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Chemical Signal Detection

Department of Health and Human Services, Food and Drug Administration | Published August 3, 2014  -  Deadline August 8, 2014
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See attached solicitation: SOL FDA-14-223-1132869 - Chemical Signal Detection.pdf (please note additonal attachments are referenced from within the main solicitation attachment).

Chemical Feasibility Study

Department of Health and Human Services, National Institutes of Health | Published February 9, 2016  -  Deadline February 24, 2016
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Chemical Feasibility Study HHS-NIH-NIDA-SSSA-CSS-16-104 This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. This acquisition is being conducted in accordance with the procedures of FAR Part 13--Simplified Acquisition Procedures, FAR Subpart 13.5--Test Program for Certain Commercial Items, and FAR Part 12--Acquisition of Commercial Items. The solicitation number is HHS-NIH-NIDA-(SSSA)-CSS-16-104 and the solicitation is issued as a PRE-SOLICITATION, NOTICE OF INTENT, to award a contract on a noncompetitive basis with Data2Discovery Inc, 901 E. 10th Street, Bloomington, IN 47408 This is a Total Small Business Set-Aside. This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13--Simplified Acquisition Procedures, Subpart 13.5--Test Program for Certain Commercial Items, and Subpart 6.302-1, Only one responsible source and no other supplies or services will satisfy agency requirements, and is expected to exceed the simplified acquisition threshold. Contracts awarded using FAR Part 13--Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6--Competition Requirements. The non-competitive determination is based upon the market research conducted as prescribed in FAR Part 10--Market Research, specifically the results of market research concluded no other source of supply or service has access to the requirement in this acquisition. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-86, dated February 5, 2016. The associated NAICS code for this requirement is 325199, All Other Basic Organic Chemical Manufacturing size standard 1000 employees. The National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people's health and save lives.   Purpose and Objectives: The purpose of this acquisition is to acquire Drug repositioning for rare and neglected diseases using unprecedented resources from NCATS and EU OpenPHACTS See Attachment - Statement of Work This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations. Respondents that believe that they are manufacturers or authorized resellers of the brand-name product specified in this announcement must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in the purchase description; quantity; estimated price or cost; shipping, handling, and/or installation charges; and delivery date after receipt of order. The following FAR provisions shall apply to this solicitation: 52.212-1, Instructions to Offerors--Commercial Items, 52.212-2, Evaluation--Commercial Items. Evaluation factors that will be used to evaluate the offer most advantageous to the Government, price and other factors considered, include ability to meet the technical requirements stated in this pre-solicitation and on basis of best value to the government. Offerors must include a completed copy of the provision at 52.212-3, Offeror Representations and Certifications Commercial Items, with their offer. The Clause at 52.212-4, Contract Terms and Conditions Commercial Items, applies to this acquisition and the Clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items applies to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All Offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency. All responses must be received by February 24, 2016 at 4:00 pm, Eastern Standard Time (EST) and must reference solicitation number HHS-NIH-NIDA-SSSA-CSS-16-104. Responses may be submitted electronically to amcgee@mail.nih.gov or by U.S. mail to the National Institute of Drug Abuse (NIDA), Station Support / Simplified Acquisition Branch (SS/SA), 31 Center Drive, Building 31, Room 1B59, Bethesda, Maryland 20892-2080, Attention: Andrea McGee. Fax responses will be accepted at (301) 480-1358. For information regarding this solicitation, contact Andrea McGee by email at amcgee@mail.nih.gov or by phone at (301) 435-8781.

Small Molecules for NCATS Pharmacologically Active Chemical Toolbox

Department of Health and Human Services, National Institutes of Health | Published February 18, 2015  -  Deadline March 2, 2015
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INTRODUCTION This is a combined synopsis/solicitation for commercial items. This announcement constitutes the only solicitation; quotations are being requested and a written solicitation will not be issued. This acquisition is being conducted in accordance with the procedures of FAR Part 13 - Simplified Acquisition Procedures. The solicitation number is HHS-NIH-NIDA-SSSA-CSS-15-146 and the solicitation is issued as a request for quotation (RFQ). NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 325199 with a Size Standard of 1000 Employees. SET-ASIDE STATUS This acquisition is 100% set-aside for small businesses under NAICS code 325199. ACQUISITION AUTHORITY This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures. This acquisition is not expected to exceed the simplified acquisition threshold. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-78, dated December 26, 2014. The resultant purchase order will include all applicable provisions and clauses in effect through this date. DESCRIPTION OF REQUIREMENT Purpose The purpose of this potential requirement is acquisition of five (5) milligrams (mg) of eight hundred sixty-one (861) medically relevant, novel small molecules. The National Center for Advancing Translational Sciences (NCATS) Division of Preclinical Innovation (DPI) will include these molecules in the NCATS Pharmacologically Active Chemical Toolbox (NPACT) small molecule collection. NPACT aims to broadly cover all biological mechanisms known in literature or patents and provides information access for NCATS investigators to accelerate their research. 5mg of 861 particular molecules are required at this time and high purity of molecules is imperative Project Requirements The specific requirements are as follows: 1. The Contractor must be able to provide the NCATS DPI with 5 mg each of at least 95% of the molecules listed in the attached Excel document titled "Required Small Molecules List." 2. Each molecule provided must be guaranteed to be 80% pure or better. 3. PLEASE NOTE: Molecules shall be provided to the NCATS in barcoded vials that shall be provided to the successful Contractor by the NCATS at time of award. 4. In addition to the molecules themselves, the Contractor must be able to provide the following electronic information for each required molecule: chemical structure, compound name, molecular weight, simplified molecular-input line-entry system (SMILES) or equivalent chemical structure information, accurate weight of amount of compound shipped. This information shall be provided via email referencing individual compound vial barcodes. 5. The contractor must provide for shipping and handling to send small molecules in the provided vials to the NCATS. Period of Performance/Delivery Requirements Delivery of compounds and associated information shall be required within two (2) months following Contractor receipt of barcoded vials provided by NCATS. Contract Type The Government intends to issue a firm fixed price purchase order for this requirement. APPLICABLE CLAUSES AND PROVISIONS FAR clause 52.213-4 Terms and Conditions - Simplified Acquisitions applies to this acquisition. FAR clause 52.217-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items applies to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. EVALUATION CRITERIA The Government will award a purchase order resulting from this solicitation on the basis of lowest price technically acceptable. Technical acceptability will be evaluated based upon the following: 1. The Offeror must specifically indicate ability to meet each of the above-detailed project requirements in its response. 2. The Offeror must indicate ability to meet the delivery schedule required. RESPONSE FORMAT Responses to this solicitation must include clear and convincing evidence of the offeror's capability of fulfilling the requirement as it relates to the technical evaluation criteria. The price quotation must include service descriptions per the requirements listed above as well as associated pricing. Contractors must provide their Company Name, Dun & Bradstreet Number (DUNS), Taxpayer Identification Number (TIN), Business Size, Physical Address, and Point of Contact Information in their responses. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." All responses must be received by the closing date of this announcement and must reference solicitation number HHS-NIH-NIDA-SSSA-CSS-15-146. Responses shall be submitted electronically via email to Lauren Phelps, Contract Specialist, at lauren.phelps@nih.gov.

