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Upgrade of Core EVOS Auto FL Cell Imaging System to include On-Stage Incubator and Integration of existing microscope objectives and proprietary LED light cubes

Department of Health and Human Services, National Institutes of Health | Published March 11, 2016  -  Deadline March 21, 2016
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Contracting Office Address:Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E144, Bethesda, MD 20892, UNITED STATES. Description:National Cancer Institute (NCI), Center for Cancer Research (CCR), Laboratory of Cancer Biology and Genetics (LCBG), plans to procure on a sole source basis an upgrade to the core of the Government owned EVOS Auto FL cell imaging system to include an on-stage incubator system that is compatible with existing Government-owned existing microscope objectives and proprietary LED light cubes from Life Technologies, Corp., a division of Thermo Fisher Scientific, Inc., 5791 Van Allen Way, Carlsbad, CA 92008. The response close date of this notice for this requirement is in accordance with FAR 5.203(a)(1). This acquisition will be processed under FAR Part 12 - Acquisition for Commercial Items and in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1), and is exempt from the requirements of FAR Part 6.The North American Industry Classification System code is 334516 and the business size standard is 500 employees. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The period of performance is twelve (12) months from date of award. It has been determined there are no opportunities to acquire green products or services for this procurement. The LCBG conducts an integrated research program to elucidate the molecular and biological mechanisms underlying cancer progression and to use this information to develop novel anti-cancer therapies. Investigators in the LCBG have recently developed a powerful fluorescent imaging approach to studying the cancer stem cells, a clinically critical subpopulation of cells in a tumor that are responsible for maintenance of the tumor and recurrence after therapy. With this approach, cancer stem cell properties can be monitored in real time and the effect of drugs on this cell population assessed through fate-mapping studies. However, to meet these objectives, the additional capabilities of accurate image registration and environmental control (temperature, gas composition, humidity) necessitate the upgrade to an instrument that has an automated X-Y scanning stage and has an on-stage incubator.The LCBG requires an epifluorescent microscope for cell imaging for many aspects of the laboratory cancer research program to understand the mechanisms underlying the progression of cancer from early lesion to late stage metastatic disease. Specifically there is currently a need for a Cell Imaging system that will allow cell fate mapping by time-lapse videomicroscopy to address the role of the cancer stem cell in therapeutic resistance. This information should help in the design of more effective cancer therapies. The LCBG's existing EVOS instrument can be upgraded to acquire this capability by trading in the core instrument for credit and exchanging it for an instrument core that includes an automated motorized X-Y scanning stage (to allow regions of the sample to be repeatedly imaged over time) and an on-stage incubator (to keep the cancer cell cultures alive during the extended periods of the time-lapse microscopic imaging). In going for a trade-in, The LCBG can re-use the microscope objectives and proprietary light cubes from the original system. The upgraded microscope will be a multi-user instrument, and the EVOS system is uniquely robust because of the proprietary integrated instrument design which means there are no bulbs to change and the optics cannot be misaligned during use and it is user-friendly due to the embedded operating system and its unique software.Contractor shall perform one (1) hardware upgrade of the EVOS auto FL cell imaging system to include on-stage incubator and integration of existing microscope objectives and proprietary LED light cubes system, and software upgrade on the Government-owned EVOS Auto FL Cell Imaging System; hardware upgrade to include 22" Multi-Touch Monitor; External PC with 16 GB RAM; FL Auto Accessory kit; 3 US Power Cords; Condenser Slider, Diffusion; Condenser Slider, Block; Vessel Holder for Slides (AMEPVH001); Intermediate Stage Plate (AMEPVH022); Light Shield; Dust Cover; USB A to B cable (6Ft)/ DVI cable (6Ft); USB stick; Cartridge Extraction Tool; Corded Optical USB Mouse; Light Cube Access Door; and software upgrade to include advanced system software featuring high-resolution mosaic tiling, multi-position scanning, object counting, and time-lapse interface software during the contract period. The upgrade shall be performed by technically qualified factory trained personnel. Life Technologies, Corp. is the only known manufacturer of the required EVOS FL Auto Cell Imaging System (AMAFD1000). It is the only imaging system available on the market with all the required specifications in the Statement of Work, provided in this notice. Furthermore, the required incubator integrates into the microscope software which is a unique feature, and the small footprint and portability of the instrument are not found in other cell imaging systems. This system is replacing an existing EVOS system, and laboratory scientists will be familiar with the upgraded system. Use of the imaging system will be easy to learn because of the similar setup as the system being replaced. The compatibility and integration of the existing equipment elements with the upgraded equipment core is crucial for efficient equipment operation, and the throughput of the laboratory. ,Any deviation from the required specifications could ruin countless hours of work, distort and destroy the integrity of information and/or ruin further studies. The data collection software supplied with this equipment, which acts as the instruments operating system, is proprietary and updates and patches are solely available through the proposed Vendor. The proposed Vendor has unlimited access to parts and technical support both of which are of a proprietary nature and included in the contract price. This notice is not a request for competitive quotation. However, if any interested party, especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 4:00PM EDT, on March 21, 2016. All responses and questions must be in writing and faxed (240) 276-5401 or emailed to Catherine Muir, Contracting Officer via electronic mail at muirca@mail.nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, Contractors must be registered and have valid, current Entity Record, including current Representations and Certifications, in the System for Award Management (SAM) through SAM.gov. Reference: N02RC62547-76 on all correspondence.    

Nursing Continuing Educaton Outreach Project

Department of Health and Human Services, National Institutes of Health | Published August 21, 2015  -  Deadline September 4, 2015
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The National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intends to award a purchase order to First Candle/SIDS Alliance, 1314 Bedford Avenue, Suite 210, Baltimore, MD 21208 for the Nursing Continuing Education Outreach Project. The NICHD, the National Institute of Nursing Research (NINR) and First Candle/SIDS Alliance developed a Nursing Continuing Education (CE) Program on SIDS risk reduction to reduce the incidence of SIDS. The goal of the program is to increase the capacity of Nurses to educate families and caregivers about ways to reduce factors known to increase SIDS and other sleep-related causes of infant death risk. In the first three years of the CE program, First Candle Staff developed a general abstract submission form to submit to national and regional nursing and health related conferences. Through the customization of 70 abstract submissions, First Candle was successful at securing acceptances to over 22 national conferences and 23 regional conferences and 2,022 nurses have completed the CE module. Currently, over 47,000 nurses have completed the CE program and received credit either from the provider-led or online program. First Candle is to conduct an outreach with organizations that influence nursing infant care practices in health care settings and to conduct a follow-up survey to participants to assess if a change in behavior or policy has resulted from the CE completion. The sole source determination is based on that First Candle/SIDS Alliance has been a collaborator of the NICHD-led Safe to Sleep (formerly Back to Sleep) campaign since inception in 1994 and has worked with NICHD through contractual agreements to support educational outreach activities in campaign-related activities and is currently a collaborator for the latest expansion to the Safe to Sleep campaign. In compliance with Federal Acquisition Regulation (FAR) 13.106-1(b) Soliciting from a single source. This solicitation is not a Small Business Set-Aside. This notice of intent is not a request for competitive proposals, however; all responses received, before the closing date, of this announcement will be considered by the Government. A determination by the Government not to compete this proposed acquisition is based upon responses to this notice and is solely within the discretion of the Government. It is anticipated that the RFQ NIH-NICHD-15-069 will be available fifteen (15) days after the publication date of this synopsis. Receipt of quotations will be due five (5) days after the release of the RFQ. All interested parties to this solicitation may request a copy of the RFQ package in writing to the attention of Ms. Patricia Haun at National Institute Child Health and Human Development (NICHD), 6100 Executive Blvd., Room 5C01, Rockville, MD 20815 or via email Haunp@mail.nih.gov. All requests must contain offerors name, address, telephone number and fax number. Email addresses are encouraged but not mandatory.

Two Fixed-Staged Microscopes and One Manual Microscope

Department of Health and Human Services, National Institutes of Health | Published August 12, 2015  -  Deadline August 22, 2015
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INTRODUCTION This is a combined synopsis/solicitation for commercial items. This announcement constitutes the only solicitation; quotations are being requested and a written solicitation will not be issued. This acquisition is being conducted in accordance with the procedures of FAR Part 13 - Simplified Acquisition Procedures. The solicitation number is HHS-NIH-NIDA-SSSA-CSS-15-740 and the solicitation is issued as a request for quotation (RFQ). NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 333314 with a Size Standard of 500 Employees. SET-ASIDE STATUS This acquisition is not a set-aside and is issued for full and open competition. ACQUISITION AUTHORITY This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures. This acquisition is not expected to exceed the simplified acquisition threshold. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-83, dated July 2, 2015. The resultant purchase order will include all applicable provisions and clauses in effect through this date. DESCRIPTION OF REQUIREMENT Purpose The National Institute of Mental Health requires two fixed-stage microscopes for patch-clamp studies and an additional manual microscope for histological studies. These components will be fundamental in conducting patch-clamp electrophysiology studies to investigate the synaptic connectivity of defined stress circuits in brain slices from mice, and also post-experiment histology of the brain tissue. Project Requirements The Contractor must be able to provide a brand name or equal agreement that includes the following: Olympus BX51WI: (Quantity: 2) • Microscope stand with front fine/coarse focus • Coarse focus lock lever to maintain rigidity and z position when moving between various objectives. • The nosepiece must be removable to be able to accommodate other specialized nosepieces for various applications. • An external power supply to minimize electrical noise. • The fluorescence illuminator must be removable to be able to mount an intermediate device below it. • The ability to easily remove both the field stop and aperture stop on the fluorescence illuminator for access to various image and illumination planes. • The ability to raise both the fluorescence illuminator along with the nosepiece carrier to accommodate an additional 40mm of space to accommodate whole animals. • The ability to remove the substage condenser assembly to accommodate whole animals. This must be easily removable by NIMH staff and not require a service technician or representative of the company. • Patch clamping techniques require a minimal amount of disturbance of the sample and instruments surrounding the microscope therefore the instrument should adhere to the following conditions. o Coarse/Fine focusing knobs mounted in the front of the microscope. o The IR DIC contrast adjustments using the Senararmont method to be done below the stage rather than risk bumping stage, specimen, manipulators and nosepiece. o The 60x water objective should have a 1.0 numerical aperture, IR transmission,working distance of 2mm. o Polarizers and IR filters should be mounted on the field diaphragm on a rotating filter wheel facing the front for easy access. Olympus BX43: (Quantity: 1) • Fluorescence and Unique Monochrome and Color Camera • Microscope can be automated to include automatic nosepiece, fluorescence turret, and condenser. Manual microscope can be upgraded with any or all of these automated components at a later date. • UIS2 objectives that are suitable for use with all observation methods, including bright field, phase, dark field, DIC and fluorescence. • Fluorescence encoded illuminator that delivers a higher intensity of light to the sample, and therefore results in brighter fluorescence images o Includes Fly-Eye technology providing perfectly even illumination critical for image analysis. The encoded illuminator allows the software to know which fluorescence filter is in position. • A filter turret capable of simultaneously holding 8 fluorescence filter cubes. As the needs of the laboratory grow, a 8-position filter turret will offer plenty of room for expansion. • Unique focus knob design that allows the movement of the fine focus knob to either side of the microscope to accommodate left or right-handed operators. • Ergonomic Y-Shaped design that maximizes access to the sample while minimizing desk space used. • Ergonomic tilting trinocular observation tube with prism camera port for the attachment of the camera system with three light settings: 50% eyepieces/50% camera, 100% eyepieces, and 100% camera. The primary 50%/50% position eliminates the need to switch back and forth between eyepiece viewing and the digital camera while the 100% settings allow for maximum light transmission to the eyes or digital camera. • Patented LED transmitted light provides evenly illuminated field of view critical for imaging. Also provides long lifetime, approximately 12000 hours of use. • Color-balanced LED with light intensity management system that diminishes eye fatigue and the strain of repetitive adjustments. • LED light source that offers superb color reproduction from purple to cyan to red, with ultra-long lifespan. Anticipated Period of Performance This equipment shall be delivered within 4 weeks after receipt of order. Contract Type The Government expects to issue a firm fixed price purchase order for this requirement. APPLICABLE CLAUSES AND PROVISIONS FAR Clause 52.213-4: Terms and Conditions -- Simplified Acquisitions The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. EVALUATION CRITERIA The Government will award a purchase order resulting from this solicitation on the basis of lowest price technically acceptable. Technical acceptability will be evaluated based upon the following: 1. The Offeror must include all the brand name or equal project requirements detailed in this notice in its quotation. 2. If proposing equal equipment, the Offeror must provide specification information for the equipment so that the brand name or equal status may be verified. 3. Technical factors are more important than cost or price. Selection of the contractor to perform this work will be based on the Government's assessment of the best overall value. RESPONSE FORMAT Responses to this solicitation must include clear and convincing evidence of the offeror's capability of fulfilling the requirement as it relates to the technical evaluation criteria. The price quote must include equipment descriptions and specifications per the requirements listed above as well as associated pricing. The quotation must also indicate the trade-in value of the equipment to be traded-in. Contractors must provide their Company Name, Dun & Bradstreet Number (DUNS), Taxpayer Identification Number (TIN), Business Size, Physical Address, and Point of Contact Information in their responses. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." All responses must be received by the closing date of this announcement and must reference solicitation number HHS-NIH-NIDA-SSSA-CSS-15-740. Responses shall be submitted electronically to Jennifer Burns, Contract Specialist, at jennifer.burns2@nih.gov.

