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Structure From Motion Software

Department of Agriculture, Forest Service | Published April 22, 2016  -  Deadline May 11, 2016
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This Request for Quote (RFQ) serves to issue a U.S. Department of Agriculture, Forest Service solicitation number AG-7604-S-16-0026.This RFQ is for the award of a firm, fixed-price requirement to provide Enterprise Image Processing - Structure from Motion Software, per the attached Performance Work Statement.The contractor shall provide all requirements detailed in the attached documents, and evaluation criteria. All quotes must be ubmitted no later than the date and time stated in Block 8 of the SF1449, to Mr. Nicolas Nunez-Hidalgo at nnunezhidalgo@fs.fed.us. Any questions may be submitted in writing to nnunezhidalgo@fs.fed.us prior to 2:00 pm Eastern Time on Friday, April 29, 2016.No deviations or substitutions will be made to this order without prior approval from the Contracting Officer. Changes will be issued in writing and signed by the Contracting Office. No action on any change unless and until a formal solicitation amendment is issued.  

Title Search, Update and Closing Services

Department of Agriculture, Natural Resources Conservation Service | Published January 14, 2016  -  Deadline February 15, 2016
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A. OBJECTIVE The objective of this contract is to obtain title search, preliminary title commitment, final title policy, and closing services for acquisitions of conservation easements in the State of Florida on behalf of the United States of America, acting by and through the Natural Resources Conservation Service (NRCS), U.S. Department of Agriculture (USDA), pursuant to Title II of the Agricultural Act of 2014 (Public Law 113-79). B. BACKGROUND The Agricultural Conservation Easement Programs (ACEP) authorizes the acquisition of easement rights from willing landowners. NRCS is the lead USDA agency that is charged with administering those programs. 1. SCOPE OF SERVICES The objective of this contract is to obtain title search and closing services for acquisition of property easements throughout the state of Florida in support of the National Resource Conservation Service (NRCS) Agricultural Conservation Easement Programs, including obtaining title insurance from a title company approved/certified in the State of Florida by the United States Attorney General. The Contractor will perform the same closing services as in a commercial transaction, including the following: • Obtaining and updating chain(s) of title, including copies of all instruments that created rights, interests, or encumbrances on the property • Providing preliminary title commitments and issuing final title insurance policies • Providing easement boundary and ingress and egress descriptions • Working with landowners to clear exceptions on title to the property • Obtaining signatures on Warranty Easement Deeds • Any necessary curative instruments to assure merchantable insurable title in the name of the United States of America to the wetland easement • Disbursement of funds at closing • Closing Protection Letter in favor of the United States of America • Other services, as necessary, to finalize easement transactions. The closing services will be performed in the county courthouse of the county in which the ACEP easement is located, unless the Contractor, NRCS and the landowner mutually agree to a different location.

73--553-17-1-120-0003

Department of Veterans Affairs, Indianapolis VAMC | Published September 7, 2016  -  Deadline September 14, 2016