Small Molecules for NCATS Pharmacologically Active Chemical Toolbox (NPACT)

Department of Health and Human Services, National Institutes of Health | Published April 10, 2015  -  Deadline April 24, 2015
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Combined Synopsis/Solicitation Introduction: This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The solicitation number is HHS-NIH-NIDA(SSSA)-2015-CSS-213 and the solicitation is issued as an request for quotation (RFQ). Competition Status: This requirement is posted as unrestricted. North American Industry Classification System (NAICS) Code: The intended procurement classified under NAICS code 325199 with a Size Standard of 1000 Employees. Acquisition Authority: This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures; FAR Subpart 13.5-Test Program for Certain Commercial Items; and FAR Part 12-Acquisition of Commercial Items, and is expected to exceed the simplified acquisition threshold. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-05-80, dated March 2, 2015. Description of Requirement: Purpose: The purpose of this requirement, for the National Center for Advancing Translational Sciences (NCATS) Division of Preclinical Innovation (DPI), is the acquisition of five (5) milligrams (mg) of 2,712 medically relevant, novel small molecules to be included in the NCATS Pharmacologically Active Chemical Toolbox (NPACT) small molecule collection. Project Requirements: The compounds must already exist in the Contractor's catalog to ensure that the compounds are readily available. The specific requirements are as follows: 1. The Contractor must be able to provide the NCATS DPI with 5 mg each of at least 95% of the small molecules listed in the attached Excel document titled "Required Small Molecules List." Please note due to the nature of natural products, the list includes their IUPAC, a chemical nomenclature generated based on the rules set forth by the "International Union of Pure and Applied Chemistry" as no CAS numbers or MFCD numbers can be provided for these types of compounds. 2. Each molecule provided must be guaranteed to be 80% pure or better. 3. PLEASE NOTE: Molecules shall be provided to the NCATS in barcoded vials that shall be provided to the successful Contractor by the NCATS at time of award. 4. In addition to the molecules themselves, the Contractor must be able to provide the following electronic information for each required molecule: chemical structure, compound name, molecular weight, simplified molecular-input line-entry system (SMILES) or equivalent chemical structure information, accurate weight of amount of compound shipped. This information shall be provided via email referencing individual compound vial barcodes. 5. The contractor must provide for shipping and handling to send small molecules in the provided vials to the NCATS. Anticipated Period of Performance: Compounds and associated information must be delivered within two (2) months following Contractor receipt of the barcoded vials provided by NCATS. Place of Performance: 9800 Medical Center Drive Rockville, Maryland 20850 Contract Type: The Government intends to issue a firm fixed price Contract for this requirement. Applicable Clauses and Provisions: All Offerors MUST be actively registered in the System for Award Management (SAM) www.sam.gov The provision of FAR clause 52.212-1, Instructions to Offerors - Commercial Items applies to this acquisition. The provision of FAR clause 52.212-2, Evaluation - Commercial Items applies to this acquisition. A completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications - Commercial Items, is required with any offer submitted. The FAR clause is located at http://www.acquisition.gov/far/. This requirement may be met by completion of the provision in the System for Award Management. FAR clauses 52.212-4, Contract Terms and Conditions - Commercial Items and 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial items apply to this acquisition. FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items, applies to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. Award Criterion: Will be lowest price technically acceptable. There are no additional contract requirement(s) or terms and conditions determined by the contracting officer to be necessary for this acquisition and consistent with customary commercial practices. Response Format: Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement. The price quote shall include: unit price, list price, shipping and handling costs, the delivery period after contract award, delivery terms, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), the certification of business size, product or catalog numbers, product description and other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." All questions to this solicitation must be received by April 15, 2015 at 12:00PM EST and must reference number HHS-NIH-NIDA(SSSA)-2015-CSS-213. Responses may be submitted electronically to Samantha Kelly, Contract Specialist at samantha.kelly2@nih.gov. All responses must be received by April 24, 2015 at 12:00PM EST and must reference number HHS-NIH-NIDA(SSSA)-2015-CSS-213. Responses may be submitted electronically to Samantha Kelly, Contract Specialist at samantha.kelly2@nih.gov. "All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency."

Small Molecules for NCATS Pharmacologically Active Chemical Toolbox (NPACT)

Department of Health and Human Services, National Institutes of Health | Published June 18, 2015  -  Deadline June 29, 2015
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INTRODUCTION: THIS IS A PRE-SOLICIATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPOSIS TO AWARD A PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR PROPOSAL. A SOLICITATION WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Institute on Drug Abuse (NIDA), Station Support Contracts and Simplified Acquisitions Branch (SS/SA) on behalf of the National Center for Advancing Translational Services (NCATS) intends to negotiate and award a purchase order without providing for full and open competition (including brand-name) to Chemdiv, Inc at Nancy Ridge Drive, San Diego, CA 92121 for novel, target-focused small molecules to be included in the NCATS screening libraries. The solicitation number is HHS-NIH-NIDA-SSSA-2015-PSOL367 and the solicitation is issued as a pre-solicitation notice of intent to award on a sole-source basis. NORTH AERMICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE: The intended procurement is classified under NAICS code 325199 with a Size Standard of 1000 employees. REGULATORY AUTHORITY: The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-82, dated May 7, 2015. This acquisition is conducted under the procedures as prescribed in FAR subpart 13.5-Test Program for Certain Commercial Items and FAR subpart 12-Acquisition of Commercial Items at an amount exceeding the simplified acquisition threshold ($150,000) and not exceeding $6.5 million. STATUTORY AUTHORITY: This acquisition is conducted under the authority of 41 U.S.C 3304(a)(1) under provisions of the statutory authority of FAR Subpart 6.302-1(a)(2)(i)(A)- Only one responsible source and no other supplies or services will satisfy agency requirements. DESCRIPTION OF REQUIREMENT: The National Center for Advancing Translational Services (NCATS) intends to procure, on a sole source basis, targeted, novel small molecules to be included in the NCATS screening libraries. Background: The National Center for Advancing Translational Services (NCATS) requires targeted small molecules to be included in the NCATS screening libraries. Adding diversity to chemical libraries is imperative to NCATS operations as NCATS screens a variety of targets against these in-house collections. Screening is the starting point in the development and knowledge obtained from screening a diverse collection. It provides the starting point of all information for medicinal chemistry's structure-activity relationship (SAR) design to synthesize novel compounds that have more desirable properties. A diverse and novel screening collection provides the backbone of our operation and is imperative for translation sciences to obtain effective small molecules with on-target effects. These small molecules have been designed around targeted activity and will have a few variations around each scaffold to best explore chemical space within the target. This will allow for a much faster SAR expansion upon completed screening and allow for a much thorough bioinformatics analysis. Purpose and Objectives: The purpose of this requirement is to procure 20,000 compounds from the Discovery Chemistry and New Chemistry Collection and 20,000 compounds from the Innovative Chemistry Collection, for a total of 40,000 target-focused small molecules to be included in the NCATS screening libraries. Deliverables/Period of Performance: Compounds shall be delivered within six (6) weeks after Contractor receipt of barcoded vials provided by NCATS. Contractor Requirements: The compounds must already exist in the Contractor's catalog to ensure that the compounds are readily available. The specific requirements are as follows: 1. The Contractor must be able to provide the NCATS DPI with 4 mg each of 20,000 compounds from the Discovery Chemistry and New Chemistry Collection and 20,000 compounds from the Innovative Chemistry Collection, for a total of 40,000 target-focused small molecules. 2. The Contractor must be able to provide small molecules that have been designed around analysis of available chemical and biological information, identification of key pathways modules/targets, computational and "wet biology" assessment of target druggability and potential binding domains. 3. Each small molecules must be guaranteed to have a purity of >85% that is to be confirmed by HPLC/ELSD or HPLC/UV or NMR. 4. The contractor must confirm identity of all compounds by MS and/or NMR. 5. PLEASE NOTE: Molecules shall be provided to the NCATS in barcoded vials that shall be provided to the successful Contractor by the NCATS at time of award. 6. In addition to the molecules themselves, the Contractor must be able to provide the following electronic information for each required molecule: chemical structure, compound name, molecular weight, simplified molecular-input line-entry system (SMILES) or equivalent chemical structure information, accurate weight of amount of compound shipped. This information shall be provided via email referencing individual compound vial barcodes. 7. The contractor must provide for shipping and handling to send small molecules in the provided vials to the NCATS. CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATION: The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted as prescribed in FAR Part 10-Market Research, specifically the review and evaluation of the responses to the sources sought notice published in the FedBizOpps on May 27, 2015, synopsis number HHS-NIH-NIDA-SSSA-SBSS-2015-385, entitled Semi-Synthetic Natural Products and Fragments for inclusion of NCATS screening library. This sources sought was posted on May 27, 2015 for the compound libraries, for which there were two responses as of the closing date, June 5, 2015. The program official has assessed the capabilities statements and determined that they are not technically capable. Due to the proprietary nature, with specific target activity, of these unique small molecule compounds; there are no other sources besides the proposed Contractor that can provide the requested compound library. Therefore, Chemdiv, Inc is the intended source for this award. CLOSING STATEMENT: This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to include ability to meet each of the project requirements and specify which molecules or compound libraries, for which the party is able to provide, to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All questions must be received by June 23, 2015 at 8:00AM and must reference number HHS-NIH-NIDA-SSSA-2015-PSOL367. Responses may be submitted electronically to Samantha Kelly at Samantha.Kelly2@nih.gov. All responses must be received by June 29, 2015 at 8:00AM and must reference number HHS-NIH-NIDA-SSSA-2015-PSOL367. Responses may be submitted electronically to Samantha Kelly at Samantha.Kelly2@nih.gov. Fax responses will not be accepted. "All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency."