Photography and Video Equipment

Department of Health and Human Services, National Institutes of Health | Published August 12, 2015  -  Deadline August 18, 2015
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(i) "This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued." (ii) The solicitation number is HHS-NIH-NHLBI-CSB-HG-2015-209-DLM and the solicitation is being posted as a request for proposal (RFP). (iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-83, August 5, 2015. (iv) This is NOT a set-aside, the associated NAICS code is 423410, Photographic Equipment and Supplies Merchant Wholesalers and small business size standard is 500. The acquisition is being conducted in accordance with the procedures of FAR Part 12 and FAR Part 13. All responsible offerors may submit a proposal, which if timely received, shall be considered by the agency. Offers are due by 8:00 A.M. Eastern Time (EST) on August 18, 2015. PROCUREMENT: (v) Photography Equipment: 1. Canon EOS 5D Mark III DSLR Camera (Body Only) 2. Canon EF 24-50mm f/2.8L II USM Lens 3. Canon EF 70-200mm f/2.8L IS II USM Lens 4. B+W 77mm XS-Pro UV MRC-Nano 010M Filter 5. B+W 82mm XS-Pro UV MRC-Nano 010M Filter 6. Profoto B2 250 Air TTL Location Kit 7. Profoto Air Remote TTL-C for Canon 8. Think Tank Photo Airport Security V 2.0 Rolling Camera Bag 9. Profoto OCF Octa Softbox (2') 10. Profoto Speedring for OCF Flash Heads 11. Profoto Grid Kit for OCF Flash Heads 12. Kirk BL-5D3 L-Bracket for Canon 5D Mark III, 5DS, and 5DS R Video Equipment: 13. 1 QuikLok MP892 Small Rubber Mic Clip for Wired Microphones 14. 1 K&M 210/3 Tripod Microphone Stand with Telescoping Book (Nickel) 15. 1 Sennheiser MKH-416-Short Shotgun Interference Tube Microphone 16. 1 Panasonic BT-LH2170PJ 21.5² LCD Studio Monitor 17. 2 Kino Flo Lollipop with Short Baby Receiver Mount 18. 1 Blackmagic Design MultiView 16 19. 2 Porta Brach RIG-2SRK Rig Camera Case (Black) 20. 2 Kino Flo Off-Set Femaile Mounting Plate Adapter - 5/8² 21. 2 Kino Flo Barndoors Set for Celebrity 200 LED Light 22. 2 Watson 25ft AC Power Extension Cord AWG (Black) 23. 3 Manfrotto 008BU Black Cine Stand -7¹ 24. 2 Kino Flo Kino Flo Celeb 200 DMX LED Kit with Light Pack Case 25. 1 Arri L7-C Color LED Fresnel with Hybrid Cooling (stand mount) 26. 4 Samsung 1TB 850 Pro Series SATA 2.5² SSD 27. 1 Datavideo DAC-70 SD/HD/3G-SDI Up/Down/Cross Converter (vi) The National Institute of Health (NIH) is the nation's leading medical research agency and the primary Federal agency mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people's health and save lives. The National Human Genome Research Institute (NHGRI) mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. The Communications and Public Liaison Branch of the Division of Policy, Communications, and Education at the National Human Genome Research Institute (NHGRI) provides the latest news and background information about NHGRI, the Human Genome Project and NHGRI research. The staff handles media requests, inquiries from the scientific community and questions from the general public. Evaluation of Proposals: The Government will evaluate proposals that are determined technically acceptable in accordance with the Technical Evaluation factors. The Government intends to award a single contract from this solicitation. The Government reserves the right not to award a contract. Evaluation of Proposals: The Government reserves the right to make an award without discussions based solely upon initial proposals. Evaluation Factors: A. Price (This will be Firm-Fixed Price): An evaluation of the offeror's price proposal will be made to determine if proposed prices are realistic for the work to be performed, reflect a clear understanding of the requirements, and are consistent with the technical proposal. Reasonableness determinations will be made by determining if competition exists, by comparing proposed prices with established commercial or GSA price schedules (if applicable), and/or by comparing proposed prices with the Independent Government Cost Estimate (IGCE). (vii) Delivery will be made to National Institutes of Health, National Human Genome Research Institute, 31 Center Drive, Building 31, Bethesda, MD 20892. (viii) The FAR Provision 52.212-1, Instructions to Offerors -- Commercial, applies to this acquisition and is hereby incorporated by reference. All Federal Acquisition Regulations (FAR) clauses may be viewed at http://acquisition.gov/comp/far/index.html. The proposal must reference the RFP Number: HHS-NIH-NHLBI-CSB-(HG)-2015-209-DLM. All responsible offerors may submit a proposal, which if timely received, shall be considered by the agency. All proposals shall contain the following: 1. Name of Contracting Organization; 2. Solicitation number; 3. Contract Type; 4. Total Contract Value and Discounts; 5. Description of Requirement; 6. North American Industry Classification System (NAICS) Code; and 7. DUNS Number. (ix) In accordance to FAR clause 52.212-2, Evaluation - Commercial Items (x) In accordance with FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items, offerors must complete annual representations and certifications on- line at https://www.sam.gov/portal/public/SAM/. (xi) FAR clause 52.212-4, Contract Terms and Conditions - Commercial Items applies to this acquisition. (xii) FAR clause 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items applies to this Acquisition. Additional FAR Clauses include: FAR clause 52.204-10, Reporting Executive Compensation and First-Tier Subcontract Awards (JUL2013) (Pub.L. 109-282) (31 U.S.C. 6101 note). FAR clause 52.223-18, Encouraging Contractor Policies to Ban Text Messaging while Driving (AUG2011). FAR clause 52.225-13, Restrictions on Certain Foreign Purchases (JUN 2008) (E.O.'s, proclamations, and statutes administered by the Office of Foreign Assets Control of the Department of the Treasury). FAR clause 52.232-33, Payment by Electronic Funds Transfer-System for Award Management (JUL2013) (31 U.S.C. 3332). (xiii) There are no additional contract requirement(s) or terms and conditions (such as contract financing arrangements or warranty requirements) determined by the contracting officer to be necessary for this acquisition and consistent with customary commercial practices. (xiv) The Defense Priorities and Allocations System (DPAS) and assigned rating does not apply to this acquisition. (xv) All responsible offerors may submit a proposal, which if timely received, shall be considered by the agency. Offers are due by 8:00 A.M. Eastern Time (EST) on August 18, 2015. (xvi) Proposals can be emailed to the Contracting Officer, Dorothy Maxwell at maxwelld@mail.nih.gov, place Solicitation Number: HHS-NIH-NHLBI-CSB-(HG)-2015-209-DLM on the quotation. Quotations shall not be deemed received by the Government until the quotation is entered into the e-mail address inbox set forth above. Faxed proposals will NOT be accepted.

Tri-Carb 4810 Scintillation Counter

Department of Health and Human Services, National Institutes of Health | Published May 29, 2015  -  Deadline June 8, 2015
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Contracting Office Address Department of Health and Human Services, National Institutes of Health (NIH), National Library of Medicine Office of Acquisitions, National Institute of Diabetes and Digestive Kidney Diseases (NIDDK) Acquisitions Branch, 6707 Democracy Boulevard, II Democracy Plaza, Suite 700W, Bethesda, Maryland 20817. Description National Institute of Diabetes and Digestive Kidney Diseases (NIDDK) plans to procure, on a sole source basis, with PerkinElmer Health Sciences, Inc., 710 Bridgeport Avenue, Shelton, CT 06484, for the following equipment: • TRI-CARB 4810TR 100V Liquid Scintillation Counter This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1). The North American Industry Classification System Code is 334516 and the business size standard is 500 employees. Only one award will be made as a result of this solicitation. This will be awarded as a firm-fixed price type contract. This is a replacement scintillation counter for one that is over twenty years old and because it is so old, can no longer be repaired. This equipment is a computer controlled bench-top liquid scintillation analyzer for detecting small amounts of beta, alpha and gamma radioactivity. The results of most of the assays in our labs such as cyclic AMP stimulation, Inositol phosphate stimulation, receptor binding, and many others are all determined by measuring the radioactivity of our samples. This new Tri-Carb has 100% of the existing features we are familiar with plus more, including Windows8 operating system and LED status indicator (see attached for additional information). This is not a solicitation for competitive quotations. However, if any interested party believes they can meet the above requirement, they may submit a statement of capabilities. All information furnished must be in writing and must contain sufficient detail to allow the NIDDK to determine if it can meet the above unique specifications described herein. An original and one copy of the capability statement must be received in the DK Acquisitions Branch on or before 11:30 AM EST on June 8, 2015. Electronic capability statements (via e-mail) will be accepted. All questions must be in writing and can be faxed to 301-480-4226 or emailed to Lisa Josephowitz, Contract Specialist, at josephol@mail.nih.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractor must be registered and have valid certification in the System for Award Management (SAM). No collect calls will be accepted. Please reference solicitation number NIHLM2015489 on all correspondences.