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This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotes are being requested and a written solicitation shall not be issued. This solicitation VA250-16-Q-0693_1 is issued as a request for quote (RFQ). The North American Industry Classification System (NAICS) 424410 Merchant Wholesalers, Nondurable Goods and General Line Grocery Merchant Wholesalers that are Service Disable Veterans Owned Small Business (SDVOSB) and Veterans Owned Small Business (VOSB). Business Size Standard of 500 employees is applicable (FAR 19.102 (f) (1). This solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) 2005-88. No telephone requests shall be accepted. Quote is requested for the following: The Department of Veterans Affairs John D. Dingell VAMC, 4646 John R. Street, Detroit, MI 48201 is hereby soliciting offers to provide items listed below. We anticipate entering into a fixed price contract with the contractor meeting the Brand Name or Equal requirements and providing the best value to the Government. Items shall be delivered to the VA Center location noted above. Please include warranty information and delivery/shipping terms and conditions and cost clearly on your quote. All quotes must provide the above items/options in as much detail as possible to assist the VA with determining the most advantageous selection. This award shall be made based on the lowest price technically acceptable. It is the responsibility of the offeror to demonstrate compatibility of items offered other than the part numbers described above. Invoices shall be submitted in accordance with Federal Regulations 52.212-4(g) to VA Financial Services Center through the Tungsten (OB10) electronic invoicing system. Full text of the following clauses and/or provisions can be viewed through Internet access at http://farsite.hill.af.mil. The provisions at FAR 52.212-1, Instructions to Offerors-Commercial Items, applies to this acquisition. Offerors shall submit with their offer, a completed copy of the provisions at FAR 52.212-3, Offeror Representations and Certifications-Commercial Items or confirm this has already been completed in their SAM registration. The clause at 52.212.4 Contract Terms and Conditions-Commercial Items, applies to this acquisition. The clause at 52.212-5, Contract Terms and Conditions Required to Implement Statues or Executive Orders-Commercial Items, applies to this acquisition which shall include the following clauses: 52.222-21, 52.222-26, 52.222-35, 52.222-36, 52.222-37, 52.232-34. Offerors shall submit their quotation by e-mail to lee.morris@va.gov. Offers are due no later than 3:00 pm. EST, 14 SEP 2016. NO LATE QUOTES SHALL BE ACCEPTED OR CONSIDERED. Any question must also be submitted in writing and shall be addressed by the Contract Officer as quickly as possible. The successful offeror must be registered with SAM to be awarded a contract. You may register or update your registration on-line at https://www.sam.gov. STATEMENT OF WORK Provide Bread and Bakery Products listed in the Schedule for the period of _October 1, 2016 through September 30, 2017, with four (4) 12-month option years for the following Department of Veterans Affairs, Medical Centers: John D. Dingell VAMC, 4646 John R. Street, Detroit, MI 48201 OPTION TO EXTEND: This contract may be extended up to four (4), one-year periods at the option of the Government in accordance with FAR 52.217-9, Option to Extend the Term of the Contract, subject to the availability of funds. The Government will evaluate offers for award purposes by adding the total price for all options to the total price for the basic requirement. The Government may determine that an offer is unacceptable if the option prices are significantly unbalanced. Exercise of the option will be based on whatever is the most advantageous to the Government. Evaluation of options shall not obligate the Government to exercise the option. 