Small Molecules for NCATS Pharmacologically Active Chemical Toolbox (NPACT)

Department of Health and Human Services, National Institutes of Health | Published March 24, 2015  -  Deadline April 2, 2015
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Combined Synopsis/Solicitation Introduction: This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The solicitation number is HHS-NIH-NIDA(SSSA)-2015-CSS-183 and the solicitation is issued as an request for quotation (RFQ). North American Industry Classification System (NAICS) Code: The intended procurement classified under NAICS code 325199 with a Size Standard of 1000 Employees. Set-Aside Status This acquisition is 100% set-aside for small business under NAICS code 325199. Acquisition Authority: This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures; FAR Subpart 13.5-Test Program for Certain Commercial Items; and FAR Part 12-Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition threshold. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-05-80, dated March 2, 2015. Description of Requirement: Purpose: The purpose of this requirement, for the National Center for Advancing Translational Sciences (NCATS) Division of Preclinical Innovation (DPI), is the acquisition of two (2) milligrams (mg) of 2,583 medically relevant, novel small molecules to be included in the NCATS Pharmacologically Active Chemical Toolbox (NPACT) small molecule collection. 2mg each of 2,583 particular molecules are required, at this time, and high purity of molecules is imperative. NPACT aims to broadly cover all biological mechanisms known in literature or patents and provides information for NCATS investigators to accelerate their research. Project Requirements: The specific requirements are as follows: 1. The Contractor must be able to provide the NCATS DPI with 2 mg each of at least 95% of the small molecules listed in the attached Excel document titled "Required Small Molecules List." Please note due to the nature of natural products, the list includes their IUPAC, a chemical nomenclature generated based on the rules set forth by the "International Union of Pure and Applied Chemistry". 2. Each molecule provided must be guaranteed to be 80% pure or better. 3. PLEASE NOTE: Molecules shall be provided to the NCATS in barcoded vials that shall be provided to the successful Contractor by the NCATS at time of award. 4. In addition to the molecules themselves, the Contractor must be able to provide the following electronic information for each required molecule: chemical structure, compound name, molecular weight, simplified molecular-input line-entry system (SMILES) or equivalent chemical structure information, accurate weight of amount of compound shipped. This information shall be provided via email referencing individual compound vial barcodes. 5. The contractor must provide for shipping and handling to send small molecules in the provided vials to the NCATS. Anticipated Period of Performance: Compounds and associated information must be delivered within two (2) months following Contractor receipt of the barcoded vials provided by NCATS. Place of Performance: 9800 Medical Center Drive Rockville, Maryland 20850 Contract Type: The Government intends to issue a firm fixed price purchase order for this requirement. Applicable Clauses and Provisions: All Offerors MUST be actively registered in the System for Award Management (SAM) www.sam.gov The provision of FAR clause 52.212-1, Instructions to Offerors - Commercial Items applies to this acquisition. The provision of FAR clause 52.212-2, Evaluation - Commercial Items applies to this acquisition. A completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications - Commercial Items, is required with any offer submitted. The FAR clause is located at http://www.acquisition.gov/far/. This requirement may be met by completion of the provision in the System for Award Management. FAR clauses 52.212-4, Contract Terms and Conditions - Commercial Items and 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial items apply to this acquisition. FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items (September 2013), applies to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. Evaluation Criteria: FAR clause 52.212-2, Evaluation - Commercial Items applies to this acquisition and the specific evaluation criteria to be included in paragraph (a) of that provision are as follows: The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, technical, price and other factors considered. There are no additional contract requirement(s) or terms and conditions determined by the contracting officer to be necessary for this acquisition and consistent with customary commercial practices. Response Format: Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement. The price quote shall include: unit price, list price, shipping and handling costs, the delivery period after contract award, delivery terms, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), the certification of business size, product or catalog numbers, product description and other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." All responses must be received by April 2, 2015 at 12:00pm EST and must reference number HHS-NIH-NIDA(SSSA)-2015-CSS-183. Responses may be submitted electronically to Samantha Kelly, Contract Specialist at samantha.kelly2@nih.gov. "All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency."

Small Molecules for NCATS Pharmacologically Active Chemical Toolbox (NPACT)

Department of Health and Human Services, National Institutes of Health | Published May 7, 2015  -  Deadline May 15, 2015
cpvs

Combined Synopsis/Solicitation Introduction: This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The solicitation number is HHS-NIH-NIDA(SSSA)-2015-CSS-296 and the solicitation is issued as an request for quotation (RFQ). Competition Status: This requirement is posted as unrestricted. North American Industry Classification System (NAICS) Code: The intended procurement classified under NAICS code 325199 with a Size Standard of 1000 Employees. Acquisition Authority: This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures; FAR Subpart 13.5-Test Program for Certain Commercial Items; and FAR Part 12-Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition threshold. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-05-80, dated March 2, 2015. Description of Requirement: Purpose: The purpose of this requirement, for the National Center for Advancing Translational Sciences (NCATS) Division of Preclinical Innovation (DPI), is the acquisition of five (5) milligrams (mg) of 819 medically relevant, novel small molecules to be included in the NCATS Pharmacologically Active Chemical Toolbox (NPACT) small molecule collection. Project Requirements: The compounds must already exist in the Contractor's catalog to ensure that the compounds are readily available. The specific requirements are as follows: 1. The Contractor must be able to provide the NCATS DPI with 5 mg each of at least 95% of the small molecules listed in the attached Excel document titled "Required Small Molecules List." Please note due to the nature of natural products, the list includes their IUPAC, a chemical nomenclature generated based on the rules set forth by the "International Union of Pure and Applied Chemistry" as no CAS numbers or MFCD numbers can be provided for these types of compounds. 2. Each molecule provided must be guaranteed to be 80% pure or better. 3. PLEASE NOTE: Molecules shall be provided to the NCATS in barcoded vials that shall be provided to the successful Contractor by the NCATS at time of award. 4. In addition to the molecules themselves, the Contractor must be able to provide the following electronic information for each required molecule: chemical structure, compound name, molecular weight, simplified molecular-input line-entry system (SMILES) or equivalent chemical structure information, accurate weight of amount of compound shipped. This information shall be provided via email referencing individual compound vial barcodes. 5. The contractor must provide for shipping and handling to send small molecules in the provided vials to the NCATS. Anticipated Period of Performance: Compounds and associated information must be delivered within two (2) months following Contractor receipt of the barcoded vials provided by NCATS. Place of Performance: 9800 Medical Center Drive Rockville, Maryland 20850 Contract Type: The Government intends to issue a firm fixed price purchase order for this requirement. Applicable Clauses and Provisions: All Offerors MUST be actively registered in the System for Award Management (SAM) www.sam.gov The provision of FAR clause 52.212-1, Instructions to Offerors - Commercial Items applies to this acquisition. The provision of FAR clause 52.212-2, Evaluation - Commercial Items applies to this acquisition. A completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications - Commercial Items, is required with any offer submitted. The FAR clause is located at http://www.acquisition.gov/far/. This requirement may be met by completion of the provision in the System for Award Management. FAR clauses 52.212-4, Contract Terms and Conditions - Commercial Items and 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial items apply to this acquisition. FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items (September 2013), applies to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. Award Criterion: Will be lowest price technically acceptable. There are no additional contract requirement(s) or terms and conditions determined by the contracting officer to be necessary for this acquisition and consistent with customary commercial practices. Response Format: Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement. The price quote shall include: unit price, list price, shipping and handling costs, the delivery period after contract award, delivery terms, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), the certification of business size, product or catalog numbers, product description and other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." All questions must be received by May 12, 2015 at 12:00PM EST and must reference number HHS-NIH-NIDA(SSSA)-2015-CSS-296. Responses may be submitted electronically to Samantha Kelly, Contract Specialist at samantha.kelly2@nih.gov. All responses must be received by May 15, 2015 at 12:00PM EST and must reference number HHS-NIH-NIDA(SSSA)-2015-CSS-296. Responses may be submitted electronically to Samantha Kelly, Contract Specialist at samantha.kelly2@nih.gov. "All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency."