Upright microscope

Other Defense Agencies, Uniformed Services University of the Health Sciences | Published July 6, 2016  -  Deadline July 14, 2016
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* Refer to the attachments for the complete detailGeneral Overview: The Uniformed Services University of the Health Sciences (USU) is the Nation's federal health sciences university and is committed to excellence in military medicine and public health during peace and war. We provide the Nation with health professionals dedicated to career service in the Department of Defense and the United States Public Health Service and with scientists who serve the common good. We serve the uniformed services and the Nation as an outstanding academic health sciences center with a worldwide perspective for education, research, service, and consultation; we are unique in relating these activities to military medicine, disaster medicine, and military medical readiness. USU is located in Bethesda, MD on the grounds of the Naval Support Activity Bethesda. Additional information regarding USU can be found on our website: www.usuhs.mil. USU has a requirement for an upright microscope. This is a combined synopsis/solicitation for commercial items in accordance with the format in FAR subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotes are being requested and a written solicitation will not be issued. This is a request for quotes (RFQ) for commercial items in accordance with the procedures of FAR part 12 Acquisition of Commercial Items and FAR part 13 Simplified Acquisition Procedures. This RFQ incorporates all provisions and clauses in effect through Federal Acquisition Circular (FAC) 2005-88-1 (June 15, 2016) and Defense Federal Acquisition Regulation Supplement (DFARS) (June 30, 2016). In order to be eligible for award, offerors must be registered in www.sam.gov, with completed representations and certifications by the close date of the solicitation. Offerors are encouraged to submit multiple quotes for alternative solutions meeting the requirements. Each quote will be evaluated separately by the Government. Specifications: Required Specifications Offerors responding to this RFQ must submit a quote for an upright microscope meeting the following required specifications. Required Specifications Justificationa. 2x, 4x, 10x, 20x, 40x, 60x, 100x plan-fluorite objectives. Plan-fluorite objectives or better (e.g., plan-apochromat) are required as photos will be taken for publication. Microscope will be used primarily for bright field reading of H&E slides and immunohistochemistry stains and not for fluorescence. b. Tilting trinoc head with multiple positions. Microscope must be able to be adjusted in order to be ergonomically compliant as it will be used frequently and by multiple researchers.c. Tilting binocular OBS tube. Microscope must be able to be adjusted in order to be ergonomically compliant as it will be used frequently and by multiple researchers.d. Right-hand mechanical stage, rackless, long stalk. Majority of users are right-handed.e. Seven position nosepiece. Nose piece must hold the 7 objectives ordered.f. Dual observation unit, front-back user with LED pointer. Will be used as an instructional scope so dual observation and LED is required.g. Camera. For imaging purpose (see Desired Specifications below).h. Image analysis software. Software must be allowed by IT department. Ideally software is known to be already used and compatible with USUHS/DoD requirements. i. Minimum of Windows 64-bit desktop workstation with 8 GB RAM, 256 GB SDD, TB HHD. Hardware must be allowed by IT department. Ideally hardware is known to be already used and compatible with USUHS/DoD requirements. j. Display monitor/TV. To view images (see Desired Specifications below). Desired Specifications The following specifications are desired. Offerors responding to this requirement are not required to quote an upright microscope meeting all the desired specifications listed below. However, quotes that meet or exceed the desired specifications may be considered more desirable by the Government. DESIRED SPECIFICATIONSa. Color camera. b. Flat panel display monitor/TV. The Government may consider purchasing installation, training, and extended warranty (up to five years). No Government-furnished equipment or supplies will be provided to the selected contractor for installation or training. Installation and training must be coordinated with the technical end-user, who will be identified in the purchase order (PO), and conducted during normal Government business hours (Monday through Friday 8:00AM local time to 4:00PM local time, excluding Federal holidays). The desired delivery date is August 31, 2016. Offerors should note the expected delivery and installation timelines in their quotes. Evaluation / Award Detail: The Government intends to award a single firm-fixed priced (FFP) purchase order to the offeror representing the best value to the Government based on the evaluation factors listed below. Evaluation factors are listed in order of importance, with most important listed first. The Government will conduct a trade-off between price and non-price factors. The Government is not required to award to the lowest priced offeror or the highest technically rated offeror. The Government reserves the right to award without discussions. Evaluation Factors (in order of importance): 1. Technical. Offerors must provide product literature, which demonstrates the capabilities of the quoted item(s). At a minimum the product literature must demonstrate how the quoted item meets the required specifications and the desired specifications quoted. Information on warranty, installation, training and delivery lead-time must be included in the quote submission and will be evaluated. The Government reserves the right to utilize technical (e.g. trade magazines) and customer reviews/references, if deemed necessary, as part of the technical evaluation for the quoted item(s). 2. Price. Offerors must include all applicable costs, such as components, installation, and shipping, in their quote. The total quoted price will be the evaluated price. 3. Past Performance. IAW DFAR subpart 213.106-2, the Government will consider data available in the statistical reporting module of the Past Performance Information Retrieval System (PPIRS-SR). Offerors without a record of relevant past performance information in PPIRS-SR for the FSC or PSC being procured, will not be evaluated favorably or unfavorably for its past performance history. In addition to providing the product literature, offerors must also submit a copy of the completed CLIN Structure Excel spreadsheet [refer to the RFQ attachments]* in the quote package. Those offerors who fail to provide this copy in the quote package may be deemed nonresponsive: CLIN 0001: Upright microscope *1. REQUIRED SPECIFICATIONS Quoted Specifications Reference Page No. in the Quote Package / Product Literaturea. 2x, 4x, 10x, 20x, 40x, 60x, 100x plan-fluorite objectives. b. Tilting trinoc head with multiple positions. c. Tilting binocular OBS tube. d. Right-hand mechanical stage, rackless, long stalk. e. Seven position nosepiece. f. Dual observation unit, front-back user with LED pointer. g. Camera. h. Image analysis software. i. Minimum of Windows 64-bit desktop workstation with 8 GB RAM, 256 GB SDD, TB HHD. j. Display monitor/TV. 2. DESIRED SPECIFICATIONS Quoted Specifications Reference Page No. in the Quote Package / Product Literaturea. Color camera. b. Flat panel display monitor/TV. 3. Basic Warranty 4. Extended Warranty (Up to five years) 5. Country of Manufacture *Complete and return the CLIN Structure attachment. Offerors must also submit the following with their quote, if not completed in SAM registration:1. Completed copy of provision 52.209-2**,2. Completed copy of provision 252.209-7991**,3. Completed copy of provision 252.225-7035**,4. Estimated delivery lead-time.**Complete and return the Required Provisions attachment. See attached list for applicable provisions and clauses for this requirement. Quoted items must be new. Quotes for refurbished equipment will not be considered. Offerors must also indicate in quote where item is manufactured. Items will be shipped to Bethesda, MD. Deadlines: Questions/clarifications regarding this solicitation must be submitted via email to andrew.lee@usuhs.edu by 2:00PM ET on July 12, 2016. Any question received after 2:00PM ET on July 12, 2016 will not be answered. Questions will not be answered over the phone or submitted by any other means. All questions will be answered in an amendment to the solicitation posted on or around July 13, 2016. Quote packages are due by 10:00PM Eastern Local Time on July 14, 2016. Quotes must be submitted via email to andrew.lee@usuhs.edu. Quotes will not be accepted by any other means. Late quotes will not be considered. Offerors will receive an email confirmation that they quote was received and whether it was on time or late within two (2) business days. Quote packages should include a cover sheet that provides the following information:a. Official Company Name;b. Point-of-contact (PoC), including name, email address, and phone number;c. DUNS Number;d. Statement that acknowledges the latest amendment number-only if an amendment had been issued for this RFQ. Failure to acknowledge the most recent amendment number, may render an offeror's quote non-responsive; ande. Preferred method of payment (Visa or EFT).

Brand Name or Equal Celigo S Imaging Cytometer

Department of Health and Human Services, Program Support Center | Published July 21, 2015  -  Deadline July 31, 2015
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This is a combined synopsis/solicitation for commercial items, prepared in accordance with format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation, No. N02RC52616-85, includes all applicable provisions and clauses in effect through FAR Federal Acquisition Circular (FAC) 2005-81, simplified procedures for commercial items. This acquisition will be conducted under the procedures for acquiring commercial items authorized in FAR Part 12 and under the authority to use simplified procedures for commercial requirements as provided in FAR 13.501. This requirement is assigned North American Industry Classification System (NAICS) code 334516 with a size standard of 500 employees. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. BACKGROUND The National Cancer Institute (NCI) plans to procure one (1) Brand Name or Equal Celigo S Imaging Cytometer, in support of the Center for Cancer Research (CCR), Laboratory of Tumor Immunology and Biology (LTIB). The salient characteristics that apply to the Celigo S Imaging Cytometer are as follows: • Image acquisition and analysis software • SQL Server 2012 database managed data • Rapid LED-based hardware auto-focus Computer System (with Microsoft Windows 7) • Brightfield & Fluorescence Proprietary large-field F-theta optics with superior edge contrast • Galvanometric mirrors for imaging of large areas • LED-based brightfield imaging with uniform illumination • LED-based fluorescence imaging (3 channels, Blue, Green & Red) • 4 Mega-pixel CCD camera Magnification (3.5x, resolution 1 μm/pixel to 8 μm/pixel; 0.25NA) • Rapid microplate-based in situ cellular analysis with the ability to accept and image whole wells of entire 6, 12, 24, 48, 96, 384 and 1536 well plates as well as T-25 and T-75 flasks • Instrument is capable of imaging whole wells of an entire 96 well plate in two colors in less than 9 min and in less than 6 min for one color • Capable of imaging three fluorescence channels and a bright field channel sequentially • Enables bright field and fluorescence analysis of cells in their natural state based on high-speed full well or partial well imaging • Instrument permits the rapid counting of the total number of cells in a designated well • Instrument software able to distinguish and count individual cells • Compatible with non-invasive in situ analysis of various adherent and non-adherent cell types based on morphology and/or fluorescence labeling • User-friendly 4-step workflow from image acquisition and analysis to plate-level data output The NCI also requires: • Installation and operational verification • Two (2) days of user training at customer site • One (1) year service and maintenance ("Limited Warranty") PAYMENT Payment shall be made upon the delivery and acceptance of all required items listed in the SOW. CONTRACT CLAUSES/PROVISIONS The following Federal Acquisition Regulation and Health & Human Services Acquisition Regulation Provisions/Clauses apply to this acquisition: FAR 52.252-2 CLAUSES INCORPORATED BY REFERENCE (FEB 1998) This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at this/these address(es): http://www.acquisition.gov/far/ and/or http://www.hhs.gov/policies/hhsar/. FAR 52.211-6 BRAND NAME OR EQUAL (AUG 1999) FAR 52.212-1 INSTRUCTIONS TO OFFERORS-COMMERCIAL ITEMS (APR 2014) FAR 52.212-3 OFFEROR REPRESENTATIONS AND CERTIFICATIONS- COMMERCIAL ITEMS (MAR 2015) FAR 52.212-4 CONTRACT TERMS AND CONDITIONS-COMMERCIAL ITEMS (MAY 2015) FAR 52.212-5 CONTRACT TERMS AND CONDITIONS REQUIRED TO IMPLEMENT STATUTES OR EXECUTIVE ORDERS-COMMERCIAL ITEMS (MAY 2015). The following FAR clauses cited in paragraph (b) of the clause at FAR 52.212-5 are also applicable to this acquisition: FAR Clause 52.203-6 Restrictions on Subcontractor Sales to the Government FAR Clause 52.219-4 Notice of Price Evaluation Preference for HUBZone Small Business Concerns. FAR Clause 52.219-6 Notice of Total Small Business Set-Aside FAR Clause 52.219-8 Utilization of Small Business Concerns FAR Clause 52.219-28 Post Award Small Business Program Representation FAR Clause 52.222-3 Convict Labor FAR Clause 52.222-19 Child Labor-Cooperation with Authorities and Remedies FAR Clause 52.222-21 Prohibition of Segregated Facilities FAR Clause 52.222-26 Equal Opportunity FAR Clause 52.222-35 Equal Opportunity for Special Disabled Veterans, Veterans of the Vietnam Era, and Other Eligible Veterans FAR Clause 52.222-36 Affirmative Action for Workers with Disabilities FAR Clause 52.222-37 Employment Reports of Special Disabled Veterans, Veterans of the Vietnam Era, and Other Eligible Veterans FAR Clause 52.222-39 Notification of Employee Rights Concerning Payment of Union Dues or Fees FAR Clause 52.225-5 Trade Agreements FAR Clause 52.225-13 Restrictions on Certain Foreign Purchases Far Clause 52.232-33 Payment by Electronic Funds Transfer-System for Award Management FAR Clause 52.247-64 Preference for Privately Owned U.S.-Flag Commercial Vessels HHSAR 352.203-70 ANTI-LOBBYING (MAR 2012) Pursuant to the current HHS annual appropriations act, Public Law 112-74, except for normal and recognized executive-legislative relationships, the Contractor shall not use any HHS contract funds for: (a)Publicity or propaganda purposes; (b)The preparation, distribution, or use of any kit, pamphlet, booklet, publication, electronic communication, radio, television or video presentation designed to support or defeat the enactment of legislation before the Congress or any State or local legislature or legislative body, except in presentation to the Congress or any State or local legislature itself; or designed to support of defeat any proposed or pending regulation, administrative action, or order issued by the executive branch of any State or local government, except in presentation to the executive branch of any State or local government itself; or (c)Payment of salary or expenses of the Contractor, or any agent acting for the Contractor, related to any activity designed to influence the enactment of legislation, appropriations regulation, administrative action, or Executive order proposed or pending before the Congress or any State government, State legislature or local legislature or legislative body, other than for normal and recognized executive-legislative relationships or participation by an agency or officer of a State, local or tribal government is policymaking and administrative processes within the executive branch of that government. The prohibitions in subsections (a), (b), and (c) above shall include any activity to advocate or promote any proposed, pending, or future Federal, State or local tax increase, or any proposed, pending, or future requirement for, or restriction on, any legal consumer product, including its sale or marketing, including, but not limited to, the advocacy or promotion of gun control. HHSAR 352.222-70 CONTRACTOR COOPERATION IN EQUAL EMPLOYMENT OPPORTUNITY (JAN 2010) HHSAR 352.242-71 TOBACCO-FREE FACILITIES (JAN 2006) SUBMISSION INFORMATION Proposals must be submitted on an SF-1449 with a completed 52.212-3 Offeror Representations and Certifications-Commercial Items-with DUNS Number Addendum, signed by an authorized representative of the offeror OR provide a copy of valid certification in the System for Award Management (SAM) at www.sam.gov. Questions must be submitted electronically (via email) to Contract Specialist, Megan Kisamore, at megan.kisamore@nih.gov in MS Word or Adobe Portable Document Format (PDF), no later than Wednesday, July 23, 2015, 11:00 am, EST. Proposals must be submitted electronically (via email) to Contract Specialist, Megan Kisamore, at megan.kisamore@nih.gov in MS Word or Adobe Portable Document Format (PDF), no later than Monday, July 31, 2015, 11:00 am, EST. All responses must be received by the specified due date and time in order to be considered. PROPOSALS RECEIVED AFTER THIS DATE AND TIME WILL NOT BE CONSIDERED. No collect calls will be accepted. Please refer to solicitation no: N02RC52616-85 on all correspondence. EVALUATION The award decision will be based on a Lowest Price Technically Acceptable (LPTA) determination. Award will be made on all or none basis. If you are providing an "equal" product, you must submit additional documentation that highlights and describes how your offering is equal in accordance with FAR Clause 52.211-6. PRICE QUOTE The Offeror shall prepare a price quote that contains all information necessary to allow for a comprehensive evaluation of the prices quoted. Specifically, your quote must include the following: Federal Tax Identification Number (TIN); Data Universal Numbering System (DUNS) Number; and Business Size (e.g., small or large).