1. PRODUCT SPECIFICATIONS: a. All products offered within a Bid Group will be available to be ordered for delivery at the location. b. Bread shall not be more than 24 hours old upon arrival at receiving point. Bread shall be packaged in accordance with the commercial practice. Bread shall not have been frozen prior to arrival. The package shall afford adequate protection against deterioration and physical damage during shipment from the supply source to the medical center. c. If an item has been ordered and is not available at the time of delivery, it will be the vendor's responsibility to obtain the necessary product that day. d. All delivery tickets and invoices referencing the purchase order number must show the total loaves/packages delivered for each line item and the total weight delivered for each line item. e. All items may be purchased by each item. It is not required to purchase by the flat. f. The Government does not guarantee the estimated yearly quantity. 2. AUTHORIZATION FOR CHANGES: The contractor shall contact the Contracting Officer Representative (COR) on all matters pertaining to administration. The Contracting Officer Representative is authorized to make commitments to issue changes which will affect the price, quantity and quality or delivery of this contract. 3. ALTERNATE ITEMS, PACKAGING AND PACKING: Offerors may not propose alternate items, packaging or packing. 4. PRODUCT QUALITY AND FRESHNESS: a. All bread shall be delivered to the requested destinations as listed in the schedule. All bread and bread products furnished under this contract shall be fresh and of the highest quality. b. All products furnished under this contract shall be processed and packed under sanitary conditions in strict accordance with guidelines provided by the U.S. Food and Drug Administration and the U.S. Department of Agriculture, using the best commercial practices that are standard for the industry. All containers shall be clean, sound and securely covered or sealed to provide adequate protection from dirt, filth or contamination. c. Unless otherwise specified in the item specification or solicitation, marking shall be in accordance with best commercial practice. d. Any commercial or additional labeling as specified which complies with the U.S. Food, Drug and Cosmetic Act and regulations promulgated there under, is acceptable. e. Breads and Buns that contain seeds must be labeled or identified as such. f. Products manufactured to metric dimensions will be considered on an equal basis with those manufactured using inch-pound units, providing they fall within the tolerances specified using conversion dimensions and those dimensions exceed the tolerances specified in the inch-pound units, a request should be made to the Contracting Officer to determine if the product is acceptable. The COR, in accordance with the Contracting Officer, will accept or reject the product. 5. DELIVERIES OR PERFORMANCE: a. The Contracting Officer shall authorize personnel to place delivery orders for products listed in the schedule of pricing. b. Orders shall be placed no less than 1 work day prior to the required delivery date, upon delivery at the receiving location, items ordered shall be less than 24 hours old. c. Deliveries shall be made as requested by the COR or his/her designee, excluding Saturday, Sunday and federal holidays. Federal Holidays are as follows and include any other days specifically declared by the President of the United States to be a national holiday: Memorial Day Thanksgiving 4th of July Christmas Labor Day New Years Columbus Day MLK Day Veteran's Day Presidents Day Base, For the period of 1 OCTOBER, 2016 through 30 SEPTEMBER 