Chemicals & chemical products / Chemicals, Equipment, & Lab Supplies

Department of Health and Human Services, National Institutes of Health | Published August 31, 2016  -  Deadline September 8, 2016
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The National Institute of Allergy and Infectious Diseases (NIAID), Laboratory of Molecular Microbiology (LMM) intends to negotiate on an other than full and open competition basis with Life Technologies Corporation, 3175 Staley Road, Grand Island, New York 14072 to procure the following chemicals, equipment, and lab supplies: 1) Cathode Buffer Container, #44082566, qty-6 each, 2) POP-7, #A26073, qty-24 each, 3) Anode Buffer Container, #4393927, qty-6 packs, 4) BigDye XTerminator Purification Kit, #4376484, qty-3 each, 5) Septa for 3500/3500, #4412614, qty-10 each, 6) Conditioning Reagent, 3500 Series, #4393718, qty-12 each, 7) BigDye Terminator Cycle Sequencing Kit, #4337457, qty-3 each, 8) MicroAmp Optical 96-well Reaction Plate, #4306737, qty-10 each, 9) 3500xL Genetic Analyzer 24-Capillary Array, #4404689, qty-8 each, 10) GeneAmp, N8080010, qty-10 each, 11) DNTP Mix, #4303442, qty-1 each, 12) Random Hexamer Primers, #N8080127, qty-30 each, 13) RNASE Inhibitor, #N8080119, qty-10 each, 14) Multiscribe Reverse Transcriptase, #4311235, qty-25 each, 15) 4 PK Cap A, #4340860, qty-1 each, 16) 4 PK Cap B, #4340861, qty-1 each, 17) CE Phosphoramidite, #401161, qty-1 each, and 18) Proflex Dual 96Well PCR System, #4484076, qty-1. This acquisition will be processed under FAR Part 12 - Acquisition for Commercial Items. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type of contract. Delivery to Rockville, Maryland 20852 approximately 2 to 3 weeks after receipt of award. The main focus of LMM scientist is murine (MuLV) and primate retroviruses (HIV, SIV, and HTLV) with the principal area research activity involving human immunodeficiency virus (HIV-1). The lab requires the chemicals, equipment, and lab supplies to provide high volume SNA sequencing of all plasmids and PCR fragments produced by the LMM investigators as related to their respective research projects. The items are needed for ongoing experiments with the continuity of the chemicals and equipment must be maintained to ensure experimental results are not influenced by other variables. Failure to obtain the required items would result in the inability to perform experiments. The statutory authority for this sole source requirement is 41 U.S.C. 253 (c) (1) as implemented by FAR 6.302-1 only one source available, no substitutions possible. THIS IS NOT A SOLICITATION FOR COMPETITIVE QUOTATIONS. All responsible sources who can provide the same chemicals, equipment and lab supplies may submit their capabilities in writing and must contain sufficient detail information that could be considered by email (subject line to reference NIAID-NOI-16-1804798) to Tonia Alexander at talexander@niaid.nih.gov, by 5:00 pm eastern standard time Thursday, September 8, 2016. All responses received by the closing date of this solicitation will be considered by the Government. A determination not to compete this requirement, based upon responses to this notice, is solely within the discretion of the Government.

Small Molecules to be included in the NCATS Pharmacologically Active Chemical Toolbox (NPACT)

Department of Health and Human Services, National Institutes of Health | Published May 7, 2015  -  Deadline May 15, 2015
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Combined Synopsis/Solicitation Introduction: This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The solicitation number is HHS-NIH-NIDA(SSSA)-2015-CSS-295 and the solicitation is issued as an request for quotation (RFQ). Competition Status: This requirement is posted as unrestricted. North American Industry Classification System (NAICS) Code: The intended procurement classified under NAICS code 325199 with a Size Standard of 1000 Employees. Acquisition Authority: This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures; FAR Subpart 13.5-Test Program for Certain Commercial Items; and FAR Part 12-Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition threshold. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-05-80, dated March 2, 2015. Description of Requirement: Purpose: The purpose of this requirement, for the National Center for Advancing Translational Sciences (NCATS) Division of Preclinical Innovation (DPI), is the acquisition of ten (10) milligrams (mg) of 1,554 medically relevant, novel small molecules to be included in the NCATS Pharmacologically Active Chemical Toolbox (NPACT) small molecule collection. Project Requirements: The compounds must already exist in the Contractor's catalog to ensure that the compounds are readily available. The specific requirements are as follows: 1. The Contractor must be able to provide the NCATS DPI with 10 mg each of at least 95% of the small molecules listed in the attached Excel document titled "Required Small Molecules List." Please note due to the nature of natural products, the list includes their IUPAC, a chemical nomenclature generated based on the rules set forth by the "International Union of Pure and Applied Chemistry" as no CAS numbers or MFCD numbers can be provided for these types of compounds. 2. Each molecule provided must be guaranteed to be 80% pure or better. 3. PLEASE NOTE: Molecules shall be provided to the NCATS in barcoded vials that shall be provided to the successful Contractor by the NCATS at time of award. 4. In addition to the molecules themselves, the Contractor must be able to provide the following electronic information for each required molecule: chemical structure, compound name, molecular weight, simplified molecular-input line-entry system (SMILES) or equivalent chemical structure information, accurate weight of amount of compound shipped. This information shall be provided via email referencing individual compound vial barcodes. 5. The contractor must provide for shipping and handling to send small molecules in the provided vials to the NCATS. Anticipated Period of Performance: Compounds and associated information must be delivered within two (2) months following Contractor receipt of the barcoded vials provided by NCATS. Place of Performance: 9800 Medical Center Drive Rockville, Maryland 20850 Contract Type: The Government intends to issue a firm fixed price purchase order for this requirement. Applicable Clauses and Provisions: All Offerors MUST be actively registered in the System for Award Management (SAM) www.sam.gov The provision of FAR clause 52.212-1, Instructions to Offerors - Commercial Items applies to this acquisition. The provision of FAR clause 52.212-2, Evaluation - Commercial Items applies to this acquisition. A completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications - Commercial Items, is required with any offer submitted. The FAR clause is located at http://www.acquisition.gov/far/. This requirement may be met by completion of the provision in the System for Award Management. FAR clauses 52.212-4, Contract Terms and Conditions - Commercial Items and 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial items apply to this acquisition. FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items (September 2013), applies to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. Award Criterion: Will be lowest price technically acceptable. There are no additional contract requirement(s) or terms and conditions determined by the contracting officer to be necessary for this acquisition and consistent with customary commercial practices. Response Format: Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement. The price quote shall include: unit price, list price, shipping and handling costs, the delivery period after contract award, delivery terms, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), the certification of business size, product or catalog numbers, product description and other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." All questions must be received by May 12, 2015 at 12:00PM EST and must reference number HHS-NIH-NIDA(SSSA)-2015-CSS-295. Responses may be submitted electronically to Samantha Kelly, Contract Specialist at samantha.kelly2@nih.gov. All responses must be received by May 15, 2015 at 12:00PM EST and must reference number HHS-NIH-NIDA(SSSA)-2015-CSS-295. Responses may be submitted electronically to Samantha Kelly, Contract Specialist at samantha.kelly2@nih.gov. "All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency."