Shotgun Metagenomic Sequencing of Buccal Cell DNA Samples

Department of Health and Human Services, National Institutes of Health | Published September 12, 2016  -  Deadline September 15, 2016
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The U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Occupational and Environmental Epidemiology Branch (OEEB), plans to procure, on a sole source basis, services for shotgun metagenomic sequencing of buccal cell DNA samples for a study titled: "Microbiome and Lung Cancer in Shanghai Women's Health Study and Shanghai Men's Health Study"; from BGI Americas Corporation, One Broadway, Cambridge, MA, United States, 02142-1187. The response close date of the notice for this requirement is in accordance with FAR 5.203(a)(1). This acquisition will be processed under FAR Part 12 - Acquisition for Commercial Items and will be made pursuant to the authority in FAR Part 13.106-1(b)(1); and is exempt from the requirements of FAR Part 6. The North American Industry Classification System code is 541990 and the business size standard is $15 million. The period of performance shall be 12 months from the date of award. It has been determined there are no opportunities to acquire green products or services for this procurement. Contractor Requirements The Contractor shall collaborate with the NCI/DCEG/OEEB to accomplish the following tasks: - The Contractor shall apply metagenome shotgun sequencing to sequence for 198 buccal cell DNA samples (99 lung cancer cases and 99 controls). Government Responsibilities NCI/DCEG/OEEB shall provide the following: - NCI shall ship 3 µg buccal cell DNA for each of 198 samples (99 lung cancer cases and 99 controls), in one batch, to the Contractor within 2 weeks of purchase order award. Samples shall be coded and shall not have any personal identifiers attached. The NCI principal investigators shall review the final report from this project. Place of PerformanceAll work performed under the subject order shall take place at the Contractor's facility. Inspection and Acceptance Criteria NCI shall have 30 days in which to review and accept the data provided by the Contractor. If no comments or request for revisions are provided within 30 days, the deliverables shall be considered acceptable. Deliverables No later than 10 months after the period of performance start date, the Contractor shall deliver the following to the NCI/DCEG/OEEB technical point of contact, via email: - Written report in Microsoft Excel format to include results of each sample that enables further statistical analyses at NCI. Unique Qualifications of the Contractor The NCI co-directs the SWHS and collaborates with the SMHS with investigators at Vanderbilt University. Vanderbilt University is conducting a series of related microbiome studies of other cancers within the SWHS and SMHS and other cohorts including stomach cancer, which involves use of stomach cancer cases and healthy controls. The successful completion of the NCI study of lung cancer cases and healthy controls will require using data obtained from the healthy control subjects analyzed by Vanderbilt University study of stomach cancer, and combining this data into the database for the NCI study of lung cancer cases and its healthy controls. This will allow NCI to have a large enough group of healthy controls to have adequate statistical power to achieve the lung cancer study goals. Results from the NCI study will be compared to other studies being analyzed by Vanderbilt University. As such, it is critical that scientific results of the analysis of the NCI study of lung cancer including lung cancer cases and its healthy controls are scientifically comparable to the results obtained by the analysis of the study of stomach cancer cases and healthy controls being led by Vanderbilt. Analysis under the study of stomach cancer at Vanderbilt University is done by BGI America Corporation. It is critical that the samples of the NCI-led nested case-control study of lung cancer are analyzed in the same laboratory where samples from the Vanderbilt-led nested case-control study of gastric cancer and healthy controls is being conducted. Using an alternative laboratory would produce results that would not be scientifically comparable with data from the Vanderbilt study and would result in a failure of the NCI study to achieve its goal. This notice is not a request for competitive quotation. However, if any interested party, especially small business believes it can meet the above requirement, it may submit a proposal or quote for the Government to consider. The response and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 1:00 PM EST, on September 15, 2016. All responses and questions must be via email to Contracting Officer, Megan Kisamore, at megan.kisamore@nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must be registered and have valid certification through SAM.GOV and have Representations and Certifications filled out. Reference: N02CO62711-8 on all correspondence.

Structural Genomics Centers for Infectious Diseases

Department of Health and Human Services, National Institutes of Health | Published May 10, 2016
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Introduction The National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH), Department of Health and Human Services (DHHS) supports research related to the basic understanding, treatment and ultimately prevention of infectious, immune-mediated and allergic diseases that threaten millions of human lives. The NIAID Division of Microbiology and Infectious Diseases (DMID) supports a comprehensive extramural research program focused on the prevention and control of diseases caused by virtually all infectious agents (with the exception of the Human Immunodeficiency Virus). This includes basic research, such as studies of microbial biology and physiology; applied research, including the development of medical diagnostics, therapeutics and vaccines; and clinical trials to evaluate experimental drugs and vaccines.Description The NIAID has made a significant investment in genomic-related activities that provide comprehensive genomic, functional genomic, bioinformatics, proteomic, and systems biology resources to the scientific community for basic and applied research to rapidly address the Institute's mission and the Nation's biodefense needs (http://www.niaid.nih.gov/topics/pathogengenomics/pages/relatedinitiatives.aspx).The NIAID-supported genomics programs and activities include: • Genome Sequencing Centers, which provide rapid and cost-efficient production of high-quality genome sequences of human pathogens and invertebrate vectors of diseases and human and microbial genotyping.• Bioinformatics Resource Centers, which collect, integrate and provide open access to research data of microbial organisms and vectors of infectious diseases; develop and share open source software tools; and provide bioinformatics services and training to the scientific community.• Structural Genomics Centers for Infectious Diseases, which experimentally characterize the three-dimensional atomic structure of proteins of pathogenic organisms.• Functional Genomics Centers, which apply state-of-the-art technologies to determine the biochemical and physiological roles of uncharacterized genes including hypothetical genes, unknown open reading frames, and noncoding RNAs.• Systems Biology for Infectious Diseases Centers, which identify and analyze the molecular interaction networks of microbial pathogens and their host cells through a combination of computational and experimental high-throughput technologies.• An Integrated Approach to Understanding Host-Pathogen Interactions, the goal of which is to generate a diversity of experimental data through multiple high-throughput "-omics" technologies, with the goal to develop and/or validate computational models of host- pathogen molecular interaction networks and pathways through the analysis and integration of the experimental datasets generated by the high-throughput technologies. These genomics programs have not only provided the scientific community with valuable research resources, but have also enhanced the NIAID's research efforts in a number of areas including pathogen identification, investigation of pathogen virulence mechanisms, and drug and diagnostics development. Projects within these programs have utilized high-throughput technologies to investigate the genome, transcriptome, proteome, or metabolome of a living organism, either as independent entities or as highly interrelated and interdependent components of biological systems. To build upon the objectives of the NIAID Genomics programs and continue to address the Institute's need to further expand the knowledge of the proteome of microbes and the understanding of functional roles of proteins in biological systems, and to support structure-guided design and discovery of new vaccines and therapeutics against infectious diseases, NIAID is re-competing the Structural Genomics Centers for Infectious Diseases program, herein referred to as the Structural Genomics Centers for Infectious Diseases (SGCID) program. In 2007, the NIAID established two five-year contracts to support the SGCID program. These SGCID centers focused on determining three-dimensional (3D) structures of protein targets of biomedical interest. The targets' 3D structure information, as well as the expression clones and peptide materials for thousands of protein targets are made available to the scientific community. The SGCID program was re-competed in 2012 and two five-year contracts were awarded to (http://www.niaid.nih.gov/labsandresources/resources/dmid/sg/Pages/default.aspx): 1. SSGCID: Seattle Structural Genomics Center for Infectious Diseases     (Contract No. HHSN272201200025C)2. CSGID: Center for Structural Genomics for Infectious Diseases     (Contract No. HHSN272201200026C) To date, this program has determined more than 1559 3D structures of protein targets of biomedical interest from bacterial, viral, and eukaryotic pathogens. The solved protein structures are instrumental in gaining new insights into protein binding domains and functions of unknown and known proteins. The determination of the structures of proteins involved in a specific biological system and process has revolutionized views of the biological system architecture, expanded understanding of proteins' functional roles, and opened up new avenues of research. Both SGCID centers have been utilizing small molecule/ligand screening to increase crystallization success rate and to gain functional insight through the newly observed protein-ligand interactions. The targets' 3D structure information, as well as the expression clones and peptide materials for thousands of protein targets are made freely available to the scientific community. Importantly, these SGCID centers have also been providing a 3D structure determination service to the scientific community and more than 896 experimental 3D structures were solved for targets requested from the community. The functional projects have led to collaboration with experimental laboratories who used the three-dimensional protein structures to better characterize the function of the target protein, to explain the ligand-binding activities identified during pilot screening, or to design a more effective immunogen. These SGCID Centers have provided unique structural biology resources for investigators focused on basic research as well as discovery and development of therapeutics and vaccines for infectious diseases. For example, the solved structures of several proteins in complexes have led to follow-up drug discovery efforts funded by Gates Foundation, including mycobacterial apartyl-tRNA synthetase, an enzyme genetically identified to be involved in the resistance of Mycobaterium tuberculosis (Mtb) to drugs, FadD32 from Mtb, the enzyme that catalyzes the penultimate step in mycolic acid biosynthesis and whose inhibition is lethal for Mtb, and Plasmodium falciparum Prolyl-tRNA synthetase. The goal of the SGCID program is to continue the experimental determination of 3D atomic structures of proteins and other molecules with an important biological role in human pathogens themselves, or molecules involved in host-pathogen interactions, by applying state-of-the art high-throughput (HTP) technologies and methodologies. Pathogens include those included on the NIAID Category A-C Priority Pathogen lists and organisms causing emerging and re-emerging infectious diseases (http://www.niaid.nih.gov/topics/BiodefenseRelated/Biodefense/research/Pages/CatA.aspx). This program will also support research projects that utilize experimental approaches to better characterize the molecular mechanisms of protein targets and gain further insight into the functional roles of these targets. The knowledge of the 3D structures and molecular functions of protein targets will provide: 1) a structural view of biological processes and pathways to assist investigation at the systems level; and 2) insights into the target functional mechanisms, in interaction with other biological molecules or with synthetic compounds. In addition, this program will support projects that perform structure-guided vaccine design and drug discovery, and conduct evaluation and validation of the underlying mechanism of action required for therapeutic use against infectious diseases. The structure-guided approach will provide improved selectivity, specificity and optimization of drug and vaccine identification and development in a rational way. The 3D structure information, reagents including expression clones and purified proteins, and services provided by the SGCID centers will be made freely available to the broad scientific community. The purpose of this contract is to provide scientific support to the SGCID through a) Generation of 3D structures for targets derived from bacterial, viral, eukaryotic and other human pathogens using HTP technologies and methodologies; b) Conduct of studies to characterize molecular functions and biochemical properties of selected targets; c) Conduct of studies for structure-guided design and functional evaluation of drug targets and vaccine candidates; d) Provision of a 3D structure determination service to the external scientific community; and e) Dissemination of contract generated resources, including all 3D structure information and reagents. It is anticipated that one or more cost reimbursement, level of effort type contracts will be awarded with a one-year base period of performance beginning on or around June 1, 2017. Awards are expected to include 4 one-year option periods. The total period of performance, including options, is five years. The Government's base level of effort requirement is estimated at 35,360 labor hours for each contract year, equating to 17 FTE's with an FTE being defined as 2,080 hours. In addition to the base level of effort, each year of performance is anticipated to contain an option quantity for up to 6 additional FTEs. Any responsible offeror may submit a proposal which will be considered by the Agency. This RFP will be available electronically on/about May 25, 2016, and may be accessed through FedBizOpps http://www.fedbizopps.gov/. This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted. For this solicitation, the NIAID requires proposals to be submitted via the NIAID electronic Contract Proposal Submission (eCPS) website. Submission of proposals by facsimile or e-mail is not acceptable. For directions on using eCPS, go to the website https://ecps.nih.gov/NIAID/home/howto and then click on "How to Submit."  