2017 ITEM DESCRIPTION Unit Measure TOTAL AMOUNT Unit Cost Total Price 0001. BREAD-WHOLE WHEAT-PAN,BAKED-SANDWICH SALIENT (B) 100% WHOLE GRAINS 3 GRAMS OF DIETARY FIBER PER SLICE AND WRAPPED, 1.5 LB/LOAF FG 4 (NSN:9020-00-753-5779) FOOD GROUP: 4 PKG: 1 PER (CONTRACT#), ECMS LINE ID 10334154 FOOD GROUP: 4 UN 2190 0002. ROLLS WHITE FRANKFURTER BUN-ENRICHED-PAN-BAKED-SOFT-SALIENT CHARACTERISTIC (B) SLICED-CID A-A-20053 1 1/2 TO 1 3/4 OZ. EA. 6" FG 4 (NSN:8920-000753-5769) FOOD GROUP: 4 PKG. 12 PER DZ. (CONTRACT#) FOOD GROUP: 4 EA 10 0003. ROLLS-WHEAT-HAMBURGER-SANDWICH-ENRICHED PAN BAKED-SOFT-SLICED-SALIENT CHARACTERISTICS 3 GRAMS OF DIETARY FIBER PER ROLL (C) CID A-A-2053 4" DIAMETER 1 1/2 TO 1 3/4 OZ. EA. PKG: 12 PER DZ. FOOD GROUP: 4 DZ 52 0004. ROLLS-KAISER-HEARTH BAKED 2 3/4 OZ. EA. 4-5" DIAMETER SLICED PG 4 (NSN: 8920-00-753-5770) FG 4 PKG: 12 PER DZ. (CONTRACT#) FOOD GROUP: 4 DZ 1825 0005. ROLL-WHEAT-SPLIT TOP ENRICHED PAN CHARACTERISTICS 2 GRAMS OF DIETARY FIBER PER ROLL (D) CID A-A-20071-1-1.13 OZ/EA FG 4 (NSN:8920-00-753-5775) FG 4 16 ROLLS PER 18 OZ. PKG. PG 1460 0006. BREAD-WHITE ENRICHED-PAN, BAKED-ROUND TOP SALIENT, CHARACTERISTICS A-SLICED & WRAPPED 1.00 LB. LOAF-CIDA-A-20052, PG 4 (NSN:8920-00-753-5576) FG 4, PKG. 1 PER EA. EA 3650 0007. BREAD TEXAS TOAST, SLICED 1" THICK, 14-15 SLICES PER LOAD (NSN:7310-99-999-9999) FG 4 PKG: 1 PER EA. FOOD GROUP 4 EA 730 Estimated Total for Base Year $ _____________________________________ Option Year 1, For the period of 1 OCTOBER, 2017 through 30 SEPTEMBER 2018 ITEM DESCRIPTION Unit Measure TOTAL AMOUNT Unit Cost Total Price 0001. BREAD-WHOLE WHEAT-PAN,BAKED-SANDWICH SALIENT (B) 100% WHOLE GRAINS 3 GRAMS OF DIETARY FIBER PER SLICE AND WRAPPED, 1.5 LB/LOAF FG 4 (NSN:9020-00-753-5779) FOOD GROUP: 4 PKG: 1 PER (CONTRACT#), ECMS LINE ID 10334154 FOOD GROUP: 4 UN 2190 0002. ROLLS WHITE FRANKFURTER BUN-ENRICHED-PAN-BAKED-SOFT-SALIENT CHARACTERISTIC (B) SLICED-CID A-A-20053 1 1/2 TO 1 3/4 OZ. EA. 6" FG 4 (NSN:8920-000753-5769) FOOD GROUP: 4 PKG. 12 PER DZ. (CONTRACT#) FOOD GROUP: 4 EA 10 0003. ROLLS-WHEAT-HAMBURGER-SANDWICH-ENRICHED PAN BAKED-SOFT-SLICED-SALIENT CHARACTERISTICS 3 GRAMS OF DIETARY FIBER PER ROLL (C) CID A-A-2053 4" DIAMETER 1 1/2 TO 1 3/4 OZ. EA. PKG: 12 PER DZ. FOOD GROUP: 4 DZ 52 0004. ROLLS-KAISER-HEARTH BAKED 2 3/4 OZ. EA. 4-5" DIAMETER SLICED PG 4 (NSN: 8920-00-753-5770) FG 4 PKG: 12 PER DZ. (CONTRACT#) FOOD GROUP: 4 DZ 1825 0005. ROLL-WHEAT-SPLIT TOP ENRICHED PAN CHARACTERISTICS 2 GRAMS OF DIETARY FIBER PER ROLL (D) CID A-A-20071-1-1.13 OZ/EA FG 4 (NSN:8920-00-753-5775) FG 4 16 ROLLS PER 18 OZ. PKG. PG 1460 0006. BREAD-WHITE ENRICHED-PAN, BAKED-ROUND TOP SALIENT, CHARACTERISTICS A-SLICED & WRAPPED 1.00 LB. LOAF-CIDA-A-20052, PG 4 (NSN:8920-00-753-5576) FG 4, PKG. 1 PER EA. EA 3650 0007. BREAD TEXAS TOAST, SLICED 1" THICK, 14-15 SLICES PER LOAD (NSN:7310-99-999-9999) FG 4 PKG: 1 PER EA. FOOD GROUP 4 EA 730 Estimated Total for Option 1 Year $ ___________________________________ Option Year 2, For the period of 1 OCTOBER, 2018 through 30 SEPTEMBER 2019 ITEM DESCRIPTION Unit Measure TOTAL AMOUNT Unit Cost Total Price 0001. BREAD-WHOLE WHEAT-PAN,BAKED-SANDWICH SALIENT (B) 100% WHOLE GRAINS 3 GRAMS OF DIETARY FIBER PER SLICE AND WRAPPED, 1.5 LB/LOAF FG 4 (NSN:9020-00-753-5779) FOOD GROUP: 4 PKG: 1 PER (CONTRACT#), ECMS LINE ID 10334154 FOOD GROUP: 4 UN 2190 0002. ROLLS WHITE FRANKFURTER BUN-ENRICHED-PAN-BAKED-SOFT-SALIENT CHARACTERISTIC (B) SLICED-CID A-A-20053 1 1/2 TO 1 3/4 OZ. EA. 6" FG 4 (NSN:8920-000753-5769) FOOD GROUP: 4 PKG. 12 PER DZ. (CONTRACT#) FOOD GROUP: 4 EA 10 0003. ROLLS-WHEAT-HAMBURGER-SANDWICH-ENRICHED PAN BAKED-SOFT-SLICED-SALIENT CHARACTERISTICS 3 GRAMS OF DIETARY FIBER PER ROLL (C) CID A-A-2053 4" DIAMETER 1 1/2 TO 1 3/4 