agency intends to award a contract for goods, services or construction to a pre-identified supplier, thereby allowing other suppliers to signal their interest in bidding, by submitting a statement of capabilities. If no supplier submits a statement of capabilities that meets the requirements set out in the ACAN, on or before the closing date stated in the ACAN, the contracting officer may then proceed with the award to the pre-identified supplier. 2. Definition of the requirement Health Canada has a requirement for the supply, installation, familiarization, training and manuals for one Triple Quadrupole ICP-MS. The instrument will be used for measurement of long-lived radioactive contaminants in environmental and human urine samples. 3. Criteria for assessment of the Statement of Capabilities Any interested supplier must demonstrate by way of a statement of capabilities that its equipment meets the following requirements: A. Technical Specifications: 1. The triple quadrupole ICP-MS system must have a tandem ICP-MS/MS configuration which consists of a Collision Reaction Cell between the two Quadrupole Mass Filters (QMFs), each of 1 atomic mass unit (amu) resolution. 2. Each of the QMFs must be independently controlled by system software to permit selective mass filtering/transmission capability. 3. The triple quadrupole ICP-MS must have a guaranteed abundance sensitivity specification of less than or equal to 10-10. 4. The triple quadrupole ICP-MS must have a background of less than or equal to 0.2 counts per second (cps) over the mass range 9 to 238 amu. 5. The triple quadrupole ICP-MS must have sensitivity of greater than or equal to 200,000 cps/ppb above mass 205 amu. 6. The triple quadrupole ICP-MS must have oxide ratio (CeO+/Ce+) of less than or equal to 1.5%. 7. The triple quadrupole ICP-MS must have doubly-charged ratio (Ce++/Ce+) of less than or equal to 3%. 8. The triple quadrupole ICP-MS system must to robust enough to handle a total dissolved solid = 1%. 9. The Collision Reaction Cell must accept up to 4 cell gases, each fully and independently mass flow controlled, and must allow mixing of different gases within the cell by the system software. 10. The triple quadrupole ICP-MS system must have an additional (5th) Mass Flow Controller for addition of alternative gas (oxygen/argon) in the plasma for organics/matrix removal. 11. The triple quadrupole ICP-MS system must have a Recirculating Chiller for a controlled supply of cooling water for the radio-frequency (RF) generator, turbo molecular pump, load coil, spray chamber, and interface. 12. The triple quadrupole ICP-MS system must have an auto-sampler with samples racks to accommodate 17mm and 30mm (outer diameter) sample tubes. The auto sampler must be controlled by the system software. 13. The triple quadrupole ICP-MS system must have high purity (2 stage, stainless steel body + diaphragm) gas regulators for Cell gases. 14. The quotation price must include Carrier Gas cleaning kit, connection tubing, tube cutter, wall mounting bracket, and stainless steel tubing for external cell gas lines. 15. The triple quadrupole ICP-MS system must have a noise reduction enclosure for the roughing pump. 16. The triple quadrupole ICP-MS system must include appropriate elemental standard solutions for instrument performance validation and tuning. 17. The triple quadrupole ICP-MS system must include appropriate connection kit for Liquid Chromatography. 18. The triple quadrupole ICP-MS system must include a separate set of inert sample introduction kit, appropriate interface cones and ion lenses for very high sensitivity measurement option. 19. The triple quadrupole ICP-MS system must include a table (84" X 30" X 35"; W, D, H) on heavy duty casters that lock in swivel and roll. The weigh capacity of the table must be adequate to support the auto sampler, the ICP-MS, computer, monitor, keyboard and a printer. 20. The triple quadrupole ICP-MS system must include a Personal Computer (PC) with Windows 7 or higher (64 bit) operating system, a monitor and a laser printer. The PC must have adequate processor speed, memory and disk space for complete instrument control, data acquisition and data analysis. 21. Quoted price must include installation and onsite training on the operation and maintenance of the system. B. Operating Software and Accessories 1. Must provide an instrument and operational manual. 2. Operating software must allow instrument control, data acquisition, and data processing. 3. Must have operating software for chromatographic data analysis. 4. Operating software must be compatible with Windows 7. 5. Operating software must allow for standard and customizable data reporting. 6. Operating software must allow data export to Microsoft Excel. 4. Applicability of the trade agreement(s) to the procurement This procurement is subject to the following trade agreements: Agreement on Internal Trade (AIT) North American Free Trade Agreement (NAFTA) The World Trade Organization Agreement on Government Procurement (WTO-AGP) 5. Justification for the Pre-Identified Supplier Agilent Technologies Canada Inc. offers the only Triple Quadrupole ICP-MS available in the market that meets all of Health Canada's requirements. For this reason, it is proposed to negotiate directly with the OEM, Agilent Technologies Canada Inc., Mississauga, Ontario. 6. Government Contracts Regulations Exception(s) The following exception to the Government Contracts Regulations is invoked for this procurement under subsection 6(d) - "only one person is capable of performing the work". 7. Exclusions and/or Limited Tendering Reasons The following exclusion(s) and/or limited tendering reasons are invoked under the: Agreement on Internal Trade (AIT) Article 506.12 (b) North American Free Trade Agreement (NAFTA) Article 1016.2 (b) The World Trade Organization - Agreement on Government Procurement (WTO-AGP) XV(1b) 8. Period of the proposed contract or delivery date Delivery must be received on or before 31 March 2016. 9. Name and address of the pre-identified supplier Name: Agilent Technologies Canada Inc. Address: Mississauga, ON 10. Suppliers' right to submit a statement of capabilities Suppliers who consider themselves fully qualified and available to provide the goods, services or construction services described in the ACAN, may submit a statement of capabilities in writing to the contact person identified in this notice on or before the closing date of this notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements. 11. Closing date for a submission of a statement of capabilities The closing date and time for accepting statements of capabilities is 9 November, 2016 at 2:00 p.m. EST. 12. Inquiries and submission of statements of capabilities Inquiries and statements of capabilities are to be directed to: Christina Martins Supply Specialist Commercial and Consumer Products Directorate Commercial Acquisitions and Supply Management Sector Public Works and Government Services Canada Gatineau, QC K1A 0S5 Place du Portage, Phase III, 6A2-29 Telephone 613-355-1973 Facsimile 819-956-3814 Christina.Martins@pwgsc.gc.ca Delivery Date: Above-mentioned You are hereby notified that the government intends to negotiate with one firm only as identified above. Should you have any questions concerning this requirement, contact the contracting officer identified above. An Advance Contract Award Notice (ACAN) allows departments and agencies to post a notice, for no less than fifteen (15) calendar days, indicating to the supplier community that it intends to award a good, service or construction contract to a pre-identified contractor. If no other supplier submits, on or before the closing date, a Statement of Capabilities that meets the requirements set out in the ACAN, the contracting authority may then proceed with the award. However, should a Statement of Capabilities be found to meet the requirements set out in the ACAN, then the contracting authority will proceed to a full tendering process. Suppliers who consider themselves fully qualified and available to provide the services/goods described herein, may submit a statement of capabilities in writing to the contact person identified in this Notice on or before the closing date of this Notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements. The PWGSC file number, the contracting officer's name and the closing date of the ACAN must appear on the outside of the envelope in block letters or, in the case of a facsimile transmission, on the covering page. The Crown retains the right to negotiate with suppliers on any procurement. Documents may be submitted in either official language of Canada.
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