GENIE HUB ANALYSIS SOFTWARE

Department of Health and Human Services, National Institutes of Health | Published July 14, 2016  -  Deadline July 22, 2016
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This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NICHD-16-127 and is issued as a Request for Quotation (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-88. The North American Industry Classification (NAICS) Code is 511210 and the business size standard is $38.5m. However, this solicitation is not set aside for small business. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intend to contract on a sole source basis with Leica Microsystems (Biosystems), Inc. of Buffalo Grove, IL to procure the following items:1. ITEM# 23GHL - Genie Hub Image Analysis - Loyalty - Quantity (1) EA2. ITEM# 23S9154S - Area Quant BF Application - Perpetual- Quantity (1) EA 3. ITEM# 9IMPESLIDE1 - Software Installation Service - Quantity (1) EA4. ITEM# 9TRAINHR - Instructor-Led Online Training - per hour - Quantity (4) EAThe above items/products are needed for upgrading the E-slide manager software server for the digital analysis of patient samples. This is a digital pathology image server and software scanning, storage and analysis of >10,000 images of histopathological specimens of breast cancer patient tumors analyzed by histochemical and immumo-histochemical analysis operated and main by Gardner Lab. It is a central component for studying breast cancer cohorts from different parts of the country and around the world. This upgrade provides a heavily required component for background correction that will be used during the daily analytical operation of the image server and essential to the ongoing study of molecular basis of moderate risk in breast cancer conducted by Gardner Lab. Leica Microsystems installed this system in the lab and they are the sole proprietary owners of the software patent and sole providers of the service for this instrument. This software is only available and compatible with products supplied by Leica Biosystems.The proposed contract action is for supplies or services for which the Government intends to solicit and negotiate with only one source under authority of the 41 U.S.C. 253(c) (1), FAR 6.302. The offeror must include a completed copy of the provision of FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items with its offer. The provisions of FAR Clause 52.212-1 Instructions to Offerors - Commercial Items; FAR Clause 52.212-2, Evaluation - Commercial Items; FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; and FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions applies to this acquisition. The offeror must include their Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. The clauses are available in full text at http://www.acquisition.gov/far/. Interested vendors capable of furnishing the government with the product specified in this synopsis should submit a copy of their quotation to the below address or via email to robinsti@mail.nih.gov. Offers must also be accompanied by descriptive literature, delivery timeframe, warranties and/or other information that demonstrates that the offer meets all of the foregoing requirements. Quotations will be due (9) calendar days from the publication date of this synopsis or by July 22, 2016 before noon (12:00pm) EST. via email or postal mail. The quotation must reference "Solicitation number" NICHD-16-127. Quotations sent by postal mail or other mailing services must be submitted to the following address: Eunice Kennedy Shriver National Institute of Child Health and Human Development 6710B Rockledge Drive, Room 1159B, MSC 7000 Bethesda, MD 20892. Note: Fed Ex/Ups/other courier use 20817. Attention: Tina Robinson, by the date and time mentioned above. Any questions must be sent via email to robinsti@mail.nih.gov and must include solicitation# NICHD-16-127 in the subject line of email. Faxed copies/responses will not be accepted. Note: In order to receive an award, contractor must be registered and have valid certification for all awards in the SAM database @www.sam.gov.

Electronic Medical Records (EMR) Dataset

Department of Health and Human Services, National Institutes of Health | Published July 19, 2016  -  Deadline July 28, 2016
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The National Library of Medicine (NLM) intends to award a sole source, fixed-price purchase order under the authority of FAR 6.302-1, to Indiana University at 509 E 3rd Street, Bloomington, IN 46202, to purchase and deploy portable mobile x-ray equipment to Kenya. The university awarded to perform this work must be an AMPATH member with appropriate agreements and relationships in place to purchase and ship medical equipment to the Moi facilities in Eldoret, Kenya. The Lister Hill National Center for Biomedical Communications (LHNCBC) an intramural R&D division of the National Library of Medicine (NLM) requires a large university in the United States, that is a member of the Kenya Academic Model Providing Access to Healthcare (AMPATH) consortium, to acquire portable digital x-ray equipment and a radiologist to test and install the software, to support research on the development of image analysis tools and algorithms to distinguish normal from abnormal x-rays. This is an essential component of an LHC research project investigating "Computer capture and automatic processing of digital radiology images in remote and difficult to access settings."AMPATH is a partnership between Moi University School of Medicine, Moi Teaching and Referral Hospital (MTRH - Kenya's second national referral hospital in Eldoret, Kenya), and a consortium of U.S. medical schools founded in 1997. It is a provider of healthcare resources in rural Western Kenya. Medical institutions providing healthcare and conducting clinical and informatics research in Kenya must be members of AMPATH, and only participating U.S. medical schools may be involved in healthcare delivery, and clinical and informatics research. Membership is essential to acquire and ship equipment since AMPATH will not accept items from non-member organizations. Non-member organizations will not be able to ship medical equipment to Kenya without proper justification afforded by AMPATH membership and its collaboration with the Ministry of Health in the Government of Kenya. The consortium is led by Indiana University School of Medicine and includes Brown University School of Medicine, Duke University School of Medicine, Lehigh Valley Hospital, Providence Portland Medical Center, University of Utah School of Medicine, and University of Toronto Faculty of Medicine. AMPATH also has collaborations in place with more than 20 other universities and research organizations. The AMPATH mission is to address and reduce barriers to high quality care in the resource-constrained setting of Eldoret, the fifth largest city in Kenya, located on the Western side of the Rift valley. In partnership with USAID, AMPATH (www.iukenya.org/hiv.aids.html) now manages the largest AIDS prevention and treatment program in sub-Saharan Africa, and cares for more than 200,000 HIV-infected adults and children, in 48 sites across a 300-mile swath of western Kenya. Nearly one-half of these patients are on anti-retroviral drugs. Four-wheel drive vehicles can only access most of these sites due to difficult, unpaved roads. The period of performance will be for eighteen (18) months. The North American Industry Classification System (NAICS) code for this requirement is 541712: Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology) with the small business size standard of 1,000.This is not a Request for Quotation (RFP), nor is a RFP available. Notwithstanding, any responsive source that believes it is capable of meeting NLM's requirement, as stated herein, may submit their corporate capabilities, which, if received by the response date of this announcement, may be considered. Responses to this posting must be submitted via NLM's Electronic Contract Proposal Submission (eCPS) system at https://ecps.nih.gov/nlm, no later than 1:00 p.m., (Eastern Daylight Savings Time), Thursday, July 28, 2016. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. NOTE: For directions on using eCPS, go to https://ecps.nih.gov/nlm, and click on "How to Submit." To submit your electronic proposal using eCPS, all offerors must have a valid NIH External Directory Account, which provides authentication and serves as a vehicle for secure transmission of documents and communication with the NLM. The NIH External Directory Account registration process may take up to 24 hours to become active. Submission of proposals by facsimile or e-mail is not accepted.  