OZ. EA. PKG: 12 PER DZ. FOOD GROUP: 4 DZ 52 0004. ROLLS-KAISER-HEARTH BAKED 2 3/4 OZ. EA. 4-5" DIAMETER SLICED PG 4 (NSN: 8920-00-753-5770) FG 4 PKG: 12 PER DZ. (CONTRACT#) FOOD GROUP: 4 DZ 1825 0005. ROLL-WHEAT-SPLIT TOP ENRICHED PAN CHARACTERISTICS 2 GRAMS OF DIETARY FIBER PER ROLL (D) CID A-A-20071-1-1.13 OZ/EA FG 4 (NSN:8920-00-753-5775) FG 4 16 ROLLS PER 18 OZ. PKG. PG 1460 0006. BREAD-WHITE ENRICHED-PAN, BAKED-ROUND TOP SALIENT, CHARACTERISTICS A-SLICED & WRAPPED 1.00 LB. LOAF-CIDA-A-20052, PG 4 (NSN:8920-00-753-5576) FG 4, PKG. 1 PER EA. EA 3650 0007. BREAD TEXAS TOAST, SLICED 1" THICK, 14-15 SLICES PER LOAD (NSN:7310-99-999-9999) FG 4 PKG: 1 PER EA. FOOD GROUP 4 EA 730 Estimated Total for Option Year 2 $ _______________________________ Option Year 3, For the period of 1 OCTOBER, 2019 through 30 SEPTEMBER 2020 ITEM DESCRIPTION Unit Measure TOTAL AMOUNT Unit Cost Total Price 0001. BREAD-WHOLE WHEAT-PAN,BAKED-SANDWICH SALIENT (B) 100% WHOLE GRAINS 3 GRAMS OF DIETARY FIBER PER SLICE AND WRAPPED, 1.5 LB/LOAF FG 4 (NSN:9020-00-753-5779) FOOD GROUP: 4 PKG: 1 PER (CONTRACT#), ECMS LINE ID 10334154 FOOD GROUP: 4 UN 2190 0002. ROLLS WHITE FRANKFURTER BUN-ENRICHED-PAN-BAKED-SOFT-SALIENT CHARACTERISTIC (B) SLICED-CID A-A-20053 1 1/2 TO 1 3/4 OZ. EA. 6" FG 4 (NSN:8920-000753-5769) FOOD GROUP: 4 PKG. 12 PER DZ. (CONTRACT#) FOOD GROUP: 4 EA 10 0003. ROLLS-WHEAT-HAMBURGER-SANDWICH-ENRICHED PAN BAKED-SOFT-SLICED-SALIENT CHARACTERISTICS 3 GRAMS OF DIETARY FIBER PER ROLL (C) CID A-A-2053 4" DIAMETER 1 1/2 TO 1 3/4 OZ. EA. PKG: 12 PER DZ. FOOD GROUP: 4 DZ 52 0004. ROLLS-KAISER-HEARTH BAKED 2 3/4 OZ. EA. 4-5" DIAMETER SLICED PG 4 (NSN: 8920-00-753-5770) FG 4 PKG: 12 PER DZ. (CONTRACT#) FOOD GROUP: 4 DZ 1825 0005. ROLL-WHEAT-SPLIT TOP ENRICHED PAN CHARACTERISTICS 2 GRAMS OF DIETARY FIBER PER ROLL (D) CID A-A-20071-1-1.13 OZ/EA FG 4 (NSN:8920-00-753-5775) FG 4 16 ROLLS PER 18 OZ. PKG. PG 1460 0006. BREAD-WHITE ENRICHED-PAN, BAKED-ROUND TOP SALIENT, CHARACTERISTICS A-SLICED & WRAPPED 1.00 LB. LOAF-CIDA-A-20052, PG 4 (NSN:8920-00-753-5576) FG 4, PKG. 1 PER EA. EA 3650 0007. BREAD TEXAS TOAST, SLICED 1" THICK, 14-15 SLICES PER LOAD (NSN:7310-99-999-9999) FG 4 PKG: 1 PER EA. FOOD GROUP 4 EA 730 Estimated Total for Option Year 3 $ _______________________________ Option Year 4, For the period of 1 OCTOBER, 2020 through 30 SEPTEMBER 2021 ITEM DESCRIPTION Unit Measure TOTAL AMOUNT Unit Cost Total Price 0001. BREAD-WHOLE WHEAT-PAN,BAKED-SANDWICH SALIENT (B) 100% WHOLE GRAINS 3 GRAMS OF DIETARY FIBER PER SLICE AND WRAPPED, 1.5 LB/LOAF FG 4 (NSN:9020-00-753-5779) FOOD GROUP: 4 PKG: 1 PER (CONTRACT#), ECMS LINE ID 10334154 FOOD GROUP: 4 UN 2190 0002. ROLLS WHITE FRANKFURTER BUN-ENRICHED-PAN-BAKED-SOFT-SALIENT CHARACTERISTIC (B) SLICED-CID A-A-20053 1 1/2 TO 1 3/4 OZ. EA. 6" FG 4 (NSN:8920-000753-5769) FOOD GROUP: 4 PKG. 12 PER DZ. (CONTRACT#) FOOD GROUP: 4 EA 10 0003. ROLLS-WHEAT-HAMBURGER-SANDWICH-ENRICHED PAN BAKED-SOFT-SLICED-SALIENT CHARACTERISTICS 3 GRAMS OF DIETARY FIBER PER ROLL (C) CID A-A-2053 4" DIAMETER 1 1/2 TO 1 3/4 OZ. EA. PKG: 12 PER DZ. FOOD GROUP: 4 DZ 52 0004. ROLLS-KAISER-HEARTH BAKED 2 3/4 OZ. EA. 4-5" DIAMETER SLICED PG 4 (NSN: 8920-00-753-5770) FG 4 PKG: 12 PER DZ. (CONTRACT#) FOOD GROUP: 4 DZ 1825 0005. ROLL-WHEAT-SPLIT TOP ENRICHED PAN CHARACTERISTICS 2 GRAMS OF DIETARY FIBER PER ROLL (D) CID A-A-20071-1-1.13 OZ/EA FG 4 (NSN:8920-00-753-5775) FG 4 16 ROLLS PER 18 OZ. PKG. PG 1460 0006. BREAD-WHITE ENRICHED-PAN, BAKED-ROUND TOP SALIENT, CHARACTERISTICS A-SLICED & WRAPPED 1.00 LB. LOAF-CIDA-A-20052, PG 4 (NSN:8920-00-753-5576) FG 4, PKG. 1 PER EA. EA 3650 0007. BREAD TEXAS TOAST, SLICED 1" THICK, 14-15 SLICES PER LOAD (NSN:7310-99-999-9999) FG 4 PKG: 1 PER EA. FOOD GROUP 4 EA 730 Estimated Total for Option Year 4 $ ________________________________ Estimated Total for Base Year $ __________________________ Estimated Total for Option Year 1 $ _______________________ Estimated Total for Option Year 2 $ _______________________ Estimated Total for Option Year 3 $ _______________________ Estimated Total for Option Year 4 $ _______________________ Estimated Total Base Year and All Option Years Renewal Period (if exercised) $ ________________________________ Vendor's Information Vendor's Name: _____________________ Address: ____________________________ City: _______________________________ State: _______________________________ Zip code: ____________________________ DUNNS# ___________________________ Point of Contact: _____________________ Telephone: __________________________ Email: _____________________________ Government Contract: _________________

Preclinical PREVENT Cancer Program-Toxicology and Pharmacology Testing

Department of Health and Human Services, National Institutes of Health | Published January 5, 2015  -  Deadline January 20, 2015
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FEDERAL BUSINESS OPPORTUNTIES PRESOLICIATION NOTICE RFP - N01CN45009-45 Contracting Office Address Department of Health and Human Services, National Institutes of Health (NIH), National Cancer Institute (NCI), Office of Acquisitions, 8490 Progress Drive, Suite 400, Room 4041, Frederick, Maryland 21701. Note: This synopsis follows a Sources Sought notice that was released on July 24, 2014 under HHSN-NIH-NCI-SBSS-PCPSB-45009-45 Description The Division of Cancer Prevention (DCP) of the National Cancer Institute (NCI) is planning to award multiple contracts under the Preclinical PREVENT Cancer Program: Toxicology and Pharmacology Testing. These contracts will support the conduct of toxicological and pharmacological evaluations of potential cancer preventive agents for Investigational New Drug (IND) applications to the Food and Drug Administration (FDA) for phase 0, 1-3 clinical studies, New Drug Applications (NDA) to the FDA, and to selection appropriate first-in-human (FIH) doses. The contracts will require the Contractors to perform studies in four areas: genotoxicity testing; general toxicology in experimental animals; reproductive toxicology studies in rodents and rabbits; and, specialized studies. The Successful Contractor shall be able to perform work in these Task Areas as outlined in each Task Order: TASK AREA 1 -- GENOTOXICITY TESTING The Contractor shall determine the homogeneity, concentration, and stability of the test substance/ test substance mixture under the conditions of use, as defined in the Task Order Statement of Work (TO SOW). A. Bacterial reverse mutation test B. An in vitro test with cytogenetic evaluation of chromosomal damage with mammalian cells C. An in vivo test for chromosomal damage using mouse or rat hematopoietic cells D. Follow-up strategies for positive tests TASK AREA 2 -- GENERAL TOXICOLOGY IN EXPERIMENTAL ANIMALS The Contractor shall conduct studies in mice, rats and dogs. However, on rare occasions the Contractor shall use other species such as rabbits, guinea pigs, hamsters, monkeys or other animals that are deemed more appropriate due to the inherent nature of the chemopreventive agent. A. Fourteen-day dose ranging oral toxicity in rodents B. Twenty-eight day studies in rodents and dogs C. Ninety day, oral toxicity studies in rodents and dogs D. Six month rodent and nine month dog chronic toxicity studies E. Carcinogenicity studies in rodents TASK AREA 3 -- REPRODUCTIVE TOXICITY STUDIES IN RODENTS AND RABBITS The Contractor shall conduct studies in this Task Area using mice, rats and rabbits. However, the Contractor shall use other species when appropriate due to the inherent nature of the