Chemical Economics Handbook (CEH) Program Renewal

Department of Health and Human Services, Food and Drug Administration | Published June 8, 2016
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Link To Document

Analysis of Chemical Constituents and HPHCs in Waterpipe

Department of Health and Human Services, Food and Drug Administration | Published July 17, 2015  -  Deadline August 7, 2015
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Link To Document N/A

Chlorpyrifos Diethyl-D10, 99 ATOM% D, 97% Chemical purity (100 mg)

Department of Health and Human Services, Food and Drug Administration | Published January 6, 2016  -  Deadline January 13, 2016
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Please see attached solicitation.

CATALYTIC REDUCTION/ LAB SERVICE

Department of Health and Human Services, National Institutes of Health | Published April 9, 2015  -  Deadline April 15, 2015
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This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NICHD-15-037 and is issued as a Request for Quotation (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-80. The North American Industry Classification (NAICS) Code is 541380 and the business size standard is $14.0m. However, this solicitation is not set aside for small business. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intend to procure on a sole source basis with Pressure Chemical - 3419 Smallman Street - Pittsburgh, PA 15201 to carry out a number of experiments to be performed in their 2L autoclave for the catalytic reduction of racemic ethyl (R)-3-hydroxybutyrate or (EBH) to (R)-1,3-butanediol. This is a continuation of work done by Pressure Chemical where we are trying with them to reduce an ester to an alcohol using a catalyst and high pressure hydrogen. The purpose of these experiments are for the investigational proof of concept to test certain reaction conditions in order to break and make the correct bonds to yield the final product with good selectivity. The project will be based on results and lesson learned from the previous projects carried out at Pressure Chemical for the National Institutes of Health. The proposed contract action is for supplies or services for which the Government intends to solicit and negotiate with only one source under authority of the 41 U.S.C. 253(c) (1), FAR 6.302. Only one responsible source and no other supplies or services will satisfy agency requirements. The offeror must include a completed copy of the provision of FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items with its offer. The provisions of FAR Clause 52.212-1 Instructions to Offerors - Commercial Items; FAR Clause 52.212-2, Evaluation - Commercial Items; FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; and FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions applies to this acquisition. The offeror must include their Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. The clauses are available in full text at http://www.acquisition.gov/far/. Interested vendors capable of furnishing the government with the services specified in this synopsis should submit a copy of their quotation to the below address or via email to robinsti@mail.nih.gov. Offers must also be accompanied by descriptive literature, delivery timeframe, warranties and/or other information that demonstrates that the offer meets all of the foregoing requirements. Quotations will be seven (7) calendar days from the publication date of this synopsis or by April 14, 2015 by 10 am, EST. via email or postal mail. The quotation must reference "Solicitation number" NICHD-15-037. Quotations sent by postal mail or other mailing services must be submitted to the following address: Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 5C01, Bethesda, MD 20852. Attention: Tina Robinson, by the date and time mentioned above. Any questions must be sent via email to robinsti@mail.nih.gov and must include solicitation# NICHD-15-037 in the subject line of email. Faxed copies/responses will not be accepted. Note: In order to receive an award, contractor must be registered and have valid certification in the SAM database @www.sam.gov.

Small Molecules Collection

Department of Health and Human Services, National Institutes of Health | Published April 16, 2015  -  Deadline April 30, 2015
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SOLICITATION NUMBER: HHS-NIH-NIDA-SSSA-NOI-15-201 TITLE: Small Molecules Collection INTRODUCTION This is a pre-solicitation non-competitive (notice of intent) synopsis to award a contract without providing for full or open competition (including brand-name). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR PROPOSAL. A SOLICITATION WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Institute on Drug Abuse (NIDA), Consolidated Station Support and Simplified Acquisitions (CSS/SA) Branch intends to negotiate and award a purchase order to MicroSource Discovery Systems Inc for small molecules without providing for full and open competition (including brand-name). NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE This acquisition is unrestricted. The associated NAICS code 325199 with a size standard of 1000. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses in effect through the through Federal Acquisition Circular (FAC) 2005-80 effective March 2, 2015. This acquisition is for a commercial item or service and is conducted under the procedures as prescribed in FAR subpart 13-Simplified Acquisition Procedures. This acquisition is NOT expected to exceed the simplified acquisition threshold. STATUTORY AUTHORITY This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Subpart 13.106-1. DESCRIPTION OF REQUIREMENT Purpose and Objectives The purpose of this acquisition is to purchase 2,400 medically relevant, novel small molecules to be included in the NCATS Pharmacologically Active Chemical Toolbox (NPACT) small molecule collection. The National Center for Advancing Translational Sciences (NCATS) Division of Preclinical Innovation (DPI) requires 5 mg of 2,400 medically relevant, novel small molecules to be included in the NCATS Pharmacologically Active Chemical Toolbox (NPACT) small molecule collection. NPACT aims to broadly cover all biological mechanisms known in literature or patents and provides information access for NCATS investigators to accelerate their research. 5 mg each of 2,400 particular molecules are required at this time and high purity of molecules is imperative. Project Description Specifically, the NCATS DPI requires the following: 1. The Contractor must be able to provide the NCATS DPI with 5 mg each of at least 95% of the small molecules listed in the attached Excel document titled "Required Small Molecules List." 2. Each molecule provided must be guaranteed to be 80% pure or better. 3. PLEASE NOTE: Molecules shall be provided to the NCATS in barcoded vials that shall be provided to the successful Contractor by the NCATS at time of award. 4. In addition to the molecules themselves, the Contractor must be able to provide the following electronic information for each required molecule: chemical structure, compound name, molecular weight, simplified molecular-input line-entry system (SMILES) or equivalent chemical structure information, accurate weight of amount of compound shipped. This information shall be provided via email referencing individual compound vial barcodes. 5. The contractor must provide for shipping and handling to send small molecules in the provided vials to the NCATS. Compounds and associated information must be delivered within two (2) months following Contractor receipt of the barcoded vials provided by NCATS. Delivery of compounds and associated information shall be made to 9800 Medical Center Drive, Rockville, Maryland 20850. Delivery/Period of Performance: 2 months CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATION The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, MicroSource Discovery Systems Inc is the only vendor in the current market place that can provide the unique services required by the of National Center for Advancing Translational Sciences. In accordance with FAR part 10, extensive market research was conducted to reach this determination. Specifically, a small business sources sought notice was posted to FedBizOpps referencing the above detailed requirements and no responses were received. Therefore, only MicroSource Discovery Systems Inc is capable of meeting the needs of this requirement. The intended source is: MicroSource Discovery Systems Inc 11 George Washington Plaza Gaylordsville, CT 06755 CLOSING STATEMENT THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses shall be submitted no later than April 30, 2015 at 4:30pm EST. Responses may be submitted electronically to amcgee@nih.gov or by U.S. mail to the National Institute of Drug Abuse (NIDA), Station Support / Simplified Acquisition Branch (SS/SA), Attention: Andrea McGee. Fax responses will not be accepted.