Chemiluminescence System

Department of Health and Human Services, National Institutes of Health | Published August 7, 2015  -  Deadline August 21, 2015
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This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NIHLM2015584 and is issued as a Request for Quotation (RFQ). The solicitation /contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-72. The North American Industry Classification (NAICS) Code is 334516 with a size standard of 500 employees. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. The National Institutes of Health (NIH), National Library of Medicine (NLM), NIDDK Acquisitions has a need for a new chemiluminesence systems for developing western blots. The Metabolic Disease branch uses chemiluminescence for developing the western blots, followed by few autoradiography film exposures in a dark room to detect the bands, and a film developer machine (20-30 minutes). The image analysis includes scanning the autorad film into image analysis software, and image analysis for quantitation of bands on the autorad (20-30 minutes). New Chemidoc systems can directly image the western blots after chemiluminescence and has software to analyze data, and no additional scanning is required (10-20 minutes). New personnel who recently joined the lab have never used the dark room and film method, because their former labs have moved on to the new method of Chemidoc for western blots. Chemidoc is a routine instrument and necessity in the modern lab, and it is important to purchase it for use in the lab and MDB members. There will also be a huge reduction in the exposure to harmful dark room chemicals and exposure to bad odor, save a lot of time, and save money used for purchasing films and chemicals to develop the films. Currently, the images are being developed in a darkroom. The existing darkroom is being decommissioned and it is important to acquire a new Chemidoc Imaging system. The system must meet the following specifications: 6.0 Mega Pixel, True 16 bit, ultra cooled CCD Camera Motorized f0.95 lens with auto focus UV Filter (572-625nm) Epi White Light LED Module Viewing Platform Digital Thermal Printer Kit (Paper, cables, driver, software & user module) Image Acquisition Software Desk Top PC with 23" touch screen display The offeror must include a completed copy of the following provisions: 1) FAR Clause 52.212-1 Instructions to Offerors - Commercial items; 2) FAR Clause 52.212-2, Evaluation - Commercial Items. As stated in FAR Clause 52.212-2 (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be advantageous to the Government, price and other factors considered. The following factors will be used equally to evaluate offers: Technical Evaluation, Price, and Past Performance. Note: Past Performance Information: Vendors must submit a listing of the most recent contracts/awards (minimum of 3) which demonstrate similar work in nature to this Solicitation. Contracts/awards may include those entered with the Federal Government, state and local governments and commercial concerns. Include the following information for each contract or subcontract: 1. Name of Contracting Organization 2. Contract Number (for subcontracts provide the prime contract number and the subcontract number) 3. Contract Type 4. Total Contract Value 5. Description of Requirement 6. Contracting Officer's Name and Telephone Number 7. Program Manager's Name and Telephone Number 3) FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items; 4) FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; 5) FAR Clause 52-212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions. The Dun and Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN) and the certification of business size shall be included. The clauses are available in full text at http://www.arnet.gov/far. PLEASE NOTE: In order to receive an award, contractor must be registered and have valid certification in the System For Award Management (SAM) http://www.sam.gov Interested vendors capable of providing the Government with the items specified in this synopsis should submit their quotation to the below address. Quotations will be due fifteen (15) calendar days from the publication date of this synopsis August 21 at 11:00 a.m. EST. Offersors shall provide an original and two copies of your quotation. The quotation must reference Solicitation number NIHLM2015584. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Quotations must be submitted in writing to the National Institutes of Health, National Library of Medicine, 6707 Democracy Blvd., Suite 700W, Bethesda, Maryland 20892, Attention: Linda Smith. Faxed copies will not be accepted.

Zeiss Axiovert 200M Microscope Components

Department of Health and Human Services, National Institutes of Health | Published July 17, 2015  -  Deadline July 27, 2015
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This is a Notice of Intent (NOI). The Government intends to negotiate on a sole source basis Carl Zeiss Microscopy, LLC for the procurement of 2 microscope component parts in order to upgrade existing Zeiss Axiovert 200 M Microscope system. This acquisition will be made in accordance with the format in Federal Acquisition Regulation (FAR) Subpart 12.6 "Streamlined Procedures for Evaluation and solicitation for commercial Items," as applicable, and as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotes are not being requested and a written solicitation will not be issued. This acquisition is a Notice of Intent (NOI). The solicitation documents and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) 2005-82 June 08, 2015. The North American Industry Classification System (NAICS) code for this procurement is 333314, optical instrument and lens manufacturing with a small business size standard of 500 employees. A small business set aside is not applicable. The National Institute of Allergy and Infectious Diseases (NIAID) intends to procure on a sole source basis from Carl Zeiss Microscopy, LLC 2 microscope components; 1) X-cite 120 LED System and 2) Axiocam 506 Mono camera and mount. These items will be added to an existing Zeiss Axiovert 200 M Microscope system in the Laboratory of Clinical and Infectious Diseases, Molecular Microbiology Section. Place of Performance: NIH, 9000 Rockville Pike, BLDG 10 Clinical Center, Bethesda, MD 20892, United States. FOB: Destination The government intends to award a firm fixed price purchase order as a result of this notice of intent that will include the terms and conditions set forth herein. The award will be based on the following; price, capability to meet the requirements, delivery and the best value to the government. The following FAR provisions apply to this acquisition: FAR 52.212-1 Instructions to Offerors Commercial Items (April 2014) FAR 52.212-3 Offerors Representations and Certifications - Commercial Items (March 2015) Offerors must complete annual representations and certifications on-line at http://www.sam.gov/ in accordance with FAR 52.212-3 Offerors Representations and Certifications- Commercial Items (Please ensure 52.209-2 -- Prohibition on Contracting with Inverted Domestic Corporations--Representation. (Dec 2014) is updated in your SAM record) FAR 52.222-25 Affirmative Action Compliance (April 1984) The following contract clauses apply to this acquisition: FAR 52-212-4 Contract Terms and Conditions Commercial Items (May 2015) FAR 52-212.5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items (May 2015) HHSAR 352.222-70, Contractor Cooperation in Equal Employment Opportunity Investigations (January 2010) *The applicable subparagraphs of FAR52.212-5 are included in the attachment to this posting. By submission of an offer, the offeror acknowledges the requirement that a prospective awardee shall be registered in the System for Award Management (SAM) database prior to award, during performance, and through final payment of any contract, basic agreement, basic ordering agreement, or blanket purchasing agreement resulting from this solicitation (http://www.sam.gov/). Copies of the above-referenced provisions and clauses are available from http://www.acquisition.gov/far/loadmainre.html & http: //www.hhs.gov/regulation/index.html or, upon request, either by telephone or fax. To facilitate the award process all quotes must include a statement regarding the terms and conditions herein as follows: "The Terms and conditions in the solicitation are acceptable to be included in the award document without modification, deletion or addition." OR "The terms and conditions in the solicitation are acceptable to be included in the award document with the exception, deletion, or addition of the following:" (Quoter shall list exception(s) and rationale for the exception(s).) Submission shall be received not later than 06/27/15. Offers may be mailed, e-mailed or faxed to Bevin Feutrier; (Fax - 406-363-9288), (E-Mail/ bevin.feutrier@nih.gov). Late submissions shall be treated in accordance with the solicitation provision at FAR 52.212-1(f) All responsible sources may submit an offer that will be considered by this Agency. Any questions or concerns regarding this solicitation should be forwarded in writing via e-mail to Bevin Feutrier @ bevin.feutrier@nih.gov.

The Chameleon ULTRA II Refurbished Hands-Free Ultrafast Ti Sapphire Laser

Department of Health and Human Services, National Institutes of Health | Published May 21, 2015  -  Deadline May 27, 2015
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The National Cancer Institute (NCI), Center for Cancer Research (CCR), Experimental Transplantation and Immunology Branch plans to procure on a sole source a Chameleon ULTRA II refurbished, hands-free ultrafast Ti Sapphire laser with Coherent Laser Group, 5100 Patrick Henry Drive, Santa Clara, CA 95054-1112. The purpose of this acquisition is to purchase a Coherent Chameleon ultrafast near-infrared tunable laser system for flow cytometry. This laser will be integrated into the NCI's current BD LSR II system for pilot studies and eventual routine analysis by two-photon flow cytometry, an emerging and concurrent technology with two- and multi-photon confocal microscopy for a recently developed array of fluorescent proteins and other fluorescent probes. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1) and is exempt from the requirements of FAR Part 6. The North American Industry Classification System code is 334516 and the business size standard is 500 employees. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. It has been determined there are no opportunities to acquire green products or services for this procurement. The NCI Experimental Transplantation and Immunology Branch, Flow Cytometry Facility provides essential optical biology services to the Branch and to other investigators in the NCI and NIH. The core is committed to maintaining an up-to-date array of instrumentation for its investigators. Two-photon and multi-photon laser confocal microscopy are now widely utilized techniques in the biomedical sciences, and is starting to be applied to flow cytometry as well. This technology uses ultrafast near infrared laser technology to excite fluorescent probes by the two photon phenomenon, permitting extremely low backgrounds, minimal tissue damage and high levels of tissue penetration in live tissue sections. This technology has led to the development of a series of fluorescent proteins, termed long Stokes shift (LSS) proteins, specifically developed for two-photon microscopy and requiring an ultrafast NIR laser source for their excitation. In addition, the latest generation of fluorescent probes for immunolabeling, including the organic polymer based Brilliant dyes (such as the Brilliant Violet or BV dyes), show considerably higher levels of fluorescence and far lower autofluorescence background when excited with a NIR laser source. Even traditional fluorescent proteins and dyes such as GFP and fluorescein also demonstrate far lower levels of autofluorescence background when using NIR sources. Two photon dyes are seeing increasing use in cell biology, and there is a need to be able to simultaneously analyze these probes by flow cytometry as well. The two photon phenomenon has been demonstrated to work in flow cytometry, and has been demonstrated on-site by the NCI. An ultrafast tunable laser system (the Coherent Chameleon Ultra II) traditionally used for two photon microscopy has been adapted for flow cytometer use, and can be readily added to the government owned BD LSR II system to provide excitation of next-generation LSS fluorescent proteins, as well as providing conventional fluorochrome excitation with far lower autofluorescence backgrounds. Coherent, Inc. is the only known manufacturer of high power ultrafast (picosecond pulse duration) high-repetition rate (~80 MHz) lasers. A high repetition rate laser is essential for flow cytometry, where the dwell time of a cell in the laser beam is less than one microsecond. The laser will be covered by the manufacturer's warranty for 12 months following installation, including service engineer visits and parts. The Coherent Chameleon Ultra II is also the highest power laser in the Chameleon series, again required for flow cytometry given the short dwell time of cells in the laser beam. The emission energy of the laser is between 200 mW and 4 W per nanometer, the highest level available in the industry. The Coherent Chameleon Ultra II also has a wide tenability range, from 680 to 1080 nm, also required for the wide variety of fluorescent probes required for flow cytometry. The Coherent Chameleon Ultra II is the only known manufacturer that supplies all of the characteristics mentioned above. This notice is not a request for competitive quotation. However, if any interested party, especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 10:00 AM EST, on May 27, 2015. All responses and questions must be in writing and faxed 240-276-5401 or emailed to Kimesha Leake, Contract Specialist OR via electronic mail at kimesha.leake@nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractors must be registered and have valid certification in the System for Award Management (SAM) through sam.gov. Reference: N02RC52593-24 on all correspondence.

Service and Maintenance of Cellomics Arrayscan XTI Unit

Department of Health and Human Services, National Institutes of Health | Published April 2, 2015  -  Deadline April 13, 2015
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INTRODUCTION This is a pre-solicitation non-competitive (notice of intent) synopsis to award a contract without providing for full or open competition (including brand-name). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR PROPOSAL. A SOLICITATION WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Institute on Drug Abuse (NIDA), Consolidated Station Support and Simplified Acquisitions (CSS/SA) Branch intends to negotiate and award a purchase order to Teledyne Isco for annual maintenance service of equipment without providing for full and open competition (including brand-name). NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 811219 with a Size Standard of $20.5 Million. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-72 dated January 30,2014. This acquisition is for a commercial item or service and is conducted under the procedures as prescribed in FAR subpart 13-Simplified Acquisition Procedures. This acquisition is NOT expected to exceed the simplified acquisition threshold. STATUTORY AUTHORITY This acquisition is conducted under the authority of the authority of FAR Subpart 13.106-1. DESCRIPTION OF REQUIREMENT Purpose and Objectives The Tox21 group of National Center for Advancing Translational Sciences (NCATS) requires an existing service agreement with the original manufacturer of ArrayScan VTI unit to cover maintenance and service for the ArrayScan VTI and its modules. Period of Performance One (1) year after receipt of order Project Description The contractor shall provide unlimited break/fix site visits, unlimited parts as determined by FSE, unlimited technical support (phone, WebEx), 1 PM visit per year contract, BioApplication support from FAS, Informatics Support (Store database, Applications Server), vHCS client SW support (Discovery Toolboxes, vHCS View), ArrayScan instrument (Brightfield Module, Emission FW, ApoTome included). Includes software updates released during term of agreement. Also included Maintenance and Support for the Confocal Module and its associated LED light engine, cabling, and power supply. This item must be purchased in conjunction with SS00051, SS00051A or SS00051B for the main ArrayScan Vti. As well as provides maintenance and support for the Live Cell Chamber and controlling components on the main ArrayScan asset. Must be purchased in conjunction with SS00051, SS00051A, or SS00051B for the base Array Scan unit. CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATION The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, only Life Technologies Corporation is capable of meeting the needs of this requirement due to Life Technologies being the sole commercial provider of maintenance and repair service for the Arrayscan XTI Live+Confocal System. Life Technologies Corporation's parent company, Thermo Fisher Scientific, does not permit any party other than Life Technologies Corporation to service the equipment. The intended source is: Life Technologies Corporation 3175 Staley Road Grand Island, NY 14072 CLOSING STATEMENT THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by the closing date and time of this announcement and must reference the solicitation number. Responses may be submitted electronically to Megan Ault, Contract Specialist, at megan.ault@nih.gov. US Mail and Fax responses will not be accepted.