chemopreventive agent or a suggestion by the regulatory agencies, and could include guinea pigs, hamsters, monkeys or other animals. A. Segment ii teratogenicity studies B. Two generation reproduction studies in rodents TASK AREA 4 -- SPECIALIZED STUDIES The Contractor shall conduct studies in this Task Area using mice, rats, dogs, rabbits, guinea pigs, hamsters, monkeys or other appropriate species to evaluate drug-specific mechanisms of toxicity. Interspecies differences in drug metabolism, pharmacokinetics, and pharmacodynamics are well recognized and shall be considered in the development of protocols. A. Bioanalytical methodology studies B. Pharmacokinetic and pharmacokinetic-pharmacodynamic studies C. Pioavailability and bioequivalence studies D. Drug metabolism/drug interaction studies E. Specific safety studies F. Genomics/proteomics/metabolomics G. Computational (predictive) pharmacology/toxicology H. Vaccine development studies In addition to the Task Areas, the animal facility of the successful Contractor shall be accredited or registered as follows: 1. Animal Facility: a) Office of Laboratory Animal Welfare (OLAW) (http://grants.nih.gov/grants/olaw/olaw.htm), b) Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) http://www.aaalac.org/accreditation/. c) Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals (http://grants.nih.gov/grants/olaw/references/phspol.htm) and Guide for the Care and Use of Laboratory Animals http://www.nap.edu/catalog.php?version=b&utm_expid=4418042-5.krRTDpXJQISoXLpdo1Ynw.1&record_id=12910&utm_referrer=http%3A%2F%2Fgrants.nih.gov%2Fgrants%2Folaw%2Folaw.htm ) d) The United States Department of Agriculture (USDA). http://www.aphis.usda.gov/wps/portal/aphis/ourfocus/animalwelfare e) Institutional Animal Care and Use Committee (IACUC) The following Mandatory Qualification Criteria apply to this requirement: The qualification criterion establishes conditions that must be met at the time of receipt of Proposals by the Contracting Officer's Representative and the Contracting Officer, in order for your proposal to be considered any further for award. 1) Demonstration of compliance to perform studies in accordance with the Food and Drug Administration (FDA) Good Laboratory Practice Regulations (GLP) as published in the CFR Title 21, Part 58 and as updated. Compliance shall be documented with the two most recent FDA inspection reports. 2) Current Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) (or equivalent) accreditation. 3) National Regulatory Commission licensure for use of radioactive materials and presence of organizational unit monitoring safe use and disposal. 4) Documented participation of an American College of Laboratory Animal Medicine (ACLAM) certified veterinarian It is anticipated that multiple Indefinite Delivery Indefinite Quantity (IDIQ) type contracts will be awarded for a 3-year period of performance beginning on or about September 15, 2015. Request for Proposal Number RFP - N01CN45009-45 will be available on or about December 10, 2014, and may be accessed through the FedBizOpps website and the National Cancer Institute home page at http://rcb.cancer.gov/rcb-internet/index.jsp The NAICS Code is 541711. All responsible sources may submit a proposal which shall be considered by the agency. This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND ANY POSSIBLE AMENDMENTS. ALL INQUIRIES SHALL BE SUBMITTED ELECTRONICALLY TO THE CONTRACT SPECIALIST LISTED AS THE POINT OF CONTRACT HEREIN. Point of Contact Dawn Albertini, Contracting Officer, Phone (301) 624-8760 - Dawn.Albertini@nih.gov Alternate Point of Contact Tim Crilley, Contracting Officer, Team Lead, Phone (301) 624-8743 - Tcrilley@mail.nih.gov
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