Software Licenses

Department of Health and Human Services, National Institutes of Health | Published September 8, 2015  -  Deadline September 17, 2015
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Software Licenses HHS-NIH-NIDA-SSSA-PSOL-15-669 This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. This acquisition is being conducted in accordance with the procedures of FAR Part 13--Simplified Acquisition Procedures, FAR Subpart 13.5--Test Program for Certain Commercial Items, and FAR Part 12--Acquisition of Commercial Items. The solicitation number is HHS-NIH-NIDA-(SSSA)-PSOL-15-669 and the solicitation is issued as a PRE-SOLICITATION, NOTICE OF INTENT, to award a contract on a noncompetitive basis Cresset Biomolecular Discovery Ltd, New Cambridge House, Royston Hertfordshire, UK SG8 OSS This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13--Simplified Acquisition Procedures, Subpart 13.5--Test Program for Certain Commercial Items, and Subpart 6.302-1, Only one responsible source and no other supplies or services will satisfy agency requirements, and is expected to exceed the simplified acquisition threshold. Contracts awarded using FAR Part 13--Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6--Competition Requirements. The non-competitive determination is based upon the market research conducted as prescribed in FAR Part 10--Market Research, specifically the results of market research concluded no other source of supply or service has access to the requirement in this acquisition. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-83, dated August 3, 2015. The associated NAICS code for this requirement is 334614, Software and Other Prerecorded Compact Disc, Tape, and Record Reproducing, size standard 750 employees. The National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people's health and save lives. Purpose and Objectives: The purpose of this acquisition is to provide program with chemical modeling software that uses field technology. NCATS is in need of chemical modeling software that uses field technology to intuitively, comprehensively, and effectively integrate biological data into chemical structures to aid SAR analysis and design for the medicinal chemist. Project Background: NCATS is a translational science center that prides itself on its tremendously productive pipeline and is innovative in a number of ways. First, our quantitative high throughput screening (qHTS) paradigm, which tests all compounds at multiple concentrations in the primary screen, is unique. However, more and more academic and pharmaceutical groups are now adopting it in their own operations due to the enhanced data generation that enable compound bioactivity assessment and probe production efficiency. This efficiency derives not only from savings in post-screen cherry-picking, reconfirmation, dose-response testing, and initial SAR assessment, but also from the ability to perform reliable "virtual counter screens," thus allowing us to make more informed decisions on which scaffolds to pursue for probe development. Second, the NCATS is distinctive in its focus on collaboration with outside investigators to produce high- quality chemical probes to define new biology. This focus is reflected in our unprecedented Outreach program, which reaches hundreds of potential new investigators every year, and accounts for much of the new science being done at the NCATS. Third, the NCATS is uniquely focused on new technologies and paradigms to improve the process of probe development, typified by qHTS, our informatics platform, our utilization of structural biology to accelerate probe development, development of new synthetic and analytical chemistry paradigms. As such, NCATS is in need of an annual license for 5 users to help them with 3D SAR analysis, generate novel and diverse structures using bioisoteres, and help them in understanding SAR design by relating molecules by biological activity and comparing molecules from the same or different series. NCATS is also requesting training session to help users acclimate to the new software. This software is needed to aid NCATS chemist with comparing their synthesized small molecules using NCATS generated biological data for their effectiveness and suggest novel SAR design based on the information obtained. Project Requirements: Specifically, the NCATS requires the following: 1. TorchV10 w/Activity Miner 5 users (Annually) 2. ForgeV10 5 users (Annually) 3. SparkV10 5 users (Annually) 4. Software Training (2 sessions) 5. Blaze Search Screens (3 sessions) • The software shall be based on field technology, a feature that uses biological activity rather than chemical similarities as the key descriptors of the molecule • The software shall have 3D SAR capability by comparing the molecule's fields • The software shall be able to relate molecules by biological activity • The software shall be able to compare molecules from the same or different series and use the comparison to allow for new designs or even a structural series • The software shall be able to generate novel and diverse structures by finding biologically equivalent replacements for key moieties • The software shall be able to create qualitative and quantitative 3D models of activity using the shape and electrostatic character of NCATS molecules • The software shall have activity models are calculated through a patented ligand comparison method This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations. Respondents that believe that they are manufacturers or authorized resellers of the brand-name product specified in this announcement must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in the purchase description; quantity; estimated price or cost; shipping, handling, and/or installation charges; and delivery date after receipt of order. The following FAR provisions shall apply to this solicitation: 52.212-1, Instructions to Offerors--Commercial Items, 52.212-2, Evaluation--Commercial Items. Evaluation factors that will be used to evaluate the offer most advantageous to the Government, price and other factors considered, include ability to meet the technical requirements stated in this pre-solicitation and on basis of best value to the government. Offerors must include a completed copy of the provision at 52.212-3, Offeror Representations and Certifications Commercial Items, with their offer. The Clause at 52.212-4, Contract Terms and Conditions Commercial Items, applies to this acquisition and the Clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items applies to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All Offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency. All responses must be received by September 17, 2015 at 4:00 pm, Eastern Standard Time (EST) and must reference solicitation number HHS-NIH-NIDA-SSSA-PSOL-15-669. Responses may be submitted electronically to amcgee@mail.nih.gov and to NIDASSSAPurchaseRequ@mail.nih.gov or by U.S. mail to the National Institute of Drug Abuse (NIDA), Station Support / Simplified Acquisition Branch (SS/SA), 31 Center Drive, Building 31, Room 1B59, Bethesda, Maryland 20892-2080, Attention: Andrea McGee. Fax responses will be accepted at (301) 480-1358. For information regarding this solicitation, contact Andrea McGee by email at amcgee@mail.nih.gov or by phone at (301) 435-8781.