NINDS Biotechnology Products and Biologics Discovery and Development Consulting Services

Department of Health and Human Services, National Institutes of Health | Published March 13, 2015  -  Deadline April 13, 2015
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THIS ANNOUNCEMENT CONSTITUTES THE ONLY SOLICITATION AND A SEPARATE SOLICITATION WILL NOT BE ISSUED. This is a combined synopsis/solicitation for commercial services prepared in accordance with the format in Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The Solicitation Number for this acquisition is HHS-NIH-NIDA-(SSSA)-15-105 and is being issued as a Request for Proposal (RFP). The solicitation documents and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) 2005-80 effective March 2, 2015. This acquisition is a small business set aside. The North American Industry Classification System (NAICS) Code for this procurement is 541690 and the Small Business Size Standard is 14.0 million dollars; Other Scientific and Technical Consulting Services. STATEMENT OF OBJECTIVES The NIH is seeking senior-level, industry-experienced drug discovery and development consultants with expertise in the following specific disciplines to provide leadership and technical guidance on drug discovery and development projects in the Blueprint Neurotherapeutics Network and possibly other NIH neuroscience-focused drug discovery and development programs. • Biologics Regulatory Affairs Consultant • Biologics CMC Development Consultant STATEMENT OF WORK The Cooperative Research to Enable and Advance Translational Enterprises for Biotechnology Products and Biologics (CREATE Bio) projects are funded through a cooperative agreement award mechanism, a collaborative team is formed between the principal investigators (PI) group with NINDS program staff participation in guiding the project plan. The PI's team performs all of the experiments while NINDS role is to establish performance milestones for each project to facilitate go/no-go decision making and then monitor research progress and achievement of project milestones. Each consultant is expected to provide technical guidance and advice pertaining to their area of expertise on advancing discovery and development projects through nonclinical development and submission of an IND or BLA package, and in some cases, design of early clinical protocol and launch of a first in human clinical trial. Consulting services will be for biologics-focused projects from the Cooperative Translational Research program such as CREATE Bio, Intramural NINDS projects or any other NINDS program with similar needs as outlined in the scope of this statement of work. Consulting contracts will include as many areas of expertise as possible as outlined in this Statement of Work, and will reflect the NIH time commitment and needs for the specific areas of expertise. Consultants will be expected to provide feedback and guidance on projects to NINDS staff through written documents, conference calls, and by email. The consultants' major responsibility will be in offering review, guidance and advice on projects. They will be expected to offer technical review and feedback on project milestones, progress reports, or development plans, study design, and data interpretation. Specific consulting responsibilities will depend on the expertise of the individual consultant and the needs of individual projects. On rare occasion, consultants may be asked to give oral presentations to NINDS staff or at an NINDS sponsored webinar, workshop or conference to provide training to investigators in their area of expertise. General Requirements Consultants will be asked to provide strategic and expert technical guidance for biotechnology products and biologic discovery and development projects. Consultants will serve as a resource to NINDS staff from the start of early discovery stage projects to structurally modify and optimize design characteristics of leads through IND-enabling activities necessary to advance potential development candidates through scale up and early phase clinical trials. Consulting advice and guidance shall be required to supplement NINDS program experience from the pre-application stage and then throughout the life of each project to review and monitor progress. Each project team is led by a PI and supported by NINDS staff with disease and therapy development expertise. The joint team establishes project milestones and monitors progress at least annually. The PIs conduct all of the research activities and report progress to NINDS. NINDS staff will interact directly with the PI and request assistance from consultants to review and provide expert advice on specific topics. Consultants shall directly advise NINDS staff, and in some cases communicate directly with the PI on team calls. The following attachments are provided to assist you in preparing your proposal responding to this solicitation. Attachment No. 1: Statement of Work Attachment No. 2: Invoice Instructions Attachment No. 3: Security Clauses

Genome Transplant Dynamics Antibody Testing

Department of Health and Human Services, National Institutes of Health | Published September 8, 2016  -  Deadline September 14, 2016
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INTRODUCTION THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION. The National Heart, Lung, and Blood Institute (NHLBI), Office of Acquisitions (OA), intends to negotiate and award a purchase order on a noncompetitive sole source basis to The Johns Hopkins University, 3400 N Charles St, Baltimore, MD, 21218, to perform HLA and non-HLA antibody testing for Dr. Hannah Valentine's laboratory within NHLBI's Division of Intramural Research. BACKGROUND Dr. Valentine has studied the causes of heart-transplant rejection since the beginning of her clinical medicine career. Her research has led to fundamental discoveries about why heart transplants fail, including the pathogenesis of CAV. She has made significant contributions to areas such as the use of echocardiography for evaluating transplant rejection, the role of insulin sensitivity on cardiac allograft adverse outcomes, clinical testing of next-generation immunosuppressive agents to improve patient outcomes, and most recently, non-invasive methods to monitor transplant rejection. After organ transplantation, some patients produce antibodies against the transplanted organ (graft). A fraction of these patients develop rejection (and may die), while others with the same antibodies do not develop rejection and do just fine. The reason for this observed difference is still not known. The lab suspects that the patients who develop rejection undergo injury on their graft caused by the antibodies. So far, there is no research to show whether or when these antibodies cause injury to the graft. The lab's existing clinical tool for detecting graft injury-biopsy is insensitive and often misses graft injury when it occurs. Attempting to use this tool to characterize when and how these antibodies cause injury has been limited with variable results. The lab has developed a more sensitive tool-cell-free DNA that detects graft injury better and often weeks to months before biopsy. This newer tool is quite sensitive and may provide a mechanism to assess the correlation between these antibodies and graft injury in transplant patients. Thus, we will like to assess whether and when these antibodies cause injury using this new sensitive tool. Several groups have reported two types of antibodies that a patient may produce after transplantation, HLA and non-HLA antibodies. Both of these antibodies are associated with transplant rejection and early death. While most clinical laboratories are able to measure HLA antibodies, only Johns Hopkins University measures the non-HLA antibodies. Measuring only HLA antibodies will miss a subset of transplant patients who only develop anti-HLA antibodies. Additionally, these two antibodies are different and may not have the same significance in transplant patients. Thus, it is critically important to assess the importance of both antibodies using this novel more sensitive tool-cell-free DNA. PURPOSE The purpose of this acquisition is to procure the services of an outside contractor to perform HLA and non-HLA antibody testing for Dr. Hannah Valentine's laboratory within NHLBI's Division of Intramural Research. This testing will assess when and if these antibodies cause injury to the transplanted organ (graft) as a mechanism towards the associated early mortality. JUSTIFICATION The sole source determination is based on the fact that Johns Hopkins University's Immunogenetics Laboratory is the only institution that offers non-HLA antibody testing. We must have this crucial data in addition to the HLA antibody testing in order to receive the most complete data set on which to base future studies. REGULATORY AUTHORITY This acquisition is conducted under the authority of the Federal Acquisition Regulations (FAR) Subpart 13.106-1(b), soliciting from a single source (for purchases not exceeding the simplified acquisition threshold) and only one responsible source and no other supplies or services will satisfy agency requirements. ADDITIONAL INFORMATION Industry Classification (NAICS) Code is 541990, All Other Professional, Scientific, and Technical Services, and the Small Business Size Standard is $15.0 million. The acquisition is being conducted under FAR Part 13, Simplified Acquisition Procedures, therefore the requirements of FAR Part 6, Competitive Requirements, are not applicable (FAR Part 6.001). The resultant award will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-89 (August 15th, 2016). This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by September 14, 2016 at 9:00AM EST and must reference synopsis number NHLBI-CSB-HL-2016-308-KMA. Responses shall be submitted to the National Heart, Lung, and Blood Institute, Office of Acquisitions, COAC Services Branch, 6701 Rockledge Drive, Room 6127, Bethesda, Maryland 20892-7902, Attention: Kevin Alvarez. Responses may be submitted electronically to kevin.alvarez@nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."

TI-E Nikon Inverted Microscope System

Department of Health and Human Services, National Institutes of Health | Published August 15, 2016  -  Deadline August 30, 2016
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This notice is a Notice of Intent. The Government intends to negotiate on a sole source basis with Nikon Instruments Inc. for the procurement of a TI-E Nikon Inverted Microscope System. This acquisition will be made in accordance with the format in Federal Acquisition Regulation (FAR) Subpart 12.6 "Streamlined Procedures for Evaluation and solicitation for commercial Items," as applicable, and as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotes are not being requested and a written solicitation will not be issued. Submit offers on NOI-RML-E-1806531. This acquisition is a Notice of Intent (NOI). The solicitation documents and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) 2005-88-1 06/15/2016.The associated North American Industry Classification System (NAICS) code for this procurement is 334516 with a small business size standard of 1000. This requirement is not set aside for small business. The National Institute of Allergy and Infectious Diseases (NIAID), is seeking to purchase the following parts to a TI-E Inverted Microscope System, only this brand and model will fill the requirement:POWER CORD (LEAD FREE UL LISTED). (TI-E INVERTED MICROSCOPE parts and motorized stage components)catalog#79035Qty4 USB 2.0 A-B DEVICE CABLE 15' (TI-E INVERTED MICROSCOPE parts)catalog#97050Qty1 CFI 10X EYEPIECE F.N. 22MM-NC (TI-E INVERTED MICROSCOPE parts) catalog#MAK10110Qty2 LIDA LIGHT ENGINE, RGB CHANLS (TI-E INVERTED MICROSCOPE parts)catalog#77060081 Qty1 4 CHANL BREAK OUT CABLE F/LIDA (TI-E INVERTED MICROSCOPE parts)catalog#77060082 Qty1 LE CNTRLR POD F/SPECTX/SOLA SE/MIRA/LIDA (TI-E INVERTED MICROSCOPE parts) catalog#77060083 Qty1 4 SLIDE HOLDER F/H107 STG (Motorized Stage components)catalog#77011013 Qty1 SLIDE HOLDER, 1X3 INCH SLIDE F/H117 STG (Motorized Stage components)catalog#77011446Qty1 INSERT ADPTR F/ PRIOR INSERTS, HLD117NN (Motorized Stage components)catalog#77011565Qty1 cMOS monochrome camera-ORCA-FLASH 4.0 LTS SCMOS; USB 3.0, 30FPS catalog#77054092Qty1 C-DA C-MOUNT/ISO CAMERA ADAPTER 1X (cMOS monochrome camera part)catalog#MQD42005 Qty1 SOLA SE II 365 LIGHT ENGINE W/CNTRL POD (Fluorescence Module component)catalog#77060086 Qty1 LUMENCOR LIQUID LIGHT GUIDE; 3MM, 2M VIS (Fluorescence Module component)catalog#77060021 Qty1 C-HGFIB HG 100W ADAPTER R-NC (Fluorescence Module component)catalog#MBF72315 Qty1 24" LED IPS MONITOR, Z24N Catalog#77019700 Qty1 64BIT Z440 64GB/256GB SS DR/4TB DR WIN7 workstation catalog#77019698 Qty1 Quotes must include shipping and warranty.FOB Point shall be Destination; Bethesda, MD 20814. Place of Performance:NIH/NIAIDBldg 1010 Center DriveBethesda, MD 20814United States Award will be based on the capability of the item offered to meet the above stated salient characteristics, price, past performance, delivery, warranty, and the best value to the government. PROVISIONS AND CLAUSESThe government intends to award a single firm, fixed price purchase order as a result of this solicitation that will include the terms and conditions set forth herein. The following FAR and HHSAR provisions and clauses apply to this acquisition: FAR 52.212-1 Instructions to Offerors Commercial Items (Oct 2015)FAR 52.212-3 Offerors Representations and Certifications - Commercial Items (Mar 2016)Offerors must complete annual representations and certifications on-line at http://www.sam.gov in accordance with FAR 52.212-3 Offerors Representations and Certifications- Commercial ItemsFAR 52.203-98 Prohibition on Contracting with Entities that Require Certain Internal Confidentiality Agreements - Representation (DEVIATION 2015-02)FAR 52.203-99 Prohibition on Contracting with Entities that Require Certain Internal Confidentiality Agreements - Representation (DEVIATION 2015-02)52.232-40 Providing Accelerated Payments to Small Business Subcontractors (DEC 2013)The following contract clauses apply to this acquisition:FAR 52-212-4 Contract Terms and Conditions Commercial Items (May 2015)FAR 52-212.5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items (June 2016)*The applicable subparagraphs of FAR52.212-5 are included in the attachment to this posting.HHSAR 352.222-70 Contractor Cooperation in Equal Employment Opportunity Investigations (Jan 2010) By submission of an offer, the offeror acknowledges the requirement that a prospective awardee shall be registered in the System for Award Management (SAM) database, under an active status for All Awards, prior to award, during performance, and through final payment of any contract, basic agreement, basic ordering agreement, or blanket purchasing agreement resulting from this solicitation (www.sam.gov). Copies of the above-referenced provisions and clauses are available from http://farsite.hill.af.mil/vffara.htm or, upon request, either by telephone or fax. Submission shall be received not later than 8/30/2016 2:00 PM Mountain Time. Offers may be mailed, e-mailed or faxed to Janna Weber; (Fax - 406-363-9288), (E-Mail/ janna.weber@nih.gov). Late submissions shall be treated in accordance with the solicitation provision at FAR 52.212-1(f) All responsible sources may submit a capability statement, proposal, or quotation which shall be considered by the agency. Any questions or concerns regarding this solicitation should be forwarded in writing via e-mail to (janna.weber@nih.gov).