Small Molecules

Department of Health and Human Services, National Institutes of Health | Published December 2, 2015  -  Deadline December 17, 2015
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Combined Synopsis/Solicitation Introduction: This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The solicitation number is HHS-NIH-NIDA(SSSA)-2015-CSS-13 and the solicitation is issued as an request for quotation (RFQ). North American Industry Classification System (NAICS) Code: The intended procurement classified under NAICS code 325199 with a Size Standard of 1000 Employees. Acquisition Authority: This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures and FAR Part 12-Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition threshold. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-05-84, dated October 5, 2015. Description of Requirement: Purpose: The purpose of this requirement, for the National Center for Advancing Translational Sciences (NCATS) Division of Preclinical Innovation (DPI), is the acquisition of 716 small molecules to be included in the NCATS Pharmacologically Active Chemical Toolbox (NPACT) library. Project Requirements: The compounds must already exist in the Contractor's catalog to ensure that the compounds are readily available. The specific requirements are as follows: • The Contractor must be able to provide the NCATS DPI with each varying amounts of at least 95% of the small molecules listed in the attached Excel document titled "Required Small Molecules List." • Each molecule provided must be guaranteed to be 80% pure or better. • PLEASE NOTE: Molecules shall be provided to the NCATS in barcoded vials that shall be provided to the successful Contractor by the NCATS at time of award. • In addition to the molecules themselves, the Contractor must be able to provide the following electronic information for each required molecule: chemical structure, compound name, molecular weight, simplified molecular-input line-entry system (SMILES) or equivalent chemical structure information, accurate weight of amount of compound shipped. This information shall be provided via email referencing individual compound vial barcodes. • The contractor must provide for shipping and handling to send small molecules in the provided vials to the NCATS. Anticipated Period of Performance: Compounds and associated information must be delivered within four (4) weeks following Contractor receipt of the barcoded vials provided by NCATS and installment shipping is acceptable. Place of Performance: 9800 Medical Center Drive Rockville, Maryland 20850 Contract Type: The Government intends to issue a firm fixed price purchase order for this requirement. There will not be up-front payment options for this requirement. Applicable Clauses and Provisions: All Offerors MUST be actively registered in the System for Award Management (SAM) www.sam.gov The provision of FAR clause 52.212-1, Instructions to Offerors - Commercial Items applies to this acquisition. The provision of FAR clause 52.212-2, Evaluation - Commercial Items applies to this acquisition. A completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications - Commercial Items, is required with any offer submitted. The FAR clause is located at http://www.acquisition.gov/far/. This requirement may be met by completion of the provision in the System for Award Management. FAR clauses 52.212-4, Contract Terms and Conditions - Commercial Items and 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial items apply to this acquisition. FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items (September 2013), applies to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. Award Criterion: The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered. Response Format: Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement. The price quote shall include: unit price, list price, shipping and handling costs, the delivery period after contract award, delivery terms, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), the certification of business size, product or catalog numbers, product description and other information or factors that may be considered in the award decision. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." All questions must be received by December 10, 2015, 2015 at 8:00AM EST and must reference number HHS-NIH-NIDA(SSSA)-2015-CSS-13. Responses may be submitted electronically to Andrea McGee, Contract Specialist at amcgee@mail.nih.gov. All responses must be received by December 17, 2015, 2015 at 4:00PM EST and must reference number HHS-NIH-NIDA(SSSA)-2015-CSS-13. Responses may be submitted electronically to Andrea McGee, Contract Specialist at amcgee@mail.nih.gov. "All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency."

Small Molecules for the NCATS Small Molecule Library

Department of Health and Human Services, National Institutes of Health | Published March 12, 2015  -  Deadline March 23, 2015
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INTRODUCTION This is a combined synopsis/solicitation for commercial items. This announcement constitutes the only solicitation; quotations are being requested and a written solicitation will not be issued. This acquisition is being conducted in accordance with the procedures of FAR Part 13 - Simplified Acquisition Procedures. The solicitation number is HHS-NIH-NIDA-SSSA-CSS-15-189 and the solicitation is issued as a request for quotation (RFQ). NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 325199 with a Size Standard of 1000 Employees. SET-ASIDE STATUS This acquisition is 100% set-aside for small businesses under NAICS code 325199. ACQUISITION AUTHORITY This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures. This acquisition is not expected to exceed the simplified acquisition threshold. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-80, dated March 2, 2015. The resultant purchase order will include all applicable provisions and clauses in effect through this date. DESCRIPTION OF REQUIREMENT Purpose The purpose of this potential requirement is acquisition of five (5) milligrams (mg) of at least 95% of 2,312 medically relevant, novel small molecules. The National Center for Advancing Translational Sciences (NCATS) Division of Preclinical Innovation (DPI) will include these molecules in the NCATS Pharmacologically Active Chemical Toolbox (NPACT) small molecule collection. NPACT aims to broadly cover all biological mechanisms known in literature or patents and provides information access for NCATS investigators to accelerate their research. Project Requirements The specific requirements are as follows: 1. The Contractor shall provide 5 mg of at least 95% of the 2,312 compounds listed in the attached Appendix. CAS numbers are provided in the appendix to identify the compounds. CAS numbers are unique numerical identifiers assigned by Chemical Abstracts Service (CAS) to every chemical substance described in the open scientific literature. 2. The Contractor shall provide the compounds to NCATS in NCATS provided vials or its own vials and shall use NCATS provided instructions to allow for easy integration of compounds into online compound storage. 3. The contractor must provide for shipping and handling. Government Furnished Property The Government shall provide vials if the successful offeror is able to use them. Period of Performance/Delivery Requirements Delivery of compounds and associated information shall be required within five (5) weeks after contractor receipt of order and receipt of NCATS vials. Contract Type The Government intends to issue a firm fixed price purchase order for this requirement. APPLICABLE CLAUSES AND PROVISIONS FAR clause 52.213-4 Terms and Conditions - Simplified Acquisitions applies to this acquisition. FAR clause 52.217-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items applies to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. EVALUATION CRITERIA The Government will award a purchase order resulting from this solicitation on the basis of lowest price technically acceptable. Technical acceptability will be evaluated based upon the following: 1. The Offeror must specifically indicate ability to meet each of the above-detailed project requirements in its response. 2. The Offeror must indicate ability to meet the delivery schedule required. RESPONSE FORMAT Responses to this solicitation must include clear and convincing evidence of the offeror's capability of fulfilling the requirement as it relates to the technical evaluation criteria. The price quotation must include the required compounds per the requirements listed above as well as associated pricing, including shipping and handling and delivery estimate. Contractors must provide their Company Name, Dun & Bradstreet Number (DUNS), Taxpayer Identification Number (TIN), Business Size, Physical Address, and Point of Contact Information in their responses. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All responses must be received by the closing date of this announcement and must reference solicitation number HHS-NIH-NIDA-SSSA-CSS-15-189. Responses shall be submitted electronically via email to Lauren Phelps, Contract Specialist, at lauren.phelps@nih.gov.

Microplate Consumables

Department of Health and Human Services, National Institutes of Health | Published July 15, 2016  -  Deadline July 28, 2016
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PRE-SOLICITATION NOTICE OF INTENTSolicitation Number HHSN-NIH-NIDA-SSSA-PSOL-16-537 TITLEMicroplate Consumables (Robotic Well Plates) Contracting Office AddressDepartment of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, MD 20892, UNITED STATES. INTRODUCTIONTHIS IS A PRE-SOLICITATION NOTICE OF A PROPOSED CONTRACT TO ACTION. The National Institute on Drug Abuse (NIDA), Station Support Contracts and Simplified Acquisitions Branch (SS/SA) on behalf of the National Center for Advancing Translational Sciences (NCATS) intends to negotiate and award multiple (3-5) indefinite delivery indefinite quantity type contracts for a 5-year (12-month base period and four (4) 12-month option periods) period of performance for Microplate Consumables (Robotic Well Plates). EXTENT OF COMPETITIONThis acquisition is a partial small business socio-economic set-aside. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODEThe intended procurement is classified under NAICS code 326199-All Other Plastics Products Manufacturing with a Size Standard of 750 Employees. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) number 2005-89-1 dated July 14, 2016. DESCRIPTION This acquisition is conducted under the procedures of FAR Subpart 13.5-Test Program for Certain Commercial Items and FAR Part 15-Contracting by Negotiation in amounts greater than the simplified acquisition threshold ($150,000) but not exceeding $6.5 million. The Microplate Consumables (Robotic Well Plates) are used on NCATS' multiple robotic screening systems for assay optimization and validation. At NCATS data on small molecule compounds are screened, identified, and distributed to the research community to accelerate translation of the completed human genome into advancements in human health. Components of NCATS include a repository of up to 500,000-1,000,000 chemical compounds, assay development capacity, Robotic compound screening, also termed high throughput screening (HTS), medicinal chemistry to transform ‘hits' identified by HTS into workable chemical probes, Chem-informatics capacity for data mining and virtual screening; and distribution capacity to efficiently disseminate the reagents to the biomedical research community.The microplate consumables (robotic well plates) are used throughout NCATS on several robotic screening platforms. These include the Kalypsys primary screening robot, the Tox 21 toxicology profiling robot and the Agilent BioCel system used for the RNAi group. In addition to these screening systems, several of the plates required will be used in the Sartorius SelecT automated tissue culture system. CLOSING STATEMENTThe solicitation will be issued on or about July 28, 2016 and bids or proposals will be tentatively due about thirty (30) calendar days after the solicitation release date. Potential offerors may request a copy of the solicitation electronically from lindbj@nida.nih.gov Please reference solicitation number HHS-NIH-NIDA-SSSA-PSOL-2016-537.