PATHWAY Pain & Sensory Evaluation System

Department of Health and Human Services, National Institutes of Health | Published March 1, 2016  -  Deadline March 10, 2016
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INTRODUCTIONThis is a pre-solicitation non-competitive (notice of intent) synopsis to award a contract without providing for full or open competition (including brand-name). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR PROPOSAL. A SOLICITATION WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Institute on Drug Abuse (NIDA), Consolidated Station Support and Simplified Acquisitions (CSS/SA) Branch intends to negotiate and award a purchase order to the Medoc Advance Medical Systems for the PATHWAY Pain & Sensory Evaluation (CHEPS/ATS models) System without providing for full and open competition (including brand-name). NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODEThe intended procurement is classified under NAICS code 334510 with a Size Standard of 500 Employees. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2005-85 dated February 28, 2016. This acquisition is for a commercial item or service and is conducted under the procedures as prescribed in FAR subpart 13-Simplified Acquisition Procedures. This acquisition is NOT expected to exceed the simplified acquisition threshold. STATUTORY AUTHORITY This acquisition is conducted under the authority of the authority of FAR Subpart 13.106-1. DESCRIPTION OF REQUIREMENT Purpose and ObjectivesThe National Institute of Mental Health (NIMH) on Section Development and Affective Neuroscience (SDAN) conducts considerable research on various aspects of fear and pain. This research requires very precise control of stimulus features, as the research involves work with children, a vulnerable population. Fear and pain must be manipulated in a way that creates emotions that are genuine but in no way traumatizing. This project uses a particular device, known as "The Medoc device". The Medoc device is unusual in that it is the only device, which possesses the precise level of control that is needed to generate such manipulations. This has led the device to emerge as a standard in the field. Period of PerformanceThe equipment shall be delivered within 60 days ARO. Project DescriptionThe Contractor must be able to provide the following: Specifically, the NIMH requires the following:1. fMRI PATHWAY - Model ATS/CHEPS (Combined non-magnetic) 2. ATS Thermode (standard) 16x16mm activation area 3. CHEPS Thermode (standard) 27mm diameter activation area 4. fmri ATS 16x16mm Thermode5. Pathway External Control Interface CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATIONThe National Institute of Mental Health (NIMH), Section on Development and Affective Neuroscience (SDAN) requires the PATHWAY Pain & Sensory Evaluation (CHEPS/ATS models) for use in future scientific studies. Medoc Advanced Medical Systems is the only sales and services source for this piece of equipment. This equipment is protected by U.S. Patent 2007010860. This means that the following features and functions are protected:a. Use of an electrically controlled heat element adapted for contact with human tissue.b. Use of a thermal sink that can rapidly change the temperature of the heat control element at a rate of above 10 degrees celsius from a temperature of below 100 degrees celsius. The thermal capacity of the thermal sink is at least 4 times the thermal capacity of the heat control element.c. Use of a Peltier element and a heat pump for the cooling element.d. Use of a closed loop feedback to control the temperature of the cooling element.e. Sampling of the temperature sensor is done faster than 10Hzf. Ability to apply short pulses of heat or cold.g. Ability to stimulate A-delta fibers or subgroups of those fibersh. Ability to stimulate either high or low threshold fibers.i.Ability to stimulate C fibersj. Ability to generate a windup effect.k. Fast increase and decrease of temperature - over 30 degrees celsius per second.l. Ability to sense brain activity and display degree of pain blocking and consciousness level.m. Ability to control temperatures and produce sharp temperature changes using high differential thermal masses (up to 1:1000)n. Ability to control the duration of temperature spikes such that a spike of 10 degrees celsius is shorter than 2 seconds.o. Ability to control the linearity of the temperature changes.p. Ability to synchronize through TTL in/out with other recording devices The above capabilities and specifications are unique to the Medoc PATHWAY Pain & Evaluation System. These capabilities are not available in any other device distributed. NIMH must obtain this piece of equipment for scientific research. In order to prevent a lapse in the continuity of science, NIMH must obtain the PATHWAY Pain & Evaluation System from Medoc Advanced Medical Systems. CLOSING STATEMENTTHIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by the closing date and time of this announcement and must reference the solicitation number. Responses may be submitted electronically to Jennifer Burns, Contract Specialist, at Jennifer.burns2@nih.gov. US Mail and Fax responses will not be accepted.

Rat Operant Chambers

Department of Health and Human Services, National Institutes of Health | Published September 3, 2015  -  Deadline September 10, 2015
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INTRODUCTION This is a pre-solicitation non-competitive (notice of intent) synopsis to award a contract without providing for full or open competition (including brand-name). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR PROPOSAL. A SOLICITATION WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Institute on Drug Abuse (NIDA), Consolidated Station Support and Simplified Acquisitions (CSS/SA) Branch intends to negotiate and award a purchase order to Med Associates for rat operant chambers without providing for full and open competition (including brand-name). NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 334515 with a Size Standard of 500 Employees. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-83 dated July 2, 2015. This acquisition is conducted under the procedures as prescribed in FAR subpart 13.5—Test Program for Certain Commercial Items and FAR subpart 12—Acquisition of Commercial Items at an amount exceeding the simplified acquisition threshold ($150,000) and not exceeding $6.5 million. STATUTORY AUTHORITY This acquisition is conducted under the authority of 41 U.S.C. 253(c) under provisions of the statutory authority of FAR Subpart 6.302- [specify the applicable authority: (1) FAR 6.302-1—Only one responsible source and no other supplies or services will satisfy agency requirements 41 U.S.C. 253(c)(1). DESCRIPTION OF REQUIREMENT Purpose and Objectives Drug self-administration in animals is a behavioral paradigm that that can be used to model patterns of drug intake, abuse, and addiction development in humans. This behavioral paradigm will be implemented alongside other assays and imaging modalities in both mice and rats. This acquisition is required to ensure high quality performance in evaluating the contribution of discrete neurochemical mechanisms in vulnerability and development of addictive behaviors. PURPOSE AND OBJECTIVES: This purpose of this acquisition is to provide 16 rat operant chambers from Med Associates that are equipped for both drug and food self-administration experiments. These will be utilized for examining behaviors relating to the self-administration behavior of natural stimuli (e.g. food pellets) as well as a variety of psychoactive substances. Project Requirements These operant chambers are specially designed to interface with the MED-PC IV and are the only chambers available that are compatible with this software. Additionally, Med Associates, Inc. is the sole manufacturer and supplier of this equipment. The following items and quantities are needed for full chamber set-up: 16.000 EA ENV-018MD Extra Tall MDF Sound Attenuating Cubicle Interior: 22"W x 22"H x 16"D 16.000 EA ENV-007CT-PH Extra Tall Modular Test Chamber with Modified Top, IR Beam Modification 16.000 EA ENV-005 Stainless Steel Grid Floor for Rat or Small Primate 32.000 EA ENV-229M Stimulus Light, 1" LED 16.000 EA ENV-215M House Light, Hooded, 100 ma, 28 V DC 32.000 EA ENV-112CM Retractable Lever 16.000 EA ENV-203M-45 Modular Pellet Dispenser for Rat, 45 mg 16.000 EA ENV-200R2M-6.0 Pellet Receptacle, Trough Type with Extra Tall 6" Opening 16.000 EA ENV-254-CB Head Entry Detector for Rat 16.000 EA DIG-716P2 SmartCtrl 8 Input, / 16 Output Package 16.000 EA PHM-107 Variable Infusion Rate Syringe Pump 99 Speeds 16.000 EA PHM-VAH95AB Vascular Access Harness™, Rat 16.000 EA PHM-KVAH95T/MED VAH™ Tether Kit for Rat 16.000 EA PHM-110-SAI Drug Delivery Arm Assembly with 3/8" ID Gimbal Ring 1.000 EA SG-6510D Large Tabletop Cabinet and Power Supply 120V 60 Hz 1.000 EA DIG-700P2-R2 PCI Interface Package, Full Height 1.000 EA SOF-700RA-10 Drug Self Infusion Utility 64.000 EA ENV-253SD Individual IR Source and Detector 16.000 EA ENV-253 4 Channel IR Controller 1.000 EA COM-104 Med Intel i3 3.0Ghz 3MB, 4GB RAM, 500GB HD, 24x DVD, Win7 32bit, 19" Mont 1.000 EA SHIPPING - Shipping Charges Delivery time Delivery shall occur 90 days from notice of award. CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATION The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, the The laboratory needs to acquire rat operant chambers that are compatible with existing laboratory software: MED-PC IV Research Control and Data Acquisition Software. This equipment is specially designed to interface with the MED-PC IV software and no other rat operant chambers are compatible with this particular software. Additionally, in order to maintain scientific continuity of ongoing experiments and for statistical validity when comparing future results to that of data acquired in prior experiments, it is necessary to have the same rat operant chambers that NIDA IRP currently utilizes in their laboratories. Med Associates, Inc. is the sole manufacturer and supplier of this equipmentThe intended source is: Med Associates, Inc P.O. Box 319 St. Albans VT 05478 CLOSING STATEMENT THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.” A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by the closing date and time of this announcement and must reference the solicitation number. Responses may be submitted electronically to Farrin Stanton, Contract Specialist, at Farrin.Stanton@nih.gov. US Mail and Fax responses will not be accepted.