Microplate Consumables (Robotic Well Plates)

Department of Health and Human Services, National Institutes of Health | Published March 23, 2016
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PRE-SOLICITATION NOTICE OF INTENTSolicitation Number HHSN-NIH-NIDA-SSSA-PSOL-16-260 TITLEMicroplate Consumables (Robotic Well Plates) Contracting Office AddressDepartment of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, MD 20892, UNITED STATES. INTRODUCTIONTHIS IS A PRE-SOLICITATION NOTICE OF A PROPOSED CONTRACT TO ACTION. The National Institute on Drug Abuse (NIDA), Station Support Contracts and Simplified Acquisitions Branch (SS/SA) on behalf of the National Center for Advancing Translational Sciences (NCATS) intends to negotiate and award multiple (3-5) indefinite delivery indefinite quantity type contracts for a 5-year (12-month base period and four (4) 12-month option periods) period of performance for Microplate Consumables (Robotic Well Plates). EXTENT OF COMPETITIONThis acquisition is a partial small business socio-economic set-aside. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODEThe intended procurement is classified under NAICS code 326199-All Other Plastics Products Manufacturing with a Size Standard of 750 Employees. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) number 2005-87 dated March 7, 2016. DESCRIPTION This acquisition is conducted under the procedures of FAR Subpart 13.5-Test Program for Certain Commercial Items and FAR Part 15-Contracting by Negotiation in amounts greater than the simplified acquisition threshold ($150,000) but not exceeding $6.5 million. The Microplate Consumables (Robotic Well Plates) are used on NCATS' multiple robotic screening systems for assay optimization and validation. At NCATS data on small molecule compounds are screened, identified, and distributed to the research community to accelerate translation of the completed human genome into advancements in human health. Components of NCATS include a repository of up to 500,000-1,000,000 chemical compounds, assay development capacity, Robotic compound screening, also termed high throughput screening (HTS), medicinal chemistry to transform ‘hits' identified by HTS into workable chemical probes, Chem-informatics capacity for data mining and virtual screening; and distribution capacity to efficiently disseminate the reagents to the biomedical research community.The microplate consumables (robotic well plates) are used throughout NCATS on several robotic screening platforms. These include the Kalypsys primary screening robot, the Tox 21 toxicology profiling robot and the Agilent BioCel system used for the RNAi group. In addition to these screening systems, several of the plates required will be used in the Sartorius SelecT automated tissue culture system. CLOSING STATEMENTThe solicitation will be issued on or about April 15, 2016 and bids or proposals will be tentatively due about thirty (30) calendar days after the solicitation release date. Potential offerors may request a copy of the solicitation electronically from lindbj@nida.nih.gov Please reference solicitation number HHS-NIH-NIDA-SSSA-PSOL-2016-260.

Preventive maintenance and software upgrade service call for EDC Biosystems, three ATS 100s

Department of Health and Human Services, National Institutes of Health | Published September 17, 2015  -  Deadline September 23, 2015
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COMBINED SYNOPSIS / SOLICITATION This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The solicitation number is HHS-NIH-NIDA-(SSSA)-15-890 and the solicitation is issued as a request for quote (RFQ). This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures and FAR Part 12-Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition threshold. The solicitation documents and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) 2005-84 effective September 3, 2015. This acquisition is unrestricted. The associated NAICS code 811219 and the small business size standard $20.5. STATEMENT OF OBJECTIVES The purpose of this acquisition is to award a repair, preventive maintenance, and software upgrade service call for EDC Biosystems, three ATS 100s Title: Preventive maintenance and software upgrade service call for EDC Biosystems, three ATS 100s The National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people's health and save lives. The mission of the NCATS is to apply the tools of small molecule screening and discovery to the development of chemical probe research tools, for use in the study of protein and cell functions, and biological processes relevant to physiology and disease. NCATS will optimize biochemical, cellular and model organism-based assays submitted by the biomedical research community; perform automated high-throughput screening (HTS); and perform chemistry optimization on confirmed hits to produce chemical probes for dissemination to the research community. The ATS 100s in NCATS groups: Tox 21, ACOMM Compound Management and Laboratory of Assay Technology Development are used to transfer chemical compounds typically in the 20 nanoliter range from a compound microplate to an assay microplate. Unlike the Pintool transfer system, this transfer is accomplished with no risk of contamination, carry over from previous transfers, or need for chemical cleaning solvents. These EDC ATS-100s are in need of a factory trained service to repair two of the EDC CATS-100s and perform needed preventative maintenance and upgrade operational software on all three EDC CATS-100s. Scope of Work The requirement is for the repair, calibration, preventive maintenance, and software upgrade of three EDC ATS-100 Acoustic Transfer Systems for low-volume, high spatial precision liquid handling. Given the complex nature of these devices, there is a substantial amount of calibration and preventive maintenance required for each device after it has been in operation for over a year. Additionally an upgrade to the ATS-100 software is available. This software upgrade is designed to improve operator interface with the instrument and enhance many of the ATS's capabilities. Service technicians must (1) utilize certified manufacturer parts, (2) provide a guaranteed onsite response time, and (3) use manufacturer approved repair technicians Contract Type: A firm fixed price purchase order is anticipated. Period of Performance/Delivery Requirements: Approximately September 30, 2015 through October 20, 2015 Place of Performance: NCATS facility at 9800 Medical Center Drive, Rockville, MD 20850 FAR clause 52.212-1, Instructions to Offerors - Commercial Items, applies to this acquisition. Offerors must include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications - Commercial Items, with its offer. FAR clause 52.212.-2, Evaluation - Commercial Items, is applicable to this requirement. (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate offers: The Government will award a delivery order resulting from this solicitation on the basis of best value, technical factors and price considered. Technical factors together shall be considered more important than price. The technical evaluation factors are as follows, in order of importance: Factor 1: Technical Approach The Offeror shall provide its technical approach to performing the required tasks identified in this statement of work. Technical capability must demonstrate the contractor's capabilities relevant to this requirement. Factor 2: Corporate Experience The offeror shall provide a list of two (2) contracts or purchase orders completed during the past five (5) years, similar in size and scope to the requirements outlined in the Statement of Work. Corporate experience must document the Offeror's ability to provide service and maintenance of equipment by the requisite manufacturer. Experience must be specific to equipment that is materially the same as the equipment described herein. Offerors shall include the following information for each contract or purchase order listed: • Name of Contracting Organization • Contract Number • Contract Type • Total Contract Value • Description of Requirement and Specific Responsibilities of the Offeror as they relate to this SOW • Contract Period of Performance Technical evaluation factors and past performance, when combined, are significantly more important, when compared to price. (c) A written notice of award or acceptance of an offer, mailed or otherwise furnished to the successful offeror within the time for acceptance specified in the offer, shall result in a binding contract without further action by either party. Before the offer's specified expiration time, the Government may accept an offer (or part of an offer), whether or not there are negotiations after its receipt, unless a written notice of withdrawal is received before award. (End of Provision) FAR clause at 52.212-4, Contract Terms and Conditions - Commercial Items, applies to this acquisition. FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items, applies to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All responses must be received by September 23, 2015, 8:00 am EST and must reference number HHS-NIH-NIDA-(SSSA)-15-890. Responses may be submitted electronically to andriani.buck@nih.gov or by U.S. mail to the National Institute of Drug Abuse (NIDA), Station Support / Simplified Acquisition Branch (SS/SA), 31 Center Drive, Building 31, Room 1B59, Bethesda, Maryland 20892-2080, Attention: Andriani Buck. Fax responses will not be accepted.